LOCUS       NM_008344               1305 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus insulin-like growth factor binding protein 6 (Igfbp6),
            mRNA.
ACCESSION   NM_008344
VERSION     NM_008344.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1305)
  AUTHORS   Kheirollahi,V., Khadim,A., Kiliaris,G., Korfei,M., Barroso,M.M.,
            Alexopoulos,I., Vazquez-Armendariz,A.I., Wygrecka,M., Ruppert,C.,
            Guenther,A., Seeger,W., Herold,S. and El Agha,E.
  TITLE     Transcriptional Profiling of Insulin-like Growth Factor Signaling
            Components in Embryonic Lung Development and Idiopathic Pulmonary
            Fibrosis
  JOURNAL   Cells 11 (12), 1973 (2022)
   PUBMED   35741102
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1305)
  AUTHORS   Combes,A.N., Phipson,B., Lawlor,K.T., Dorison,A., Patrick,R.,
            Zappia,L., Harvey,R.P., Oshlack,A. and Little,M.H.
  TITLE     Single cell analysis of the developing mouse kidney provides deeper
            insight into marker gene expression and ligand-receptor crosstalk
  JOURNAL   Development 146 (12) (2019)
   PUBMED   31118232
  REMARK    Erratum:[Development. 2019 Jul 11;146(13):dev182162. doi:
            10.1242/dev.182162.. PMID: 31296520]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1305)
  AUTHORS   Junnila,R.K., Duran-Ortiz,S., Suer,O., Sustarsic,E.G.,
            Berryman,D.E., List,E.O. and Kopchick,J.J.
  TITLE     Disruption of the GH Receptor Gene in Adult Mice Increases Maximal
            Lifespan in Females
  JOURNAL   Endocrinology 157 (12), 4502-4513 (2016)
   PUBMED   27732088
REFERENCE   4  (bases 1 to 1305)
  AUTHORS   Lopez,I.P., Pineiro-Hermida,S., Pais,R.S., Torrens,R., Hoeflich,A.
            and Pichel,J.G.
  TITLE     Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role
            during Repair Kinetics after Selective Club Cell Ablation
  JOURNAL   PLoS One 11 (11), e0166388 (2016)
   PUBMED   27861515
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1305)
  AUTHORS   Marongiu,M., Marcia,L., Pelosi,E., Lovicu,M., Deiana,M., Zhang,Y.,
            Puddu,A., Loi,A., Uda,M., Forabosco,A., Schlessinger,D. and
            Crisponi,L.
  TITLE     FOXL2 modulates cartilage, skeletal development and IGF1-dependent
            growth in mice
  JOURNAL   BMC Dev Biol 15, 27 (2015)
   PUBMED   26134413
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1305)
  AUTHORS   Wang,E., Wang,J., Chin,E., Zhou,J. and Bondy,C.A.
  TITLE     Cellular patterns of insulin-like growth factor system gene
            expression in murine chondrogenesis and osteogenesis
  JOURNAL   Endocrinology 136 (6), 2741-2751 (1995)
   PUBMED   7750499
REFERENCE   7  (bases 1 to 1305)
  AUTHORS   Schuller,A.G., Groffen,C., van Neck,J.W., Zwarthoff,E.C. and
            Drop,S.L.
  TITLE     cDNA cloning and mRNA expression of the six mouse insulin-like
            growth factor binding proteins
  JOURNAL   Mol Cell Endocrinol 104 (1), 57-66 (1994)
   PUBMED   7529732
REFERENCE   8  (bases 1 to 1305)
  AUTHORS   Hahnel,A. and Schultz,G.A.
  TITLE     Insulin-like growth factor binding proteins are transcribed by
            preimplantation mouse embryos
  JOURNAL   Endocrinology 134 (4), 1956-1959 (1994)
   PUBMED   7511095
REFERENCE   9  (bases 1 to 1305)
  AUTHORS   Cerro,J.A., Grewal,A., Wood,T.L. and Pintar,J.E.
  TITLE     Tissue-specific expression of the insulin-like growth factor
            binding protein (IGFBP) mRNAs in mouse and rat development
  JOURNAL   Regul Pept 48 (1-2), 189-198 (1993)
   PUBMED   7505465
REFERENCE   10 (bases 1 to 1305)
  AUTHORS   Schuller,A.G., Zwarthoff,E.C. and Drop,S.L.
  TITLE     Gene expression of the six insulin-like growth factor binding
            proteins in the mouse conceptus during mid- and late gestation
  JOURNAL   Endocrinology 132 (6), 2544-2550 (1993)
   PUBMED   7684980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ828082.1, AK157982.1 and AW123368.1.
            
            On Feb 23, 2008 this sequence version replaced NM_008344.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X81584.1, SRR1660821.194336.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               BQ828082.1         1-320
            321-1005            AK157982.1         4-688
            1006-1305           AW123368.1         1-300               c
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.32 cM"
     gene            1..1305
                     /gene="Igfbp6"
                     /gene_synonym="IGFBP-6"
                     /note="insulin-like growth factor binding protein 6"
                     /db_xref="GeneID:16012"
                     /db_xref="MGI:MGI:96441"
     exon            1..699
                     /gene="Igfbp6"
                     /gene_synonym="IGFBP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            700..833
                     /gene="Igfbp6"
                     /gene_synonym="IGFBP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            834..956
                     /gene="Igfbp6"
                     /gene_synonym="IGFBP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1289
                     /gene="Igfbp6"
                     /gene_synonym="IGFBP-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1256..1261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igfbp6"
                     /gene_synonym="IGFBP-6"
                     /note="hexamer: AATAAA"
     polyA_site      1289
                     /gene="Igfbp6"
                     /gene_synonym="IGFBP-6"
                     /note="major polyA site"
ORIGIN      
        1 catgctaact ggatttcacg gttcaccttc tctgtcctcc cctttactcc tccctactcc
       61 acaatccctt tagccagatg tacagctccc aaattccggg cgagattccc aggaacaaag
      121 caagaaaaaa acatcagaac aatttgggaa gtaaacagcg gcggagaaga agggagggaa
      181 aagccgggtg gacccaggtg ggtggccctc cagtccaccc agttaaggga ctgccttttt
      241 cccctccccc ttcacctggc ttttaagggg ccgggcccag acctctgctt cttaaagagg
      301 agcccgcagc agcagctgca ctggactctc tggaaggagt gtacagggca aaaactctga
      361 ccatgacctg ggatgggctg cccacgcagc cgctgctcat gctgctaatg ctgttgttcg
      421 ctgcgggctc agggtccgcc ttagcggggt gccccggctg cggcgctggg atgcagactg
      481 gttgtcgcgg gggctgcgtg gaggaggaag acgcgggatc gcctgcagac ggctgtacag
      541 aagccggagg ctgtctcagg agagagggac aaccgtgcgg ggtctacagc cctaagtgcg
      601 ccccaggact gcagtgccaa ccccgagaga acgaagaggc gcctttgcgg gcgctgctaa
      661 tcggccaggg ccgctgtcaa cgcgccagag ggccgtcgga ggagactaca aaggagagca
      721 aaccccaagg aggtgcctcc cgctctcgtg acacaaacca cagagaccgg cagaagaatc
      781 cacggacctc tgctgcccct atacggccca atcctgttca agatagtgag atgggcccct
      841 gccgcagaca cttggattca gtactgcagc agctccagac tgaggtcttc cgaggcggag
      901 cacgtgggct ctatgtgcca aactgtgacc tcagaggctt ctaccgaaag cagcagtgtc
      961 gttcctcgca ggggaatcgc cgtggcccct gctggtgtgt ggatccgatg ggccagcctt
     1021 tgccagtgtc tccagatggt caaggaagca ctcagtgctc tgccaggagc agtgggtgaa
     1081 gccccgaggg agcctccagg acgccagcag gaacaggggg ctgtcatttg agctgtatgt
     1141 gaagcaatga ataactctgt gccccaagac ccaccttcac gccccacccc attgtccctg
     1201 tcacccttgg gcctttacac agctagttag aaagattgct gttggcttgt gtactaataa
     1261 aacagtattg ggggggtgtc tctggcttaa aaaaaaaaaa aaaaa
//
