LOCUS       NM_001358917            3220 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus intraflagellar transport 81 (Ift81), transcript
            variant 1, mRNA.
ACCESSION   NM_001358917 XM_006530127
VERSION     NM_001358917.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3220)
  AUTHORS   Duan S, Li H, Zhang Y, Yang S, Chen Y, Qiu B, Huang C, Wang J, Li
            J, Zhu X and Yan X.
  TITLE     Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune
            ciliary signaling
  JOURNAL   EMBO J 40 (2), e105499 (2021)
   PUBMED   33241915
REFERENCE   2  (bases 1 to 3220)
  AUTHORS   Qu W, Yuan S, Quan C, Huang Q, Zhou Q, Yap Y, Shi L, Zhang D, Guest
            T, Li W, Yee SP, Zhang L, Cazin C, Hess RA, Ray PF, Kherraf ZE and
            Zhang Z.
  TITLE     The essential role of intraflagellar transport protein IFT81 in
            male mice spermiogenesis and fertility
  JOURNAL   Am J Physiol Cell Physiol 318 (6), C1092-C1106 (2020)
   PUBMED   32233951
  REMARK    GeneRIF: IFT81 plays an essential role during spermatogenesis by
            modulating the assembly and elongation of the sperm flagella.
REFERENCE   3  (bases 1 to 3220)
  AUTHORS   Agbu SO, Liang Y, Liu A and Anderson KV.
  TITLE     The small GTPase RSG1 controls a final step in primary cilia
            initiation
  JOURNAL   J Cell Biol 217 (1), 413-427 (2018)
   PUBMED   29038301
REFERENCE   4  (bases 1 to 3220)
  AUTHORS   Xin D, Christopher KJ, Zeng L, Kong Y and Weatherbee SD.
  TITLE     IFT56 regulates vertebrate developmental patterning by maintaining
            IFTB complex integrity and ciliary microtubule architecture
  JOURNAL   Development 144 (8), 1544-1553 (2017)
   PUBMED   28264835
REFERENCE   5  (bases 1 to 3220)
  AUTHORS   Katoh Y, Terada M, Nishijima Y, Takei R, Nozaki S, Hamada H and
            Nakayama K.
  TITLE     Overall Architecture of the Intraflagellar Transport (IFT)-B
            Complex Containing Cluap1/IFT38 as an Essential Component of the
            IFT-B Peripheral Subcomplex
  JOURNAL   J Biol Chem 291 (21), 10962-10975 (2016)
   PUBMED   26980730
REFERENCE   6  (bases 1 to 3220)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3220)
  AUTHORS   Peng J, Yu L, Horiuchi M, Zhang P, Huang X, Zhang Y, Li D, Jalil MA
            and Zhao S.
  TITLE     Identification of human CDV-1R and mouse Cdv-1R, two novel proteins
            with putative signal peptides, especially highly expressed in
            testis and increased with the male sex maturation
  JOURNAL   Mol Biol Rep 29 (4), 353-362 (2002)
   PUBMED   12549821
  REMARK    GeneRIF: inconsistent expression levels of human CDV-1 and mouse
            Cdv-1 in heart implied that cardiac hypertrophy in human SCD might
            not be associated with the abnormal expression of CDV-1.
REFERENCE   8  (bases 1 to 3220)
  AUTHORS   Higashi M, Kobayashi K, Iijima M, Wakana S, Horiuchi M, Yasuda T,
            Yoshida G, Kanmura Y and Saheki T.
  TITLE     Genomic organization and mapping of mouse CDV (carnitine
            deficiency-associated gene expressed in ventricle)-1 and its
            related CDV-1R gene
  JOURNAL   Mamm Genome 11 (12), 1053-1057 (2000)
   PUBMED   11130971
REFERENCE   9  (bases 1 to 3220)
  AUTHORS   Jalil A, Horiuchi M, Nomoto M, Kobayashi K and Saheki T.
  TITLE     Catecholamine metabolism inhibitors and receptor blockades only
            partially suppress cardiac hypertrophy of juvenile visceral
            steatosis mice with systemic carnitine deficiency
  JOURNAL   Life Sci 64 (13), 1137-1144 (1999)
   PUBMED   10210276
REFERENCE   10 (bases 1 to 3220)
  AUTHORS   Masuda M, Kobayashi K, Horiuchi M, Terazono H, Yoshimura N and
            Saheki T.
  TITLE     A novel gene suppressed in the ventricle of carnitine-deficient
            juvenile visceral steatosis mice
  JOURNAL   FEBS Lett 408 (2), 221-224 (1997)
   PUBMED   9187371
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114632.9 and AC113285.9.
            
            [WARNING] On May 15, 2023 this sequence was replaced by
            NM_001358917.2.
            
            On Dec 13, 2017 this sequence version replaced XM_006530127.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.40396.1,
                                           SRR7974084.24906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               AC114632.9         73087-73437         c
            352-516             AC114632.9         69836-70000         c
            517-620             AC114632.9         68971-69074         c
            621-801             AC114632.9         68066-68246         c
            802-891             AC114632.9         65861-65950         c
            892-957             AC114632.9         61578-61643         c
            958-1068            AC114632.9         61161-61271         c
            1069-1153           AC114632.9         59333-59417         c
            1154-1317           AC114632.9         53418-53581         c
            1318-1413           AC114632.9         51943-52038         c
            1414-1560           AC114632.9         49973-50119         c
            1561-1710           AC113285.9         1974-2123
            1711-1839           AC113285.9         5724-5852
            1840-1929           AC113285.9         7413-7502
            1930-2016           AC113285.9         14018-14104
            2017-2088           AC113285.9         14995-15066
            2089-2174           AC113285.9         15523-15608
            2175-2220           AC113285.9         19221-19266
            2221-3220           AC113285.9         23560-24559
FEATURES             Location/Qualifiers
     source          1..3220
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.44 cM"
     gene            1..3220
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /note="intraflagellar transport 81"
                     /db_xref="GeneID:12589"
                     /db_xref="MGI:MGI:1098597"
     exon            1..351
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..516
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..2403
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /note="isoform a is encoded by transcript variant 1;
                     intraflagellar transport protein 81 homolog; carnitine
                     deficiency-associated protein expressed in ventricle 1;
                     carnitine deficiency-associated gene expressed in
                     ventricle 1; intraflagellar transport 81 homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 81 homolog
                     isoform a"
                     /protein_id="NP_001345846.1"
                     /db_xref="CCDS:CCDS19650.1"
                     /db_xref="GeneID:12589"
                     /db_xref="MGI:MGI:1098597"
                     /translation="MSDQIKFIVDSLNKEPFKKNYNLITFDSLGPMQLLQVLNDVLAE
                     IDPKQDVDIREEMPEQTAKRMLNLLGILKYKPPGNATDMSTFRQGLVIGSKPVIYPVL
                     HWLLQRSNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKECEQ
                     LKTSGFSTAEIRRDISAMEEEKDQLMKRVERLKKRVETVQNHQRMLKIARQLRVEKER
                     EEFLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRHAAADAKPESLMKRLEEEIKFNSYM
                     VTEKFPKELESKKKELHFLQKVVSEPAMGHSDLLELETKVNEVNTEINQLIEKKMMRN
                     EPIEGKLSLYRQQASIISRKKEAKAEELQETKEKLASLEREVLVKTNQTREFDGTEVL
                     KGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRQETIQHQLRTIE
                     EKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPVI
                     KELRQLRQKCQELTQECDEKKAQYDSCAAGLESNRSKLEQEVRGLREECLQEESKYHY
                     TNCMIKNLEVELRRATDEMKAYVSSDQQEKRKAIREQYTKNITEQENLGKKLREKQKA
                     VRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSPASIGQVIQEGGEDRLVL"
     exon            517..620
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..801
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..891
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..957
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1068
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1153
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1317
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1413
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1560
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1710
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1839
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1929
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2016
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2088
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2174
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2220
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..3220
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgacgtcac cgcatggcaa ccgttgccaa ggagcggtct ctaagaaccc gcaagcgccc
       61 cagtgcctcc cgagggtggg gaggtggttt cgtgaggagg atttgaggta acccccgcca
      121 actcgcggtc gggaactccg cgaacccccg aatcccgtca agctgcgccc gctcccggcc
      181 ggtggcggca gcagggcctg tcggggggcg gggggtcggc cgcgcgggtc cccctcggtc
      241 tccgggcgtc gcaggaggcc gtaggcctgc gcgcgctgcc ccggctgggc cggataccac
      301 gcgcgtcctg gttttaattc ttgccccggc tccccctggg tgctgcagtg gttttaagct
      361 ataacattaa tcatgagtga ccaaatcaaa ttcatcgtgg acagcctcaa taaggagcct
      421 tttaagaaga attataactt aatcacattt gattctttgg gaccaatgca actattgcaa
      481 gttctcaatg atgtcctggc tgagattgac cccaagcaag atgttgatat cagagaggag
      541 atgccagagc agacagccaa acgaatgttg aatcttcttg gtatccttaa gtacaaacct
      601 ccgggaaatg ccacagacat gagcaccttc cgtcagggct tggtgattgg aagtaaacct
      661 gtgatttacc cagtgctcca ctggcttctt cagcggagta atgaactaaa gaaaagggca
      721 tatttagctc gtttcttaat aaaactggag gtgccaagtg agtttcttca agatgagacc
      781 gtggctgaca ccaataaaca gtatgaagag ctgatggaag cctttaaaac tctgcataaa
      841 gagtgtgagc agctcaaaac atctggattc tctacagcag aaatcagaag ggatatcagc
      901 gcaatggagg aggaaaaaga ccagctcatg aagagagttg aacggctgaa gaagagggtg
      961 gagaccgttc agaaccatca gcgaatgctt aaaatagcaa gacagcttcg agttgagaaa
     1021 gagagagaag aatttcttgc acaacagaaa caggaacaaa agaatcagct gtttcatgcg
     1081 gtgcagagat tgcagagagt gcaaaatcag ctgaagagca tgcggcacgc agcagcggat
     1141 gcaaagcctg agagtttaat gaagaggcta gaggaggaga taaaatttaa ctcatacatg
     1201 gtcactgaaa aatttccaaa agaattagaa agcaagaaaa aggaattaca ttttttacag
     1261 aaggtggttt ctgagccagc tatgggccac tctgaccttc tcgaacttga gactaaagtc
     1321 aatgaagtaa acacggagat caatcagttg attgaaaaga aaatgatgag aaacgagcca
     1381 attgaaggca agctctcact gtacaggcaa caggcatcca tcatttctcg taagaaagaa
     1441 gccaaagctg aggagctgca ggagaccaag gagaagctgg ccagccttga gagagaggtg
     1501 ttggtgaaaa caaaccagac ccgggagttc gacggcactg aggttctgaa gggagatgag
     1561 ttcaagcgat acgtcagtaa acttcgaagc aaaagcacag ttttcaaaaa gaagcatcag
     1621 ataatagctg aatttaaggc tgagtttggc ctcctgcaga ggacagaaga acttctgaag
     1681 cagcgtcagg aaaccattca gcatcaactg cgaactattg aagaaaagaa gggtatatct
     1741 ggatacagtt acacccaaga ggagcttgag agagtgtcgg ccctgaagag tgaggttgac
     1801 gagatgaaag gccggaccct ggatgacatg tcagagatgg tgaaaaaact gaattccttg
     1861 gtatcagaaa agaagtcagc tttagcccca gttataaaag aactacggca gttgcgtcag
     1921 aaatgtcaag aactaaccca ggagtgtgat gagaagaaag cccagtatga tagctgtgca
     1981 gcaggccttg aaagcaaccg gtccaaatta gagcaggaag tgcgaggact tcgtgaggaa
     2041 tgtcttcaag aagaaagtaa ataccactat acaaactgca tgattaagaa cctagaagtt
     2101 gagcttcgtc gagcgactga tgagatgaag gcgtacgtct cttctgatca gcaagagaag
     2161 aggaaagcaa ttagggaaca gtataccaaa aatattactg agcaagaaaa ccttggtaag
     2221 aaactccggg aaaaacaaaa agctgtacga gaaagtcatg gtccaaacat gaagcaagca
     2281 aaaatgtggc gtgatcttga acaactgatg gaatgcaaaa aacagtgctt tctaaagcag
     2341 caaagcccag cttccatcgg ccaggtaatt caagagggcg gagaggaccg gctggttctc
     2401 tgagccctgt gtcggccggg cttaagtcgc atctgcgtaa cgtgatttct tctcggaagt
     2461 gacttattca tcctttgctt tcagactagc cgtcccttct cagttgtctt ggaaatgaag
     2521 tgaaggcaga tgaggtttta aaggtctttt taactgcagg agaggctttc gttgtttgtt
     2581 tagcttagcc gtctagtggt gtctcctgag ttttatggga aagggctaag tttgctctct
     2641 gtaatgtaag catgtgtcca ttaagaacca cgtagcttct caagctgtga ggactgacgg
     2701 gtaatgctct tctcagtctg tctctgactt ggaggactct tttaggaact aggagttcgt
     2761 ttgaagaagc ttttgtctga agtcagcagt cgctacagtt tcacttcagt ttctttctct
     2821 tctataaaat acaaaccagt taatgttgtg aaaagcaatt gtgatgtgat gtgattgcaa
     2881 agtaaataaa gcctgcggtg gcctgccgta gctgttgatc ttaaagaaca tagttgtgtc
     2941 aagattgttt taaagtattt tataacattc atgtctcatc tcaggattct cactcatttt
     3001 catcaaatgt ggacttcata atacaatact tgcattgtcc tgaggactgt tattataaat
     3061 ataaaaattg tcataaaata tacatgcaac ataggctgga aagctaacac aggattccta
     3121 gtgaaattaa gactctcatg tgctcccagc ctctgttcca tgtggactac atacttacag
     3181 atttctttgg ttttcattaa agaaagatat taaacttgta
//
