LOCUS       NM_010513              12345 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus insulin-like growth factor I receptor (Igf1r), mRNA.
ACCESSION   NM_010513
VERSION     NM_010513.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12345)
  AUTHORS   Basu,S., Mautner,L., Whiting,K., Hasenpusch-Theil,K., Borkowska,M.
            and Theil,T.
  TITLE     Identification of Pappa and Sall3 as Gli3 direct target genes
            acting downstream of cilia signaling in corticogenesis
  JOURNAL   Cereb Cortex 34 (12) (2024)
   PUBMED   39716738
REFERENCE   2  (bases 1 to 12345)
  AUTHORS   Gusmao,D.O., de Sousa,L.M.M., de Sousa,M.E., Rusew,S.J.R.,
            List,E.O., Kopchick,J.J., Gomes,A.F., Campideli-Santana,A.C.,
            Szawka,R.E. and Donato,J. Jr.
  TITLE     Characterization and Regulation of the Neonatal Growth Hormone
            Surge
  JOURNAL   Endocrinology 165 (12) (2024)
   PUBMED   39446366
REFERENCE   3  (bases 1 to 12345)
  AUTHORS   Wang,T., Zhu,C., Zhang,K., Gao,J., Xu,Y., Duan,C., Wu,S., Peng,C.,
            Guan,J. and Wang,Y.
  TITLE     Targeting IGF1/IGF1r signaling relieve pain and autophagic
            dysfunction in NTG-induced chronic migraine model of mice
  JOURNAL   J Headache Pain 25 (1), 156 (2024)
   PUBMED   39304806
  REMARK    GeneRIF: Targeting IGF1/IGF1r signaling relieve pain and autophagic
            dysfunction in NTG-induced chronic migraine model of mice.
            Erratum:[J Headache Pain. 2024 Oct 8;25(1):173. doi:
            10.1186/s10194-024-01884-2.. PMID: 39379801]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12345)
  AUTHORS   Annibalini,G., Di Patria,L., Valli,G., Bocconcelli,M.,
            Saltarelli,R., Ferri,L., Barberi,L., Fanelli,F., Morrone,A.,
            Barone,R., Guerrini,R., Musaro,A., Stocchi,V. and Barbieri,E.
  TITLE     Impaired myoblast differentiation and muscle IGF-1 receptor
            signaling pathway activation after N-glycosylation inhibition
  JOURNAL   FASEB J 38 (13), e23797 (2024)
   PUBMED   38963344
  REMARK    GeneRIF: Impaired myoblast differentiation and muscle IGF-1
            receptor signaling pathway activation after N-glycosylation
            inhibition.
REFERENCE   5  (bases 1 to 12345)
  AUTHORS   Zhang,Y., Kunii,M., Taniguchi,M., Yoshimura,S.I. and Harada,A.
  TITLE     Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is
            Essential for the Establishment of Neuronal Polarity and Brain
            Formation
  JOURNAL   J Neurosci 44 (27), e2334232024 (2024)
   PUBMED   38830762
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12345)
  AUTHORS   Leff,S.E., Brannan,C.I., Reed,M.L., Ozcelik,T., Francke,U.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Maternal imprinting of the mouse Snrpn gene and conserved linkage
            homology with the human Prader-Willi syndrome region
  JOURNAL   Nat Genet 2 (4), 259-264 (1992)
   PUBMED   1303276
REFERENCE   7  (bases 1 to 12345)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   8  (bases 1 to 12345)
  AUTHORS   Rappolee,D.A., Sturm,K.S., Behrendtsen,O., Schultz,G.A.,
            Pedersen,R.A. and Werb,Z.
  TITLE     Insulin-like growth factor II acts through an endogenous growth
            pathway regulated by imprinting in early mouse embryos
  JOURNAL   Genes Dev 6 (6), 939-952 (1992)
   PUBMED   1317321
REFERENCE   9  (bases 1 to 12345)
  AUTHORS   Surmacz,E., Nugent,P., Pietrzkowski,Z. and Baserga,R.
  TITLE     The role of the IGF1 receptor in the regulation of cdc2 mRNA levels
            in fibroblasts
  JOURNAL   Exp Cell Res 199 (2), 275-278 (1992)
   PUBMED   1371961
REFERENCE   10 (bases 1 to 12345)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158584.9 and AC101879.8.
            
            On Nov 16, 2022 this sequence version replaced NM_010513.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF056187.1, BC138869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1062              AC158584.9         74810-75871         c
            1063-1608           AC158584.9         23407-23952         c
            1609-1921           AC101879.8         98706-99018         c
            1922-2073           AC101879.8         93963-94114         c
            2074-2218           AC101879.8         90636-90780         c
            2219-2433           AC101879.8         80453-80667         c
            2434-2560           AC101879.8         79154-79280         c
            2561-2799           AC101879.8         76783-77021         c
            2800-2967           AC101879.8         74271-74438         c
            2968-3172           AC101879.8         73861-74065         c
            3173-3456           AC101879.8         70381-70664         c
            3457-3593           AC101879.8         68906-69042         c
            3594-3753           AC101879.8         68262-68421         c
            3754-3856           AC101879.8         62665-62767         c
            3857-3927           AC101879.8         62039-62109         c
            3928-4157           AC101879.8         56531-56760         c
            4158-4268           AC101879.8         56138-56248         c
            4269-4431           AC101879.8         51855-52017         c
            4432-4561           AC101879.8         48963-49092         c
            4562-4696           AC101879.8         45475-45609         c
            4697-12345          AC101879.8         30343-37991         c
FEATURES             Location/Qualifiers
     source          1..12345
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 37.27 cM"
     gene            1..12345
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /note="insulin-like growth factor I receptor"
                     /db_xref="GeneID:16001"
                     /db_xref="MGI:MGI:96433"
     exon            1..1062
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             969..5078
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /EC_number="2.7.10.1"
                     /note="insulin-like growth factor 1 receptor; IGF-I
                     receptor; line 186"
                     /codon_start=1
                     /product="insulin-like growth factor 1 receptor precursor"
                     /protein_id="NP_034643.2"
                     /db_xref="CCDS:CCDS21355.1"
                     /db_xref="GeneID:16001"
                     /db_xref="MGI:MGI:96433"
                     /translation="MKSGSGGGSPTSLWGLVFLSAALSLWPTSGEICGPGIDIRNDYQ
                     QLKRLENCTVIEGFLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPN
                     LTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLI
                     LDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSV
                     CGKRACTENNECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRC
                     VDRDFCANIPNAESSDSDGFVIHDDECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGD
                     EEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIR
                     HSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFA
                     FNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIII
                     TWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPG
                     ILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNS
                     SSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDVE
                     EVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRR
                     RDVMQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESRVDNKERTVISNLRPFT
                     LYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEP
                     ENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGN
                     GSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGV
                     LYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETR
                     VAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDL
                     KSYLRSLRPEVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA
                     EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVL
                     WEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
                     EIIGSIKDEMEPSFQEVSFYYSEENKPPEPEELEMEPENMESVPLDPSASSASLPLPE
                     RHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRANERALPLPQSSTC"
     exon            1063..1608
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1921
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2073
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2218
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2433
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2560
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2799
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2967
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3172
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3456
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3593
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3753
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3856
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..3927
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4157
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..4268
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            4269..4431
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            4432..4561
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            4562..4696
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..12345
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12325..12330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /note="hexamer: AATAAA"
     polyA_site      12345
                     /gene="Igf1r"
                     /gene_synonym="A330103N21Rik; CD221; D930020L01; hyft;
                     IGF-1R"
                     /note="major polyA site"
ORIGIN      
        1 agagccccca gtgtgtggcg gcggcggcgg cggcgcggtg aggctgaggt tcttgtttac
       61 cagcattaac tccgctgagc ggaaaaaaaa aggagggggg gggggaaccg aggaggagcg
      121 agcgcaccgg gcgaactcga gagaggcgag cgacagggaa gctgcctgcg agcctgtccc
      181 ggcgcgcccg gcgctcgcag accctcggcc ccgctctccg gaccctccac gcctctcccc
      241 gtgcctgcga gagctccacg gcacgcggcg tgctcggctt tgaccttcag cgagccggag
      301 cccccgcgca cggagtcggc ggcgggcggg ggccgacgcg gggcggcggg agcgctgagc
      361 gctgcgcggc cgccgctttg tgtgtgtcct ggatttggga aggagctcgc ggcggcggcg
      421 ctgagggagg aggcggcggc gagcggagcc cagaggagga ggaggagccg gaggaggggg
      481 aaccgctcat tcatttccac tccgcatttc tgcccctcgc cggcctcgcc cgcgcccggg
      541 acttcggacc agtctcgcca actgcgtcgc gctctcccgc cgcgtaggct ccggtggtcg
      601 ttccctccgg ggatcgggtg gcgtttgtcc tcgcctgcgg cgatttgggc tttgctcctc
      661 tttctgtaca gttttcctcc ttcttctgca tctctgcgtt tgcaaatgga ggccgacgac
      721 gccgacagcc cgccccggcg cgccccggct tcccgactcc gccgccccgt gggccgctgc
      781 tgccggcgct gaggggccgc cccgcgccac cctccttgtc cacgccgctt tccgaggatc
      841 gtcgcctgcg ctcttgtttt tggacgagag tgaggactga gttggagact ttttttttct
      901 ttttttcttt tctttttttt ttttttttct atttttgaga aaagggaatt tcgtcccaaa
      961 taaaaggaat gaagtctggc tccggaggag ggtccccgac ctcgctgtgg gggctcgtgt
     1021 ttctctccgc cgcgctctct ctctggccga cgagtggaga aatctgtggg cccggcattg
     1081 acatccgcaa cgactatcag cagctgaagc gcctggaaaa ctgcacggtg atcgagggct
     1141 tcctccacat cctgctcatc tccaaggccg aggactaccg aagctaccgc ttccccaagc
     1201 tcaccgtcat cactgagtac ttgctgctct tccgagtcgc tggcctcgag agcctgggag
     1261 acctcttccc caacctcaca gtcatccgtg gctggaaact cttctacaac tacgcactgg
     1321 tcatcttcga gatgaccaat ctcaaggata ttgggcttta taatctgagg aacattactc
     1381 ggggggccat caggattgag aagaacgccg acctctgtta cctctccacc atagactggt
     1441 ctctcatctt ggatgcggtg tccaataact acattgtggg gaacaagccc ccgaaggaat
     1501 gtggggacct gtgtccaggg acattggagg agaagcccat gtgtgagaag accaccatca
     1561 acaatgagta caactaccgc tgctggacca caaatcgctg ccagaaaatg tgcccaagtg
     1621 tgtgcgggaa gcgagcctgc accgagaaca acgagtgctg ccacccggag tgcctgggca
     1681 gctgccacac accggacgac aacacaacct gcgtggcctg cagacactac tactacaaag
     1741 gcgtgtgtgt gcctgcctgc ccgcctggca cctacaggtt cgagggctgg cgctgtgtgg
     1801 atcgcgattt ctgcgccaac atccccaacg ctgagagcag tgactcggat ggcttcgtta
     1861 tccacgacga tgagtgcatg caggagtgtc cctcaggctt catccgcaac agcacccaga
     1921 gcatgtactg tatcccctgc gaaggcccct gccccaaagt ctgcggcgat gaagagaaga
     1981 aaacgaaaac catcgattcg gtgacttctg ctcaaatgct ccaaggatgc accatcctga
     2041 agggcaatct gcttattaac atccggagag gcaataacat tgcctcggag ttggagaact
     2101 tcatggggct catcgaggtg gtgaccggct acgtgaagat ccgccattct catgccttgg
     2161 tctccttgtc cttcctgaag aaccttcgtc tcatcttagg agaggagcag ctggaaggga
     2221 actactcctt ctatgtccta gacaaccaga acttgcagca gctgtgggac tggaaccacc
     2281 ggaacctgac cgtcaggtcc ggaaagatgt actttgcttt caatcccaag ctgtgtgtct
     2341 ccgaaattta ccgcatggag gaagtgaccg gaaccaaggg acgccagagc aaaggggaca
     2401 taaacaccag gaacaacgga gagcgagctt cctgtgaaag tgatgttctc cgtttcacct
     2461 ccaccacgac ctggaagaac cgaatcatca taacgtggca ccggtaccgg ccgccggact
     2521 accgggatct catcagcttc acagtttact acaaggaggc accatttaaa aacgttacgg
     2581 aatatgacgg gcaggatgcc tgtggctcca acagctggaa catggtggat gtagacctgc
     2641 ctccgaacaa ggagggcgag cctggcattt tactgcatgg gctgaagccc tggacccagt
     2701 atgctgtcta tgtcaaggct gtgaccctca ccatggtgga aaacgaccat atccgtgggg
     2761 ccaaaagtga aatcttgtac attcgcacca atgcttcagt cccttccatt cccctagatg
     2821 tcctctcagc atcaaactct tcctctcagc tgattgtgaa gtggaatcct ccaactctgc
     2881 ccaatggtaa cttgagttac tacattgtga ggtggcagcg gcagccccag gatggttacc
     2941 tgtaccggca caactactgc tccaaagaca aaatacccat cagaaagtac gccgatggta
     3001 ccatcgacgt ggaggaggtg acggaaaatc ccaagacaga agtgtgtggt ggtgataaag
     3061 ggccatgctg cgcttgccct aaaactgaag ctgagaagca ggctgagaag gaggaggctg
     3121 agtaccgtaa agtctttgag aatttccttc acaattccat ctttgtgccc aggcccgaaa
     3181 ggaggcggag agacgtcatg caagtggcca acacgaccat gtccagccga agcaggaaca
     3241 ccacggtagc tgacacctac aatatcacag acccggagga gttcgagaca gagtaccctt
     3301 tctttgagag cagagtggat aacaaggaga ggactgtcat ctccaacctc cggcctttca
     3361 ctctgtaccg catcgatatc cacagctgca accacgaggc tgagaagctg ggctgcagcg
     3421 cctccaactt cgtctttgcg agaaccatgc cagcagaagg agcagatgat atccctggtc
     3481 cggtgacctg ggagccaaga cccgaaaact ccatcttttt aaagtggcca gaacccgaga
     3541 accccaacgg attgatccta atgtatgaaa ttaaatacgg gtcgcaagtc gaggatcagc
     3601 gggaatgtgt gtccagacag gagtacagga agtacggagg ggccaaactc aaccgtctaa
     3661 acccagggaa ctatacagcc cggattcagg ctacctccct ctctgggaat gggtcatgga
     3721 cagatcctgt gttcttctat gtccccgcca aaacgacgta tgagaacttc atgcatctga
     3781 tcattgctct gccggttgcc atcctgctga tcgttggggg gctggttatc atgctgtatg
     3841 tcttccatag aaagagaaat aacagcaggt tgggcaatgg agtgctgtat gcttctgtga
     3901 accccgagta tttcagcgca gctgatgtgt acgtgcctga tgaatgggag gtagctcgag
     3961 agaagatcac catgaaccgg gagctcggac aagggtcctt tgggatggtc tatgaaggag
     4021 tggccaaggg tgtggtcaag gatgaacccg aaaccagagt ggccatcaag acggtaaacg
     4081 aggctgcaag tatgcgtgaa agaatcgagt ttctcaacga ggcctcggtg atgaaggagt
     4141 tcaattgtca ccatgtggtc cggttgctgg gtgtggtatc ccaaggccag cccaccctgg
     4201 tcatcatgga actaatgaca cgcggtgatc tcaaaagtta tctccggtct ctgaggccag
     4261 aagtggagca gaataatcta gtcctcattc ctccgagctt aagcaagatg atccagatgg
     4321 ctggagagat tgcagatggc atggcctacc tcaatgccaa caagttcgtc cacagagacc
     4381 ttgctgctag gaactgcatg gtagccgaag atttcacagt caaaattgga gatttcggta
     4441 tgacacgaga catctacgag acggactact accggaaagg cgggaagggg ttgctgcctg
     4501 tgcgctggat gtctcccgag tccctcaagg atggtgtctt cactactcat tctgatgtct
     4561 ggtccttcgg ggtcgtcctc tgggagatcg ccacgctggc tgagcagccc taccagggct
     4621 tgtccaacga gcaagttctt cgtttcgtca tggagggtgg ccttctggac aagccggaca
     4681 actgccctga tatgctgttt gaacttatgc gcatgtgctg gcagtataac cccaagatgc
     4741 ggccctcctt cctggagatc atcggcagca tcaaggatga gatggagccc agcttccagg
     4801 aggtctcctt ctactacagc gaggagaaca agcctcccga gccagaggag ctggagatgg
     4861 agcctgagaa catggagagc gtcccactgg acccttcggc ctcctcagcc tccctgcctc
     4921 tgcctgaaag acactcagga cacaaggctg agaatggccc gggccctggc gtgctcgttc
     4981 tccgcgccag ttttgatgag agacagcctt acgctcacat gaacggggga cgcgccaacg
     5041 agagggcctt gcctctgccc cagtcctcga cctgctgatc ctcggacaca ccgaagcacg
     5101 cgccaacagt aacgtgtgtg cgcccactcg gtgggcgggg gggcggggag gggagagcag
     5161 gttgtaacaa tctattcaca agcctcctgt acctcagtgg atcttcagac ctgccattgc
     5221 tgcccacggg agacggcttc tctgcagtaa acacatttgg gaccttcctt ttttcaatat
     5281 gcaagcagct ttttatttcc tttacccgaa cccttaactg acatgggcct ctgcaaacct
     5341 taatgacaac acttaatagc aacaggacac tcgagaattg agtctcttcg ttctctgcct
     5401 ttttctctcc tctgccttcc ctctctgccc tctccccttc cacttccacg ctctcctttc
     5461 tctcttttct gctttacagt ggaaaaatgt ttgtgaacgc ccatctggga agccttcttt
     5521 tttaaaaaaa aaaaaaaaat cagattgact taatggctgc ccctggggct cctcatcacc
     5581 ccgcatacac ctgcctgaca ccgtaggtct tttaaaaaaa agaaaaggaa agaaaaagaa
     5641 aaaaaattca cacactgaga tggaattttt tttaaccttt tttagggtca ccccaaaatt
     5701 taaaagggcc attgttcatc cgtggctatc atttttcacg ctgccatttt tgccaaaatc
     5761 ctgttttcgg tttggttttt ctcacacgca tatactccct gcgctgattt ccctttgtcc
     5821 agaggcgtgg gatgaaccat ggtgtctggt tgatgataac atttgagaga cacgtgctga
     5881 ggccccccac tgtgcccggc tctcccagcc cacatctcct gggtctcgtt gcatggttac
     5941 cgtttgggag aactggacaa gatggaactc gccctccttg aagaagggga aagcagaact
     6001 ggttctccac ccctccccca cccacagcac cccaagaatt ctggaggaag tggccatggg
     6061 caagcttgaa ggtcaggttg tgggtcaagg tggtcctcac accagcctcg tccccctccc
     6121 cgacctccct cctgcccctc ccctgagggc cacacactcg aaagggttcc ggggactcgg
     6181 cctggctgtt ggttatggat gttcgaggaa gggattcaga gccacagcag cctggagccg
     6241 cccgcccagg cagtggatcc aagcagtgtg agctttcaca tggtctgtta ctaggacttc
     6301 ttcatgggtc tctcagttct atgttagacc gtgaaacatt tgcatacaca tcgtctttaa
     6361 tgtcagtttt ataacttttt tacagttcag atattcatct atacatctgt acaggaaaag
     6421 aaaagctgct attttttttt tgttctttat ctttgtggat ttaatctatg aaactttcag
     6481 gtctacccct tcttcctttc tgctcactcc aagaaacttc ctctgcttat cactagagtg
     6541 tggtttttct tcctcttctc cggcaactga tgcttctagg acataacttg ccgtgaactg
     6601 tttgatgcct tttttataaa tacatctccc ttcccctgct ccctgcagcc ccattcatta
     6661 ccctctaacc cataggctct gtgagcacag tcacaggtga gggagtgggg agggtgggag
     6721 tccagagccc acagactcct gggccctact ctctcctttc cttgcttccc cgcacacagc
     6781 atctgctcca gggcaaggca tgccacaaac tcaggtcaga aacaaaaagg ttaaaaatcc
     6841 cacacatcct ggtttagtgt ttctagtccc tgttgttgaa agtcacactt tgctttctct
     6901 ccttgctttg gttcacacac acacacacac acacacacac acacacacac acacacccca
     6961 atttgggaat acaatagcag ttttaactgc agacaatagt cattggatta ttatttaaat
     7021 gaatatttga tctttcacac acacacacac acacacaata gctgctgagt ccccaggatg
     7081 cagcagagct ggtccagtgg cccatctgcc acctccttca caagcaggcc cacctgtctt
     7141 tagaaccagc ttgtctgaag gggtggcctc cctgggagca agatgtaaga caccaactcc
     7201 ccatggccag gagcagcaac tttagtgggt gtgctataaa gcccactccc gggccggaaa
     7261 tcccaaagtg gagtagagct gaccctacag tggccctaga gccccttgct gttcctcctt
     7321 aaccagaatc ccggagctct gggcttggag gcccctcccc ctggagtggg gttgggggag
     7381 gggtcctgtc ttgtttcgat ttagcacttc ttaccagagc agtgacagcg cgagagatgc
     7441 ttctgggtgg aaatatttaa attaggagta ggaaaactgt tggatgatga tggttgcagt
     7501 tgtgactgga gattagatgc aggaaggaaa gctggagttg tctggcttgt ctgtaggttc
     7561 aggcttgtgg ctcttcctag cctctgccct taaagggaaa aggagggggg aagcttatta
     7621 agaaggtatt tcatgtagga gttttaattt attttgtgat acctgtttta atcactgtag
     7681 aaaagcccct gttatggatt taaatgctga ggaaagggta catgtatctc tgtgtatgtg
     7741 tgtattagat gggacagttt tggggggttt ttttgggggg gcttgttttt caaacattta
     7801 tctacctcac tcttgttttt catgtgtgtg tgtgcatata tatatatcac atatatatat
     7861 atatatataa tacatctcac acttctcagt acctgacagt aggccaatga tcctggtaac
     7921 ctcagccact ccgcaggcca catacccagg tgaagcagag aggggccagg ctggattctg
     7981 gggttaaagc aacgctaact caaatgagca gcctcttcct gctctgtctc caaaagccca
     8041 cttttcctag ggcaactctg gtctttctcc tcacctggtc ccctactttt caacccagca
     8101 gtcaccatga gcacagcacg ccagtggagg ggggctcccc ggcccatcct cagctggctg
     8161 actttggaac agaactttct ctacagattg aatgactgac aaattctatc cctaagagag
     8221 caggtactcc caggttttga gggcaggagg cacccacacg taggttgtct tgagagtccc
     8281 aatgtgtgca catgtcaggg tgccctgtca gccccctcag ctgctcctct gagacctgca
     8341 ccgaggcagg ggcatgccac cattgctctc ctggcattgg ttcctcttgg aggtacagcg
     8401 gtcagggagc tcccccttct gcttctgaca gaaggccagt ataaaaaagg gggcaagacg
     8461 aagcctgtgc cccctgcagg ctgctgtcct tccctcttct tccctccctt cccccccccc
     8521 ccccgcaacc cccagggcta aacaaggact gaccaaatct tgaggctgga aggccagtgg
     8581 ttggcgccta gccttccccg tgctctgcct ctgtccaccc atccgtctgc tgctcacagg
     8641 tggacagtgc aatcctcaac tccagcagct gctcttacag gccctgggga cttcagctgg
     8701 ggaccgcggt ggctaatctt ttcccccagt atggagaaac tgcctaacag ttcggttaag
     8761 ctcaggagcc cttcgcctcc tgctggaatg ctgcccttct ctgggttcct agatgctcac
     8821 agggtcactg ggagatactg tttgatcagg gttttcttct acactgtagg tgacactctg
     8881 ggatagtggc ctatcctctc gcacatacct gccggttttc cacaactgga tttctacagt
     8941 tcattcaatt gattttaagg gttttttttt ttccttatta ttattatttt tgaaactgtc
     9001 cgagttgttg gtgttttgtt tttgcgtggg tgttattttt ttttttcctt taagtagaga
     9061 gacggcacca acagcgtagt ggccgtcata aactaatgct ccagaaacac ttcaataaaa
     9121 agaaaaggtt ggcttgtacg agggtgcagt cgttctgctg gactgacgcg ccccgactat
     9181 tgcaaggcat catatccaca gttctagcct gatctcatgc tgatgttccc cgcctcttcc
     9241 tgatttttct ctttacaagc ttcaagtact cctaccaagc tgagtcgtgg cctttttcac
     9301 tcgagcccac ccccacccaa cccccccttc tgataggagc tcacactgct tgaagtcaca
     9361 tgaaccactg aggcacagca tgcaggtgac gtgaacatcc aggtgtgccc ccacacagcc
     9421 cttcctgagg cgtggagata gagctgaacc tgagctgggt ggggcccacg cttcgccatc
     9481 tcctttcagg aatgtcctaa cattggattc agagatggga tgaggctccc tccttgagat
     9541 ataaaagact gttcaaggtt gctctttttc ctacctgcct gtttcttatg actcgggact
     9601 gttcaacggt aggaaaagca gcttcataaa ctagaaaagc gatcacggtg agacgagcag
     9661 atggcggagt ggtatacagg agtttttagg gtgggctgac agatggatga gctctgtatg
     9721 atgccaagtc ctaagccagc ctgagctccc ggagcctcgg ccttagcagc ccacctcttt
     9781 tggcagtgcc tgtgcctgag gtaagcaagc agtggtggca aggtcacact gagctcatgt
     9841 gggtgaggag tctaggatgc ttacccaagg ccctctgttg tcatcgttgg gtcctctgag
     9901 agtggccaca gagtgctgaa agcatctcct ttcctaaaca ctggcatcca ggaggagaca
     9961 ggaccactcc atcaaaatgc tttggcccat tttagcagta atgaatttac ggtttgggat
    10021 tttttttttc cctttggttt ttgtttttaa tgttactttt atgtttgtct gatgtctttt
    10081 catttcctgg gctaagcagc tgcattggga gacctggacc agagagatcc accccttaag
    10141 aaccagtgat gatggtcaaa cttttaacag tccactttga actaggtggt ggtacaaatg
    10201 agaacttcaa gacaggatgt ctgtgtaaaa ttgaacctct cttgccagag atgctgaaga
    10261 tacagacctt ggacaggcca ggggtctttg ctttgggctt ccagcttgga tgaccagttg
    10321 gcgatttaga gaaacgaaca ttccttgatg ggatgacaga gtgacggtgc agtaggcacc
    10381 cttggtaacc ggcatcgtga catgacggga attgctgaca gagggttaaa gggcctggaa
    10441 gaagcatgga ccatatttgg acttgatggt gtctgaaggt gtcagagcat gtggaggctg
    10501 gggagtcaac tgtgggcatt tggtttcaga taagacactt ggcatcctgc tctggaaact
    10561 tctccttaga gctaagtcac gtgcggaagg actcagactc catcacactc atcagatgag
    10621 ttgtcggtct ggggcatgac gttagggatt gatttgattt tggtttctgt gagaacttca
    10681 taatcactga tttgtgtgtc cacatttgtg tctgcatctt tccagtaaac cattctttaa
    10741 attactcatt atcctttcaa tagggcttct aagtccagta gattacgggt agtcgttgac
    10801 gaagctctgg tttacaagaa ctaattcaat gtttcattgc atttttgtaa gaacatagaa
    10861 taattttata aaatgtttgt agtttataat tgccgaaaat aatttaaaaa cacttttttt
    10921 ttctctctgt gtgtgcaaaa atatgtgttt gtggtctttt ttccccctct ttgtttcctt
    10981 tttctttttt gacacttgtt tactagctag ctttacaata tgccaaaaat aaaaaataaa
    11041 aacttaaaaa aattaattaa aaagaaattc tccccaggac caattgtggt tcaccctctt
    11101 tcccacatgc tttctgctct agtttgtaaa aaaataaata ataaataaat aaaacaaaaa
    11161 aaaataaaac agataaaaat aaaaacaaaa caaaaggaat gccagtggtt taaaaagtac
    11221 ttctgtattc ttcagtatct tgatcttgga accctttgct ggggaaagga attatctggg
    11281 actcactgtt ccctgtggag tgtagcagcc caaacagatg gaaagaactg ctggccatgg
    11341 aaatagcagt gtgtggccac ccagcaaaga gatggcactc catggtgaca tctggctggt
    11401 atggctggtc ctagctctgc aacactatgg agatgggagg gtttcaggac actggaatgg
    11461 cttcacagtg atcacatgac tctgatgtgc agcccgtggg cacatgtgcc tcagatccta
    11521 acgaatgctg tgcctacctg tatctaatgg cgaacgccga aggtccattg ttttctaata
    11581 cagaacaaac tggtaacaaa aaccacaatg tgtgtcccct cgcccccttt tttcaaatta
    11641 agatccatgt cctttggctc cccgtgcatt attggccatg tctctctggt tccacaagat
    11701 accgttgttg aaaacacatg gaactttcta acactgcagg aaaaaggtct gggaaccatt
    11761 tgtgggtttg gtttggtctt tcagtttctt gtgggtgttg ggcagtgtgc agacacatgt
    11821 acaggtggag taggtgcctg cctggtgaca acccctgtct gcttcctatg ccagtgaggt
    11881 tgaagtaaga gttttgccag agttcatcta cctctgggat ttaaaaaaac aaaacaaaag
    11941 tcaaaaggct cgatggagcg gacacatcgc caataatgca tttctgagtt ttcttgttaa
    12001 attttttctt aaaaaaagaa aaaaaaagtc taaaaaagat aataatatgg ccaatttgtt
    12061 acataaaata actttctgtg tataaattat tcctaaaaaa aaaaaccctc tgtttatata
    12121 taaaagaaaa tcagtagatg aaaaaaaatt caatgttttt gtatattctg ttgtaagaat
    12181 ttattcctgt tactgcgaca tactcgggat tctttacatt atgaaaaaag aaactttgtc
    12241 tattttgaat ggctaaagct aaggccactt gagtctatta ctctgctttt ttctagtagt
    12301 taaagtacca catggattaa gttaaataaa agaattctgt atgca
//
