LOCUS       NP_001345846             676 aa            linear   ROD 02-MAY-2024
DEFINITION  intraflagellar transport protein 81 homolog isoform a [Mus
            musculus].
ACCESSION   NP_001345846 XP_006530190
VERSION     NP_001345846.1
DBSOURCE    REFSEQ: accession NM_001358917.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 676)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 676)
  AUTHORS   Zhang,K., Da Silva,F., Seidl,C., Wilsch-Brauninger,M., Herbst,J.,
            Huttner,W.B. and Niehrs,C.
  TITLE     Primary cilia are WNT-transducing organelles whose biogenesis is
            controlled by a WNT-PP1 axis
  JOURNAL   Dev Cell 58 (2), 139-154 (2023)
   PUBMED   36693320
REFERENCE   3  (residues 1 to 676)
  AUTHORS   Duan,S., Li,H., Zhang,Y., Yang,S., Chen,Y., Qiu,B., Huang,C.,
            Wang,J., Li,J., Zhu,X. and Yan,X.
  TITLE     Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune
            ciliary signaling
  JOURNAL   EMBO J 40 (2), e105499 (2021)
   PUBMED   33241915
REFERENCE   4  (residues 1 to 676)
  AUTHORS   Qu,W., Yuan,S., Quan,C., Huang,Q., Zhou,Q., Yap,Y., Shi,L.,
            Zhang,D., Guest,T., Li,W., Yee,S.P., Zhang,L., Cazin,C., Hess,R.A.,
            Ray,P.F., Kherraf,Z.E. and Zhang,Z.
  TITLE     The essential role of intraflagellar transport protein IFT81 in
            male mice spermiogenesis and fertility
  JOURNAL   Am J Physiol Cell Physiol 318 (6), C1092-C1106 (2020)
   PUBMED   32233951
  REMARK    GeneRIF: IFT81 plays an essential role during spermatogenesis by
            modulating the assembly and elongation of the sperm flagella.
REFERENCE   5  (residues 1 to 676)
  AUTHORS   Agbu,S.O., Liang,Y., Liu,A. and Anderson,K.V.
  TITLE     The small GTPase RSG1 controls a final step in primary cilia
            initiation
  JOURNAL   J Cell Biol 217 (1), 413-427 (2018)
   PUBMED   29038301
REFERENCE   6  (residues 1 to 676)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 676)
  AUTHORS   Peng,J., Yu,L., Horiuchi,M., Zhang,P., Huang,X., Zhang,Y., Li,D.,
            Jalil,M.A. and Zhao,S.
  TITLE     Identification of human CDV-1R and mouse Cdv-1R, two novel proteins
            with putative signal peptides, especially highly expressed in
            testis and increased with the male sex maturation
  JOURNAL   Mol Biol Rep 29 (4), 353-362 (2002)
   PUBMED   12549821
  REMARK    GeneRIF: inconsistent expression levels of human CDV-1 and mouse
            Cdv-1 in heart implied that cardiac hypertrophy in human SCD might
            not be associated with the abnormal expression of CDV-1.
REFERENCE   8  (residues 1 to 676)
  AUTHORS   Higashi,M., Kobayashi,K., Iijima,M., Wakana,S., Horiuchi,M.,
            Yasuda,T., Yoshida,G., Kanmura,Y. and Saheki,T.
  TITLE     Genomic organization and mapping of mouse CDV (carnitine
            deficiency-associated gene expressed in ventricle)-1 and its
            related CDV-1R gene
  JOURNAL   Mamm Genome 11 (12), 1053-1057 (2000)
   PUBMED   11130971
REFERENCE   9  (residues 1 to 676)
  AUTHORS   Jalil,A., Horiuchi,M., Nomoto,M., Kobayashi,K. and Saheki,T.
  TITLE     Catecholamine metabolism inhibitors and receptor blockades only
            partially suppress cardiac hypertrophy of juvenile visceral
            steatosis mice with systemic carnitine deficiency
  JOURNAL   Life Sci 64 (13), 1137-1144 (1999)
   PUBMED   10210276
REFERENCE   10 (residues 1 to 676)
  AUTHORS   Masuda,M., Kobayashi,K., Horiuchi,M., Terazono,H., Yoshimura,N. and
            Saheki,T.
  TITLE     A novel gene suppressed in the ventricle of carnitine-deficient
            juvenile visceral steatosis mice
  JOURNAL   FEBS Lett 408 (2), 221-224 (1997)
   PUBMED   9187371
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114632.9 and AC113285.9.
            
            On Dec 13, 2017 this sequence version replaced XP_006530190.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777531.216124.1,
                                           ERR3363658.4600580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.44 cM"
     Protein         1..676
                     /product="intraflagellar transport protein 81 homolog
                     isoform a"
                     /note="intraflagellar transport protein 81 homolog;
                     carnitine deficiency-associated protein expressed in
                     ventricle 1; carnitine deficiency-associated gene
                     expressed in ventricle 1; intraflagellar transport 81
                     homolog"
                     /calculated_mol_wt=79154
     Region          2..121
                     /region_name="CH (calponin-homology)-like region.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O35594.4)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q8WYA0; propagated from
                     UniProtKB/Swiss-Prot (O35594.4)"
     Region          3..126
                     /region_name="IFT81_CH"
                     /note="Intraflagellar transport 81 calponin homology
                     domain; pfam18383"
                     /db_xref="CDD:465736"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q8WYA0; propagated from
                     UniProtKB/Swiss-Prot (O35594.4)"
     Region          <177..673
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          611..632
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35594.4)"
     CDS             1..676
                     /gene="Ift81"
                     /gene_synonym="Cdv-1; Cdv-1r; Cdv1"
                     /coded_by="NM_001358917.2:348..2378"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19650.1"
                     /db_xref="GeneID:12589"
                     /db_xref="MGI:MGI:1098597"
ORIGIN      
        1 msdqikfivd slnkepfkkn ynlitfdslg pmqllqvlnd vlaeidpkqd vdireempeq
       61 takrmlnllg ilkykppgna tdmstfrqgl vigskpviyp vlhwllqrsn elkkraylar
      121 fliklevpse flqdetvadt nkqyeelmea fktlhkeceq lktsgfstae irrdisamee
      181 ekdqlmkrve rlkkrvetvq nhqrmlkiar qlrvekeree flaqqkqeqk nqlfhavqrl
      241 qrvqnqlksm rhaaadakpe slmkrleeei kfnsymvtek fpkeleskkk elhflqkvvs
      301 epamghsdll eletkvnevn teinqliekk mmrnepiegk lslyrqqasi isrkkeakae
      361 elqetkekla slerevlvkt nqtrefdgte vlkgdefkry vsklrskstv fkkkhqiiae
      421 fkaefgllqr teellkqrqe tiqhqlrtie ekkgisgysy tqeelervsa lksevdemkg
      481 rtlddmsemv kklnslvsek ksalapvike lrqlrqkcqe ltqecdekka qydscaagle
      541 snrskleqev rglreeclqe eskyhytncm iknlevelrr atdemkayvs sdqqekrkai
      601 reqytknite qenlgkklre kqkavreshg pnmkqakmwr dleqlmeckk qcflkqqspa
      661 sigqviqegg edrlvl
//
