LOCUS       NM_008340               2166 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus insulin-like growth factor binding protein, acid
            labile subunit (Igfals), transcript variant 1, mRNA.
ACCESSION   NM_008340
VERSION     NM_008340.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2166)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2166)
  AUTHORS   Liu,Z., Han,T., Fishman,S., Butler,J., Zimmermann,T., Tremblay,F.,
            Harbison,C., Agrawal,N., Kopchick,J.J., Schaffler,M.B. and Yakar,S.
  TITLE     Ablation of Hepatic Production of the Acid-Labile Subunit in
            Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth
  JOURNAL   Endocrinology 158 (8), 2556-2571 (2017)
   PUBMED   28475811
REFERENCE   3  (bases 1 to 2166)
  AUTHORS   Marongiu,M., Marcia,L., Pelosi,E., Lovicu,M., Deiana,M., Zhang,Y.,
            Puddu,A., Loi,A., Uda,M., Forabosco,A., Schlessinger,D. and
            Crisponi,L.
  TITLE     FOXL2 modulates cartilage, skeletal development and IGF1-dependent
            growth in mice
  JOURNAL   BMC Dev Biol 15, 27 (2015)
   PUBMED   26134413
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2166)
  AUTHORS   Kennedy,O.D., Sun,H., Wu,Y., Courtland,H.W., Williams,G.A.,
            Cardoso,L., Basta-Pljakic,J., Schaffler,M.B. and Yakar,S.
  TITLE     Skeletal response of male mice to anabolic hormone therapy in the
            absence of the Igfals gene
  JOURNAL   Endocrinology 155 (3), 987-999 (2014)
   PUBMED   24424061
  REMARK    GeneRIF: the Igfals gene has a role in skeletal response of male
            mice to anabolic hormone therapy
REFERENCE   5  (bases 1 to 2166)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2166)
  AUTHORS   Boisclair,Y.R., Hurst,K.R., Ueki,I., Tremblay,M.L. and Ooi,G.T.
  TITLE     Regulation and role of the acid-labile subunit of the
            150-kilodalton insulin-like growth factor complex in the mouse
  JOURNAL   Pediatr Nephrol 14 (7), 562-566 (2000)
   PUBMED   10912519
  REMARK    Review article
REFERENCE   7  (bases 1 to 2166)
  AUTHORS   Kargul,G.J., Nagaraja,R., Shimada,T., Grahovac,M.J., Lim,M.K.,
            Nakashima,H., Waeltz,P., Ma,P., Chen,E., Schlessinger,D. and
            Ko,M.S.
  TITLE     Eleven densely clustered genes, six of them novel, in 176 kb of
            mouse t-complex DNA
  JOURNAL   Genome Res 10 (7), 916-923 (2000)
   PUBMED   10899141
REFERENCE   8  (bases 1 to 2166)
  AUTHORS   Ueki,I., Ooi,G.T., Tremblay,M.L., Hurst,K.R., Bach,L.A. and
            Boisclair,Y.R.
  TITLE     Inactivation of the acid labile subunit gene in mice results in
            mild retardation of postnatal growth despite profound disruptions
            in the circulating insulin-like growth factor system
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6868-6873 (2000)
   PUBMED   10823924
REFERENCE   9  (bases 1 to 2166)
  AUTHORS   Suwanichkul,A., Boisclair,Y.R., Olney,R.C., Durham,S.K. and
            Powell,D.R.
  TITLE     Conservation of a growth hormone-responsive promoter element in the
            human and mouse acid-labile subunit genes
  JOURNAL   Endocrinology 141 (2), 833-838 (2000)
   PUBMED   10650966
REFERENCE   10 (bases 1 to 2166)
  AUTHORS   Boisclair,Y.R., Seto,D., Hsieh,S., Hurst,K.R. and Ooi,G.T.
  TITLE     Organization and chromosomal localization of the gene encoding the
            mouse acid labile subunit of the insulin-like growth factor binding
            complex
  JOURNAL   Proc Natl Acad Sci U S A 93 (19), 10028-10033 (1996)
   PUBMED   8816745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166102.2, AK004926.1 and BP768883.1.
            
            On Jul 13, 2018 this sequence version replaced NM_008340.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220290.1, AK004926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC166102.2         63569-63591         c
            24-2134             AK004926.1         3-2113
            2135-2166           BP768883.1         19-50               c
FEATURES             Location/Qualifiers
     source          1..2166
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..2166
                     /gene="Igfals"
                     /gene_synonym="Albs; ALS"
                     /note="insulin-like growth factor binding protein, acid
                     labile subunit"
                     /db_xref="GeneID:16005"
                     /db_xref="MGI:MGI:107973"
     exon            1..78
                     /gene="Igfals"
                     /gene_synonym="Albs; ALS"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1874
                     /gene="Igfals"
                     /gene_synonym="Albs; ALS"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; insulin-like growth factor-binding protein
                     complex acid labile subunit"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein
                     complex acid labile subunit isoform 1 precursor"
                     /protein_id="NP_032366.2"
                     /db_xref="CCDS:CCDS37497.1"
                     /db_xref="GeneID:16005"
                     /db_xref="MGI:MGI:107973"
                     /translation="MALRTGSPALVVLLAFWVALGPCYLQGTDPGASADAEGPQCPVT
                     CTCSYDDYTDELSVFCSSRNLTQLPDSIPVSTRALWLDGNNLSSIPSAAFQNLSSLDF
                     LNLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLGR
                     LEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCGLG
                     ELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHN
                     RVAGLLEDTFPGLLGLHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTF
                     EGLGQLEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGNCLRSLPEHVFQGLGRLHSLH
                     LEHSCLGRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLP
                     RQLFQGLGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRL
                     RYLNLRNNSLQTFVPQPGLERLWLDANPWDCSCPLKALRDFALQNPGVVPRFVQTVCE
                     GDDCQPVYTYNNITCAGPANVSGLDLRDISETLFVHC"
     exon            79..2137
                     /gene="Igfals"
                     /gene_synonym="Albs; ALS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2116..2121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igfals"
                     /gene_synonym="Albs; ALS"
                     /note="hexamer: ATTAAA"
     polyA_site      2137
                     /gene="Igfals"
                     /gene_synonym="Albs; ALS"
                     /note="major polyA site"
ORIGIN      
        1 agcctgtgct gtagacggcc cttgctcact gcctgcctgc ggccagctct gtacaaggaa
       61 caatggctct gagaacagga agcccagccc tggtggtgct tctggctttc tgggtggcac
      121 tgggcccctg ttacctgcag gggacagatc ctggagcatc agcagatgcc gagggccccc
      181 agtgccctgt cacctgtacc tgcagctatg atgactacac agatgagctc agcgtctttt
      241 gcagttcaag gaacctcact cagctgcccg atagcatccc agtcagcacc agggctctgt
      301 ggcttgacgg aaacaacctg tcctccatcc cctcagcggc cttccagaac ctgtccagcc
      361 tagacttcct caacctgcag ggcagctggc tgaggagcct ggagccacag gcactgctgg
      421 gcctgcagaa tctctaccat ctgcacctgg aacggaacct gctccggagc ctagctgcag
      481 gcttgttcag acacacacca agtctggctt cactcagttt gggcaacaac ctcctgggcc
      541 ggctggaaga agggctgttc cggggcctca gtcacctttg ggacctcaac ctgggttgga
      601 acagcctagt ggtcctgcct gacacggtgt tccagggcct gggcaacctc catgagctgg
      661 tgcttgctgg caacaaactg acttacctgc agcctgcgct cttgtgtggc ttgggcgagc
      721 tgcgggagct ggacctgagc aggaacgctc tccgcagcgt caaagctaat gtctttatac
      781 atctgccccg gctgcagaag ctctacctgg accgcaacct catcacagct gtggcccccc
      841 gtgccttcct gggcatgaag gcactgcgtt ggctggacct gtcacacaac cgtgtggctg
      901 gcctcctgga ggacaccttc cctggcctgc tgggtctgca tgtcctgcgc ctggcacaca
      961 acgccatcac tagcttgcgg ccgcgtactt tcaaagatct acacttcctg gaggaactgc
     1021 agctcggcca caatcgtatc aggcagttag gtgagaagac gtttgagggc ctggggcagc
     1081 tggaggtact gacgctcaat gacaatcaga tccatgaggt caaggtgggc gccttctttg
     1141 gcctcttcaa cgtggctgtt atgaatctct ccggcaactg tctgaggagc ctccccgagc
     1201 atgtgttcca agggctgggc aggctgcaca gcttgcacct ggagcacagc tgcctgggcc
     1261 gcatccgcct gcacactttc gccggcctct cagggctgcg caggctcttc ctccgggaca
     1321 acagcatctc cagcatcgaa gaacagagcc tggcagggct ctcagagctc ctggaactcg
     1381 atcttaccgc caaccagctc acgcatctgc cccgccagct tttccagggc cttggccagc
     1441 tggaatatct gcttctgtcc aacaaccaac tgacaatgct ctctgaggat gtcctgggcc
     1501 ctctgcagcg ggccttctgg ctggacctct cacacaaccg cctcgagacc ccggctgaag
     1561 gccttttctc atctctgggg cggcttcgct acctcaacct caggaataac tccttgcaga
     1621 cttttgtgcc gcagcctggc ctggagcgcc tgtggctcga tgccaacccc tgggactgca
     1681 gttgtcccct caaggcgctt cgtgactttg ccctacagaa ccctggtgtt gtcccccgct
     1741 ttgttcagac tgtctgtgag ggagatgact gccagccggt gtacacttac aacaacatca
     1801 cttgtgctgg ccccgccaac gtctcaggcc tcgaccttcg agacatcagt gaaacactct
     1861 ttgtgcactg ctgaccctgc tacttactgg cctggtctgg ctgaacactg ccttatggcc
     1921 aggatagtgt ttcactgtta cagaataagc tggctctgga atacttaccc atctcaaggg
     1981 gataggtcat ggctgctcac ttcctggatg cagggcagta ccggaagcga tgtggcctaa
     2041 atagggtggg cacaggccaa gtgcccgagg gcccaaagga ggggaggtgc tcagcagcac
     2101 accctgctgg caacaattaa agcaaatctg aagcataaaa aaaaaaaaaa aaaaaaaaaa
     2161 aaaaaa
//
