LOCUS       NM_001003393             575 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus IGF-like family member 3 (Igfl3), mRNA.
ACCESSION   NM_001003393 XM_149891
VERSION     NM_001003393.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 575)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 575)
  AUTHORS   Kim,C., Kwak,W., Won,D.H., Kim,J., Hwang,D.B., Kim,N., Kang,M.,
            Jeon,Y., Park,Y.I., Park,J.W. and Yun,J.W.
  TITLE     Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through
            regulation of the Igfl-MAPK pathway axis
  JOURNAL   Cell Biol Toxicol 39 (6), 3197-3217 (2023)
   PUBMED   37603122
  REMARK    GeneRIF: Loss of Dact2 alleviates cisplatin-induced nephrotoxicity
            through regulation of the Igfl-MAPK pathway axis.
REFERENCE   3  (bases 1 to 575)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 575)
  AUTHORS   Lobito,A.A., Ramani,S.R., Tom,I., Bazan,J.F., Luis,E.,
            Fairbrother,W.J., Ouyang,W. and Gonzalez,L.C.
  TITLE     Murine insulin growth factor-like (IGFL) and human IGFL1 proteins
            are induced in inflammatory skin conditions and bind to a novel
            tumor necrosis factor receptor family member, IGFLR1
  JOURNAL   J Biol Chem 286 (21), 18969-18981 (2011)
   PUBMED   21454693
  REMARK    GeneRIF: Murine insulin growth factor-like (IGFL) and human IGFL1
            proteins are induced in inflammatory skin conditions and bind to a
            novel tumor necrosis factor receptor family member, IGFLR1.
REFERENCE   5  (bases 1 to 575)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 575)
  AUTHORS   Emtage,P., Vatta,P., Arterburn,M., Muller,M.W., Park,E., Boyle,B.,
            Hazell,S., Polizotto,R., Funk,W.D. and Tang,Y.T.
  TITLE     IGFL: A secreted family with conserved cysteine residues and
            similarities to the IGF superfamily
  JOURNAL   Genomics 88 (4), 513-520 (2006)
   PUBMED   16890402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY672115.1.
            
            On Sep 3, 2004 this sequence version replaced XM_149891.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY672115.1, AA760247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..575
                     /gene="Igfl3"
                     /gene_synonym="Gm580; Igfl; Rprc483"
                     /note="IGF-like family member 3"
                     /db_xref="GeneID:232925"
                     /db_xref="MGI:MGI:2685426"
     exon            1..52
                     /gene="Igfl3"
                     /gene_synonym="Gm580; Igfl; Rprc483"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..456
                     /gene="Igfl3"
                     /gene_synonym="Gm580; Igfl; Rprc483"
                     /note="insulin growth factor-like family member"
                     /codon_start=1
                     /product="insulin growth factor-like family member
                     precursor"
                     /protein_id="NP_001003393.1"
                     /db_xref="CCDS:CCDS52049.1"
                     /db_xref="GeneID:232925"
                     /db_xref="MGI:MGI:2685426"
                     /translation="MKIRNACAVLIEVLLFILEGVTGARKISTFSGPGSWPCNPKCDG
                     RTYNPSEECCVHDTILPFKRINLCGPSCTYRPCFELCCPESYSPKKKFIVKLKVHGER
                     SHCSSSPISRNCKSNKIFHGEDIEDNQLSLRKKSGDQP"
     exon            53..380
                     /gene="Igfl3"
                     /gene_synonym="Gm580; Igfl; Rprc483"
                     /inference="alignment:Splign:2.1.0"
     exon            381..450
                     /gene="Igfl3"
                     /gene_synonym="Gm580; Igfl; Rprc483"
                     /inference="alignment:Splign:2.1.0"
     exon            451..575
                     /gene="Igfl3"
                     /gene_synonym="Gm580; Igfl; Rprc483"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccacttac aaccacacag cctatccaga aacatgaaga taagaaatgc ttgtgctgtc
       61 cttattgaag tactcctgtt tatacttgaa ggagttacag gagctcgaaa aatttcaact
      121 ttctcaggcc ctggctcatg gccgtgcaat cccaagtgtg atggcagaac ttacaacccc
      181 tcagaggagt gttgtgttca tgacaccatc ctgcccttta agcggattaa cctctgtggc
      241 cctagctgca cctacaggcc ctgctttgag ctctgctgtc ctgagtccta tagccccaag
      301 aagaaattta ttgtcaagct taaagttcat ggagagagat cccattgcag ttcatcccct
      361 atctccagga actgtaaaag caacaagatt tttcatggag aagatattga agacaaccaa
      421 ctttctctta ggaaaaaaag tggtgaccag ccttgagagt ctgctttctt cctgcaagca
      481 ccagttcctg aatgttctta cttgaagaat ggatacctga agcattgggg tgcagtgata
      541 tatgtgtctc attacaatgc tcctttggat attgt
//
