LOCUS       NM_145580               1192 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus IGF-like family receptor 1 (Igflr1), mRNA.
ACCESSION   NM_145580
VERSION     NM_145580.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1192)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1192)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 1192)
  AUTHORS   Lobito,A.A., Ramani,S.R., Tom,I., Bazan,J.F., Luis,E.,
            Fairbrother,W.J., Ouyang,W. and Gonzalez,L.C.
  TITLE     Murine insulin growth factor-like (IGFL) and human IGFL1 proteins
            are induced in inflammatory skin conditions and bind to a novel
            tumor necrosis factor receptor family member, IGFLR1
  JOURNAL   J Biol Chem 286 (21), 18969-18981 (2011)
   PUBMED   21454693
  REMARK    GeneRIF: Murine insulin growth factor-like (IGFL) and human IGFL1
            proteins are induced in inflammatory skin conditions and bind to a
            novel tumor necrosis factor receptor family member, IGFLR1.
REFERENCE   4  (bases 1 to 1192)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 1192)
  AUTHORS   Heyd,F., ten Dam,G. and Moroy,T.
  TITLE     Auxiliary splice factor U2AF26 and transcription factor Gfi1
            cooperate directly in regulating CD45 alternative splicing
  JOURNAL   Nat Immunol 7 (8), 859-867 (2006)
   PUBMED   16819553
REFERENCE   6  (bases 1 to 1192)
  AUTHORS   Shepard,J., Reick,M., Olson,S. and Graveley,B.R.
  TITLE     Characterization of U2AF(6), a splicing factor related to U2AF(35)
  JOURNAL   Mol Cell Biol 22 (1), 221-230 (2002)
   PUBMED   11739736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167970.4, AW553050.2 and AI661657.1.
            
            On Nov 3, 2006 this sequence version replaced NM_145580.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154129.1, SRR5189670.184468.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC167970.4         54825-54864         c
            41-258              AC167970.4         53910-54127         c
            259-446             AC167970.4         53355-53542         c
            447-589             AC167970.4         53006-53148         c
            590-1002            AW553050.2         1-413               c
            1003-1192           AI661657.1         1-190               c
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.62 cM"
     gene            1..1192
                     /gene="Igflr1"
                     /gene_synonym="F630003I17Rik; Tmem149"
                     /note="IGF-like family receptor 1"
                     /db_xref="GeneID:101883"
                     /db_xref="MGI:MGI:3655979"
     exon            1..40
                     /gene="Igflr1"
                     /gene_synonym="F630003I17Rik; Tmem149"
                     /inference="alignment:Splign:2.1.0"
     exon            41..258
                     /gene="Igflr1"
                     /gene_synonym="F630003I17Rik; Tmem149"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1130
                     /gene="Igflr1"
                     /gene_synonym="F630003I17Rik; Tmem149"
                     /note="U2 small nuclear RNA auxiliary factor 1-like 4;
                     transmembrane protein 149"
                     /codon_start=1
                     /product="IGF-like family receptor 1 precursor"
                     /protein_id="NP_663555.2"
                     /db_xref="CCDS:CCDS39886.1"
                     /db_xref="GeneID:101883"
                     /db_xref="MGI:MGI:3655979"
                     /translation="MGPSWLLWTVAVAVLLLTRAASMEASSFCGHLEYWNSDKRCCSR
                     CLQRFGPPACPDHEFTENCGLNDFGDTVAHPFKKCSPGYCNPNGTELCSQCSSGAAAA
                     PAHVESPGRTHKQCRKKPVPPKDVCPLKPEDAGASSSPGRWSLGQTTKNEVSSRPGFV
                     SASVLPLAVLPLLLVLLLILAVVLLSLFKRKVRSRPGSSSAFGDPSTSLHYWPCPGTL
                     EVLESRNRGKANLLQLSSWELQGLASQPLSLLLDELEVLEELIMLLDPEPGPSGSTAY
                     GTTRHLAARYGLPATWSTFAYSLRPSRSPLRALIEMVVAREPSATLGQFGTYLAQLGR
                     TDALQVLSKLG"
     exon            259..446
                     /gene="Igflr1"
                     /gene_synonym="F630003I17Rik; Tmem149"
                     /inference="alignment:Splign:2.1.0"
     exon            447..804
                     /gene="Igflr1"
                     /gene_synonym="F630003I17Rik; Tmem149"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1186
                     /gene="Igflr1"
                     /gene_synonym="F630003I17Rik; Tmem149"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1162..1167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igflr1"
                     /gene_synonym="F630003I17Rik; Tmem149"
                     /note="hexamer: AATAAA"
     polyA_site      1184
                     /gene="Igflr1"
                     /gene_synonym="F630003I17Rik; Tmem149"
                     /note="major polyA site"
ORIGIN      
        1 agaggaactt ggagccagct tggggtctgg gtctgcactg aaacagtgtg ggtggaagtg
       61 gtcacagccc tcaagctgca ggctctgctg agatggggcc cagctggctt ctctggacag
      121 tggcggtggc agtgctgctc ctgacccggg ctgcgtcaat ggaagcctct agcttctgtg
      181 gccaccttga gtactggaac tctgacaaga ggtgctgcag ccgctgcctg caacgctttg
      241 ggcctcctgc atgtcctgat cacgagttca cggaaaactg cgggctcaat gacttcggcg
      301 atactgtagc acatcctttc aaaaagtgtt cccctgggta ttgcaacccc aatggcacag
      361 agctgtgtag ccagtgtagc agcggagccg ccgcagcccc agctcacgtg gagagccctg
      421 gtagaaccca caagcagtgt agaaagaagc ccgtccctcc caaggatgtc tgtcctctta
      481 aacctgaaga cgcaggtgcc tctagctcac ctgggaggtg gagccttggg cagacaacca
      541 agaatgaggt ctccagccga ccaggttttg tctcagcctc agtgctgcct ctggcagtgt
      601 tgccactgtt gctggtgctg cttctgatat tggcagtggt cttgctctct ttgttcaaga
      661 gaaaagtccg ttcccgtcct ggttccagct cagcttttgg agatcccagc acctctctac
      721 attactggcc ctgcccaggt accctggagg tattggaaag tagaaacaga gggaaagcta
      781 atctgctgca gctctcaagc tgggagcttc agggtctggc ctctcagccc ctctccctcc
      841 tgctggatga gctggaagtt ctggaggagc tgattatgct attggaccct gagcctgggc
      901 cgagcgggag cacggcttat ggtaccacac gacacctggc tgcaagatac gggctgcctg
      961 ccacctggtc taccttcgcc tactcacttc ggcccagtcg ctcacccctg cgggccctga
     1021 ttgagatggt tgtggcaagg gagccttctg ctactctggg tcaattcggc acatatttgg
     1081 ctcagctagg tcgcacagat gctctgcagg tgctatctaa acttggctga gtcagagttt
     1141 gctggggctt actactccat caataaagtt tcccttgaag ccagtaaaaa aa
//
