LOCUS       NM_023670               4366 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus insulin-like growth factor 2 mRNA binding protein 3
            (Igf2bp3), mRNA.
ACCESSION   NM_023670
VERSION     NM_023670.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4366)
  AUTHORS   Yu,J., Gao,Y., Liu,F., Zhang,Y., Li,J., Ding,L., Ren,S., Yang,J.,
            Jiao,J., Feng,G., Chen,Z., Sun,W. and Wu,J.
  TITLE     m6A-modified exosome-derived circHIF1alpha binding to KH domain of
            IGF2BP3 mediates DNA damage and arrests G1/S transition phase to
            resists bacterial infection in bacteremia
  JOURNAL   J Nanobiotechnology 22 (1), 654 (2024)
   PUBMED   39443946
  REMARK    GeneRIF: m6A-modified exosome-derived circHIF1alpha binding to KH
            domain of IGF2BP3 mediates DNA damage and arrests G1/S transition
            phase to resists bacterial infection in bacteremia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4366)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4366)
  AUTHORS   Yuan,D., Li,H., Dai,W., Zhou,X., Zhou,W. and He,L.
  TITLE     IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of
            renal tubule to alleviate diabetic nephropathy
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167022 (2024)
   PUBMED   38216068
  REMARK    GeneRIF: IGF2BP3-stabilized CAMK1 regulates the mitochondrial
            dynamics of renal tubule to alleviate diabetic nephropathy.
REFERENCE   4  (bases 1 to 4366)
  AUTHORS   Jin,D., Hui,Y., Liu,D., Li,N., Leng,J., Wang,G., Wang,Q. and Lu,Z.
  TITLE     LINC00942 inhibits ferroptosis and induces the immunosuppression of
            regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular
            carcinoma
  JOURNAL   Funct Integr Genomics 24 (1), 29 (2024)
   PUBMED   38353724
  REMARK    GeneRIF: LINC00942 inhibits ferroptosis and induces the
            immunosuppression of regulatory T cells by recruiting
            IGF2BP3/SLC7A11 in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4366)
  AUTHORS   Huang,X., He,W., Fan,S., Li,H. and Ye,G.
  TITLE     IGF2BP3-mediated enhanced stability of MYLK represses MSC
            adipogenesis and alleviates obesity and insulin resistance in HFD
            mice
  JOURNAL   Cell Mol Life Sci 81 (1), 17 (2024)
   PUBMED   38196046
  REMARK    GeneRIF: IGF2BP3-mediated enhanced stability of MYLK represses MSC
            adipogenesis and alleviates obesity and insulin resistance in HFD
            mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4366)
  AUTHORS   Mueller-Pillasch,F., Pohl,B., Wilda,M., Lacher,U., Beil,M.,
            Wallrapp,C., Hameister,H., Knochel,W., Adler,G. and Gress,T.M.
  TITLE     Expression of the highly conserved RNA binding protein KOC in
            embryogenesis
  JOURNAL   Mech Dev 88 (1), 95-99 (1999)
   PUBMED   10525192
REFERENCE   7  (bases 1 to 4366)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 4366)
  AUTHORS   Nielsen,J., Christiansen,J., Lykke-Andersen,J., Johnsen,A.H.,
            Wewer,U.M. and Nielsen,F.C.
  TITLE     A family of insulin-like growth factor II mRNA-binding proteins
            represses translation in late development
  JOURNAL   Mol Cell Biol 19 (2), 1262-1270 (1999)
   PUBMED   9891060
REFERENCE   9  (bases 1 to 4366)
  AUTHORS   Funke,B., Zuleger,B., Benavente,R., Schuster,T., Goller,M.,
            Stevenin,J. and Horak,I.
  TITLE     The mouse poly(C)-binding protein exists in multiple isoforms and
            interacts with several RNA-binding proteins
  JOURNAL   Nucleic Acids Res 24 (19), 3821-3828 (1996)
   PUBMED   8871564
REFERENCE   10 (bases 1 to 4366)
  AUTHORS   Duh,J.L., Zhu,H., Shertzer,H.G., Nebert,D.W. and Puga,A.
  TITLE     The Y-box motif mediates redox-dependent transcriptional activation
            in mouse cells
  JOURNAL   J Biol Chem 270 (51), 30499-30507 (1995)
   PUBMED   8530481
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147140.1, BC045138.1 and CB524241.1.
            
            On Mar 21, 2009 this sequence version replaced NM_023670.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147140.1, AK088465.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               AK147140.1         5-374
            371-2448            BC045138.1         1-2078
            2449-4337           AK147140.1         2453-4341
            4338-4366           CB524241.1         480-508
FEATURES             Location/Qualifiers
     source          1..4366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.82 cM"
     gene            1..4366
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /note="insulin-like growth factor 2 mRNA binding protein
                     3"
                     /db_xref="GeneID:140488"
                     /db_xref="MGI:MGI:1890359"
     exon            1..658
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..2223
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /note="mIMP-3; VICKZ family member 3; IGF2 mRNA-binding
                     protein 3; IGF-II mRNA-binding protein 3; insulin-like
                     growth factor 2, binding protein 3"
                     /codon_start=1
                     /product="insulin-like growth factor 2 mRNA-binding
                     protein 3"
                     /protein_id="NP_076159.3"
                     /db_xref="CCDS:CCDS39485.1"
                     /db_xref="GeneID:140488"
                     /db_xref="MGI:MGI:1890359"
                     /translation="MNKLYIGNLSDHAGPADLESVFKDAKIPVAGPFLVKTGYAFVDC
                     PDEGWALKAIEALSGKMELHGKPMEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLV
                     QYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDETAA
                     QQNPSPQLRGRRGPGQRGSSRQASPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATI
                     RNITKQTQSKIDVHRKENTGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEE
                     IPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGSVE
                     TCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPST
                     LTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAK
                     VRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGK
                     TVNELQSLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQ
                     KALQSGPPQSRRK"
     exon            659..719
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            720..768
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            769..820
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            821..884
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1166
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1301
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1424
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1560
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1686
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1803
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1878
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2010
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2124
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..4347
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4323..4328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /note="hexamer: AATAAA"
     polyA_site      4347
                     /gene="Igf2bp3"
                     /gene_synonym="2610101N11Rik; IMP-3; IMP3; Koc13; mimp3;
                     Neilsen"
                     /note="major polyA site"
ORIGIN      
        1 ttgaacacgt ggctcattca aaaagccgga cactcggagc ggctgccccc gccccgctcc
       61 cctcgccgct gccagtcacc cctcggggtt tttttttttt acggggaggc ggcgcctgcc
      121 ccacgtagtg tgatattttc acagcccgct ggccgctgcc aaaggggttg gggaggaaga
      181 gacaaaaagt agtttccccc cgcgcctcct cctttctctc gctaatcccg cctcctcccc
      241 agagttagga agactcgacg ctgggctcgt cgctaggctt tttctttctc tctttttttt
      301 aatacccaga agaggaaaaa ggaccctggg atctggtttt cgcccgccgc tcccgtgctt
      361 gggtcactgt gtgggtttga aagccaagag gagaggaaca aaatccaccg gctccatcct
      421 ccgccgtggg tgcttttttt aatttagcat tttcctcggg ttttaaaacg accccttttc
      481 acaatgaaca aattgtacat cgggaacctc agcgaccacg ccggccccgc ggacctggaa
      541 agtgtcttca aggacgctaa gatcccggtg gcgggcccct tcctggtgaa gacgggctac
      601 gcgttcgtgg actgcccgga cgagggctgg gccctcaagg ccatcgaggc gctttcaggt
      661 aaaatggaac tacatgggaa accgatggaa gttgagcact cggtccctaa acggcagagg
      721 attcgtaaac ttcagatacg aaatatcccg ccccacttac aatgggaggt gctggatagt
      781 ttactagtcc agtatggagt ggtggagagc tgtgagcaag tgaacacgga ttcggaaacg
      841 gcagttgtaa atgtaaccta ttccagtaag gaccaagcta gacaagcctt agacaaactg
      901 aatggattcc agttagagaa cttcaccttg aaggttgcct acatcccaga tgaaactgct
      961 gcccagcaaa atccctcgcc acagctccgg gggcgccggg ggccagggca gcggggctca
     1021 tccaggcagg cgtctccagg atcggtgtcc aagcagaaac cctgtgacct gccactgcgc
     1081 ctgctggttc ccacccagtt tgttggagcc attataggaa aagaaggtgc taccattcgc
     1141 aacatcacaa agcagaccca gtctaaaatc gatgtccatc gtaaggagaa tacaggggcc
     1201 gcggagaagt ccattactat cctctctacc cctgaaggca cctctgcagc ttgtaagtct
     1261 attctggaga ttatgcataa ggaagctcaa gatataaaat tcacagagga gattcccttg
     1321 aagatcttag ctcacaataa ctttgtaggc cgtctcattg gtaaagaagg aagaaacctt
     1381 aaaaaaatcg agcaagacac ggacactaaa atcacaatat ctccattgca ggaactgacg
     1441 ctgtacaatc cggaacgcac cattacagtg aaaggcagtg ttgagacgtg tgccaaggcg
     1501 gaggaggaaa taatgaagaa gatcagggag tcttatgaaa atgatattgc ttccatgaat
     1561 cttcaagcac atttaatccc tggattaaat ctgaatgcct tgggtctgtt cccacccacg
     1621 tcagggatgc cacctcccac ctcagggccc ccttcaaccc tgactcctcc ctacccacaa
     1681 tttgagcaat cagagacgga gactgtgcat ctgtttattc ccgccctgtc cgttggcgcc
     1741 atcattggca agcagggcca acacatcaaa cagctttctc gctttgcggg agcttcgatt
     1801 aagatcgctc cagccgaagc accagatgct aaagtgcgga tggtgattat cactggacca
     1861 ccagaggctc agttcaaggc tcagggaaga atttatggaa aaattaaaga agaaaacttt
     1921 gttagtccta aagaagaggt gaaacttgaa gctcacatca gagtgccgtc ctttgctgct
     1981 ggcagagtta ttgggaaagg aggcaaaacg gtgaatgagc tccagagttt atcaagtgct
     2041 gaagttgtcg tcccccgtga ccagacacct gatgagaatg atcaagtagt tgtcaaaata
     2101 actggccact tctatgcttg ccaggttgcc cagaggaaaa ttcaggaaat tctgactcag
     2161 gtaaagcagc accagcagca gaaagctctg cagagtggac cacctcagtc aaggcggaag
     2221 taaaggctca ggagacagcc accacagagg cagatgccaa accaaagaca gatttgctta
     2281 accaacagac gggtgctgac ccatccagaa ccacgtgcac gagtttttac ctagctggtt
     2341 gtttccgagg accaggcact cgatcctgtc tctgtgagaa tgtatacttt atgctctctg
     2401 aaatatatga cacccagctt taaaaaaaaa aaaaaaaaaa aaaaaaaagt gggggtaagg
     2461 aaagagaact ctgcacttcc cttgtgatat caaagtataa caaacgtgct aatttttctt
     2521 aatatccctc tataatgcca gaaattggca taaatggtac attcactaaa tttatcaaat
     2581 aaatttaaaa ctagattgtt cctaagtcca attgttgaaa ttggatcaaa gtagaattgt
     2641 cagaggaaca caacattaag ccattagaat agaagagctg ttgtctcctg tttctctaac
     2701 actaacatgg ataacctaag ggaagtgcca gccgctgttg gcagggtatt aaacgtgcat
     2761 ttttactcaa ctacctcagg tattcagtaa tacagttaaa agcaaaatta ttcctttttt
     2821 gaaaatttta tatactttat aaaaactcca accgtttttt taaaaaaaat aaaatttaac
     2881 agttatcagc tgataggcaa gtcattgaaa aagtaatttt acgtctggct ggtgagagta
     2941 aagttggaaa aataattttg cattttttga gcctttgaaa gttggaaagt ccactaactg
     3001 ttcaaagata aggagcagtg cctattctca agagcagcca tgccatgtac tcctttgttc
     3061 ctatctggga aggttgttga cggtactgac caagcaggca ggggctggga cggccagtgt
     3121 acaggacagc tagggtaaag gacagctagt gtacagggct ccaggagact tggggatttg
     3181 tgtttagcta tgtgtgggaa tttgcaaatg ctttgtgctt tgactgtcac cacgaaaagg
     3241 aagaaattca tgtcagtgaa gaaatgcaga atttaaacaa aatcagcttg agtttgtttt
     3301 accagatgct cagcttgcta acacacttga gatcagacca tactctgagc agacatggaa
     3361 aggattgctt tgtgaagacc agggggagtc aggtggtatg acagggccga agggcaacaa
     3421 aatctccatt tccttgtgcc tggcactgtc tcgagcctaa gctattttaa agatgtttta
     3481 aacagtggaa gaattaagtc caccaaaagt cttccatgaa atgtagcaga gtttctgtct
     3541 gccctgcatt acctgccagc gagtcaaggt aggggatcca gcaaacggtt ttgggaattc
     3601 agactgtgga aacatcggac ttccctttgc ccttcctcaa cttagtggca aagccctgta
     3661 tggatacttg taggtgcggg tgatcctcaa ggccatgctg ctttctgagt tgttcttgtt
     3721 gctttgttca taatgtggtt acagtcatat tacactgacc ctgagggtat tatgtaaccc
     3781 ttcagaaaac cactttgcct cattgtgttt caggattaac ttctacatgc ctttaagttt
     3841 ttctgagtat cagcatatca tttagacatt gtgaaaatga attcctaaac attttcataa
     3901 aaccggttaa ttttgtagtt ttagccaaaa agtgccccct ttttacaact gaattcatct
     3961 agcattttca tatggtggat ttaaactgct taaaaaagaa aatgtgaccg gctctcctgc
     4021 ttgggtctca ggggagatat gcttaaggcc agagctcttc ctcagtattt gatttttcca
     4081 gtgtttgttt tttaaaaaac tgacaggtgc tacatttcta tctgttggtt tcaattctgc
     4141 catatttcat gtctagcctt tagagtggcc aatcatgttt tactttcatt taagcactgg
     4201 tagtctggag tacctggtac tgagtaactc tataattgtg ttttgtgttc accatataca
     4261 gatcatttct catctgtagt gtgccccaaa tgcagcttca ctttccaggt accctgatgc
     4321 agaataaagt tttcatcata aaccacaaaa aaaaaaaaaa aaaaaa
//
