LOCUS       NM_008342               1342 bp    mRNA    linear   ROD 03-APR-2023
DEFINITION  Mus musculus insulin-like growth factor binding protein 2 (Igfbp2),
            transcript variant 1, mRNA.
ACCESSION   NM_008342
VERSION     NM_008342.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1342)
  AUTHORS   Wang J, Zhang F, Yang W, Gao D, Yang L, Yu C, Chen C, Li X and
            Zhang JS.
  TITLE     FGF1 ameliorates obesity-associated hepatic steatosis by reversing
            IGFBP2 hypermethylation
  JOURNAL   FASEB J 37 (4), e22881 (2023)
   PUBMED   36934380
  REMARK    GeneRIF: FGF1 ameliorates obesity-associated hepatic steatosis by
            reversing IGFBP2 hypermethylation.
REFERENCE   2  (bases 1 to 1342)
  AUTHORS   Chin C, Ravichandran R, Sanborn K, Fleming T, Wheatcroft SB,
            Kearney MT, Tokman S, Walia R, Smith MA, Flint DJ, Mohanakumar T,
            Bremner RM and Sureshbabu A.
  TITLE     Loss of IGFBP2 mediates alveolar type 2 cell senescence and
            promotes lung fibrosis
  JOURNAL   Cell Rep Med 4 (3), 100945 (2023)
   PUBMED   36787736
  REMARK    GeneRIF: Loss of IGFBP2 mediates alveolar type 2 cell senescence
            and promotes lung fibrosis.
REFERENCE   3  (bases 1 to 1342)
  AUTHORS   Szeto IYY, Chu DKH, Chen P, Chu KC, Au TYK, Leung KKH, Huang YH,
            Wynn SL, Mak ACY, Chan YS, Chan WY, Jauch R, Fritzsch B, Sham MH,
            Lovell-Badge R and Cheah KSE.
  TITLE     SOX9 and SOX10 control fluid homeostasis in the inner ear for
            hearing through independent and cooperative mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2122121119 (2022)
   PUBMED   36343245
REFERENCE   4  (bases 1 to 1342)
  AUTHORS   Harris BT, Le PT, Da Silva Martins J, Alabdulaaly L, Baron R,
            Bouxsein ML, Rosen CJ and Pletch AN.
  TITLE     Insulin-like growth factor binding protein 2 null mice (Igfbp2-/-)
            are protected against trabecular bone loss after vertical sleeve
            gastrectomy
  JOURNAL   Surg Endosc 36 (9), 6984-6996 (2022)
   PUBMED   35226161
  REMARK    GeneRIF: Insulin-like growth factor binding protein 2 null mice
            (Igfbp2-/-) are protected against trabecular bone loss after
            vertical sleeve gastrectomy.
REFERENCE   5  (bases 1 to 1342)
  AUTHORS   Kheirollahi V, Khadim A, Kiliaris G, Korfei M, Barroso MM,
            Alexopoulos I, Vazquez-Armendariz AI, Wygrecka M, Ruppert C,
            Guenther A, Seeger W, Herold S and El Agha E.
  TITLE     Transcriptional Profiling of Insulin-like Growth Factor Signaling
            Components in Embryonic Lung Development and Idiopathic Pulmonary
            Fibrosis
  JOURNAL   Cells 11 (12), 1973 (2022)
   PUBMED   35741102
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1342)
  AUTHORS   Kou K, James PL, Clemmons DR, Copeland NG, Gilbert DJ, Jenkins NA
            and Rotwein P.
  TITLE     Identification of two clusters of mouse insulin-like growth factor
            binding protein genes on chromosomes 1 and 11
  JOURNAL   Genomics 21 (3), 653-655 (1994)
   PUBMED   7525452
REFERENCE   7  (bases 1 to 1342)
  AUTHORS   Hahnel A and Schultz GA.
  TITLE     Insulin-like growth factor binding proteins are transcribed by
            preimplantation mouse embryos
  JOURNAL   Endocrinology 134 (4), 1956-1959 (1994)
   PUBMED   7511095
REFERENCE   8  (bases 1 to 1342)
  AUTHORS   Hakeda Y, Yoshizawa K, Hurley M, Kawaguchi H, Tezuka K, Tanaka K,
            Satoh T and Kumegawa M.
  TITLE     Stimulatory effect of a phorbol ester on expression of insulin-like
            growth factor (IGF) binding protein-2 and level of IGF-I receptors
            in mouse osteoblastic MC3T3-E1 cells
  JOURNAL   J Cell Physiol 158 (3), 444-450 (1994)
   PUBMED   7510294
REFERENCE   9  (bases 1 to 1342)
  AUTHORS   Donahue LR, Watson G and Beamer WG.
  TITLE     Regulation of metabolic water and protein compartments by
            insulin-like growth factor-I and testosterone in growth
            hormone-deficient lit/lit mice
  JOURNAL   J Endocrinol 139 (3), 431-439 (1993)
   PUBMED   7510770
REFERENCE   10 (bases 1 to 1342)
  AUTHORS   Agarwal N, Hsieh CL, Sills D, Swaroop M, Desai B, Francke U and
            Swaroop A.
  TITLE     Sequence analysis, expression and chromosomal localization of a
            gene, isolated from a subtracted human retina cDNA library, that
            encodes an insulin-like growth factor binding protein (IGFBP2)
  JOURNAL   Exp Eye Res 52 (5), 549-561 (1991)
   PUBMED   1712312
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC121498.12, AK012703.1,
            DV552718.1 and AI159675.1.
            
            [WARNING] On Apr 27, 2023 this sequence was replaced by
            NM_008342.4.
            
            On Aug 13, 2011 this sequence version replaced NM_008342.2.
            
            Summary: The protein encoded by this gene is one of several similar
            proteins that bind insulin-like growth factors I and II (Igf-I and
            Igf-II). The encoded protein can be secreted into the bloodstream,
            where it binds Igf-I and Igf-II with high affinity, or it can
            remain intracellular, interacting with many different ligands. Two
            transcript variants, one encoding a secreted isoform and the other
            encoding a nonsecreted isoform, have been found for this gene.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054473.1, X81580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC121498.12        5507-5518           c
            13-556              AK012703.1         3-546
            557-903             DV552718.1         85-431
            904-1342            AI159675.1         1-439               c
FEATURES             Location/Qualifiers
     source          1..1342
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.94 cM"
     gene            1..1342
                     /gene="Igfbp2"
                     /gene_synonym="IBP-2; Igfbp-2; mIGFBP-2"
                     /note="insulin-like growth factor binding protein 2"
                     /db_xref="GeneID:16008"
                     /db_xref="MGI:MGI:96437"
     exon            1..485
                     /gene="Igfbp2"
                     /gene_synonym="IBP-2; Igfbp-2; mIGFBP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1018
                     /gene="Igfbp2"
                     /gene_synonym="IBP-2; Igfbp-2; mIGFBP-2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IGF-binding protein 2"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 2
                     isoform 1 precursor"
                     /protein_id="NP_032368.2"
                     /db_xref="CCDS:CCDS15036.1"
                     /db_xref="GeneID:16008"
                     /db_xref="MGI:MGI:96437"
                     /translation="MLPRLGGPALPLLLPSLLLLLLLGAGGCGPGVRAEVLFRCPPCT
                     PERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSE
                     LPLKALVTGAGTCEKRRVGTTPQQVADSDDDHSEGGLVENHVDGTMNMLGGGSSAGRK
                     PLKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQELDQVLERI
                     STMRLPDDRGPLEHLYSLHIPNCDKHGRYNLKQCKMSLNGQRGECWCVNPNTGKPIQG
                     APTIRGDPECHLFYNEQQETGGAHAQSVQ"
     exon            486..712
                     /gene="Igfbp2"
                     /gene_synonym="IBP-2; Igfbp-2; mIGFBP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..853
                     /gene="Igfbp2"
                     /gene_synonym="IBP-2; Igfbp-2; mIGFBP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1330
                     /gene="Igfbp2"
                     /gene_synonym="IBP-2; Igfbp-2; mIGFBP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggggagg agaaagaagg caaggaggcg tctcccgcat tcgtctgggc cgtgccacct
       61 gcccgctagc tcgctgcact accgttgccc acaagccaac atgctgccga gattgggcgg
      121 ccccgcgctg ccgctgctcc tgccgtcgtt gctcttgctg ctgctcttgg gcgcgggcgg
      181 ctgcggcccc ggggtgcgcg ccgaggtgct gttccgctgc ccaccctgca cgcccgagcg
      241 tctggccgct tgcgggcccc cacccgacgc gccctgcgcc gagctggtgc gagagcccgg
      301 ctgcggctgc tgctccgtgt gcgcacggca ggagggcgaa gcatgcggcg tctacatccc
      361 gcgctgcgcc cagacgctac gctgctatcc caacccgggc tccgagctgc ccctgaaggc
      421 gcttgtcaca ggcgcgggta cctgtgaaaa gagacgcgtg ggcaccaccc cacagcaggt
      481 tgcagacagt gatgacgacc actctgaggg aggcctggtg gagaaccacg tggatgggac
      541 catgaacatg ttgggaggtg gtagcagtgc tggccggaag cccctcaagt caggcatgaa
      601 ggagctggct gtgttccggg agaaggtcaa tgaacagcac cggcagatgg gcaagggtgc
      661 caaacacctc agtctggagg agcccaagaa gttgcgcccg cctcccgcca ggaccccttg
      721 ccagcaggag ttggaccagg tcctggagcg gatctccacc atgcgccttc cggatgatcg
      781 gggccccctg gaacatctct actccctgca catccccaac tgtgacaagc atggccggta
      841 caaccttaag cagtgcaaga tgtctctgaa cggacagcgc ggggagtgct ggtgtgtgaa
      901 ccccaatacc gggaagccca tccagggagc tcccaccatc cggggagacc ccgagtgcca
      961 tctcttctac aacgagcagc aggagactgg tggggcccat gcccaaagtg tgcagtaaac
     1021 cccagccagt cggtgcctgg cttccccatc ccgaacacca gcagaaatgg agggcgtcag
     1081 ggtgacgggt gtggaggagt tcccagtttt gacacatgta tttatatttg gaaagagacc
     1141 aacactgagc tcagaagccc ccctctgacc ccccccagcg gctgttaagc tgaacctccc
     1201 ttgcttctgt tagagagggg aagggtggta tggagggcac tgggtacagg cctgggaatg
     1261 gggaaagaaa tttttatttt tgaatccctg tgtctctttt acttaagatt aaaggaagga
     1321 aaaataaaaa aaaaaaaaaa aa
//
