LOCUS       NM_008048               1115 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus insulin-like growth factor binding protein 7 (Igfbp7),
            transcript variant 2, mRNA.
ACCESSION   NM_008048
VERSION     NM_008048.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1115)
  AUTHORS   He,R., Feng,B., Zhang,Y., Li,Y., Wang,D. and Yu,L.
  TITLE     IGFBP7 promotes endothelial cell repair in the recovery phase of
            acute lung injury
  JOURNAL   Clin Sci (Lond) 138 (13), 797-815 (2024)
   PUBMED   38840498
  REMARK    GeneRIF: IGFBP7 promotes endothelial cell repair in the recovery
            phase of acute lung injury.
REFERENCE   2  (bases 1 to 1115)
  AUTHORS   Xu,Y., Sun,Y., Zhu,Y. and Song,G.
  TITLE     Structural insight into CD93 recognition by IGFBP7
  JOURNAL   Structure 32 (3), 282-291 (2024)
   PUBMED   38218180
  REMARK    GeneRIF: Structural insight into CD93 recognition by IGFBP7.
REFERENCE   3  (bases 1 to 1115)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1115)
  AUTHORS   Tang,Y., Hong,F., Ding,S., Yang,J., Zhang,M., Ma,Y., Zheng,Q.,
            Yang,D., Jin,Y. and Ma,C.
  TITLE     METTL3-mediated m6A modification of IGFBP7-OT promotes
            osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7
            axis
  JOURNAL   Cell Rep 42 (6), 112589 (2023)
   PUBMED   37270777
  REMARK    GeneRIF: METTL3-mediated m[6]A modification of IGFBP7-OT promotes
            osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7
            axis.
REFERENCE   5  (bases 1 to 1115)
  AUTHORS   Martinez,M.E., Pinz,I., Preda,M., Norton,C.R., Gridley,T. and
            Hernandez,A.
  TITLE     DIO3 protects against thyrotoxicosis-derived cranio-encephalic and
            cardiac congenital abnormalities
  JOURNAL   JCI Insight 7 (21), e161214 (2022)
   PUBMED   36166296
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1115)
  AUTHORS   Kanemitsu,N., Kato,M.V., Miki,T., Komatsu,S., Okazaki,Y.,
            Hayashizaki,Y. and Sakai,T.
  TITLE     Characterization of the promoter of the murine mac25 gene
  JOURNAL   Biochem Biophys Res Commun 279 (1), 251-257 (2000)
   PUBMED   11112448
REFERENCE   7  (bases 1 to 1115)
  AUTHORS   Degeorges,A., Wang,F., Frierson,H.F. Jr., Seth,A. and Sikes,R.A.
  TITLE     Distribution of IGFBP-rP1 in normal human tissues
  JOURNAL   J Histochem Cytochem 48 (6), 747-754 (2000)
   PUBMED   10820148
REFERENCE   8  (bases 1 to 1115)
  AUTHORS   Kato,M.V.
  TITLE     A secreted tumor-suppressor, mac25, with activin-binding activity
  JOURNAL   Mol Med 6 (2), 126-135 (2000)
   PUBMED   10859029
REFERENCE   9  (bases 1 to 1115)
  AUTHORS   Komatsu,S., Okazaki,Y., Tateno,M., Kawai,J., Konno,H., Kusakabe,M.,
            Yoshiki,A., Muramatsu,M., Held,W.A. and Hayashizaki,Y.
  TITLE     Methylation and downregulated expression of mac25/insulin-like
            growth factor binding protein-7 is associated with liver
            tumorigenesis in SV40T/t antigen transgenic mice, screened by
            restriction landmark genomic scanning for methylation (RLGS-M)
  JOURNAL   Biochem Biophys Res Commun 267 (1), 109-117 (2000)
   PUBMED   10623583
REFERENCE   10 (bases 1 to 1115)
  AUTHORS   Kato,M.V., Sato,H., Tsukada,T., Ikawa,Y., Aizawa,S. and
            Nagayoshi,M.
  TITLE     A follistatin-like gene, mac25, may act as a growth suppressor of
            osteosarcoma cells
  JOURNAL   Oncogene 12 (6), 1361-1364 (1996)
   PUBMED   8649839
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122396.4 and AC141469.4.
            
            On Jul 29, 2021 this sequence version replaced NM_008048.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1, resulting
            in an isoform (2) that is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092538.1, AB012886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               AC122396.4         131977-132482
            507-616             AC141469.4         162774-162883       c
            617-733             AC141469.4         159125-159241       c
            734-860             AC141469.4         158440-158566       c
            861-1115            AC141469.4         156457-156711       c
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 41.71 cM"
     gene            1..1115
                     /gene="Igfbp7"
                     /gene_synonym="AGM; Fstl2; Mac25"
                     /note="insulin-like growth factor binding protein 7"
                     /db_xref="GeneID:29817"
                     /db_xref="MGI:MGI:1352480"
     exon            1..506
                     /gene="Igfbp7"
                     /gene_synonym="AGM; Fstl2; Mac25"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..880
                     /gene="Igfbp7"
                     /gene_synonym="AGM; Fstl2; Mac25"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; angiomodulin; IBP-7; IGFBP-7; IGF-binding
                     protein 7"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 7
                     isoform 2 precursor"
                     /protein_id="NP_032074.4"
                     /db_xref="CCDS:CCDS51529.1"
                     /db_xref="GeneID:29817"
                     /db_xref="MGI:MGI:1352480"
                     /translation="MERPPRALLLGAAGLLLLLLPLSSSSSSDACGPCVPASCPALPR
                     LGCPLGETRDACGCCPVCARGEGEPCGGGAAGRGHCAPGMECVKSRKRRKGKAGAAAG
                     GPATLAVCVCKSRYPVCGSNGITYPSGCQLRAASLRAESRGEKAITQVSKGTCEQGPS
                     IVTPPKDIWNVTGAKVFLSCEVIGIPTPVLIWNKVKRDHSGVQRTELLPGDRENLAIQ
                     TRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASAAAKITVVDALHEIPLKKG
                     EGAQL"
     exon            507..616
                     /gene="Igfbp7"
                     /gene_synonym="AGM; Fstl2; Mac25"
                     /inference="alignment:Splign:2.1.0"
     exon            617..733
                     /gene="Igfbp7"
                     /gene_synonym="AGM; Fstl2; Mac25"
                     /inference="alignment:Splign:2.1.0"
     exon            734..860
                     /gene="Igfbp7"
                     /gene_synonym="AGM; Fstl2; Mac25"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1115
                     /gene="Igfbp7"
                     /gene_synonym="AGM; Fstl2; Mac25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1095..1100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igfbp7"
                     /gene_synonym="AGM; Fstl2; Mac25"
                     /note="hexamer: AATAAA"
     polyA_site      1115
                     /gene="Igfbp7"
                     /gene_synonym="AGM; Fstl2; Mac25"
                     /note="major polyA site"
ORIGIN      
        1 gctcactcgc gcgctcgcat ccagccacct tatgatggag cggccgccgc gcgccctgct
       61 gctgggtgca gccggactgc tgctcctgct cctgcccctc tcctcttcct cctcttcgga
      121 tgcctgcggc ccgtgcgtgc cggcctcctg ccccgcgctg ccccggctcg gctgcccgct
      181 gggtgagacc cgcgacgcgt gcgggtgctg cccggtgtgt gctcgcggcg agggtgagcc
      241 gtgcgggggc ggcgcggccg gcagggggca ctgcgcgccg ggcatggagt gcgtgaagag
      301 ccgcaagagg cggaagggta aagccggggc agcagccggc ggtcccgcga ccctcgccgt
      361 gtgcgtgtgc aagagccgct acccggtgtg cggcagcaac ggcatcacct accccagcgg
      421 ctgccagctg cgcgctgcca gcctgcgcgc cgagagccgc ggggagaagg ccatcaccca
      481 ggtcagcaag ggcacctgcg agcaaggtcc ttccatagtg acgcccccca aggacatctg
      541 gaacgtcact ggtgccaagg tgttcttgag ctgtgaggtc atcgggatcc caacccctgt
      601 cctcatctgg aacaaggtaa aaagggatca ctctggagtt cagcggacag aactcttgcc
      661 tggtgaccgg gaaaatctgg ccattcagac ccggggtggt ccagaaaagc atgaagtaac
      721 gggctgggtg ctggtatctc ctctaagtaa ggaggacgct ggagagtatg agtgccacgc
      781 atccaactcc caagggcagg cttccgcggc agccaaaatt acagtggttg atgccctcca
      841 tgaaatacca ctgaaaaaag gtgaaggtgc tcagttataa cctgcgaatc catgagcctc
      901 tgtagctaaa ggtgctctca gacagccgac agctataacc ctgctcttgc ctgacacact
      961 tctcttaacc taacccacta acactttatt acagccagct ggttttacac agagaaatca
     1021 aagataacac atcaagacta tctacaaaaa tttattattt acagaaaaaa gcacatgtag
     1081 ctttaaacaa aacaaataaa attcttatca caaca
//
