LOCUS       NM_001111275            7073 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus insulin-like growth factor 1 (Igf1), transcript
            variant 4, mRNA.
ACCESSION   NM_001111275
VERSION     NM_001111275.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7073)
  AUTHORS   Basu,S., Mautner,L., Whiting,K., Hasenpusch-Theil,K., Borkowska,M.
            and Theil,T.
  TITLE     Identification of Pappa and Sall3 as Gli3 direct target genes
            acting downstream of cilia signaling in corticogenesis
  JOURNAL   Cereb Cortex 34 (12) (2024)
   PUBMED   39716738
REFERENCE   2  (bases 1 to 7073)
  AUTHORS   Sakai,H., Uno,H., Yamakawa,H., Tanaka,K., Ikedo,A., Uezumi,A.,
            Ohkawa,Y. and Imai,Y.
  TITLE     The androgen receptor in mesenchymal progenitors regulates skeletal
            muscle mass via Igf1 expression in male mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (39), e2407768121 (2024)
   PUBMED   39292748
  REMARK    GeneRIF: The androgen receptor in mesenchymal progenitors regulates
            skeletal muscle mass via Igf1 expression in male mice.
REFERENCE   3  (bases 1 to 7073)
  AUTHORS   Sandovici,I., Fernandez-Twinn,D.S., Campbell,N., Cooper,W.N.,
            Sekita,Y., Zvetkova,I., Ferland-McCollough,D., Prosser,H.M.,
            Oyama,L.M., Pantaleao,L.C., Cimadomo,D., Barbosa de Queiroz,K.,
            Cheuk,C.S.K., Smith,N.M., Kay,R.G., Antrobus,R., Hoelle,K.,
            Ma,M.K.L., Smith,N.H., Geyer,S.H., Reissig,L.F., Weninger,W.J.,
            Siddle,K., Willis,A.E., Lam,B.Y.H., Bushell,M., Ozanne,S.E. and
            Constancia,M.
  TITLE     Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and
            leads to developmental growth restriction and metabolic dysfunction
            in mice
  JOURNAL   Cell Rep 43 (9), 114750 (2024)
   PUBMED   39283743
  REMARK    GeneRIF: Overexpression of Igf2-derived Mir483 inhibits Igf1
            expression and leads to developmental growth restriction and
            metabolic dysfunction in mice.
REFERENCE   4  (bases 1 to 7073)
  AUTHORS   Wang,T., Zhu,C., Zhang,K., Gao,J., Xu,Y., Duan,C., Wu,S., Peng,C.,
            Guan,J. and Wang,Y.
  TITLE     Targeting IGF1/IGF1r signaling relieve pain and autophagic
            dysfunction in NTG-induced chronic migraine model of mice
  JOURNAL   J Headache Pain 25 (1), 156 (2024)
   PUBMED   39304806
  REMARK    GeneRIF: Targeting IGF1/IGF1r signaling relieve pain and autophagic
            dysfunction in NTG-induced chronic migraine model of mice.
            Erratum:[J Headache Pain. 2024 Oct 8;25(1):173. doi:
            10.1186/s10194-024-01884-2.. PMID: 39379801]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7073)
  AUTHORS   Flaherty,S.E. 3rd, Bezy,O., Paulhus,B.L., Song,L., Piper,M.,
            Pang,J., Park,Y., Asano,S., Lien,Y.C., Griffin,J.D., Robertson,A.,
            Opsahl,A., Shanthappa,D.H., Ahn,Y., Pashos,E., Simmons,R.A.,
            Birnbaum,M.J. and Wu,Z.
  TITLE     SPAG7 deletion causes intrauterine growth restriction, resulting in
            adulthood obesity and metabolic dysfunction
  JOURNAL   Elife 12, 91114 (2024)
   PUBMED   39056292
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7073)
  AUTHORS   Ferguson,M.W., Sharpe,P.M., Thomas,B.L. and Beck,F.
  TITLE     Differential expression of insulin-like growth factors I and II
            (IGF I and II), mRNA, peptide and binding protein 1 during mouse
            palate development: comparison with TGF beta peptide distribution
  JOURNAL   J Anat 181 (Pt 2) (Pt 2), 219-238 (1992)
   PUBMED   1284245
REFERENCE   7  (bases 1 to 7073)
  AUTHORS   Rappolee,D.A., Sturm,K.S., Behrendtsen,O., Schultz,G.A.,
            Pedersen,R.A. and Werb,Z.
  TITLE     Insulin-like growth factor II acts through an endogenous growth
            pathway regulated by imprinting in early mouse embryos
  JOURNAL   Genes Dev 6 (6), 939-952 (1992)
   PUBMED   1317321
REFERENCE   8  (bases 1 to 7073)
  AUTHORS   Hannon,K., Smith,C.K. 2nd, Bales,K.R. and Santerre,R.F.
  TITLE     Temporal and quantitative analysis of myogenic regulatory and
            growth factor gene expression in the developing mouse embryo
  JOURNAL   Dev Biol 151 (1), 137-144 (1992)
   PUBMED   1374351
REFERENCE   9  (bases 1 to 7073)
  AUTHORS   Siddiqui,R.A., McCutcheon,S.N., Blair,H.T., Mackenzie,D.D.,
            Morel,P.C., Breier,B.H. and Gluckman,P.D.
  TITLE     Growth allometry of organs, muscles and bones in mice from lines
            divergently selected on the basis of plasma insulin-like growth
            factor-I
  JOURNAL   Growth Dev Aging 56 (1), 53-60 (1992)
   PUBMED   1601577
REFERENCE   10 (bases 1 to 7073)
  AUTHORS   Bartlett,W.P., Li,X.S. and Williams,M.
  TITLE     Expression of IGF-1 mRNA in the murine subventricular zone during
            postnatal development
  JOURNAL   Brain Res Mol Brain Res 12 (4), 285-291 (1992)
   PUBMED   1315903
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125082.3, AK081019.1 and
            AC139754.4.
            
            On Sep 24, 2015 this sequence version replaced NM_001111275.1.
            
            Summary: This gene encodes a member of the insulin-like growth
            factor (IGF) family of proteins that promote growth and development
            during fetal and postnatal life. This gene is predominantly
            expressed in the liver and the encoded protein undergoes
            proteolytic processing to generate a disulfide-linked mature
            polypeptide. Transgenic disruption of this gene in mice results in
            reduced postnatal survival and severe growth retardation. Mice
            lacking the encoded protein exhibit generalized organ hypoplasia
            including underdevelopment of the central nervous system and
            developmental defects in bone, muscle and reproductive systems.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms that may undergo similar processing to
            generate mature protein. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (4) lacks an alternate
            frame-shifting exon in the 3' coding region, compared to variant 1,
            resulting in a protein (isoform 4) with a novel C-terminus,
            compared to isoform 1. This isoform (4) is also known as IA.
            
            Sequence Note: This RefSeq was created from transcript and genomic
            sequence because transcript sequence consistent with the reference
            assembly was not available for all regions of the RefSeq
            transcript. The extent of this transcript is supported by
            transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165471.1, AK081019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC125082.3         23829-23844         c
            17-1673             AK081019.1         2-1658
            1674-7073           AC139754.4         159771-165170       c
FEATURES             Location/Qualifiers
     source          1..7073
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.7 cM"
     gene            1..7073
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
                     /note="insulin-like growth factor 1"
                     /db_xref="GeneID:16000"
                     /db_xref="MGI:MGI:96432"
     exon            1..361
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..760
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
                     /note="isoform 4 preproprotein is encoded by transcript
                     variant 4; somatomedin; insulin-like growth factor I"
                     /codon_start=1
                     /product="insulin-like growth factor 1 isoform 4
                     preproprotein"
                     /protein_id="NP_001104745.1"
                     /db_xref="CCDS:CCDS48661.1"
                     /db_xref="GeneID:16000"
                     /db_xref="MGI:MGI:96432"
                     /translation="MGKISSLPTQLFKICLCDFLKIKIHIMSSSHLFYLALCLLTFTS
                     STTAGPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDL
                     RRLEMYCAPLKPTKAARSIRAQRHTDMPKTQKEVHLKNTSRGSAGNKTYRM"
     exon            362..518
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
                     /inference="alignment:Splign:2.1.0"
     exon            519..700
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
                     /inference="alignment:Splign:2.1.0"
     exon            701..7073
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      910..915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
                     /note="hexamer: AGTAAA"
     polyA_site      923
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
                     /note="major polyA site"
     polyA_site      2655
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
     polyA_site      2663
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
                     /note="major polyA site"
     regulatory      7044..7049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
                     /note="hexamer: ATTAAA"
     polyA_site      7073
                     /gene="Igf1"
                     /gene_synonym="C730016P09Rik; Igf-1; Igf-I"
ORIGIN      
        1 actcgataac tttgccagaa gagggagaga gagagaaggc gaatgttccc ccagctgttt
       61 cctgtctaca gtgtctgtgt tttgtagata aatgtgagga ttttctctaa atccctcttc
      121 tgcttgctaa atctcactgt cactgctaaa ttcagagcag atagagcctg cgcaatggaa
      181 taaagtcctc aaaattgaaa tgtgacattg ctctaacatc tcccatctct ctggatttct
      241 ttttcgcctc attatccctg cccaccaatt catttccaga ctttgtactt cagaagcgat
      301 ggggaaaatc agcagccttc caactcaatt atttaagatc tgcctctgtg acttcttgaa
      361 gataaagata cacatcatgt cgtcttcaca cctcttctac ctggcgctct gcttgctcac
      421 cttcaccagc tccaccacag ctggaccaga gaccctttgc ggggctgagc tggtggatgc
      481 tcttcagttc gtgtgtggac cgaggggctt ttacttcaac aagcccacag gctatggctc
      541 cagcattcgg agggcacctc agacaggcat tgtggatgag tgttgcttcc ggagctgtga
      601 tctgaggaga ctggagatgt actgtgcccc actgaagcct acaaaagcag cccgctctat
      661 ccgtgcccag cgccacactg acatgcccaa gactcagaag gaagtacatt tgaagaacac
      721 aagtagagga agtgcaggaa acaagaccta cagaatgtag gaggagcctc ccacggagca
      781 gaaaatgcca catcaccgca ggatcctttg ctgcttgagc aacctgcaaa acatcgaaac
      841 acctaccaaa taacaataat aagtccaata acattacaaa gatgggcatt tcccccaatg
      901 aaatatacaa gtaaacattc caacatcgtc tttaggagtg tttgtttaaa aagctttgca
      961 ccttgcaaaa gtggtcctgg cgtgggtaga ttgctgttgg tcctttatca ataacattct
     1021 atagagaaaa aaaatatata tataactata tctcctagtc cctgcctcta aagagccgaa
     1081 aatgcatgga tgttgtagag atccagttgc tctaagtttc tctctgaatt ttggctgctg
     1141 aagccattca tttagcaact gtgtagaggt ggtttatgaa tggttccctt atcttcacct
     1201 cttcccacgt agctcaagct gcttgtttta cagagtctaa tcatcttgtc tagctgcatt
     1261 agacacaccc tttcctaaca cttgtatttg ttgaatttgg cctccttaag agcaatagca
     1321 aataagtagt caagtggcct accaagtttt aacgtacctg actccatctg tggcatttgt
     1381 accaaatata agttgaatgc atttatttta gacacaaagc tttatttttt ttgacattgt
     1441 gtttcaagaa aaaaaataga ataacaataa ctacaacttt gaggccaatc atttttaggt
     1501 gtgtgtttga agcatagaac gtctcttaaa ctctcaatgg tttcttcaaa tgataagtta
     1561 gtatgtaacc taagtatagc agtttctctc ttttttattt ttttccatat agagcactat
     1621 gtaaagttag tatatcaata atacaggaaa tatcaaacag tatgtaaaac tctgttgttg
     1681 ttgtttttta gtacaatggt gctattttgt agtttgttat atgaaagaat ctagtcaaca
     1741 cagtaaaagg agaaagcaaa gcaaaaacaa caaacgaaag cctggagcct aagatgacaa
     1801 aacgaggaag ggaactgaaa aaaaaaatcc ttcctcttgg gagatgcaaa ggcctcccca
     1861 attatgcctt ccaagaagaa cttaagatat agagtccatt aagacgcact tacttgtcaa
     1921 gtccagagag gaagctatgg agtgggaaaa gcaagaggct agggatttgg gagtcctggt
     1981 ttctttttaa tcactgaaga agtaagtatt tgcaacctgg gtcacacaaa ctcaccaccc
     2041 tgtgacctca gtcaaatcac tccacctctc ggtgcctcag ttttcctcat ctgcaaaatg
     2101 ggggcaatat gtcatctacc tacctcaaag gggtggtatg aagattaaaa agtagacctt
     2161 cagatttttg ttctgggttt ccaggagggt gcaacatcag aacccttgaa ttgctaggat
     2221 gcaaggaatt ctgtaaataa cccactaaca atgtagctcc aaggatcatt catctgtcac
     2281 tgggatgcca ccacaatatc caagttctta ttggtgaagc tgtgcaacta attagtgaca
     2341 agctaaggac tcagtctccc cagcatgtca cacggcagga gacatttgat ttgcagtttt
     2401 atttaacttc tgcatttgag cttatgacta taaagactag tgaaaagaag ggagagagga
     2461 gaaagaagat ccttgccaag taaagggtaa ttaattatta ttccatttat ccactctcat
     2521 taaagggtaa ttaattattc catgtatcca ctctcattaa tccttccagt cacttagtat
     2581 ctagaaataa ctctaacatt gtcaatgaga ctctactcag tttgccaaac acaattctcc
     2641 ttccccatag catatgaaaa aaaggcgctg acattcttaa attttgaaat agtatctatt
     2701 acaatcacag gttgctgtag cagatgtagt cttgcccttg tttgtacatg catgtatttt
     2761 ttttttaatt ttatgaaaat gtgctagcaa gaattgctac ttgaggggca aaattcttcc
     2821 ttctcaagcc tgaggttctc cctagtgtct gcttagaagg aaggatccag cttcctggaa
     2881 atgtgttgga tgcattcaac tgggcattgc taaccaaaaa catttagaaa aatgttctct
     2941 atgtatatag caagattgtc tccctctttt aaaaacaaaa tccaatattc acatcttatt
     3001 acctacaacc ttgattctct attgcaagct tccttaatat tcttataaaa tgtattaaga
     3061 aaaacaaaaa ggacaccttt agctctcctt ccgccaggtt gcctctagaa tctctgggga
     3121 aatgcagaag gtgctgttga gtaaagccct cagaaggatt ggatttagga acatcaggca
     3181 cgctgtacat cccctgatta ctgtagaaat gtaaatggaa taagaggtca gctgaccatc
     3241 cacctgcttc cccagaagga tacagggaaa agttaggccc tcacacaccc tgggtgacac
     3301 ttctgacttc tagttcttgt tcacagtgtg tactttttca aattggtaat tcccagaaaa
     3361 acacataggt ggccttctcc agatctgtgg gcttcctgcc atggttggat ttggtgattc
     3421 caagtgtcta tcacatattt tgttcactta attctatcca cagtcagaaa ttctttcaat
     3481 gaggaaagtt taaatatgca atcctttatc caatacctaa ttctctccaa ctgcatcata
     3541 aatcaagtaa taaaaattaa ttgtactaat taatcataat aatgtaccat tgtactttta
     3601 aatgaatgaa cactgcaaga caaatctatg taaactctga aaagtaactg atcattatat
     3661 ggtgaatcaa aatgactcaa gattgataga aagggacatt taaaatttta caactcaaaa
     3721 ttttgtagac tttgctatgg aggtaaattg ttttagtgcc tagagatgga gcggttttaa
     3781 taaatttaca aaagaactat aaagataggt aggaaggaat tttcatttga taggattgtt
     3841 gctgatttac ttactcaata cctaggtcaa atgttgatcc tattctccaa agactatcaa
     3901 gtgcttgaac attgtaagat gagtctgctc cactgaaaat gtaatacatc tctccattat
     3961 aatctatttt cctggggtaa aaaaatcctt tttttaaata tccacctaca tatacctacc
     4021 ctacatgtgc atttgcacat gcgtgcatac gctcatgcgc cccaccccac acacacctat
     4081 tcaccctaag actaagaaga aatcatttct ttgaaagtct tatctttcaa aaaaggcagc
     4141 ggtgcccctt gagactcctt ctccttcttt gaatgtcaat gtgaaatgtg gcatgtctgt
     4201 gtacatgaaa ccatctcata ccctatggct ccagggtttc tttatggttt gtgcacttgg
     4261 gaggatgcgc agaagacagg atgcagcctg ttttgctttc ccctttactg tttggccagc
     4321 tacgccaatg tggtgctatt gtttctttaa gaaagtactt gactaaaaaa aaagaaaaaa
     4381 agaaaaaaag aaaagaaaaa gaaaaaagaa aaaaaaagaa agcatagacc tattttttta
     4441 aagtctgaaa acaacagttc tatagtagat ggcttactga gatagcatta gatctagcca
     4501 ccaccctagc caccaccttt caactatgtg tcactcacaa gtagaatatt gttcaccaag
     4561 ttgtgagttt gggggttcag agacaaagga tggaaaagtt ttaaagttag atggctcaat
     4621 catttcattg gctctcaaat ttaacaaaat tggcaatact tcacccaatc tgaagtgttg
     4681 gtcaataact tgaactgggg gcaaaaataa cttcaggcaa atggcagaag aaaataatta
     4741 acttacttct tgcttttttt gttgattgtt tggtttcctg ttgatttttg gttttggttt
     4801 tgctgtgggt gggtgagtac atgtgtgtaa gtacgtgtgt gtgtgtgtgt gtgtgtgtgt
     4861 gtgtgtgtgt tccactcaaa aacaaatact cagaaagtgg agaaaataca acgattttaa
     4921 gagcatagac ttacctacta ctagaaccag cttctgtcac atcctctgga gaaggcactg
     4981 atttcttgtt ttgtagaggt tgctcttcca tcagtgacct gaaagagtga ccagtctcct
     5041 agagtagaca tggatctcat taggagaaga cagaagtatt tccttatgaa ttgggcttat
     5101 ctactgacaa agaaagggaa gagtttatga gaagttattg aagaagatgg ctaacagtct
     5161 gtgaagattt tgttctggtt ttttttgttg ttgttgttgt tgggtttggg ttttgatttt
     5221 tttttttttt tttttacttt atacaatctt tatgaatgga aatcttaatg ctcaaaaaga
     5281 cttggtcttt ttttctcttt cgtaacagaa tggaagatga caaactcaca tagactcttt
     5341 ctaggctggc tagcaaaggt gtggtttgac ttatttgaat cagaccattt taaatgttcc
     5401 tctctatttt taatcataaa aggctgtcat aatttattag cgtaggccct ttttggcact
     5461 tctcaaatga atgagcattc ccattcaaag catggctttc cccatggttc caaaacatga
     5521 atgattaata ttaaggaatt atttacttca aaatacagta gaagtgtgag tctctgttcc
     5581 cattccccac aaagatcatt aagtcctgaa tcgggggcgg gggtggggcg cctggatact
     5641 aagggaattt ttttgttgct tgttttttgt tttcaatgct agtgcttaat cctatagtat
     5701 acagatttgc ttcttgctat tgtgatattc tgtaagactt tcctgttagg tattagaaat
     5761 tgatacataa ataccttttt tgtgtggttt ctatttaaaa ggaaagagat aagactgtct
     5821 gaaccttaaa ttcgtaaggc acatgataaa gagatcacat taaataacaa gccatatctg
     5881 gttcaatcct ttctttctta tcattttaag gaaaacttgc ccagataaga cagaggccca
     5941 ggggactttt gaaactctct ttgttccgcc aattcatttt ggctggtgat ggtttttccc
     6001 cagtgtctgc ctcagaatct tttagaggct ggccagacta aagactgtct tttaaaacac
     6061 atttcacatg gttcctctta atgaatgatt acacttatgt agaacatgat ttttttttct
     6121 ctccacttat tttttttttc cccatcattg ataagggttc ttaaggagaa gaattcatta
     6181 acaaaactca agaaagcgta caaaaaaaaa attctaaatg tcactgccca attgaaatac
     6241 gagctaaaat ggaaatactt tctcctactt aaaacccaga ctgaatcacc ttcaaaatga
     6301 cctttcacaa tctttccaat ttgcctttgt ttaaactgtc tgggcctaaa agcaagcatt
     6361 attcattttc tcttgcccaa agtgaacttg tgtaaagtag gaaaattaaa agaaactgct
     6421 agaaatccct tccaaccagt ggctgacccc tctcactagc tcacagcaaa gtctcctctg
     6481 ttgatctatc acctagtctc atttcgtttg aatatttaca ttgtacctac tgctaaacac
     6541 ttggcaggag gctccatcca tatctcctat cggtgtctct gtatccttaa accttgcaaa
     6601 catcatacag tgtatattaa gtttacagga aagctccaaa tagcatatca gacctggtct
     6661 ctctttgtta aagatttaag gagctatggg aatctggatt acaacgcaca ttttgcttca
     6721 tttattttta tcacacttta aaggccaagg gtgatgatta acttacagac actgaattga
     6781 tttccctact gaaacctgaa agtaatattt ggtcattcat tgtatgtgtt ttacacaaaa
     6841 aaaacatctt ctatcaaatt actcctgatt gtatttgaag tggttattca attcatttat
     6901 ggcagagcaa tatctgtcct aatgactctt ataaaatgta actaactgaa tcattatctt
     6961 acatttactg tttagtaagc atattttgaa attgtatggc tagagtgtca taataaaatg
     7021 gtatatcttt ctttagtaat tacattaaaa ttaatcatgt ttgattaact ggt
//
