LOCUS       NM_010517               2108 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus insulin-like growth factor binding protein 4 (Igfbp4),
            mRNA.
ACCESSION   NM_010517 XM_979866
VERSION     NM_010517.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2108)
  AUTHORS   Basu,S., Mautner,L., Whiting,K., Hasenpusch-Theil,K., Borkowska,M.
            and Theil,T.
  TITLE     Identification of Pappa and Sall3 as Gli3 direct target genes
            acting downstream of cilia signaling in corticogenesis
  JOURNAL   Cereb Cortex 34 (12) (2024)
   PUBMED   39716738
REFERENCE   2  (bases 1 to 2108)
  AUTHORS   Tao,L., Wang,Y., Shen,Z., Cai,J., Zheng,J., Xia,S., Lin,Z., Wan,Z.,
            Qi,H., Jin,R., Wang,L., Xu,J. and Liang,X.
  TITLE     Activation of IGFBP4 via unconventional mechanism of miRNA
            attenuates metastasis of intrahepatic cholangiocarcinoma
  JOURNAL   Hepatol Int 18 (1), 91-107 (2024)
   PUBMED   37349627
  REMARK    GeneRIF: Activation of IGFBP4 via unconventional mechanism of miRNA
            attenuates metastasis of intrahepatic cholangiocarcinoma.
REFERENCE   3  (bases 1 to 2108)
  AUTHORS   Chen,W., Hu,L., Lu,X., Wang,X., Zhao,C., Guo,C., Li,X., Ding,Y.,
            Zhao,H., Tong,D., Wang,L. and Huang,C.
  TITLE     The RNA binding protein MEX3A promotes tumor progression of breast
            cancer by post-transcriptional regulation of IGFBP4
  JOURNAL   Breast Cancer Res Treat 201 (3), 353-366 (2023)
   PUBMED   37433992
  REMARK    GeneRIF: The RNA binding protein MEX3A promotes tumor progression
            of breast cancer by post-transcriptional regulation of IGFBP4.
REFERENCE   4  (bases 1 to 2108)
  AUTHORS   Jepsen,M.R., Ostergaard,J.A., Conover,C.A., Wogensen,L., Birn,H.,
            Krag,S.P., Fenton,R.A. and Oxvig,C.
  TITLE     Increased activity of the metalloproteinase PAPP-A promotes
            diabetes-induced glomerular hypertrophy
  JOURNAL   Metabolism 132, 155218 (2022)
   PUBMED   35588861
  REMARK    GeneRIF: Increased activity of the metalloproteinase PAPP-A
            promotes diabetes-induced glomerular hypertrophy.
REFERENCE   5  (bases 1 to 2108)
  AUTHORS   Kheirollahi,V., Khadim,A., Kiliaris,G., Korfei,M., Barroso,M.M.,
            Alexopoulos,I., Vazquez-Armendariz,A.I., Wygrecka,M., Ruppert,C.,
            Guenther,A., Seeger,W., Herold,S. and El Agha,E.
  TITLE     Transcriptional Profiling of Insulin-like Growth Factor Signaling
            Components in Embryonic Lung Development and Idiopathic Pulmonary
            Fibrosis
  JOURNAL   Cells 11 (12), 1973 (2022)
   PUBMED   35741102
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2108)
  AUTHORS   Boney,C.M., Moats-Staats,B.M., Stiles,A.D. and D'Ercole,A.J.
  TITLE     Expression of insulin-like growth factor-I (IGF-I) and IGF-binding
            proteins during adipogenesis
  JOURNAL   Endocrinology 135 (5), 1863-1868 (1994)
   PUBMED   7525256
REFERENCE   7  (bases 1 to 2108)
  AUTHORS   Scharla,S.H., Strong,D.D., Mohan,S., Chevalley,T. and Linkhart,T.A.
  TITLE     Effect of tumor necrosis factor-alpha on the expression of
            insulin-like growth factor I and insulin-like growth factor binding
            protein 4 in mouse osteoblasts
  JOURNAL   Eur J Endocrinol 131 (3), 293-301 (1994)
   PUBMED   7522842
REFERENCE   8  (bases 1 to 2108)
  AUTHORS   Hahnel,A. and Schultz,G.A.
  TITLE     Insulin-like growth factor binding proteins are transcribed by
            preimplantation mouse embryos
  JOURNAL   Endocrinology 134 (4), 1956-1959 (1994)
   PUBMED   7511095
REFERENCE   9  (bases 1 to 2108)
  AUTHORS   Donahue,L.R., Watson,G. and Beamer,W.G.
  TITLE     Regulation of metabolic water and protein compartments by
            insulin-like growth factor-I and testosterone in growth
            hormone-deficient lit/lit mice
  JOURNAL   J Endocrinol 139 (3), 431-439 (1993)
   PUBMED   7510770
REFERENCE   10 (bases 1 to 2108)
  AUTHORS   Cerro,J.A., Grewal,A., Wood,T.L. and Pintar,J.E.
  TITLE     Tissue-specific expression of the insulin-like growth factor
            binding protein (IGFBP) mRNAs in mouse and rat development
  JOURNAL   Regul Pept 48 (1-2), 189-198 (1993)
   PUBMED   7505465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591067.35 and AI838737.1.
            
            On Feb 15, 2018 this sequence version replaced NM_010517.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031212.1, BC019836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               AL591067.35        184668-185269
            603-748             AL591067.35        191650-191795
            749-883             AL591067.35        192518-192652
            884-2085            AL591067.35        194869-196070
            2086-2108           AI838737.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..2108
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..2108
                     /gene="Igfbp4"
                     /gene_synonym="Deb2; IBP-4; IGFBP-4"
                     /note="insulin-like growth factor binding protein 4"
                     /db_xref="GeneID:16010"
                     /db_xref="MGI:MGI:96439"
     exon            1..602
                     /gene="Igfbp4"
                     /gene_synonym="Deb2; IBP-4; IGFBP-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1018
                     /gene="Igfbp4"
                     /gene_synonym="Deb2; IBP-4; IGFBP-4"
                     /note="IGF-binding protein 4; differentially expressed in
                     B16F10 2; Band 3A"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 4
                     precursor"
                     /protein_id="NP_034647.1"
                     /db_xref="CCDS:CCDS25371.1"
                     /db_xref="GeneID:16010"
                     /db_xref="MGI:MGI:96439"
                     /translation="MLPFGLVAALLLAAGPRPSLGDEAIHCPPCSEEKLARCRPPVGC
                     EELVREPGCGCCATCALGLGMPCGVYTPRCGSGMRCYPPRGVEKPLRTLMHGQGVCTE
                     LSEIEAIQESLQTSDKDESEHPNNSFNPCSAHDHRCLQKHMAKIRDRSKMKIVGTPRE
                     EPRPVPQGSCQSELHRALERLAASQSRTHEDLFIIPIPNCDRNGNFHPKQCHPALDGQ
                     RGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFQE"
     exon            603..748
                     /gene="Igfbp4"
                     /gene_synonym="Deb2; IBP-4; IGFBP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            749..883
                     /gene="Igfbp4"
                     /gene_synonym="Deb2; IBP-4; IGFBP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            884..2094
                     /gene="Igfbp4"
                     /gene_synonym="Deb2; IBP-4; IGFBP-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2072..2077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igfbp4"
                     /gene_synonym="Deb2; IBP-4; IGFBP-4"
                     /note="hexamer: AACAAA"
     polyA_site      2085
                     /gene="Igfbp4"
                     /gene_synonym="Deb2; IBP-4; IGFBP-4"
                     /note="major polyA site"
ORIGIN      
        1 agccgctcag ccccctgccc cccgccgcct gctgggccgg ccgaggatgc agcgcagcgc
       61 ctcggtggcc aggctcgctc tgctccagcg tgcttgctaa cttccccggc tccgtctctg
      121 cctgccgggg tcgccccgtg tccctgcgcc ctccgggtct ggttctctaa gctctctggg
      181 cgctgcctcc gggtcccttg cagcccgctc gcgagcccgc gctcccctcc tgcgccccac
      241 cctcgtcctc gccatgctgc ccttcggcct cgtggccgcc ctgctgctgg ccgcagggcc
      301 tcggccgagc ctgggcgacg aagccatcca ctgcccccct tgctccgagg agaagctggc
      361 gcgctgccgc ccccccgtgg gttgcgagga gttggtgcgg gagccaggct gcggttgttg
      421 cgccacttgc gccctgggct tggggatgcc ctgcggggtg tacaccccac gctgtggctc
      481 aggcatgcgc tgctaccctc cccggggggt ggagaagccc ctgcgtacat tgatgcacgg
      541 gcaaggcgtg tgcacggagc tgtcggaaat cgaagccatc caggaaagcc tgcagacctc
      601 tgacaaggat gagagcgaac atcccaacaa cagcttcaac ccctgcagtg cccatgatca
      661 caggtgcctg cagaagcata tggccaaaat tagagatcgg agcaagatga agatcgtggg
      721 gacacctcgg gaggaacccc gtcctgtgcc ccagggttcc tgccagagcg agctgcaccg
      781 ggccctggag cggctggccg cctcacagag ccgtacccac gaagacctct tcatcatccc
      841 cattccaaac tgtgaccgca acggcaactt ccaccccaaa cagtgtcacc ccgccctgga
      901 cggacagcgt ggcaagtgct ggtgtgtgga tcggaagaca ggggtgaagc ttcctggggg
      961 tttggaaccc aagggggagc tggactgcca ccagctggct gacagcttcc aagagtgaga
     1021 cctgccagca ggtgggggac tcagtgcccc ctactaggcc cctatgctct ggggttgtag
     1081 agttgacctg gcttggagtc tgagtcctgg ctgtctgcct ctggccctgc ccaaaatttc
     1141 cctttgtgtg tgtgtgcaca cgcgtgcaca tgctcgtgtg tgtgtgttta taggatgtgc
     1201 cctacaggat aagcctgagc cttctcgtgc ccatgatggg cttagatacc cccaagaggt
     1261 ctgagtgtag caataggaat tcccagtgtg ctttcaaatc actatggaat tcattcattc
     1321 attcattcat tcatccacct gaaaacacgt attgaaaaca tactatgtgc cagctttagt
     1381 tttcagcgcc gggaagcctc gttgtgattt cctccgattg tagaatgtga cgaggtgttc
     1441 tcaactcaag gcccacggga gaagagaaac ctcattcttg gagtgagaga gaaagaaagt
     1501 ggtgaacatt gaacgccctc cctctccatc ttggccagag cgtaggaagg tgtagagtag
     1561 aggctcacgg ctcctgagac ccacctctgc tctgtgctgc tgcgtagagc tctctccttg
     1621 gggcctccag ggcacaagct tgagggacag ggcccatctt tggtcagggt attcggtcat
     1681 ccgacaatgc cttgcaggta gatctctgct gtgggaaagg aatggggtga ggaaggccgg
     1741 aaggacaggg ggcagggagg tgggctcatc actctgagcc tgcaggagag aggaaagaat
     1801 gtgagattgg attgtgtgtg tctgaggaat ggccccattc tggtccctat ttgtggttat
     1861 tggtcatgaa gtcaccagga tgactctatc tttctagttg cccaccacct gtggctttgc
     1921 ctccgtcccc atatttccct acccttatac ctcctatccc gccatctcta cccccctggg
     1981 cattttctgg cttgcctgga tagatttaga gacctgcttg ttggctataa tgtcttttca
     2041 ttctttcttc ttcctttttt aaaaaaatca gaacaaaacc aaaaagtgtc cagaaaaaaa
     2101 aaaaaaaa
//
