LOCUS       NM_010515               8948 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus insulin-like growth factor 2 receptor (Igf2r), mRNA.
ACCESSION   NM_010515 XM_489706
VERSION     NM_010515.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8948)
  AUTHORS   Basu,S., Mautner,L., Whiting,K., Hasenpusch-Theil,K., Borkowska,M.
            and Theil,T.
  TITLE     Identification of Pappa and Sall3 as Gli3 direct target genes
            acting downstream of cilia signaling in corticogenesis
  JOURNAL   Cereb Cortex 34 (12) (2024)
   PUBMED   39716738
REFERENCE   2  (bases 1 to 8948)
  AUTHORS   Chen,L., Zhong,X.L., Cao,W.Y., Mao,M.L., Liu,D.D., Liu,W.J.,
            Zu,X.Y. and Liu,J.H.
  TITLE     IGF2/IGF2R/Sting signaling as a therapeutic target in DSS-induced
            ulcerative colitis
  JOURNAL   Eur J Pharmacol 960, 176122 (2023)
   PUBMED   37863414
REFERENCE   3  (bases 1 to 8948)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8948)
  AUTHORS   Kheirollahi,V., Khadim,A., Kiliaris,G., Korfei,M., Barroso,M.M.,
            Alexopoulos,I., Vazquez-Armendariz,A.I., Wygrecka,M., Ruppert,C.,
            Guenther,A., Seeger,W., Herold,S. and El Agha,E.
  TITLE     Transcriptional Profiling of Insulin-like Growth Factor Signaling
            Components in Embryonic Lung Development and Idiopathic Pulmonary
            Fibrosis
  JOURNAL   Cells 11 (12), 1973 (2022)
   PUBMED   35741102
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8948)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (bases 1 to 8948)
  AUTHORS   Forejt,J. and Gregorova,S.
  TITLE     Genetic analysis of genomic imprinting: an Imprintor-1 gene
            controls inactivation of the paternal copy of the mouse Tme locus
  JOURNAL   Cell 70 (3), 443-450 (1992)
   PUBMED   1322799
REFERENCE   7  (bases 1 to 8948)
  AUTHORS   Rappolee,D.A., Sturm,K.S., Behrendtsen,O., Schultz,G.A.,
            Pedersen,R.A. and Werb,Z.
  TITLE     Insulin-like growth factor II acts through an endogenous growth
            pathway regulated by imprinting in early mouse embryos
  JOURNAL   Genes Dev 6 (6), 939-952 (1992)
   PUBMED   1317321
REFERENCE   8  (bases 1 to 8948)
  AUTHORS   Matzner,U., von Figura,K. and Pohlmann,R.
  TITLE     Expression of the two mannose 6-phosphate receptors is spatially
            and temporally different during mouse embryogenesis
  JOURNAL   Development 114 (4), 965-972 (1992)
   PUBMED   1319896
REFERENCE   9  (bases 1 to 8948)
  AUTHORS   Barlow,D.P., Stoger,R., Herrmann,B.G., Saito,K. and Schweifer,N.
  TITLE     The mouse insulin-like growth factor type-2 receptor is imprinted
            and closely linked to the Tme locus
  JOURNAL   Nature 349 (6304), 84-87 (1991)
   PUBMED   1845916
REFERENCE   10 (bases 1 to 8948)
  AUTHORS   Telford,N.A., Hogan,A., Franz,C.R. and Schultz,G.A.
  TITLE     Expression of genes for insulin and insulin-like growth factors and
            receptors in early postimplantation mouse embryos and embryonal
            carcinoma cells
  JOURNAL   Mol Reprod Dev 27 (2), 81-92 (1990)
   PUBMED   1701096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116804.22, BB865604.1, AC167817.4, CN530622.1, CK639250.1,
            CF167933.1, CA324933.1, CN461279.1, CD545656.1, BQ900123.1,
            AK053045.1 and BP757292.1.
            
            On Mar 20, 2007 this sequence version replaced NM_010515.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC171973.1, SRR10223970.18935.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 19141673
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC116804.22        175409-175460       c
            53-624              BB865604.1         3-574
            625-666             AC167817.4         212594-212635       c
            667-691             BB865604.1         617-641
            692-804             AC167817.4         209269-209381       c
            805-934             AC167817.4         207099-207228       c
            935-1040            AC167817.4         204710-204815       c
            1041-1203           AC167817.4         199973-200135       c
            1204-1369           AC167817.4         199492-199657       c
            1370-1473           AC167817.4         198617-198720       c
            1474-1638           AC167817.4         195430-195594       c
            1639-1776           AC167817.4         193115-193252       c
            1777-1920           AC167817.4         191954-192097       c
            1921-2058           AC167817.4         190575-190712       c
            2059-2206           AC167817.4         189871-190018       c
            2207-2311           AC167817.4         189245-189349       c
            2312-2899           CN530622.1         1-588
            2900-2988           CK639250.1         513-601
            2989-3053           AC167817.4         183939-184003       c
            3054-3238           AC167817.4         182692-182876       c
            3239-3790           CF167933.1         1-552
            3791-4096           CA324933.1         287-592
            4097-4445           CN461279.1         146-494
            4446-4871           CD545656.1         85-510
            4872-5492           BQ900123.1         199-819
            5493-6940           AK053045.1         85-1532
            6941-6941           AC167817.4         159977-159977       c
            6942-8764           AK053045.1         1534-3356
            8765-8948           BP757292.1         1-184               c
FEATURES             Location/Qualifiers
     source          1..8948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.64 cM"
     gene            1..8948
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /note="insulin-like growth factor 2 receptor"
                     /db_xref="GeneID:16004"
                     /db_xref="MGI:MGI:96435"
     exon            1..307
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..7625
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /note="cation-independent mannose-6-phosphate receptor;
                     M6PR; MPR 300; IGF-II receptor; M6P/IGF2 receptor; CI
                     Man-6-P receptor; 300 kDa mannose 6-phosphate receptor;
                     insulin-like growth factor II receptor;
                     mannose-6-phosphate receptor, cation independent;
                     IGF-II/CI-MPR; cation-independent MPR"
                     /codon_start=1
                     /product="cation-independent mannose-6-phosphate receptor
                     precursor"
                     /protein_id="NP_034645.2"
                     /db_xref="CCDS:CCDS37436.1"
                     /db_xref="GeneID:16004"
                     /db_xref="MGI:MGI:96435"
                     /translation="MRAVQLGPVPSGPRVALLPPLLLLLLLAAAGSAQAQAVDLDALC
                     SYTWEAVDSKNNAVYKINVCGNVGISSCGPTSAICMCDLKTENCRSVGDSLLRSSARS
                     LLEFNTTMGCQPSDSQHRIQTSITFLCGKTLGTPEFVTATDCVHYFEWRTTAACKKDI
                     FKADKEVPCYAFDDKLQKHDLNPLIKLNGGYLVDDSDPDTSLFINVCRDIDSLRDPST
                     QLRVCPAGTAACLLKGNQAFDVGRPKEGLKLLSKDRLVLTYVKEEGEKPDFCNGHSPA
                     VTVTFVCPSERREGTIPKLTAKSNCRYEVEWITEYACHRDYLQSESCSLSSEQHDITI
                     DLSPLAQYGGSPYVSDGREYTFFINVCGDTKVSLCNNKEAAVCQEKKADSTQVKIAGR
                     HQNQTLRYSDGDLTLIYSGGDECSSGFQRMSVINFECNKTAGKDGRGEPVFTGEVDCT
                     YFFTWDTKYACIKEKEDLLCGAINGKKRYDLSVLARHSESEQNWEAVDGSQAESEKYF
                     FINVCHRVLQEGKARNCPEDAAVCAVDKNGSKNLGKFVSSPTKEKGHIQLSYTDGDDC
                     GSDKKISTNITLVCKPGDLESAPVLRAARSDGCFYEFEWHTAAACVLSKTEGENCTVL
                     DAQAGFSFDLSLLTKKNGAYKVETEKYDFYINVCGPVSMDPCQSNSGACQVAKSGKSW
                     NLGLSSTKLTYYDGMIQLSYRNGTPYNNEKHTPRATLITFLCDRDAGVGFPEYQEEDN
                     STYNFRWYTSYACPEEPLECMVTDPSMMEQYDLSSLVKSEGGSGGNWYAMENSREHVT
                     RRKYYLNVCRPLNPVPGCDRYASACQMKYENHEGSLAETVSISNLGVAKIGPVVEESG
                     SLLLEYVNGSACTTSDGQLTTYSTRIHLVCGRGFMNSHPIFTFNWECVVSFLWNTEAA
                     CPIQTITETDQACSIRDPSSGFVFNLSPLNDSAQGHVVLGIGKTFVFNICGAMPACGT
                     VAGKPAYGCEAETQIEDIKDLRPQRPVGMERSLQLSAEGFLTLTYKGSSPSDRGTAFI
                     IRFICNDDIYPGAPKFLHQDIDSTRGIRNTYFEFETALACTPSLVDCQVTDPAGNEYD
                     LSALSMVRKPWTAVDTSAYGKRRHFYLSVCNPLPYIPGCHGIALGSCMVSEDNSFNLG
                     VVQISPQATGNGSLSILYVNGDRCGDQRFSTRIVFECAQTSGSPMFQFVNNCEYVFVW
                     RTVEACPVIREEGDNCQVKDPRHGNLYDLKPLGLNDTIVSVGEYTYYLRVCGKLSSDV
                     CSAHDGSKAVSSCQEKKGPQGFQKVAGLLSQKLTFENGLLKMNYTGGDTCHKVYQRST
                     TIYFYCDRTTQKPVFLKETSDCSYMFEWRTQYACPPFNVTECSVQDAAGNSIDLSSLS
                     RYSDNWEAVTRTGATEHYLINVCKSLSPHAGTEPCPPEAAVCLLNGSKPVNLGKVRDG
                     PQWTDGVTVLQYVDGDLCPDKIRRRSTIIRFTCSDNQVNSRPLFISAVQDCEYTFSWP
                     TPSACPVKSNTHDDCQVTNPSTGHLFDLSSLSGRAGINASYSEKGLVFMSICEENENC
                     GPGVGACFGQTRISVGKASKRLSYKDQVLQLVYENGSPCPSLSDLRYKSVISFVCRPE
                     AGPTNRPMLISLDKQTCTLFFSWHTPLACEQATECTVRNGSSIIDLSPLIHRTGGYEA
                     YDESEDDTSDTTPDFYINICQPLNPMHGVPCPAGASVCKVPVDGPPIDIGRVTGPPIF
                     NPVANEVYLNFESSTHCLADRYMNYTSLITFHCKRGVSMGTPKLIRTNDCDFVFEWET
                     PIVCPDEVKTQGCAVTDEQLLYSFNLTSLSTSTFKVTRDARTYSIGVCTAAAGLGQEG
                     CKDGGVCLLSGNKGASFGRLASMQLDYRHQDEAVILSYVNGDPCPPETDDGEPCVFPF
                     IYKGKSYDECVLEGRAKLWCSKTANYDRDHEWGFCRQTNSYRMSAIIFTCDESEDIGR
                     PQVFSEDRGCEVTFEWKTKVVCPPKKMECKFVQKHKTYDLRLLSSLTGSWDFVHEGNS
                     YFINLCQRVYKGPLDCSERASICKKSATGQVQVLGLVHTQKLEVIDETVIVTYSKGYP
                     CGGNKTASSVIELTCAKTVGRPAFKRFDSVSCTYYFYWYSRAACAVRPQEVTMVNGTL
                     TNPVTGKSFSLGEIYFKLFSASGDMRTNGDNYLYEIQLSSITSSSYPACAGANICQVK
                     PNDQHFSRKVGTSDMTKYYVQDGDLDVVFTSSSKCGKDKTKSVSSTIFFHCDPLVKDG
                     IPEFSHETADCQYLFSWYTSAVCPLGVDFEDESAGPEYKGLSERSQAVGAVLSLLLVA
                     LTGCLLALLLHKKERRETVINKLTSCCRRSSGVSYKYSKVSKEEETDENETEWLMEEI
                     QVPAPRLGKDGQENGHITTKAVKAEALSSLHGDDQDSEDEVLTVPEVKVHSGRGAEVE
                     SSQPLRNPQRKVLKEREGERLGLVRGEKARKGKFRPGQRKPTAPAKLVSFHDDSDEDL
                     LHI"
     exon            308..447
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            448..572
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            573..671
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            672..804
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            805..934
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1040
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1203
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1369
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1473
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1638
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1776
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1920
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2058
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2206
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2381
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2497
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2666
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2846
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2948
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3053
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3249
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3414
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3558
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3734
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..3822
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..4038
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            4039..4169
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            4170..4267
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            4268..4404
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4595
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            4596..4722
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..4842
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            4843..5099
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            5100..5318
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            5319..5468
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            5469..5630
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            5631..5838
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            5839..5985
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            5986..6220
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            6221..6357
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            6358..6472
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            6473..6619
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            6620..6807
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            6808..6994
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            6995..7138
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            7139..7208
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     exon            7209..8929
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8906..8911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /note="hexamer: AATAAA"
     polyA_site      8924
                     /gene="Igf2r"
                     /gene_synonym="CD222; CI-MPR; M6P/IGF2R; Mpr300"
                     /note="major polyA site"
ORIGIN      
        1 cgctccgggg acggccacgg agcgcctcct cgtcgcactc ccccctggct ccagttctct
       61 ctcctctttc tccctccagc tcccgttgca gcttcgactc cgctgtggtg gcgcgaccgt
      121 gtcccaggcg cggctccaaa cggccagccg ccgtgagccc cacgccacac gcgatgcggg
      181 ccgttcagct gggaccggtg ccctccgggc cgcgcgtcgc gctcctgccg ccgctcctgc
      241 tgctgctgct cctggcggcc gcgggctccg cgcaggccca ggccgtcgac ttggacgccc
      301 tgtgcagtta cacatgggaa gctgttgact ccaaaaacaa tgcagtttat aagatcaacg
      361 tctgtggaaa tgtgggtatt tccagctgtg ggcctacaag tgctatctgt atgtgtgacc
      421 taaagacaga gaactgccgc tcagtgggtg actcactttt gagaagttca gccagatcac
      481 tcctggaatt caacaccact atgggctgcc agccttcaga ttcacagcac agaatccaga
      541 ctagcattac atttctgtgt gggaagaccc tgggaactcc tgaatttgta actgccacag
      601 actgtgtgca ttactttgaa tggaggacta ctgcagcctg caagaaagac atatttaaag
      661 ctgataagga ggtaccatgc tatgcatttg atgacaagtt acagaagcat gatttaaacc
      721 cactgatcaa gctaaatggt ggctatctgg tagatgattc tgatcctgac acgtctctgt
      781 tcatcaacgt gtgtagagac atagactccc ttcgggaccc cagcacacag ctgagagtct
      841 gtcctgctgg cactgctgcc tgtctgctga aggggaacca ggcatttgac gttggccgac
      901 ccaaggaggg gctgaagctg ttgagcaagg acaggctcgt tctgacttat gtgaaggaag
      961 agggagaaaa gccagacttc tgtaatggtc acagccctgc agtgacagta acatttgtgt
     1021 gcccatctga gcggagagag ggtaccattc ctaaactcac tgccaagtcc aactgccgtt
     1081 atgaagttga gtggatcacc gagtatgcct gccacagaga ttacctgcaa agtgagagct
     1141 gctccctcag cagtgagcag catgatatta ctattgacct tagtcccttg gcccaatatg
     1201 gagggtcccc ctatgtttct gatggaagag aatatacgtt ttttatcaat gtctgtgggg
     1261 acacaaaggt ctcactctgt aataacaaag aggctgctgt ttgtcaagag aaaaaggcgg
     1321 attccactca agtcaaaata gcaggaagac accagaacca gacactccgg tactcagatg
     1381 gagacctcac cctcatctat tctggaggtg atgagtgtag ctctggcttc cagaggatga
     1441 gtgtcataaa ctttgagtgc aacaaaactg caggtaagga tgggagagga gagcctgtgt
     1501 tcacaggtga ggtggactgc acctacttct tcacatggga cactaaatac gcctgcatca
     1561 aagagaagga agacctcctc tgcggggcca tcaatggcaa gaaacgctat gacctgtctg
     1621 tgttggctcg tcactcagaa tcagaacaga attgggaagc agtggatggc agccaggcag
     1681 aatcagaaaa gtatttcttc atcaacgtct gtcaccgggt gctgcaggag gggaaggcca
     1741 ggaactgtcc tgaagatgct gctgtgtgcg ctgtggataa gaatgggagt aaaaaccttg
     1801 gaaaatttgt ctcttctcct acaaaagaga aaggacacat acagctctct tacactgatg
     1861 gtgatgactg tggcagtgat aagaaaatat caactaacat cacacttgtg tgcaaaccag
     1921 gtgatctaga aagtgctcca gtgctaagag ctgcaagatc tgatggctgc ttctatgagt
     1981 ttgagtggca tacggctgct gcctgtgtac tgtcgaagac agaaggagag aactgcacgg
     2041 tccttgatgc ccaggcaggg ttttcctttg atttgtcact cctcacgaag aagaatggtg
     2101 catataaagt tgagacagag aagtatgact tctacataaa tgtttgtggc cctgtatcca
     2161 tggatccttg tcagtcaaac tcgggggcct gccaggtagc gaaaagtggt aagtcttgga
     2221 acttggggct gagtagtact aagctcacct actacgacgg aatgatccag ctgagctaca
     2281 ggaacggcac tccctataac aatgaaaagc acacaccgag agccacactg attaccttcc
     2341 tctgtgaccg tgacgctgga gtgggcttcc cagaatatca ggaagaggac aactctacct
     2401 acaacttccg gtggtacacc agttatgcct gcccagaaga acccctggag tgcatggtga
     2461 cagacccctc catgatggaa cagtatgacc tctccagtct agtgaagtct gaaggtggct
     2521 ctggaggaaa ctggtatgct atggaaaact cccgggaaca tgttacacgg aggaaatact
     2581 acctcaatgt gtgtcggcct ctgaatcctg tgccaggctg cgatcgatat gcatctgctt
     2641 gccagatgaa atatgaaaat catgagggct ccttggcaga gactgtatcc atcagtaact
     2701 tgggagttgc aaagataggc cctgtggtgg aggagagtgg cagcctcctc ttagagtatg
     2761 tgaacggctc tgcttgcacc accagtgatg gccagctcac cacctacagc accaggatcc
     2821 atcttgtctg tggtcgagga tttatgaact cccatcccat attcactttc aactgggaat
     2881 gtgtggtcag tttcttgtgg aacacggagg ctgcctgccc tatccagaca atcacagaaa
     2941 cagaccaggc ttgctcaata agggacccca gcagtgggtt tgtgtttaat cttagcccac
     3001 tcaacgattc tgctcaagga catgtggtct taggcatcgg aaagactttt gtgttcaata
     3061 tctgtggtgc aatgcctgcc tgtggaacgg ttgcggggaa gccagcctat ggctgcgagg
     3121 ccgaaactca gatagaagat attaaggacc taaggccaca aaggccggtc gggatggaga
     3181 ggagcctcca gttgtctgcc gagggattcc tcactctgac ctacaagggc tcttctccct
     3241 ctgacagagg cacagcattc atcatccgtt ttatttgcaa cgatgacatt tacccaggag
     3301 cccccaaatt cctgcatcag gacattgact ccacacgagg gatccggaac acttactttg
     3361 agtttgaaac tgcattggct tgtactcctt ctctagtgga ttgtcaagtg actgacccag
     3421 ctgggaacga gtatgacttg agcgccctga gcatggtcag gaagccatgg actgccgtgg
     3481 acacgtctgc atacgggaag aggaggcact tctacctgag tgtctgcaac cctctgcctt
     3541 atatccctgg ctgccacggc attgcattgg ggtcctgcat ggtgtcagaa gacaacagtt
     3601 ttaacttggg tgtggtgcag atcagtcctc aagctactgg aaatgggtct ctcagcatcc
     3661 tgtacgtgaa tggggacaga tgtggggacc agcgcttctc caccaggatc gtgttcgagt
     3721 gtgcccagac gtcgggctca cctatgttcc agttcgtgaa caactgtgag tatgtgtttg
     3781 tgtggcgaac agtggaggcc tgccctgtga tcagagagga aggagacaac tgccaggtga
     3841 aggaccccag gcatggcaat ttgtatgacc tgaagcccct gggcctcaat gacaccatcg
     3901 tcagtgttgg cgagtacacc tactacttgc gggtctgcgg gaagctgtca tcagatgtct
     3961 gctctgccca tgacggatcc aaggcagtct catcatgcca ggaaaagaaa ggaccacagg
     4021 gattccagaa agtggcagga ctccttagcc agaagctgac tttcgaaaac ggactgttga
     4081 aaatgaacta tactgggggg gatacctgcc ataaggtgta tcagcgctcc acaaccatct
     4141 atttctactg tgaccggact acacagaagc cagtgtttct gaaggaaact tcggactgct
     4201 cctatatgtt tgagtggcga acacagtatg cctgcccacc tttcaatgtg acagagtgtt
     4261 ctgtccagga tgcggctggc aactccattg acctctcctc actgtcaagg tacagtgaca
     4321 actgggaggc tgtgaccagg acaggggcca ctgagcatta cctcatcaat gtatgcaagt
     4381 ctctgtctcc acacgctggc acagagccat gccctccaga ggcagctgtt tgtctgctga
     4441 atggctctaa gcctgtgaac cttggcaagg tgagggatgg ccctcagtgg acagacggtg
     4501 tgactgtcct gcagtatgtg gatggtgact tgtgcccaga caaaattcgg agaaggtcaa
     4561 ccattattcg cttcacctgc agtgacaacc aagtgaactc caggcccctt ttcatcagtg
     4621 ctgttcagga ctgtgagtac accttctcct ggcccacccc ttctgcctgt cctgtgaaga
     4681 gcaacacaca tgatgactgc caagtcacca accccagcac aggccacctg tttgacctga
     4741 gctccttaag tggcagagct ggtatcaatg cctcctacag cgagaagggg ctggtcttca
     4801 tgagcatctg tgaggagaat gagaactgtg gccccggagt aggggcctgc tttggacaga
     4861 cgaggatcag tgtgggcaag gccagcaaga ggctgagcta caaggaccaa gtcctgcagc
     4921 tggtgtatga gaatgggtcc ccatgccctt ccctgtcaga cctgaggtac aagagtgtca
     4981 tcagctttgt gtgccggcct gaggctggac ctaccaacag gccgatgctc atctccttgg
     5041 acaagcagac gtgcacactc ttcttctcct ggcacacacc cctggcctgt gagcaagcga
     5101 cggagtgtac tgtgcggaat ggaagctcga ttattgacct gtcccctctc atccaccgca
     5161 ctggtggcta cgaagcatac gatgaaagtg aggatgacac ctctgacacc acccctgact
     5221 tctatatcaa catctgccag ccactgaatc ccatgcacgg agtgccctgc cctgcaggtg
     5281 cctcagtatg caaagttcct gtggacgggc cccctataga tattggcaga gtcacaggcc
     5341 ctccaatatt caatcctgtg gcgaatgaag tctacctgaa ctttgagagc agcactcatt
     5401 gcttagccga cagatatatg aactacacct cactcatcac atttcactgc aagagaggag
     5461 tcagcatggg aactcctaag ctgataagga ccaatgactg cgactttgtg tttgagtggg
     5521 agactccgat tgtctgtcct gacgaagtga agacacaggg ttgtgctgta acagatgagc
     5581 agctgctcta tagcttcaac ctgaccagcc tttccacaag cactttcaag gttactcggg
     5641 atgcccgcac atacagtata ggggtgtgca cagcagcagc tggcttaggc caggaaggct
     5701 gcaaggatgg cggtgtctgt ctgctctctg ggaacaaagg agcttctttt gggcgccttg
     5761 catcgatgca gctggattac aggcaccaag atgaagcagt cattctgagt tatgtgaatg
     5821 gtgatccttg ccctccagaa acggatgatg gcgagccctg tgtcttcccc ttcatttaca
     5881 aagggaagag ctatgatgaa tgtgtattag agggacgagc gaaactgtgg tgtagcaaaa
     5941 ctgcaaatta tgatcgtgac cacgagtggg gcttctgcag acagaccaac agctaccgga
     6001 tgtctgcgat catatttacg tgtgatgaaa gtgaagatat tgggagacca caagtgttca
     6061 gtgaagatcg tgggtgtgag gtgacatttg agtggaagac aaaagttgtc tgccctccaa
     6121 agaagatgga gtgcaagttt gttcagaagc ataagaccta tgacttgcga ctgctctcat
     6181 ccctcacggg gtcctgggac tttgtgcatg aaggaaactc gtactttatc aatctgtgcc
     6241 aaagagtata caaaggtccc ctggactgct ctgaaagagc cagcatttgc aagaagagtg
     6301 ccactggtca agtccaggtt ttggggcttg ttcatacaca aaaattggaa gtcatagatg
     6361 aaacggtcat tgttacttac tcgaaaggct atccttgtgg tgggaataag actgcatcgt
     6421 ctgtaatcga attgacctgt gcgaagactg tgggcaggcc tgcattcaag aggtttgaca
     6481 gtgtcagctg cacctactac ttttactggt actcacgggc tgcctgcgcg gtgaggcctc
     6541 aggaggtgac catggtgaac ggaacgctca ccaaccctgt gaccggcaag agcttcagcc
     6601 tcggcgagat ttattttaag ctcttcagcg cctctggaga catgaggacc aatggggaca
     6661 actacctgta tgaaatccag ctctcctcca tcaccagctc ttcttaccct gcatgcgctg
     6721 gtgccaacat ctgccaggtg aagcccaatg accagcattt cagcaggaaa gtaggcacct
     6781 ctgacatgac caagtactac gtccaagatg gagatctgga tgtggtgttt acctcttcct
     6841 ccaagtgtgg gaaagataag accaagtctg tttcttccac catcttcttc cactgtgacc
     6901 ctctggtgaa ggatgggatc ccagagttca gccacgagac cgctgactgc cagtacctgt
     6961 tctcctggta cacttcagct gtgtgtcctc tgggtgtgga ctttgaggat gagagcgcag
     7021 ggccagagta taaaggactc tcagagcgga gtcaggctgt tggggcagtc ctcagtcttc
     7081 tcctggtggc gctgactggc tgcttgctgg ccttactgct gcataagaag gagagaaggg
     7141 aaactgtgat aaacaagctg accagctgct gcagaagaag ctcgggcgtg tcctacaagt
     7201 actcaaaggt cagcaaggag gaggagacag atgagaatga gacagaatgg ctgatggaag
     7261 agatccaggt gccagcccca agactaggca aggacgggca agaaaatggc catatcacca
     7321 ccaaggcggt gaaagcagaa gctctctcgt ccctgcatgg ggacgaccag gacagtgagg
     7381 atgaggtcct gaccgttcca gaggtgaaag ttcactcagg ccgaggagcg gaggtggaaa
     7441 gctcacagcc cctgagaaac ccacagcgca aggtcctgaa ggaaagggag ggtgagaggc
     7501 tggggctggt ccgaggtgag aaggccagaa aagggaagtt cagacccgga cagcgcaagc
     7561 caacagcccc tgccaagctg gtgtccttcc atgatgacag cgacgaagac ctcttacaca
     7621 tctaactccg tggtgcctac agaagaaggt ggagccatgg acagccaagc acctccaacc
     7681 aaataagact tcagctcgat gatgcgtctg tcattttgcc tttaacaaaa ctgcttcaaa
     7741 gggaagagtt tctgtaatgg gggagaggat gggggaggtg ggcaccactc cttcatgatc
     7801 gtttacagtc aatggaacaa ggtgttgctt gaatcggcca aagggcggta cttcgtgccc
     7861 aggggtttgc cccaagtcct cacttacgat catagctgct gtgtgcttcc aacaggtgcc
     7921 caagccacat gcatctcaca acagagggct gtgtttgaaa aaaacccttg ctgctttaga
     7981 ccctacgggg tgaccattta tatttttagc attgtaattc tctcccctat ttattgactt
     8041 tgacaattac tactcaggtt tgcgaaaaag gaaaaacaaa aacaaaaaca aaaccagttt
     8101 cttttgccag caagggcata aggtgaagct ggccgtctgc cggagccgtt gtccatggct
     8161 cctgaactgg tccttgatgc acacttagtg agctgcagta ttctattctt cgctttgcat
     8221 tttgtgaggg cacacacaca tgcacaggtc cccgagtgcc taggtttggg aaggcccacc
     8281 tgctccgtgc cctacctcat ctctgtagtt gcagctcttt gcacgaatcc ctctgggtgt
     8341 tgctcttgcc agctggtgac tcccagcagc tcacccaggc gggcgttcgc gcacacggtg
     8401 gagtggaggc tcttggggag gagctgcgct tcaggtttga gctgtaggtc tcatctcttc
     8461 agggtctcat agtgccacct ttactgtgct ttttgctttt tttttttttt tttttaaggg
     8521 ggaaaatgtt tatcacccat tcgacctata agaagcctta atttgcacag ggtgacttat
     8581 tacagacacc gtgaaacgcg gtgggccagt gttggtgtag ggccagtgtt ggtgtagggg
     8641 ctgtgctagg gcagtgtccc aggatggaag ggcaggccca gtccactggc tgtggattct
     8701 tttcttgatg tgttcagtga cttgtcacat tatagagttg tatataggtg gcatttacat
     8761 acccaaaagc aaagtacccc gcagaatttc ttggtttatg cctgattttg ctagcttatt
     8821 tgatttcaca ttgagtgtat ttttaaaaat tgatttttct cttcattttt aatcaacttg
     8881 actgtaatat gaagtattca atttcaataa agataaatta ttaactagga aaaaaaaaaa
     8941 aaaaaaaa
//
