LOCUS       NM_008341               1522 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus insulin-like growth factor binding protein 1 (Igfbp1),
            mRNA.
ACCESSION   NM_008341
VERSION     NM_008341.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1522)
  AUTHORS   Cai,G., Qi,Y., Wei,P., Gao,H., Xu,C., Zhao,Y., Qu,X., Yao,F. and
            Yang,W.
  TITLE     IGFBP1 Sustains Cell Survival during Spatially-Confined Migration
            and Promotes Tumor Metastasis
  JOURNAL   Adv Sci (Weinh) 10 (21), e2206540 (2023)
   PUBMED   37296072
  REMARK    GeneRIF: IGFBP1 Sustains Cell Survival during Spatially-Confined
            Migration and Promotes Tumor Metastasis.
REFERENCE   2  (bases 1 to 1522)
  AUTHORS   Suzuki,H., Iwamoto,H., Seki,T., Nakamura,T., Masuda,A., Sakaue,T.,
            Tanaka,T., Imamura,Y., Niizeki,T., Nakano,M., Shimose,S.,
            Shirono,T., Noda,Y., Kamachi,N., Sakai,M., Morita,K., Nakayama,M.,
            Yoshizumi,T., Kuromatsu,R., Yano,H., Cao,Y., Koga,H. and
            Torimura,T.
  TITLE     Tumor-derived insulin-like growth factor-binding protein-1
            contributes to resistance of hepatocellular carcinoma to tyrosine
            kinase inhibitors
  JOURNAL   Cancer Commun (Lond) 43 (4), 415-434 (2023)
   PUBMED   36825684
  REMARK    GeneRIF: Tumor-derived insulin-like growth factor-binding protein-1
            contributes to resistance of hepatocellular carcinoma to tyrosine
            kinase inhibitors.
REFERENCE   3  (bases 1 to 1522)
  AUTHORS   Cheng,Y., Yang,R., Zhou,Y., Wang,J., Zhang,T., Wang,S., Li,H.,
            Jiang,W. and Zhang,X.
  TITLE     HBP1 inhibits the development of type 2 diabetes mellitus through
            transcriptional activation of the IGFBP1 gene
  JOURNAL   Aging (Albany NY) 14 (21), 8763-8782 (2022)
   PUBMED   36326689
  REMARK    GeneRIF: HBP1 inhibits the development of type 2 diabetes mellitus
            through transcriptional activation of the IGFBP1 gene.
REFERENCE   4  (bases 1 to 1522)
  AUTHORS   Kheirollahi,V., Khadim,A., Kiliaris,G., Korfei,M., Barroso,M.M.,
            Alexopoulos,I., Vazquez-Armendariz,A.I., Wygrecka,M., Ruppert,C.,
            Guenther,A., Seeger,W., Herold,S. and El Agha,E.
  TITLE     Transcriptional Profiling of Insulin-like Growth Factor Signaling
            Components in Embryonic Lung Development and Idiopathic Pulmonary
            Fibrosis
  JOURNAL   Cells 11 (12), 1973 (2022)
   PUBMED   35741102
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1522)
  AUTHORS   Yin,Y., Haller,M.E., Chadchan,S.B., Kommagani,R. and Ma,L.
  TITLE     Signaling through retinoic acid receptors is essential for
            mammalian uterine receptivity and decidualization
  JOURNAL   JCI Insight 6 (17), e150254 (2021)
   PUBMED   34292881
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1522)
  AUTHORS   Cerro,J.A., Grewal,A., Wood,T.L. and Pintar,J.E.
  TITLE     Tissue-specific expression of the insulin-like growth factor
            binding protein (IGFBP) mRNAs in mouse and rat development
  JOURNAL   Regul Pept 48 (1-2), 189-198 (1993)
   PUBMED   7505465
REFERENCE   7  (bases 1 to 1522)
  AUTHORS   Ferguson,M.W., Sharpe,P.M., Thomas,B.L. and Beck,F.
  TITLE     Differential expression of insulin-like growth factors I and II
            (IGF I and II), mRNA, peptide and binding protein 1 during mouse
            palate development: comparison with TGF beta peptide distribution
  JOURNAL   J Anat 181 (Pt 2) (Pt 2), 219-238 (1992)
   PUBMED   1284245
REFERENCE   8  (bases 1 to 1522)
  AUTHORS   O'Brien,T.P. and Lau,L.F.
  TITLE     Expression of the growth factor-inducible immediate early gene
            cyr61 correlates with chondrogenesis during mouse embryonic
            development
  JOURNAL   Cell Growth Differ 3 (9), 645-654 (1992)
   PUBMED   1419914
REFERENCE   9  (bases 1 to 1522)
  AUTHORS   Latinkic,B.V., O'Brien,T.P. and Lau,L.F.
  TITLE     Promoter function and structure of the growth factor-inducible
            immediate early gene cyr61
  JOURNAL   Nucleic Acids Res 19 (12), 3261-3267 (1991)
   PUBMED   2062642
REFERENCE   10 (bases 1 to 1522)
  AUTHORS   O'Brien,T.P., Yang,G.P., Sanders,L. and Lau,L.F.
  TITLE     Expression of cyr61, a growth factor-inducible immediate-early gene
  JOURNAL   Mol Cell Biol 10 (7), 3569-3577 (1990)
   PUBMED   2355916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ094023.1, AA060360.1, X81579.1, CF616646.1 and AI256511.1.
            
            On Nov 16, 2007 this sequence version replaced NM_008341.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X81579.1, SRR5189682.130718.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CJ094023.1         2-33
            33-80               AA060360.1         1-48
            81-239              X81579.1           1-159
            240-521             AA060360.1         208-489
            522-856             X81579.1           442-776
            857-1487            CF616646.1         64-694
            1488-1522           AI256511.1         1-35                c
FEATURES             Location/Qualifiers
     source          1..1522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.75 cM"
     gene            1..1522
                     /gene="Igfbp1"
                     /note="insulin-like growth factor binding protein 1"
                     /db_xref="GeneID:16006"
                     /db_xref="MGI:MGI:96436"
     exon            1..545
                     /gene="Igfbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..991
                     /gene="Igfbp1"
                     /note="IBP-1; IGF-binding protein 1; INSULIN-LIKE GROWTH
                     FACTOR BINDING PROTEIN 1 PRECURSOR (IGFBP-1) (IBP-1)
                     (IGF-BINDING PROTEIN 1)"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 1
                     precursor"
                     /protein_id="NP_032367.3"
                     /db_xref="CCDS:CCDS24427.1"
                     /db_xref="GeneID:16006"
                     /db_xref="MGI:MGI:96436"
                     /translation="MPEFLTVVSWPFLILLSFQIGVAAGAPQPWHCAPCTAERLGLCP
                     PVPASCPEISRPAGCGCCPTCALPMGAACGVATARCAQGLSCRALPGEPRPLHALTRG
                     QGACVPEPAAPATSTLFSSQHEEAKAAVVSADELSESPEMTEEQLLDSFHLMAPSRED
                     QPILWNAISTYSSMRAREIADLKKWKEPCQRELYKVLERLAAAQQKAGDEIYKFYLPN
                     CNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRGDPNCHQYFNVHN"
     exon            546..730
                     /gene="Igfbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..859
                     /gene="Igfbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1520
                     /gene="Igfbp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1490..1495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igfbp1"
                     /note="hexamer: AATAAA"
     polyA_site      1510
                     /gene="Igfbp1"
                     /note="major polyA site"
ORIGIN      
        1 atggtccact gcccgcggag acacacaccc agcgagcatt gaacactgca cacggccgtc
       61 tgcccagaga gctgtgacca ccattgccac tactatctac tcagaaagtc gtgaccactg
      121 agcaactgct gcctgtccag agtctcatcc acagcctgct gaaccagttg cgatgcccga
      181 gttcctaact gttgtttctt ggccgttcct gattctcctg tccttccaga ttggcgtggc
      241 cgctggagcc ccccagccat ggcactgtgc tccctgcact gctgagaggc tggggctctg
      301 tccacccgtg cccgcttcgt gccccgagat ttctcggcct gcaggctgtg gctgctgccc
      361 gacatgtgcc ttgccgatgg gtgctgcctg cggtgtggcc actgctcgct gcgcccaggg
      421 actcagctgc cgtgcgttgc caggagagcc tcgtcccctg catgccctca cccgtggtca
      481 gggagcctgt gtaccagaac ctgctgcacc cgccacgagc accttgttca gctcccagca
      541 tgaagaggca aaggctgctg tggtctccgc ggatgagctt tctgagagcc cagagatgac
      601 agaggagcag ctgctggaca gcttccacct gatggcccca tcccgcgagg atcagcccat
      661 cctgtggaac gccatcagca cctatagcag catgcgggcc cgggagatcg ccgacctcaa
      721 gaaatggaag gagccctgcc aacgagaact ctataaagtg ctagagagat tagctgcagc
      781 ccaacagaaa gcaggagatg aaatctacaa attttatctg ccaaactgca acaagaatgg
      841 attttatcac agcaaacagt gtgagacatc cctggatgga gaagctggac tctgctggtg
      901 tgtctaccca tggagtggaa agaaaatccc tgggtctctg gagactagag gggaccccaa
      961 ctgccaccag tattttaatg tacataactg aaaggagttc ttttcttttt ccgtgttcac
     1021 acaaaatatt taagtatata gtatatttat actctggagc acaccatttt atatatgtgt
     1081 atatgtatat atccaggaac tagtttttat actccacata ctgcttgata catgaagctg
     1141 gtttgtattt attcactgta agtttatttt tttctacaca gttcttgtgc tatattaatt
     1201 tatataacat gaagctcttc tcatctctgt acatgtaaat actatatctc agctcttgca
     1261 aagttctgct ttgaaagggc agagtgatgc tgcttagaac aaggcagtct gaggccggaa
     1321 gctttcagtg ggttagggga gggaggttgg cccacactcg gagatttcct catcgtctca
     1381 cacagatctg tgtctgatgc acatttgctg ggaaagttcc gatgctgatt gtgtaaccaa
     1441 agctgaacgt ggaaagctgc gtcccataca ttgttaaata cacatctgga ataaatattc
     1501 tatctggaaa tactatggaa aa
//
