LOCUS       NM_183029               3902 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus insulin-like growth factor 2 mRNA binding protein 2
            (Igf2bp2), mRNA.
ACCESSION   NM_183029
VERSION     NM_183029.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3902)
  AUTHORS   Liu,X.W., Xu,H.W., Yi,Y.Y., Zhang,S.B., Chang,S.J., Pan,W. and
            Wang,S.J.
  TITLE     Inhibition of Mettl3 ameliorates osteoblastic senescence by
            mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent
            mechanisms
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167273 (2024)
   PUBMED   38844111
  REMARK    GeneRIF: Inhibition of Mettl3 ameliorates osteoblastic senescence
            by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent
            mechanisms.
REFERENCE   2  (bases 1 to 3902)
  AUTHORS   Wu,S., Li,F., Mo,K., Huang,H., Yu,Y., Huang,Y., Liu,J., Li,M.,
            Tan,J., Lin,Z., Han,Z., Wang,L. and Ouyang,H.
  TITLE     IGF2BP2 Maintains Retinal Pigment Epithelium Homeostasis by
            Stabilizing PAX6 and OTX2
  JOURNAL   Invest Ophthalmol Vis Sci 65 (6), 17 (2024)
   PUBMED   38861275
  REMARK    GeneRIF: IGF2BP2 Maintains Retinal Pigment Epithelium Homeostasis
            by Stabilizing PAX6 and OTX2.
REFERENCE   3  (bases 1 to 3902)
  AUTHORS   Xiao,Q., Liu,L., Qian,W., Kang,T., Ying,R. and Nie,J.
  TITLE     CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2,
            Boosts Coxsackievirus B3-Induced Myocardial Inflammation via
            Interacting with TIRAP
  JOURNAL   J Cardiovasc Transl Res 17 (3), 540-553 (2024)
   PUBMED   38229002
  REMARK    GeneRIF: CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader
            IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation
            via Interacting with TIRAP.
REFERENCE   4  (bases 1 to 3902)
  AUTHORS   Zhou,Z., Zhang,B., Deng,Y., Deng,S., Li,J., Wei,W., Wang,Y.,
            Wang,J., Feng,Z., Che,M., Yang,X., Meng,J., Li,Y., Hu,Y., Sun,Y.,
            Wen,L., Huang,F., Sheng,Y., Wan,C. and Yang,K.
  TITLE     FBW7/GSK3beta mediated degradation of IGF2BP2 inhibits
            IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung
            cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 34 (2024)
   PUBMED   38281999
  REMARK    GeneRIF: FBW7/GSK3beta mediated degradation of IGF2BP2 inhibits
            IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung
            cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3902)
  AUTHORS   Cao,F., Chen,G., Xu,Y., Wang,X., Tang,X., Zhang,W., Song,X.,
            Yang,X., Zeng,W. and Xie,J.
  TITLE     METTL14 contributes to acute lung injury by stabilizing NLRP3
            expression in an IGF2BP2-dependent manner
  JOURNAL   Cell Death Dis 15 (1), 43 (2024)
   PUBMED   38218935
  REMARK    GeneRIF: METTL14 contributes to acute lung injury by stabilizing
            NLRP3 expression in an IGF2BP2-dependent manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3902)
  AUTHORS   Le,H.T., Sorrell,A.M. and Siddle,K.
  TITLE     Two isoforms of the mRNA binding protein IGF2BP2 are generated by
            alternative translational initiation
  JOURNAL   PLoS One 7 (3), e33140 (2012)
   PUBMED   22427968
REFERENCE   7  (bases 1 to 3902)
  AUTHORS   Nielsen,F.C., Nielsen,J. and Christiansen,J.
  TITLE     A family of IGF-II mRNA binding proteins (IMP) involved in RNA
            trafficking
  JOURNAL   Scand J Clin Lab Invest Suppl 234, 93-99 (2001)
   PUBMED   11713986
  REMARK    Review article
REFERENCE   8  (bases 1 to 3902)
  AUTHORS   Runge,S., Nielsen,F.C., Nielsen,J., Lykke-Andersen,J., Wewer,U.M.
            and Christiansen,J.
  TITLE     H19 RNA binds four molecules of insulin-like growth factor II
            mRNA-binding protein
  JOURNAL   J Biol Chem 275 (38), 29562-29569 (2000)
   PUBMED   10875929
REFERENCE   9  (bases 1 to 3902)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 3902)
  AUTHORS   Nielsen,J., Christiansen,J., Lykke-Andersen,J., Johnsen,A.H.,
            Wewer,U.M. and Nielsen,F.C.
  TITLE     A family of insulin-like growth factor II mRNA-binding proteins
            represses translation in late development
  JOURNAL   Mol Cell Biol 19 (2), 1262-1270 (1999)
   PUBMED   9891060
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB290059.1, BC054552.1, BU708344.1 and BY512142.1.
            
            On Apr 13, 2007 this sequence version replaced NM_183029.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049196.1, AK159654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-676               CB290059.1         1-676
            677-1701            BC054552.1         397-1421
            1702-2022           BU708344.1         147-467
            2023-3853           BC054552.1         3123-4953
            3854-3902           BY512142.1         374-422
FEATURES             Location/Qualifiers
     source          1..3902
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.02 cM"
     gene            1..3902
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /note="insulin-like growth factor 2 mRNA binding protein
                     2"
                     /db_xref="GeneID:319765"
                     /db_xref="MGI:MGI:1890358"
     exon            1..514
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..2115
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /note="insulin-like growth factor 2, binding protein 2;
                     VICKZ family member 2; IGF2 mRNA-binding protein 2; IGF-II
                     mRNA-binding protein 2"
                     /codon_start=1
                     /product="insulin-like growth factor 2 mRNA-binding
                     protein 2"
                     /protein_id="NP_898850.2"
                     /db_xref="CCDS:CCDS49797.1"
                     /db_xref="GeneID:319765"
                     /db_xref="MGI:MGI:1890358"
                     /translation="MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVD
                     YPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRRIQIRNIPPHLQWEVLDGLL
                     AEYGTVENVEQVNTDTETAVVNVTYMTREEAKLAIEKLSGHQFEDYSFKISYIPDEEV
                     SSPSPPHRAREQGHGPGSSSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQS
                     RVDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEVPLKILAHN
                     GFVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIYNPERTITVRGTIEACANAEIEI
                     MKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLPPPAGPRGVPPSPPYHPF
                     ATHSGYFSSLYPHHHFGPFPHHHSYPEQETVSLFIPTQAVGAIIGKKGAHIKQLARFA
                     GASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIR
                     VPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQR
                     KIREIVQQVKQQEQRYPQGVAPQRSK"
     exon            515..575
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            576..624
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            625..676
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            677..740
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            741..992
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1127
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1250
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1386
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1515
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1584
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1701
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1776
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1908
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2022
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..3899
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3879..3884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /note="hexamer: AATATA"
     polyA_site      3899
                     /gene="Igf2bp2"
                     /gene_synonym="C330012H03Rik; IMP-2; Imp2; Neilsen"
                     /note="major polyA site"
ORIGIN      
        1 ggacgggcag ggcgcgcact ctcggcggtg cacacgccgc tccaactctc aggcgcgcgg
       61 ggtgcgtccg cccgccgccg ccgccccggc accgggaggc agagcaagcg ctttgtccgc
      121 acgcccgctc gggactctgc ccggaggagg cagccgcgcc gagtccccgc ctccgcctct
      181 gcccccgggc gggccgggcc ggccgcggtg gggggagcca ggctgagggc gagggtgggg
      241 gcgggggcgg gcgcaggagg agagaggagg gcagcggagg cggcgggagc gccgggtgcc
      301 gggccggggg agccgcgggc tctcgggaag acgcggatga tgaacaagct gtacattggg
      361 aacctgagcc ccgccgtcac cgccgacgac ctccggcagc tcttcgggga caggaagctg
      421 cccctggcgg gacaggtcct actcaagtcc ggctacgcct tcgtggacta ccccgaccag
      481 aactgggcca tccgcgccat cgagaccctc tcgggtaaag tggaattgca tgggaaaatc
      541 atggaagttg actactcagt ctctaaaaag ctaaggagca gaagaatcca gattcggaac
      601 atcccgcctc acctgcagtg ggaggtgttg gatgggctgt tggctgaata tgggacagtg
      661 gagaacgtgg agcaagtcaa cacagataca gaaactgccg ttgtcaacgt cacctatatg
      721 acaagagaag aggcaaagct agctattgag aagctcagtg ggcatcagtt tgaggactac
      781 tccttcaaga tttcctacat ccccgatgaa gaggtgagct ctccttcacc ccctcatcgt
      841 gcccgggaac aaggccacgg ccccgggagc tcttctcagg ccagacagat tgatttcccg
      901 ctgcggatcc tggtccccac ccagtttgtt ggtgccatca tcggaaagga gggcttgacc
      961 ataaagaaca tcactaagca gacccagtcc cgggtagaca tccacagaaa ggagaactct
     1021 ggggctgcag agaagcctgt cacaatccat gctaccccag aagggacatc tgaagcatgc
     1081 cgcatgattc ttgagattat gcaaaaagaa gctgatgaga ccaaactggc tgaggaggtt
     1141 cctctgaaaa tcctggccca caatggcttc gttggaagac tgattggcaa agaaggcaga
     1201 aacctgaaga aaatagaaca tgagacaggg accaagataa ccatctcatc cttgcaggat
     1261 ttgagcattt ataaccccga gagaaccatc accgtgaggg gcaccattga agcctgtgcc
     1321 aatgctgaga tagagattat gaagaagctc cgagaggcct ttgagaacga catgctggcc
     1381 gttaaccaac aagccaatct gatcccaggg ctaaacctca gtgcacttgg catcttttcg
     1441 actggactgt ctgtgcttcc tccaccagca gggccccgtg gagttccccc cagtcctccc
     1501 tatcacccct ttgctaccca ctccggatac ttctccagtc tgtaccctca tcaccatttc
     1561 ggcccattcc cacatcatca ctcctaccca gagcaggaga ctgtaagtct cttcatccca
     1621 acccaggctg tgggtgctat catcgggaag aagggggcac acatcaaaca gctcgctcga
     1681 tttgctggtg cctccatcaa gattgctcca gcagaaggtc cagatgtcag tgagaggatg
     1741 gtcatcatca ctggtcctcc tgaagcccag tttaaggctc agggacggat ctttgggaaa
     1801 ctgaaggaag aaaacttctt taatcccaaa gaagaagtga agctggaggc ccacatccga
     1861 gtcccctcgt cgaccgctgg ccgggtgatt ggcaagggcg ggaaaaccgt gaacgagctg
     1921 cagaacttga caagtgcaga agttatcgtg cctcgtgacc aaacgccaga cgagaatgag
     1981 gaagtgatcg tcagaattat cgggcatttt tttgctagcc agactgcaca acgcaagatc
     2041 agggaaattg tacagcaggt gaagcagcag gagcagagat accctcaggg agtcgcccca
     2101 cagcgcagca agtgaggctc ccacagcacc agcaagcaac cgatgaatgt agccctccca
     2161 acacctgaca gatgagacca aacagccagc agatcgggag caaaccaaag agcatcccga
     2221 ggagtgcgca gtctgcagag cagccagggc ctgcagacct ctacacatcc tgggatccag
     2281 gagggcacag ggaaggccag gttgtccaga aacaccgctt ggcctgcccc cagcttcccc
     2341 tggcttctgc aggcataaca gccatccact gcccatccaa ctcagattct cctcagttcc
     2401 caggacgcta tccctttcgg ttgaactaac ataggtgaac atgctcaaag caaagcaaaa
     2461 ttcctagccg tttctttgtt gtggaaagtt gtctctgtac atgtatgtac atatcagaag
     2521 gggaaggatg ttaagaaatg tggcctgtgg gttacacagg gtgcctgcag cgttaatata
     2581 ttttagaaat aatatatcaa ataactccac taacaacaat ttttactcag tgattaattt
     2641 tgttttcttt ttgaagagaa agcaggcttt tctagacttc caagaataaa gtattgggtg
     2701 aggtccactg gtatagaaag gaactttgag ccacccacac aaaaaattca cttggaggga
     2761 aatcttgtca aggacactta atggcagttg tgggtcacct gtgtctgtca acagaaggga
     2821 taccgtccct gaggaggggc cctaggccct ggtcacctgt ttctcccaca cacccattgc
     2881 tcagtttcac aggtttttaa actgatgatt tttggtttgt tttgtttttg ttttttgcat
     2941 actgctatat agttctgtct ctctccttat ctccctccta accttcctct gtcttcttta
     3001 cccaaaattc ttttgagtcc cttcgttctt tttctgctcc ccgtatctat gcacccctcc
     3061 cctcccccca ggcaaagcag tgctctgaat atcataccac acacaaggaa caaatgcgaa
     3121 ccacacagac cagcctcagc ttacactcgg ttactcaagc gaacaagagt cggcggtact
     3181 tgtcctagca ttcggaagag gaaagcagga tcccagcaaa taaaccagcc agccaaacaa
     3241 agaaaaatcc cacaaagaaa gaatggactc tctctccatc ttggtataca agccatcaac
     3301 atttagtgaa attctttctt tctttaaaaa tttaaagtgc aggaaaatag caatttatac
     3361 gaggttgttg gcccagggcg ttaaatttac agattttttt taaatgagaa aaacacacaa
     3421 ataaaagcta cctcaggtgt tttttacctc agcaccttgc tcttgtgttt cccttagaga
     3481 ttttgtaaaa ctgatagttg gagcattttt tattttttta ataaaaatga gttgaaaaaa
     3541 aaaaaagatg agctgccagc cccaagcagg cggcagccca ggtgtgccgc agctcttctg
     3601 tcttccgcta gccaagagcc tacgtggcct tcttgtggac aaacctaaaa atgtttattt
     3661 tttaaaaagt gacaaagaaa aacagagaat attggagccg tcctgaattt caatagggta
     3721 cgtgccgtga gggcttttgc gctgaaggat gaccacatcc tggttatgtg aagaaaccat
     3781 gacactacca gactgcgatg ccggtttcct ctactgcaag cagtgttctg tgacaaaaaa
     3841 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aggaaaaaaa tatatccaag ctaacaagaa
     3901 aa
//
