LOCUS       NM_018741               2729 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus insulin-like growth factor binding protein-like 1
            (Igfbpl1), mRNA.
ACCESSION   NM_018741
VERSION     NM_018741.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2729)
  AUTHORS   Pan,L., Cho,K.S., Wei,X., Xu,F., Lennikov,A., Hu,G., Tang,J.,
            Guo,S., Chen,J., Kriukov,E., Kyle,R., Elzaridi,F., Jiang,S.,
            Dromel,P.A., Young,M., Baranov,P., Do,C.W., Williams,R.W., Chen,J.,
            Lu,L. and Chen,D.F.
  TITLE     IGFBPL1 is a master driver of microglia homeostasis and resolution
            of neuroinflammation in glaucoma and brain tauopathy
  JOURNAL   Cell Rep 42 (8), 112889 (2023)
   PUBMED   37527036
REFERENCE   2  (bases 1 to 2729)
  AUTHORS   Butti,E., Cattaneo,S., Bacigaluppi,M., Cambiaghi,M., Scotti,G.M.,
            Brambilla,E., Ruffini,F., Sferruzza,G., Ripamonti,M., Simeoni,F.,
            Cacciaguerra,L., Zanghi,A., Quattrini,A., Fesce,R.,
            Panina-Bordignon,P., Giannese,F., Cittaro,D., Kuhlmann,T.,
            D'Adamo,P., Rocca,M.A., Taverna,S. and Martino,G.
  TITLE     Neural precursor cells tune striatal connectivity through the
            release of IGFBPL1
  JOURNAL   Nat Commun 13 (1), 7579 (2022)
   PUBMED   36482070
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2729)
  AUTHORS   Petitpre,C., Faure,L., Uhl,P., Fontanet,P., Filova,I.,
            Pavlinkova,G., Adameyko,I., Hadjab,S. and Lallemend,F.
  TITLE     Single-cell RNA-sequencing analysis of the developing mouse inner
            ear identifies molecular logic of auditory neuron diversification
  JOURNAL   Nat Commun 13 (1), 3878 (2022)
   PUBMED   35790771
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2729)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2729)
  AUTHORS   Li,J., Sun,L., Peng,X.L., Yu,X.M., Qi,S.J., Lu,Z.J., Han,J.J. and
            Shen,Q.
  TITLE     Integrative genomic analysis of early neurogenesis reveals a
            temporal genetic program for differentiation and specification of
            preplate and Cajal-Retzius neurons
  JOURNAL   PLoS Genet 17 (3), e1009355 (2021)
   PUBMED   33760820
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2729)
  AUTHORS   Abramova,N., Charniga,C., Goderie,S.K. and Temple,S.
  TITLE     Stage-specific changes in gene expression in acutely isolated mouse
            CNS progenitor cells
  JOURNAL   Dev Biol 283 (2), 269-281 (2005)
   PUBMED   15890332
REFERENCE   7  (bases 1 to 2729)
  AUTHORS   Ferguson,D.A., Chiang,J.T., Richardson,J.A. and Graff,J.
  TITLE     eXPRESSION: an in silico tool to predict patterns of gene
            expression
  JOURNAL   Gene Expr Patterns 5 (5), 619-628 (2005)
   PUBMED   15939374
REFERENCE   8  (bases 1 to 2729)
  AUTHORS   Srivastava,A.K., Kapur,S., Mohan,S., Yu,H., Kapur,S., Wergedal,J.
            and Baylink,D.J.
  TITLE     Identification of novel genetic loci for bone size and
            mechanosensitivity in an ENU mutant exhibiting decreased bone size
  JOURNAL   J Bone Miner Res 20 (6), 1041-1050 (2005)
   PUBMED   15883645
REFERENCE   9  (bases 1 to 2729)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   10 (bases 1 to 2729)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012705.1, AB006141.1, AW457842.1 and BY755041.1.
            
            On Apr 11, 2007 this sequence version replaced NM_018741.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006141.1, AK012705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK012705.1         2-13
            13-2219             AB006141.1         1-2207
            2220-2474           AW457842.1         18-272              c
            2475-2729           BY755041.1         447-701
FEATURES             Location/Qualifiers
     source          1..2729
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.36 cM"
     gene            1..2729
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
                     /note="insulin-like growth factor binding protein-like 1"
                     /db_xref="GeneID:75426"
                     /db_xref="MGI:MGI:1933198"
     exon            1..470
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..847
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
                     /note="IGFBP-rP4; IGFBP-related protein 10; insulin-like
                     growth factor-binding-related protein 4; IGFBP-like
                     protein"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein-like
                     1 precursor"
                     /protein_id="NP_061211.1"
                     /db_xref="CCDS:CCDS38756.1"
                     /db_xref="GeneID:75426"
                     /db_xref="MGI:MGI:1933198"
                     /translation="MPRLPLLLLLLPSLARGLGLRDAGRRHPECSPCQQDRCPAPSPC
                     PAPWISARDECGCCARCLGAEGASCGGPVGSRCGPGLVCASRASGTAPEGTGLCVCAQ
                     RGAVCGSDGRSYSSICALRLRARHAPRAHHGHLHKARDGPCEFAPVVLMPPRDIHNVT
                     GTQVFLSCEVKAVPTPVITWKKVKHSPEGTEGLEELPGDHVNIAVQVRGGPSDHETTS
                     WILINPLRKEDEGVYHCHAANAIGEAQSHGTVTVLDLNRYKSLYSSVPGDLL"
     exon            471..580
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
                     /inference="alignment:Splign:2.1.0"
     exon            581..697
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
                     /inference="alignment:Splign:2.1.0"
     exon            698..855
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
                     /inference="alignment:Splign:2.1.0"
     exon            856..2729
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1162..1167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
                     /note="hexamer: AACAAG"
     polyA_site      1189
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
                     /note="major polyA site"
     regulatory      2454..2459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
                     /note="hexamer: AGTAAA"
     polyA_site      2473
                     /gene="Igfbpl1"
                     /gene_synonym="2810011G06Rik; 2810453O06Rik; IGFBPL"
ORIGIN      
        1 agaggcgctg ctgccgtccg tctgggagcc ggccatgccg cgtctgccgc tgctgctcct
       61 gctcctgcca tcactggccc ggggtctcgg gctccgcgac gcgggtagac gacaccccga
      121 gtgcagcccg tgccagcagg atcgctgccc tgcgccctcg ccttgcccag cgccctggat
      181 ctccgcgcgc gacgagtgcg gctgctgcgc gcgctgcctg ggcgccgagg gcgcgagttg
      241 cgggggaccc gtgggctcac gctgtggccc tggcctggtg tgtgcgagtc gcgcctcggg
      301 gacggcgccc gagggcaccg ggctttgcgt gtgcgcgcaa cgcggcgccg tctgcggctc
      361 tgacggccgc tcctactcca gcatctgcgc gctacgtctg cgcgcccgac atgcaccccg
      421 cgcgcaccat ggccacctgc acaaggctcg cgatgggccc tgcgagttcg ctcccgtggt
      481 cctcatgccc cctcgagata ttcacaatgt cactgggact caagtattcc tttcctgtga
      541 ggtgaaggct gtgcccaccc cggtcatcac ctggaagaag gtcaagcact ctccagaggg
      601 caccgagggg ttggaggagt tgcccggaga ccatgtcaat atagctgtcc aggtgcgagg
      661 gggcccttct gaccatgaga ccacatcctg gattttgatc aaccctctga ggaaggaaga
      721 tgagggagtg taccactgcc acgcagccaa cgccattgga gaggctcagt cccacggcac
      781 ggtgacggtc ctcgatctga acagatacaa aagcctctac tcctcagttc cgggtgacct
      841 cctgtgacga acgtggcttc cagagacact tgtcacaaga cgatgatgat caaggaatgg
      901 atcattttgc tctgtgaaat tttggggaga ctgcctgtag atggctgctt ttgtatgttt
      961 tttttaaggg aatgcaaact agattcttat gcagatgtag tttttagcag ggcagacctt
     1021 ggggtggggg tggaggggat ggtcgtgcat gcagcttttt tacacttttg gagtgaatca
     1081 ggttttttag aacaattctt ttttaactct tctgtccaag aaaggccaca cactgtctgt
     1141 ttgtaattct aaagggctca aaacaaggca caggccagct gactcgtgac ttggtgtctg
     1201 taactgctta gtgggtgctc tgatttggtg cgtgttatga agggaggggg tccctgtacc
     1261 cctatccttg gagactggga tgggtgtttt tccttctctg tagcccaacc caccaagggt
     1321 gagatggcca gatggccctc ctagagtgag atggccctgg gggaactagc gcccacctag
     1381 agtgtgatgg ccctatagcc aacctagagt gagatagccc tgggaaacta taaccctggc
     1441 attcttttta aaaacatcac cttgcatgaa cagctcaggt ggctcttctg ttcctacctt
     1501 ctccctgtga caaggagctc tagctgtagg tgggacccat tggccagctg tgcacctgct
     1561 aacctagcac tctcccaaca gataaacagg agacacctga cctttactgg agacaggaca
     1621 ccaggtgtca tccgtaggtg gtggaatcac actgcagcac ggtgcatttg ttcttacccg
     1681 ggcagaaggc tgtcctccct gccttaatgg ggaaagttaa acaggagaat atcagctttc
     1741 tgaaaagcag gttcctgccc tctccccgct tttaggtttg gttttgtttt tgcttttgtt
     1801 ttttgagaca gggtttcact gtatatccct ggctgccctg gaactcactc tatagaccca
     1861 gctgacctca gctcacagga taactacctg cctctgttcc caaagtgctg ggattaaagg
     1921 tgtgtgcccg gctgactgca ggttcttaac atctgggttg gagtccctca gtgtgaccag
     1981 acctgaaagt tcacgaggca ctgtcccatc catcagccca gccatggctg gaagatcagg
     2041 gatttttgcc ttcccagtct ccactgagca ggctcaggga ggaggtgccc tgcccgtgtg
     2101 aaggccttag agcaggacag aactgagagc tgcctccctg cctcccttga cccagaatga
     2161 ccctgaacta gggagaggag atgttccacc cccacctggt cctaagcaca tctcggcctc
     2221 tggtcccagt tgctgctcat ggctgccatt gtgtattgga gttctcactc aaactgaact
     2281 ttcttccttt aaccctagca gatctgagtc tgaaatgcta ggatgtggtc gccccctgtg
     2341 tactgcacac gctgagggag acaagcctga gaatctggaa ctcagtgccc aggggcatat
     2401 tcactgtatg accctgggca agtccccttc ccttgtgggc ctctgtgtcc tcaagtaaat
     2461 atgttgaaag cctttctctg tgtataaaat cagaaatggg gatgccttag ttagggtttt
     2521 acagttctga acagacacgg tgaccaaggc aactcttaaa aaaccaacaa caacaacaac
     2581 aacacgtaat tgggtctggc tcacagaact gcccggatgc aggaggcccc agtggaagtg
     2641 ctgagacctt ctggggctgg gttgtgtgtc acacttatga gtgtcatggg taaacaatgt
     2701 gtgatgcatt gtctgaaatg ttcaccaat
//
