LOCUS       NM_010518               5854 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus insulin-like growth factor binding protein 5 (Igfbp5),
            mRNA.
ACCESSION   NM_010518
VERSION     NM_010518.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5854)
  AUTHORS   Basu,S., Mautner,L., Whiting,K., Hasenpusch-Theil,K., Borkowska,M.
            and Theil,T.
  TITLE     Identification of Pappa and Sall3 as Gli3 direct target genes
            acting downstream of cilia signaling in corticogenesis
  JOURNAL   Cereb Cortex 34 (12) (2024)
   PUBMED   39716738
REFERENCE   2  (bases 1 to 5854)
  AUTHORS   Xiao,J., Deng,Y., Xie,J., Liu,H., Yang,Q., Zhang,Y., Huang,X. and
            Cao,Z.
  TITLE     Apoptotic vesicles from macrophages exacerbate periodontal bone
            resorption in periodontitis via delivering miR-143-3p targeting
            Igfbp5
  JOURNAL   J Nanobiotechnology 22 (1), 658 (2024)
   PUBMED   39456001
  REMARK    GeneRIF: Apoptotic vesicles from macrophages exacerbate periodontal
            bone resorption in periodontitis via delivering miR-143-3p
            targeting Igfbp5.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5854)
  AUTHORS   Cai,S. and Yin,N.
  TITLE     Single-cell transcriptome and chromatin accessibility mapping of
            upper lip and primary palate fusion
  JOURNAL   J Cell Mol Med 28 (19), e70128 (2024)
   PUBMED   39392189
REFERENCE   4  (bases 1 to 5854)
  AUTHORS   Song,F., Hu,Y., Hong,Y.X., Sun,H., Han,Y., Mao,Y.J., Wu,W.Y., Li,G.
            and Wang,Y.
  TITLE     Deletion of endothelial IGFBP5 protects against ischaemic hindlimb
            injury by promoting angiogenesis
  JOURNAL   Clin Transl Med 14 (6), e1725 (2024)
   PUBMED   38886900
  REMARK    GeneRIF: Deletion of endothelial IGFBP5 protects against ischaemic
            hindlimb injury by promoting angiogenesis.
REFERENCE   5  (bases 1 to 5854)
  AUTHORS   Sinclair-Wilson,A., Lawrence,A., Ferezou,I., Cartonnet,H.,
            Mailhes,C., Garel,S. and Lokmane,L.
  TITLE     Plasticity of thalamocortical axons is regulated by serotonin
            levels modulated by preterm birth
  JOURNAL   Proc Natl Acad Sci U S A 120 (33), e2301644120 (2023)
   PUBMED   37549297
REFERENCE   6  (bases 1 to 5854)
  AUTHORS   Kou,K., Mittanck,D.W., Fu,C. and Rotwein,P.
  TITLE     Structure and function of the mouse insulin-like growth factor
            binding protein 5 gene promoter
  JOURNAL   DNA Cell Biol 14 (3), 241-249 (1995)
   PUBMED   7533502
REFERENCE   7  (bases 1 to 5854)
  AUTHORS   Schuller,A.G., Groffen,C., van Neck,J.W., Zwarthoff,E.C. and
            Drop,S.L.
  TITLE     cDNA cloning and mRNA expression of the six mouse insulin-like
            growth factor binding proteins
  JOURNAL   Mol Cell Endocrinol 104 (1), 57-66 (1994)
   PUBMED   7529732
REFERENCE   8  (bases 1 to 5854)
  AUTHORS   Kou,K., James,P.L., Clemmons,D.R., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Rotwein,P.
  TITLE     Identification of two clusters of mouse insulin-like growth factor
            binding protein genes on chromosomes 1 and 11
  JOURNAL   Genomics 21 (3), 653-655 (1994)
   PUBMED   7525452
REFERENCE   9  (bases 1 to 5854)
  AUTHORS   Kou,K., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Rotwein,P.
  TITLE     Organization, expression, and chromosomal location of the mouse
            insulin-like growth factor binding protein 5 gene
  JOURNAL   Genomics 20 (3), 412-418 (1994)
   PUBMED   7518410
REFERENCE   10 (bases 1 to 5854)
  AUTHORS   Hahnel,A. and Schultz,G.A.
  TITLE     Insulin-like growth factor binding proteins are transcribed by
            preimplantation mouse embryos
  JOURNAL   Endocrinology 134 (4), 1956-1959 (1994)
   PUBMED   7511095
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057447.1, BC029321.1 and BC018579.1.
            
            On Jul 16, 2005 this sequence version replaced NM_010518.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057447.1, L12447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2179              BC057447.1         1-2179
            2180-5771           BC029321.1         1014-4605
            5772-5854           BC018579.1         1713-1795
FEATURES             Location/Qualifiers
     source          1..5854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.94 cM"
     gene            1..5854
                     /gene="Igfbp5"
                     /gene_synonym="IGFBP-5; IGFBP-5P"
                     /note="insulin-like growth factor binding protein 5"
                     /db_xref="GeneID:16011"
                     /db_xref="MGI:MGI:96440"
     exon            1..1060
                     /gene="Igfbp5"
                     /gene_synonym="IGFBP-5; IGFBP-5P"
                     /inference="alignment:Splign:2.1.0"
     CDS             727..1542
                     /gene="Igfbp5"
                     /gene_synonym="IGFBP-5; IGFBP-5P"
                     /note="IBP-5; IGF-binding protein 5"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 5
                     precursor"
                     /protein_id="NP_034648.2"
                     /db_xref="CCDS:CCDS15037.1"
                     /db_xref="GeneID:16011"
                     /db_xref="MGI:MGI:96440"
                     /translation="MVISVVLLLLAAYAVPAQGLGSFVHCEPCDEKALSMCPPSPLGC
                     ELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNE
                     KSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKHTRISELKAEAVKKDRRKKLT
                     QSKFVGGAENTAHPRVIPAPEMRQESEQGPCRRHMEASLQEFKASPRMVPRAVYLPNC
                     DRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVE"
     exon            1061..1290
                     /gene="Igfbp5"
                     /gene_synonym="IGFBP-5; IGFBP-5P"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1410
                     /gene="Igfbp5"
                     /gene_synonym="IGFBP-5; IGFBP-5P"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..5854
                     /gene="Igfbp5"
                     /gene_synonym="IGFBP-5; IGFBP-5P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4749..4754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igfbp5"
                     /gene_synonym="IGFBP-5; IGFBP-5P"
                     /note="hexamer: AATAAA"
     polyA_site      4773
                     /gene="Igfbp5"
                     /gene_synonym="IGFBP-5; IGFBP-5P"
                     /note="major polyA site"
ORIGIN      
        1 aaaagagcta ggaaagagct gcaaagctgt ttgggctttt ttcccccttt ttgttccttt
       61 ttgttacccc ccccctcggt ctgcaccctt ctccggactt cacgcagaac ctgcgggttt
      121 cgaagaggtg gtgacagagc aggtgttggg gtccaggttt ggtgaggtct gggtttttgc
      181 cctttttccc ccctcgattt caacattttc ccgatcttgt tgtcagccgc cgacgcctct
      241 tacctgttct gcggcagcag cgcagctggc cgctgagacc gagcggagtg gggttgcgtt
      301 ttagatttta agcaaagggg ggaaaattaa gcccaatcca tttttttctt cacctcctcc
      361 cttttcaagg cctccaagct aattatttct gttgctttgg agtgagcaat tctgtggttc
      421 tctccaccac cacccccaat tctgacccga tcccgcctgg gggtttctac ggtctccgct
      481 cgctctgcgt gcacctggcg cgcctctttt tttcaccccc aacctgttgc aagtctttaa
      541 tcctcgcaat tgggacttgc gtgcaggcat ctgaatcctc cttgcctcat attttgcaag
      601 tgtttggggg agagcacctg ctctacctgc aagagattta aaaggaaaaa aatctccagg
      661 ctccctcttt ctccacacac tctcgctctc ctgccccgcc ccgaggtaaa gccagactcc
      721 gagaaaatgg tgatcagcgt ggtcctcctg ctgctggccg cctatgccgt accggctcaa
      781 ggcctgggtt ctttcgtgca ctgtgaaccc tgcgacgaga aagctctgtc catgtgtccc
      841 cccagccctc tgggctgtga gctggtcaaa gagcccggct gtggctgctg catgacttgc
      901 gccctggcgg agggacagtc gtgtggcgtc tacacggagc gctgcgccca gggtttgcgc
      961 tgcctccccc ggcaggatga ggagaagccg ctgcacgccc tgctgcacgg ccgcggggtt
     1021 tgcctcaacg aaaagagcta cggcgagcaa accaagatag agagagactc tcgggaacac
     1081 gaggaaccca ccacctccga gatggctgaa gagacctact cccccaaggt cttccggccc
     1141 aagcacactc gcatttccga gctgaaggct gaggctgtga agaaggaccg cagaaagaag
     1201 ctgacccagt ccaagtttgt ggggggtgca gagaacactg cccaccccag agtcatccct
     1261 gcacctgaga tgagacagga atccgaacaa ggcccctgcc gcagacacat ggaagcttcc
     1321 ctccaggagt tcaaagccag cccacgcatg gtgccccgtg ctgtgtacct gcccaactgt
     1381 gaccgcaaag gattctacaa gagaaagcag tgtaagccct cccgtggccg caaacgtggc
     1441 atctgctggt gtgtggacaa gtacggaatg aagctgccgg gcatggagta cgtggatggg
     1501 gactttcagt gccacgcctt cgacagcagt aacgttgagt gacgcgtccc ctcccttcct
     1561 ccccctatcc taccccccca gccccaactc cagccagcgc ctccctccac cccaggacgt
     1621 cactcatttc atctcattta ggggaaatat atatacatat atatttgagg aaactgagga
     1681 cctcggaatc tctagcaagg gctaaggaga cactccccac catgaccccg gaaatgtatt
     1741 cctttttgaa gcaagttgaa cggacagaga agggaaggag agaagaagca agagggagcg
     1801 agagatggaa agaaagcaaa gcgttggaat agaggaaaag agggaaggac agataggatt
     1861 agagagagaa gagagaaaca gcaaggcaga aaggactcca caaccaaggc tgaatctgcc
     1921 cttttgcttt cagctctagc ctggggtcag aaaaagtgtg gcattcagtg acacccagtt
     1981 tagattggtc aaggggagaa aagaaacaag gtgtgtcagt gcctctcggg tctgtcccct
     2041 cctgcagcca gcagtgtgga tggctagacc cctcaccctc ctctcctctt acccaagtgc
     2101 agggtgattt catccccaaa tttacaaaga ctaaaatgca ttccatccct ctgaaaataa
     2161 acaaaagtga gtgattgaag ataggttttc ccccagcaga caagtgaact cagaatgtgt
     2221 gcaaatttta ctcttgttaa agattttttt aagaagtcag tacgcacccc caacactgga
     2281 aagacttgat tctccagggt gacaagcaat tcagaagcgc gtggcttcgg cccttgattt
     2341 cactagactc aaagctggcc cggcagcctc tgtggaggag gatgagaggt ggagaaaacc
     2401 aaggggcttg tactcaccca caagactcca tgtagacttt ataggcatat aaatctattt
     2461 tctttacctt tttttccctt tccctttctt tcgaagtttt gcattacctc tttaaagtag
     2521 ttttttttag gacactgaag atcttcctca ttctgggaaa aatccatatt tcacaaatac
     2581 aacccagaac gccagcttgg cctgcgtcca ggcagccttt ctcgtgagct acaagtgtgg
     2641 ctcttttgtg gggcaccgat ttggatcttc tcatgattcc aaacgtgtgt tgaagtgaat
     2701 ccaccaagcc aggtaactgc cagcacccaa gggtgcatca agtgcatagc ccaggtcacc
     2761 ccatttcagc cttccaaccc gcagaaagta actgtctcac accacaccac ataaacctgc
     2821 cagatccatc tgtaacccac tggcctgccc agaccttttt ttcccatctg catttttttt
     2881 tttgaactgc attttgaaag cctccctcag atgccaggct gacagatcag agagaaacta
     2941 acatgagaga tgacagagga ggaggaagtg gagggtgggg gcagagactt ccacagagag
     3001 acatagaaga tggagcagag gtctgggggt ggggaggaca agaaagagac agagagagga
     3061 aaataccaat agaattttcc ttggtgtctc ccatctaatc aactctctga gatttgagag
     3121 gaaaaagaag gcaggggaag aacttgaggt agaaatgagg tcagttcaag tcacagggcc
     3181 cagatggtgg gtaactgagg caggatccag acttgagaca cacggttgga aacaaggctg
     3241 gttagcctga ctgggtattg aagggtgaag aggatgcctt ggaaagacag cacaacttca
     3301 gttcaacttc aggcccccaa ggaggaactg aggccaaaga atccttcaag tgcttcatga
     3361 gtctcctctg cccgactcaa acatccttcc ctgtgatgga ggatggtaga aagcccagga
     3421 caactcaggc ccggatcttc acgactgttg tcatttgcca gcctgatttt gatccaagag
     3481 aagcatctca ttgcccactg gcttcttcaa caaagaggtg cttaacaaaa ggctcaggac
     3541 tgtctttgaa gactgaagat aaccttccag gagaggagac tcggacattg gtacaggagg
     3601 ccccttttgg cgggggacac agctctttgc gctctcttga tggcatggca tagtagaggc
     3661 cccctccaac ccggaacatg gagcaacaca aagggagagc aaagaaactg acgtgcgtcg
     3721 actcatagga catgggtggc tgcgggcaca gaaagggatg cctcctgttg cctggacagg
     3781 acagttggct gggaaggaaa gagaaaattg atcttcataa gacaaagggc ctgatgggat
     3841 ggcaatagaa ggacttacca gacctgcagg gtcagtatac ccatcacccc gcacaacatc
     3901 cccaaccccc aactcaaact tcaatatatc ttaggccagt atcctagacc taagtctctc
     3961 ctttctgcca ttatttctcc gcatcttgag cagtcatctg actgagattt gccaagtgga
     4021 tactggggta ccactgcccc ccaagaaaag actgagccag gaactgccta ctcgctcccc
     4081 ctcccgagcc tggagctaac tcctgtgagg ggtgctctct tcaccccaca acttactaga
     4141 ccttgagtga gcctctgtcc cttatgtggg ctcttcgctg tgagccacag atggaggtca
     4201 ttgtatagac agttagcctt ccccaggtca gcctacctcc cccaaacttg tgagtctccc
     4261 cgctgctcat atggagaggc atgtctaaga cagcaagtct tctagaggaa gcttgccttt
     4321 aacagacaga tggaactaaa ccttccaaat gggagatctg gctgaaccca ggatacagag
     4381 accatggaca tggatggggt catcaagaga agagggatgt ccttctccag gttagggaga
     4441 gagaaggcaa gtttgcaacg atcccatcat gccctgagca agaagctttt ggcccaggct
     4501 agcctttaac tccattagag gcctctctgt tgggtttatc cacagcagta ggcccaagta
     4561 tggcctgtcc ccacctctac tatcccgtgg aaggtttctt cccacccctt tttgacaaat
     4621 gcctcactcg agcagtggaa agatagctct cttccccctc tactgccagg taacaaagag
     4681 acctaaccag gacctattct ccaccccagc cagtcttgac cagccagaac aaagcaggga
     4741 acctggagaa taaaagactc tacgttcctc tgacaaagac tctacgtttc tctgacggcc
     4801 aggcctaaac agacaaggct tgggaacatc tgccccacag gatacggagg aggtcagctg
     4861 tgctcactcc tcttctcctt ccaagaccct cttccgacca tgacttatct ccatggtaac
     4921 atcctcacca tcattctccc actaccaagg gttgccatgg caacctccca accacctgcc
     4981 catcccaggc agggcagctg tccttctgct cagaacccta gaggactcta ggtgaaattt
     5041 tacagcttaa gagaggagtg agccaaggag aagagaccct gtagtcctct ggctttcaag
     5101 agaaagaagg ctatgattta aaacacagta gaagggaaag aggtctcgtc gacctctccc
     5161 ggggagctta ggggttgtac tgtctttatt ttttaaacca ctaaagtgca atgtttcctg
     5221 cactcttgtt accccgcctc tcttccctgt taggttttca tttccttgag cagactttct
     5281 tggtttttta atggagtata gactttcacc acttcacaga ctctggcctc ctctccaagt
     5341 ctctctggat ggggaaaagg aaggtagagg gtcagagggg aaggggtccc tcgtcacccc
     5401 gcatccattc acccccactt ctctggtccc tagtcaccgg cttcagcccc catctccgac
     5461 accatcactg tcacacagta gcctgtcaca cggatagtac agttcagaca agactccttc
     5521 agattccgag acgcctaccg gttgtttttg gtttttgttt tgttttcttt tgtttgtttg
     5581 tttgtttttt acaacagcaa taaccacatc acatattact gtagctctct atagtgttac
     5641 gttcagacac cgtagctctg tcctctctta ttttgttggt tttgacttaa aaaaaaatac
     5701 ttatgctttt tactggtgaa acagattgaa aaaaaaattg aacaacaaac cagtttgtga
     5761 aaaaaaaaaa atgggaaaaa aaatcacccc gatgtggaag agctcggctc ctctttagca
     5821 ttttgtactt aaggaaataa aaaagaaaaa cctg
//
