LOCUS       NM_008343               2456 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus insulin-like growth factor binding protein 3 (Igfbp3),
            mRNA.
ACCESSION   NM_008343 XM_908036
VERSION     NM_008343.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2456)
  AUTHORS   Eom,S.Y. and Kim,M.M.
  TITLE     The effect of IGFBP3 gene knockout by the CRISPR/Cas9 system on the
            IGF-1 pathway in murine cells
  JOURNAL   Arch Gerontol Geriatr 125, 105484 (2024)
   PUBMED   38838451
  REMARK    GeneRIF: The effect of IGFBP3 gene knockout by the CRISPR/Cas9
            system on the IGF-1 pathway in murine cells.
REFERENCE   2  (bases 1 to 2456)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   3  (bases 1 to 2456)
  AUTHORS   Lai,A., Sun,J., Dai,Z., Guo,L., Tao,D., Li,H., Chen,B. and Zhou,R.
  TITLE     Unraveling IGFBP3-mediated m6A modification in fracture healing
  JOURNAL   Pathol Res Pract 255, 155220 (2024)
   PUBMED   38432050
  REMARK    GeneRIF: Unraveling IGFBP3-mediated m6A modification in fracture
            healing.
REFERENCE   4  (bases 1 to 2456)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2456)
  AUTHORS   Wang,X., Li,J., Zhang,W., Wang,F., Wu,Y., Guo,Y., Wang,D., Yu,X.,
            Li,A., Li,F. and Xie,Y.
  TITLE     IGFBP-3 promotes cachexia-associated lipid loss by suppressing
            insulin-like growth factor/insulin signaling
  JOURNAL   Chin Med J (Engl) 136 (8), 974-985 (2023)
   PUBMED   37014770
  REMARK    GeneRIF: IGFBP-3 promotes cachexia-associated lipid loss by
            suppressing insulin-like growth factor/insulin signaling.
REFERENCE   6  (bases 1 to 2456)
  AUTHORS   Schuller,A.G., Groffen,C., van Neck,J.W., Zwarthoff,E.C. and
            Drop,S.L.
  TITLE     cDNA cloning and mRNA expression of the six mouse insulin-like
            growth factor binding proteins
  JOURNAL   Mol Cell Endocrinol 104 (1), 57-66 (1994)
   PUBMED   7529732
REFERENCE   7  (bases 1 to 2456)
  AUTHORS   Kou,K., James,P.L., Clemmons,D.R., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Rotwein,P.
  TITLE     Identification of two clusters of mouse insulin-like growth factor
            binding protein genes on chromosomes 1 and 11
  JOURNAL   Genomics 21 (3), 653-655 (1994)
   PUBMED   7525452
REFERENCE   8  (bases 1 to 2456)
  AUTHORS   Hahnel,A. and Schultz,G.A.
  TITLE     Insulin-like growth factor binding proteins are transcribed by
            preimplantation mouse embryos
  JOURNAL   Endocrinology 134 (4), 1956-1959 (1994)
   PUBMED   7511095
REFERENCE   9  (bases 1 to 2456)
  AUTHORS   Donahue,L.R., Watson,G. and Beamer,W.G.
  TITLE     Regulation of metabolic water and protein compartments by
            insulin-like growth factor-I and testosterone in growth
            hormone-deficient lit/lit mice
  JOURNAL   J Endocrinol 139 (3), 431-439 (1993)
   PUBMED   7510770
REFERENCE   10 (bases 1 to 2456)
  AUTHORS   Cerro,J.A., Grewal,A., Wood,T.L. and Pintar,J.E.
  TITLE     Tissue-specific expression of the insulin-like growth factor
            binding protein (IGFBP) mRNAs in mouse and rat development
  JOURNAL   Regul Pept 48 (1-2), 189-198 (1993)
   PUBMED   7505465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607124.15, AK141690.1 and BP754524.1.
            
            On Aug 8, 2006 this sequence version replaced NM_008343.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058261.1, AK141690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AL607124.15        18303-18680         c
            379-2436            AK141690.1         1-2058
            2437-2456           BP754524.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.75 cM"
     gene            1..2456
                     /gene="Igfbp3"
                     /gene_synonym="IGFBP-3; IGgfbp3"
                     /note="insulin-like growth factor binding protein 3"
                     /db_xref="GeneID:16009"
                     /db_xref="MGI:MGI:96438"
     exon            1..539
                     /gene="Igfbp3"
                     /gene_synonym="IGFBP-3; IGgfbp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1012
                     /gene="Igfbp3"
                     /gene_synonym="IGFBP-3; IGgfbp3"
                     /note="IBP-3; IGF-binding protein 3"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 3
                     precursor"
                     /protein_id="NP_032369.2"
                     /db_xref="CCDS:CCDS24428.1"
                     /db_xref="GeneID:16009"
                     /db_xref="MGI:MGI:96438"
                     /translation="MHPARPALWAAALTALTLLRGPPVARAGAGAVGAGPVVRCEPCD
                     ARALSQCAPPPTAPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAE
                     QYPLRALLNGRGFCANASAAGSLSTYLPSQPAPGNISESEEEHNAGSVESQVVPSTHR
                     VTDSKFHPLHAKMDVIKKGHARDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREM
                     EDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGY
                     DTKGKDDVHCLSVQSQ"
     exon            540..766
                     /gene="Igfbp3"
                     /gene_synonym="IGFBP-3; IGgfbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            767..886
                     /gene="Igfbp3"
                     /gene_synonym="IGFBP-3; IGgfbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1026
                     /gene="Igfbp3"
                     /gene_synonym="IGFBP-3; IGgfbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..2447
                     /gene="Igfbp3"
                     /gene_synonym="IGFBP-3; IGgfbp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1849..1854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igfbp3"
                     /gene_synonym="IGFBP-3; IGgfbp3"
                     /note="hexamer: AATAAA"
     polyA_site      1871
                     /gene="Igfbp3"
                     /gene_synonym="IGFBP-3; IGgfbp3"
                     /note="major polyA site"
ORIGIN      
        1 agatgcgagc ttagagcggc gactgggcgc tgaggacctg cttgctcgct gctcccatcc
       61 cgccgcctca tcccgccgcc tcatcccgcg tgctccactc cgctcccctc caccgagccg
      121 tccacccggc gccatgcatc ccgcgcgccc cgcgctctgg gcggctgcgc tcactgccct
      181 cactctgctc cgcggaccgc cggtggcgcg agctggcgcg ggcgcggtgg gcgcgggccc
      241 cgtggtgcgc tgcgaaccgt gcgacgcgcg tgcgctgtcc cagtgcgcgc ctccgcccac
      301 cgcgcccgcg tgcacggagc tggtgcgaga gcccggctgc ggctgctgcc tgacttgcgc
      361 gctgcgcgaa ggcgacgcgt gcggcgtcta cacggagcgc tgtggcaccg gcctccgctg
      421 ccagccgcgg cccgcggagc agtacccgct gagggcgctg ctgaatggcc gcgggttctg
      481 cgccaacgcc agcgctgcag gcagcctaag cacctacctc ccctcccaac ctgctccagg
      541 aaacatcagt gagtccgagg aggagcacaa tgctgggagt gtggaaagcc aggttgtccc
      601 cagcacacac cgagtgaccg attccaagtt ccatccactc catgccaaga tggatgtcat
      661 caaaaaaggc cacgccaggg acagccagcg ctacaaagtt gactatgagt ctcaaagcac
      721 agacacccag aacttctcct ccgagtctaa gcgggagaca gaatacggtc cctgccgcag
      781 agaaatggag gacacactga atcatctgaa gttcctcaat gtgctgagtc ccagaggcgt
      841 ccacatccca aactgtgaca agaaggggtt ctataagaag aagcagtgcc gcccttccaa
      901 aggcagaaag cggggcttct gctggtgtgt ggacaagtat gggcagccct tgccaggcta
      961 cgacaccaag gggaaagacg acgtacattg cctcagcgtg cagagccagt agatgctccg
     1021 tgccacataa tatggagctc aaatatgcct tattttgcac aaaagactgc caacaacatg
     1081 atcagcagct ggctacagcc ttgatttata tatatatata tatattttat gtgtgtgtgt
     1141 gtgtgagtgt ggtgaactga gtgaaaacaa acacacacac aaaccaaagt ttagacagat
     1201 ttctgaaatg cctctggtca tttaaatagt gaacttgatc atcttcctac ttcccagtag
     1261 tcaacaaaaa gcagtttgaa ttttcctgtt gcttcttatg agagacactc gtgtactcca
     1321 ggccccggat gccatctgcc ccctaactca cccacccagt acgggcttca atgctgctgg
     1381 ccctctgcct tcttgatttc agacgttccg tggctgatat agacaaatcc tctttccatc
     1441 ccctgtaaat aagtgcaggc cctatggaga atggggaaac ccataaccga gtgacccgga
     1501 catctggaag catatgcctg aggctcatgg tccttattgt gccatctctg aataagggcc
     1561 tggccctgta tccgcaagtg gcctgatcta cttgggaact gtgggagagg atatgtgttg
     1621 tctctcttac taaaaatgac tgagaatgtt ctagggcact ctgggagccc ataaggacaa
     1681 ggataaggac ctttctttgt caggcatctt cttgatgact tggcccagca gaaagcccca
     1741 agtgggagga gcagcatcgg actccacgtt cagagatgtc gcaaataatg gtgcgcttag
     1801 ttcttcagat gacttcaaaa aacaatgttt tctggtccag cctctcaaaa taaagtttgt
     1861 tgtgaggtgg ggctgcggga aggcagtttt tcaaaaacac agatttcttt tcatcttcct
     1921 atctaaacag gaaagaggag tggcttgtct gagagcctgg taagagcatg gagaaaatca
     1981 cctgtatgtt gatcttgggg tccttctcaa actctcttta taattcacgc atatatgcag
     2041 acaaagtacg ttcttaattg ttaacattgt atacaacgta gcccagatat aatagaatct
     2101 gtactagata atcctagatg aagtgttaga gatgttaggt gatataactg cagacacgcc
     2161 caaggaaagg agcctgtgtc tggaggctgg gctgctctcc cccaggccga ggcggaggag
     2221 gtctggcaac gcagggtgag aggagactgt actgcatcct acggggtgga catgcgctgt
     2281 acagagcttt ccttgagagc acaaaggaat ctcaagacat tctgcctgcc tatcagcttt
     2341 tctttatttt tttaattaag ttttttgggg aaaaatgtat ttttgaaaag tttgtcttgc
     2401 aatgtattta taaatagtaa ataaagtttt tatcatttaa aaaaaaaaaa aaaaaa
//
