LOCUS       NM_008784               1518 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus immunoglobulin (CD79A) binding protein 1 (Igbp1),
            mRNA.
ACCESSION   NM_008784 XM_196586
VERSION     NM_008784.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1518)
  AUTHORS   Sakaguchi,M., Okagawa,S., Okubo,Y., Otsuka,Y., Fukuda,K., Igata,M.,
            Kondo,T., Sato,Y., Yoshizawa,T., Fukuda,T., Yamagata,K., Cai,W.,
            Tseng,Y.H., Sakaguchi,N., Kahn,C.R. and Araki,E.
  TITLE     Phosphatase protector alpha4 (alpha4) is involved in adipocyte
            maintenance and mitochondrial homeostasis through regulation of
            insulin signaling
  JOURNAL   Nat Commun 13 (1), 6092 (2022)
   PUBMED   36241662
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1518)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1518)
  AUTHORS   Chung,H.K., Wang,S.R., Xiao,L., Rathor,N., Turner,D.J., Yang,P.,
            Gorospe,M., Rao,J.N. and Wang,J.Y.
  TITLE     alpha4 Coordinates Small Intestinal Epithelium Homeostasis by
            Regulating Stability of HuR
  JOURNAL   Mol Cell Biol 38 (11), e00631-17 (2018)
   PUBMED   29555726
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1518)
  AUTHORS   Eleftheriadou,O., Boguslavskyi,A., Longman,M.R., Cowan,J.,
            Francois,A., Heads,R.J., Wadzinski,B.E., Ryan,A., Shattock,M.J. and
            Snabaitis,A.K.
  TITLE     Expression and regulation of type 2A protein phosphatases and
            alpha4 signalling in cardiac health and hypertrophy
  JOURNAL   Basic Res Cardiol 112 (4), 37 (2017)
   PUBMED   28526910
  REMARK    GeneRIF: Report the significance and altered activity of the type
            2A protein phosphatase-alpha4 complex in healthy and hypertrophied
            myocardium.
REFERENCE   5  (bases 1 to 1518)
  AUTHORS   LeNoue-Newton,M., Watkins,G.R., Zou,P., Germane,K.L.,
            McCorvey,L.R., Wadzinski,B.E. and Spiller,B.W.
  TITLE     The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding
            domains of the Alpha4 protein are both required for Alpha4 to
            inhibit PP2A degradation
  JOURNAL   J Biol Chem 286 (20), 17665-17671 (2011)
   PUBMED   21454489
  REMARK    GeneRIF: both the C-terminal Mid1-binding domain and the
            PP2Ac-binding determinants are required for Alpha4-mediated
            protection of PP2Ac from polyubiquitination and degradation.
REFERENCE   6  (bases 1 to 1518)
  AUTHORS   Nanahoshi,M., Nishiuma,T., Tsujishita,Y., Hara,K., Inui,S.,
            Sakaguchi,N. and Yonezawa,K.
  TITLE     Regulation of protein phosphatase 2A catalytic activity by alpha4
            protein and its yeast homolog Tap42
  JOURNAL   Biochem Biophys Res Commun 251 (2), 520-526 (1998)
   PUBMED   9792806
REFERENCE   7  (bases 1 to 1518)
  AUTHORS   Maeda,K., Inui,S., Sanjo,H. and Sakaguchi,N.
  TITLE     The gene structure and promoter analysis of mouse lymphocyte signal
            transduction molecule alpha 4 that is related to the yeast TAP42
            involved in a rapamycin-sensitive pathway
  JOURNAL   Gene 210 (2), 287-295 (1998)
   PUBMED   9573385
REFERENCE   8  (bases 1 to 1518)
  AUTHORS   Onda,M., Inui,S., Maeda,K., Suzuki,M., Takahashi,E. and
            Sakaguchi,N.
  TITLE     Expression and chromosomal localization of the human alpha 4/IGBP1
            gene, the structure of which is closely related to the yeast TAP42
            protein of the rapamycin-sensitive signal transduction pathway
  JOURNAL   Genomics 46 (3), 373-378 (1997)
   PUBMED   9441740
REFERENCE   9  (bases 1 to 1518)
  AUTHORS   Inui,S., Kuwahara,K., Mizutani,J., Maeda,K., Kawai,T., Nakayasu,H.
            and Sakaguchi,N.
  TITLE     Molecular cloning of a cDNA clone encoding a phosphoprotein
            component related to the Ig receptor-mediated signal transduction
  JOURNAL   J Immunol 154 (6), 2714-2723 (1995)
   PUBMED   7876543
REFERENCE   10 (bases 1 to 1518)
  AUTHORS   Kuwahara,K., Matsuo,T., Nomura,J., Igarashi,H., Kimoto,M., Inui,S.
            and Sakaguchi,N.
  TITLE     Identification of a 52-kDa molecule (p52) coprecipitated with the
            Ig receptor-related MB-1 protein that is inducibly phosphorylated
            by the stimulation with phorbol myristate acetate
  JOURNAL   J Immunol 152 (6), 2742-2752 (1994)
   PUBMED   8144881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV654442.1, AK017166.1, CX203560.1 and BC056186.1.
            
            On Aug 15, 2009 this sequence version replaced NM_008784.2.
            
            Sequence Note: An in-frame AUG is located 19 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it is not conserved and is in a weak Kozak
            sequence context.
            
            CCDS Note: A downstream start codon is annotated for this CCDS
            representation based on strong conservation in a variety of
            mammalian species. It should be noted that an alternative upstream
            start codon, which would result in a protein that is 19 aa longer
            at the N-terminus, also exists. However, the upstream start codon
            is mouse-specific and has a weak Kozak signal. It is possible that
            the upstream start codon is used in mouse at least some of the
            time, while leaky scanning by ribosomes may allow downstream start
            codon use more of the time. There is no experimental evidence
            indicating which start codon is preferentially used in vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017166.1, BC089567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-747               DV654442.1         36-782
            748-787             AK017166.1         672-711
            788-867             CX203560.1         702-781
            868-1397            BC056186.1         44-573
            1398-1426           AK017166.1         1320-1348
            1427-1436           AK017166.1         1350-1359
            1437-1518           AK017166.1         1361-1442
FEATURES             Location/Qualifiers
     source          1..1518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.72 cM"
     gene            1..1518
                     /gene="Igbp1"
                     /gene_synonym="p52; Pc52; Tap42"
                     /note="immunoglobulin (CD79A) binding protein 1"
                     /db_xref="GeneID:18518"
                     /db_xref="MGI:MGI:1346500"
     exon            1..266
                     /gene="Igbp1"
                     /gene_synonym="p52; Pc52; Tap42"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1098
                     /gene="Igbp1"
                     /gene_synonym="p52; Pc52; Tap42"
                     /note="alpha4 phosphoprotein; CD79a-binding protein 1;
                     lymphocyte signal transduction molecule alpha 4;
                     phosphoprotein, component, 52 kDa; protein phosphatase
                     2/4/6 regulatory subunit"
                     /codon_start=1
                     /product="immunoglobulin-binding protein 1"
                     /protein_id="NP_032810.4"
                     /db_xref="CCDS:CCDS30302.1"
                     /db_xref="GeneID:18518"
                     /db_xref="MGI:MGI:1346500"
                     /translation="MAASEDELLLPRLPELFETSKKLLEDVEVATEPTGSRTIQDKVS
                     KGLELLEKAAGMLSQLDLFSRNEDLEEIASTDLKYLMVPALQGALTMKQVNPSKRLDH
                     LQRAREHFVHFLTQCHCYHVAEFQLPQTKTNSAENNTASSSMAYPNLVAMASQRQAKI
                     ERYKQKKEVEHRLSALKSAVESGQADDERVREYHLLHLRRWIAVSLEELESIDQEIKI
                     LKEKDSPREETACHSSLPEKPPMKPFILTRNKAQAKVFGTGYPSLATMTVSDWYEQHQ
                     KYGVLPDRGIAKPASADFQRAAQQQEDQEQKDEESEEKALHRMREWDDWKDTHPRGYG
                     NRQNMG"
     exon            267..560
                     /gene="Igbp1"
                     /gene_synonym="p52; Pc52; Tap42"
                     /inference="alignment:Splign:2.1.0"
     exon            561..756
                     /gene="Igbp1"
                     /gene_synonym="p52; Pc52; Tap42"
                     /inference="alignment:Splign:2.1.0"
     exon            757..836
                     /gene="Igbp1"
                     /gene_synonym="p52; Pc52; Tap42"
                     /inference="alignment:Splign:2.1.0"
     exon            837..949
                     /gene="Igbp1"
                     /gene_synonym="p52; Pc52; Tap42"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1518
                     /gene="Igbp1"
                     /gene_synonym="p52; Pc52; Tap42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1361..1366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igbp1"
                     /gene_synonym="p52; Pc52; Tap42"
                     /note="hexamer: AATAAA"
     polyA_site      1397
                     /gene="Igbp1"
                     /gene_synonym="p52; Pc52; Tap42"
                     /note="major polyA site"
ORIGIN      
        1 gctttagggc tcgtctttat ggagtttacc tttgacttcg gtagaaattc ttccgggttt
       61 ctttctttcc acaagatggc agcgtctgaa gacgagttac tgctgccgcg gcttccggag
      121 ctctttgaaa caagcaaaaa acttctggag gacgtggaag tagcaactga acccaccggc
      181 tcccgaacaa tccaggataa ggtgtccaaa ggactagaac tccttgagaa ggctgctgga
      241 atgttatcgc agcttgattt gttcagccga aatgaagatc tggaagagat tgcttccacc
      301 gacctgaagt acctgatggt gccagcgttg caaggagccc tcaccatgaa acaagtcaac
      361 cccagcaagc gtctagatca tttgcagcgg gctcgagaac acttcgtaca tttcttaact
      421 cagtgtcatt gctatcatgt ggcagagttt cagctacccc aaaccaagac taactcagct
      481 gaaaataata ctgctagctc ctccatggcc tatccaaatc tcgttgctat ggcatctcaa
      541 agacaggcta aaatagagag atacaagcag aagaaggagg tggagcatag gttgtctgca
      601 ctgaaatctg ctgtggaaag tggtcaagca gatgatgagc gcgttcggga atatcacctc
      661 cttcaccttc ggaggtggat tgctgtcagc ttagaagagc ttgagagcat tgaccaggaa
      721 ataaagatcc tgaaagaaaa agactctcca agagaggaaa cagcttgtca ctcatctctt
      781 ccagagaagc ctccaatgaa acccttcatc ctcactcgga acaaggcaca agccaaagta
      841 tttggaactg gttatccaag cctggcaact atgacggtga gtgactggta tgaacaacat
      901 caaaaatacg gagtattacc cgaccgggga atagccaagc cggcatcagc tgatttccaa
      961 agagcagctc agcagcagga agatcaagag caaaaggatg aggagagtga ggagaaagcc
     1021 ttgcacagga tgcgagagtg ggacgactgg aaggacaccc atcccagggg ctacggcaac
     1081 cgacagaaca tgggctagtc atgccagaag gccaaaggac agcgtggtgc acaccttcac
     1141 accaaggaca acttcaggag ggtgcagtga gggcagccgt gtggagtctt gctttgcatt
     1201 tgatagtgtc aaataattgc ttgtacccta ggtaatgacc agtggatttt tgtttggctt
     1261 tattaatctc atcacagtgt attctgatgt cttaagtggt cagaaaagag cactaagaaa
     1321 tggatctata taaccaatga gttgattctc ttaaaaaaat aataaacccc cctctattat
     1381 gtgggcctat gtacaaatgt gggtatccgc tggttttgtt gtctacgggg agccccagga
     1441 ttcagctgtg ggtctctttg agtatctgga aatccctgtc atctgctgtc attgtgagca
     1501 agaattgccc agcatttg
//
