LOCUS       NM_009376               3074 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus intraflagellar transport 88 (Ift88), transcript
            variant 1, mRNA.
ACCESSION   NM_009376
VERSION     NM_009376.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3074)
  AUTHORS   Strobel,M.R., Zhou,Y., Qiu,L., Hofer,A.M. and Chen,X.
  TITLE     Temporal ablation of the ciliary protein IFT88 alters normal
            brainwave patterns
  JOURNAL   Sci Rep 15 (1), 347 (2025)
   PUBMED   39747370
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3074)
  AUTHORS   Dumoulin,A., Wilson,N.H., Tucker,K.L. and Stoeckli,E.T.
  TITLE     A cell-autonomous role for primary cilium-mediated signaling in
            long-range commissural axon guidance
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39157903
REFERENCE   3  (bases 1 to 3074)
  AUTHORS   Muhamad,N.A., Masutani,K., Furukawa,S., Yuri,S., Toriyama,M.,
            Matsumoto,C., Itoh,S., Shinagawa,Y., Isotani,A., Toriyama,M. and
            Itoh,H.
  TITLE     Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3
            Expression in Reactive Astrocyte
  JOURNAL   Cell Mol Neurobiol 44 (1), 48 (2024)
   PUBMED   38822888
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3074)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3074)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3074)
  AUTHORS   Sommardahl,C.S., Woychik,R.P., Sweeney,W.E., Avner,E.D. and
            Wilkinson,J.E.
  TITLE     Efficacy of taxol in the orpk mouse model of polycystic kidney
            disease
  JOURNAL   Pediatr Nephrol 11 (6), 728-733 (1997)
   PUBMED   9438653
REFERENCE   7  (bases 1 to 3074)
  AUTHORS   Yoder,B.K., Richards,W.G., Sommardahl,C., Sweeney,W.E.,
            Michaud,E.J., Wilkinson,J.E., Avner,E.D. and Woychik,R.P.
  TITLE     Differential rescue of the renal and hepatic disease in an
            autosomal recessive polycystic kidney disease mouse mutant. A new
            model to study the liver lesion
  JOURNAL   Am J Pathol 150 (6), 2231-2241 (1997)
   PUBMED   9176412
REFERENCE   8  (bases 1 to 3074)
  AUTHORS   Richards,W.G., Yoder,B.K., Isfort,R.J., Detilleux,P.G., Foster,C.,
            Neilsen,N., Woychik,R.P. and Wilkinson,J.E.
  TITLE     Oval cell proliferation associated with the murine insertional
            mutation TgN737Rpw
  JOURNAL   Am J Pathol 149 (6), 1919-1930 (1996)
   PUBMED   8952527
REFERENCE   9  (bases 1 to 3074)
  AUTHORS   Yoder,B.K., Richards,W.G., Sweeney,W.E., Wilkinson,J.E.,
            Avener,E.D. and Woychik,R.P.
  TITLE     Insertional mutagenesis and molecular analysis of a new gene
            associated with polycystic kidney disease
  JOURNAL   Proc Assoc Am Physicians 107 (3), 314-323 (1995)
   PUBMED   8608416
REFERENCE   10 (bases 1 to 3074)
  AUTHORS   Moyer,J.H., Lee-Tischler,M.J., Kwon,H.Y., Schrick,J.J., Avner,E.D.,
            Sweeney,W.E., Godfrey,V.L., Cacheiro,N.L., Wilkinson,J.E. and
            Woychik,R.P.
  TITLE     Candidate gene associated with a mutation causing recessive
            polycystic kidney disease in mice
  JOURNAL   Science 264 (5163), 1329-1333 (1994)
   PUBMED   8191288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124462.2 and AC154675.2.
            
            On Apr 9, 2022 this sequence version replaced NM_009376.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012250.1, AK135110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC124462.2         58716-58827
            113-208             AC124462.2         65178-65273
            209-271             AC124462.2         69435-69497
            272-328             AC124462.2         71867-71923
            329-382             AC124462.2         72882-72935
            383-446             AC124462.2         73506-73569
            447-516             AC124462.2         74346-74415
            517-607             AC124462.2         75571-75661
            608-712             AC124462.2         76518-76622
            713-815             AC124462.2         78995-79097
            816-930             AC124462.2         80205-80319
            931-1162            AC124462.2         82181-82412
            1163-1233           AC124462.2         85311-85381
            1234-1320           AC124462.2         90101-90187
            1321-1420           AC124462.2         107615-107714
            1421-1507           AC124462.2         110683-110769
            1508-1694           AC124462.2         112531-112717
            1695-1803           AC124462.2         114537-114645
            1804-1954           AC124462.2         115297-115447
            1955-2070           AC124462.2         116036-116151
            2071-2123           AC124462.2         122212-122264
            2124-2189           AC124462.2         123532-123597
            2190-2296           AC124462.2         130813-130919
            2297-2363           AC154675.2         127559-127625
            2364-2474           AC154675.2         137335-137445
            2475-3074           AC154675.2         137691-138290
FEATURES             Location/Qualifiers
     source          1..3074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 30.1 cM"
     gene            1..3074
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /note="intraflagellar transport 88"
                     /db_xref="GeneID:21821"
                     /db_xref="MGI:MGI:98715"
     exon            1..112
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            113..208
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2596
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transgene insert site 737, insertional mutation,
                     polycystic kidney disease; tetratricopeptide repeat domain
                     10; intraflagellar transport protein 88 homolog;
                     tgN(Imorpk)737Rpw; intraflagellar transport 88 homolog;
                     TPR repeat protein 10; tetratricopeptide repeat protein
                     10; recessive polycystic kidney disease protein Tg737"
                     /codon_start=1
                     /product="intraflagellar transport protein 88 homolog
                     isoform 1"
                     /protein_id="NP_033402.2"
                     /db_xref="CCDS:CCDS36937.2"
                     /db_xref="GeneID:21821"
                     /db_xref="MGI:MGI:98715"
                     /translation="MMENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRT
                     SHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAG
                     FSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGD
                     LKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALN
                     TYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQ
                     NIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAV
                     PLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIE
                     ASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVK
                     SAAATNLSFLYYLENEFAQASSYADLAVNSDRYNPSALTNKGNTVFANGDYEKAAEFY
                     KEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANIYELM
                     EDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVI
                     EWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIH
                     RKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSSGGSRS
                     KREGSAGSDSGQNNSASSKSERLSAKLRALPGTDEPYESSGNKEIDASYVDPLGPQIE
                     RPKTAAKKRIDEDDFADEELGDDLLPE"
     exon            209..271
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            272..328
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            329..382
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            383..446
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            447..516
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            517..607
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            608..712
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            713..815
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            816..930
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1162
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1233
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1320
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1420
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1507
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1694
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1803
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1954
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2070
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2123
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2189
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2296
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2363
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2474
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..3074
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3055..3060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /note="hexamer: AATAAA"
     polyA_site      3074
                     /gene="Ift88"
                     /gene_synonym="flexo; fxo; orpk; polaris; Tg737; Tg737Rpw;
                     TgN737Rpw; Ttc10"
                     /note="major polyA site"
ORIGIN      
        1 ccttggagtc gcgcctggca acggctgggc gtcccgctct ggcctgccta ggatcaggcg
       61 tcgcttcttc cctcggccca ctcgtggtca gcccgctcct cctcggcgcg aggtacaaat
      121 gatggaaaat gttcatctgg caccagaaac agatgaggac gacctttact ctggtttcaa
      181 cgactacaac ccagcctatg atactgagga gttggagaat gacacgggtt ttcagcaagc
      241 agtgagaacc agtcatggca gaagacctcc cgtaactgct aaaataccaa gcacagcagt
      301 cagcagaccc atagctactg gatatgggtc caagacatcc ctgacatcat caatgggaag
      361 accgatgaca gggacaattc aggatggagt tgctcgaccg atgacagcag tgagagcagc
      421 tggcttttcc aaggcagctt tgcgaggctc tgcatttgac ccccttggtc agtccagggg
      481 ccctgctcct cctttggaag ccaaaaatga agacagtcca gaagaaaaaa ttagacagtt
      541 ggagaagaaa gtaaatgagt tggtggaaga aagctgtatt gccaacagtt gtggagactt
      601 aaaactggcc ttagagaagg caaaagatgc aggaagaaaa gagagagtcc tggtgagaca
      661 acgagagcaa gtcacaagtc cagaaaatat caacttggac ttaacctact ccgttctttt
      721 caacttggcc agtcagtatt ctgctaatga aatgtatgca gaagcactga acacatacca
      781 agttatagtg aaaaacaaga tgtttagcaa tgcaggaaga ctgaaagtga atatgggaaa
      841 tatttattta aagcagagaa attattccaa agccattaag ttctaccgaa tggccttaga
      901 tcagatccca agtgtccata aagaaatgag gatcaaaata atgcagaaca ttggaatcac
      961 atttataaaa actggtcagt actcagatgc catcaactca tttgagcaca tcatgagcat
     1021 ggccccgagc ctgaaggcag gcttcaacct catccttagt tgttttgcca ttggagatcg
     1081 ggagaaaatg aagaaggcat tccaaaaatt aattgctgtt ccgttagaaa ttgatgaaga
     1141 tgataaatat atctccccaa gtgatgatcc ccatactaac ttgctgattg aagctataaa
     1201 aaatgaccac cttaggcaaa tggaacgtga aaggaaagcc atggcagaaa aatacatcat
     1261 gacagctgca aaactcattg ctcctgtgat cgaagcgtct tttgctgtgg gttataactg
     1321 gtgtgtggaa gtagtgaaag cctctcagta tgtggagctg gccaacgacc tggagattaa
     1381 caaagcaatt acttacttga gacaaaagga ctttaaccaa gctgtagaca cattgaaaat
     1441 gtttgagaag aaggacagta gagtgaagag tgcagctgcg accaacctct cgttcctgta
     1501 ttatctggaa aacgaatttg cccaagccag cagctatgca gatttagctg tgaactcgga
     1561 tagatataac ccgtcagctc tcactaataa agggaacaca gtttttgcaa atggtgatta
     1621 tgagaaggca gctgagttct ataaagaggc cctgagaaac gactcttcct gtactgaagc
     1681 actgtataac attggcctca cctataagaa gctgaaccgt ctggatgaag ccctggactc
     1741 cttcctgaaa ctgcacgcga tccttcggaa cagcgctcaa gttctttgcc agatagcaaa
     1801 catatatgag ttaatggaag atcccaatca agctattgaa tggctgatgc agttgatcag
     1861 cgttgttcca actgattccc aagctctgtc taaactggga gagttatacg atagtgaggg
     1921 agacaagtcc caggcattcc aatattacta tgagtcatac aggtatttcc cttctaacat
     1981 tgaagtcatt gaatggcttg gagcttatta cattgataca cagttctgcg agaaagccat
     2041 tcagtacttt gaaagagctt cccttataca acccacacaa gtgaagtggc agctgatggt
     2101 agctagctgc tttagaagaa gtggtaacta ccaaaaggca ttagatactt ataaagagat
     2161 tcacaggaaa tttccggaga atgttgaatg tttgcgtttc ttggttcgtc tctgcacaga
     2221 tattggatta aaagaagttc aagaatatgc cacaaaactc aagaggttgg aaaaaatgaa
     2281 agaaatgagg gaacagcgca taaaatcggg cagagacagc agcgggggtt ctcgcagcaa
     2341 acgagagggg agtgctggca gtgacagtgg ccagaacaat agtgccagta gtaagagtga
     2401 acgactgagt gccaagctca gagctttgcc tgggacagat gaaccttatg aaagtagcgg
     2461 taacaaagaa atagatgcct cctacgtgga tccactgggc cctcagatag aaagaccaaa
     2521 aactgcagcc aagaaaagaa ttgacgagga tgattttgct gatgaagagt taggagatga
     2581 cttgctccca gaataatata aactctaata tgctctgtgt gtgtgtgtgt gtcagaaaac
     2641 agcctcagat gttcctcagg caccatccat caccttttta catttgtggc agggttcctc
     2701 tggcctggaa cttgccatat aggcaagact ggctggctgg ccaccccatg ggtctgcttg
     2761 tctctgctcc ctggctgcag agatttataa gcacttgcca ccacatccag ctttctttaa
     2821 atggactcta gggcttgaac tcaggtcctc cagcttgcaa ggcaagcact tttccaattg
     2881 tgctctctct agccaaataa gtcatttacc aaagaaaaga aattgcctta taaggtaata
     2941 ttcatgttaa acctggatca aatatccaaa ctttaatttt gtacactggt gaaactttca
     3001 ataagtgtgt tttgttctct gaggatgggt ttgtgctgtc attttttaaa atggaataaa
     3061 aactatgaag ctgc
//
