LOCUS       NM_026319               2157 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus intraflagellar transport 74 (Ift74), transcript
            variant 1, mRNA.
ACCESSION   NM_026319
VERSION     NM_026319.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2157)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2157)
  AUTHORS   Bakey,Z., Cabrera,O.A., Hoefele,J., Antony,D., Wu,K., Stuck,M.W.,
            Micha,D., Eguether,T., Smith,A.O., van der Wel,N.N., Wagner,M.,
            Strittmatter,L., Beales,P.L., Jonassen,J.A., Thiffault,I.,
            Cadieux-Dion,M., Boyes,L., Sharif,S., Tuysuz,B., Dunstheimer,D.,
            Niessen,H.W.M., Devine,W., Lo,C.W., Mitchison,H.M., Schmidts,M. and
            Pazour,G.J.
  TITLE     IFT74 variants cause skeletal ciliopathy and motile cilia defects
            in mice and humans
  JOURNAL   PLoS Genet 19 (6), e1010796 (2023)
   PUBMED   37315079
  REMARK    GeneRIF: IFT74 variants cause skeletal ciliopathy and motile cilia
            defects in mice and humans.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2157)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2157)
  AUTHORS   Duan,S., Li,H., Zhang,Y., Yang,S., Chen,Y., Qiu,B., Huang,C.,
            Wang,J., Li,J., Zhu,X. and Yan,X.
  TITLE     Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune
            ciliary signaling
  JOURNAL   EMBO J 40 (2), e105499 (2021)
   PUBMED   33241915
REFERENCE   5  (bases 1 to 2157)
  AUTHORS   Shi,L., Zhou,T., Huang,Q., Zhang,S., Li,W., Zhang,L., Hess,R.A.,
            Pazour,G.J. and Zhang,Z.
  TITLE     Intraflagellar transport protein 74 is essential for
            spermatogenesis and male fertility in micedagger
  JOURNAL   Biol Reprod 101 (1), 188-199 (2019)
   PUBMED   31004481
  REMARK    GeneRIF: Intraflagellar transport protein 74 is essential for
            spermatogenesis and male fertility in micedagger.
REFERENCE   6  (bases 1 to 2157)
  AUTHORS   Follit,J.A., Xu,F., Keady,B.T. and Pazour,G.J.
  TITLE     Characterization of mouse IFT complex B
  JOURNAL   Cell Motil Cytoskeleton 66 (8), 457-468 (2009)
   PUBMED   19253336
REFERENCE   7  (bases 1 to 2157)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Ift74 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   8  (bases 1 to 2157)
  AUTHORS   Fujino,R.S., Ishikawa,Y., Tanaka,K., Kanatsu-Shinohara,M.,
            Tamura,K., Kogo,H., Shinohara,T. and Hara,T.
  TITLE     Capillary morphogenesis gene (CMG)-1 is among the genes
            differentially expressed in mouse male germ line stem cells and
            embryonic stem cells
  JOURNAL   Mol Reprod Dev 73 (8), 955-966 (2006)
   PUBMED   16705683
  REMARK    GeneRIF: Results identify a cDNA encoding the mouse ortholog of
            capillary morphogenesis gene (CMG)-1, and suggest that CMG-1 may
            play a role in the transcriptional regulation of the cyclin D2
            gene.
REFERENCE   9  (bases 1 to 2157)
  AUTHORS   Lucker,B.F., Behal,R.H., Qin,H., Siron,L.C., Taggart,W.D.,
            Rosenbaum,J.L. and Cole,D.G.
  TITLE     Characterization of the intraflagellar transport complex B core:
            direct interaction of the IFT81 and IFT74/72 subunits
  JOURNAL   J Biol Chem 280 (30), 27688-27696 (2005)
   PUBMED   15955805
REFERENCE   10 (bases 1 to 2157)
  AUTHORS   Iomini,C., Tejada,K., Mo,W., Vaananen,H. and Piperno,G.
  TITLE     Primary cilia of human endothelial cells disassemble under laminar
            shear stress
  JOURNAL   J Cell Biol 164 (6), 811-817 (2004)
   PUBMED   15024030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY237866.1, AK053369.1, BY706530.1 and CD740935.1.
            
            On Mar 14, 2014 this sequence version replaced NM_026319.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BY237866.1         1-53
            54-1259             AK053369.1         2-1207
            1260-1591           BY706530.1         365-696
            1592-2157           CD740935.1         1-566               c
FEATURES             Location/Qualifiers
     source          1..2157
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 43.34 cM"
     gene            1..2157
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /note="intraflagellar transport 74"
                     /db_xref="GeneID:67694"
                     /db_xref="MGI:MGI:1914944"
     exon            1..161
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..296
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1979
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     capillary morphogenesis protein 1; intraflagellar
                     transport protein 74 homolog; coiled-coil
                     domain-containing protein 2; capillary morphogenesis gene
                     1 protein"
                     /codon_start=1
                     /product="intraflagellar transport protein 74 homolog
                     isoform 1"
                     /protein_id="NP_080595.2"
                     /db_xref="CCDS:CCDS51232.1"
                     /db_xref="GeneID:67694"
                     /db_xref="MGI:MGI:1914944"
                     /translation="MASNHKSSAPRPISRGGIGLTGRPPSGIRPPSGNVRVATAMPPT
                     TARPGSRGGPLGTGGVLSSQIKVADRPVTQQGLSGMKTGMKGPQRQILDKSYYLGLLR
                     SKISELTTEINKLQKEIEMYNQENSVYLSYEKRAETLAVEIKDFQGQLADYNMLVDKL
                     NTNTEMEEVMSDYNMLKAQNDRETQSMDVIFTERQAKEKQIRSVEEEVEQEKQAADGI
                     IKNMSPEKQVKYIEMKTTNEKLLQELDTLQQQLDSLNMKKESLETEIAHSQVKQEAVL
                     LYEKLYELESHRDQMIAEDKSMGSPMEERERLLKQVKEDNQEIASMERQLTDIKEKIN
                     QFSEEIRQLDMDLEEHQGEMNQKYKELKKREENMDAFIETFEETKNQELERKAQIEAS
                     IITLLEHCSRNINRMKQISSITNQELKMMQDDLSFKSTEMQKSQTTARNLTSDSQRLQ
                     LDLQKMELLESKMTEEQQSLKNKIKQMTADLETYSDLAALKSSAEEKKKKLHQERTVL
                     STHRNAFKKIMEKLTSDYDTLKRQLQDNETHAQLTNLERKWQHLEQNNFVMKEFIATK
                     SQESDYQPVIKNVMKQIAEYNKTIMDALHNASRS"
     exon            297..432
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..481
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..580
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..641
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..701
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..763
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..902
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..965
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1109
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1150
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1230
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1284
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1382
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1509
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1673
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1799
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1860
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2143
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2124..2129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /note="hexamer: AATAAA"
     polyA_site      2143
                     /gene="Ift74"
                     /gene_synonym="1700029H06Rik; b2b796Clo; Ccdc2; Cmg1"
                     /note="major polyA site"
ORIGIN      
        1 taggatacgc ggcgtcgctg cggggtgggg gggactctga ggcctggctc cctgtctctg
       61 ctctggtgag cggtgaaacg cggggttggc gctcgcgttg actcctcaga aagaagttca
      121 tgtcgcgggg acctagcggc accccagtcg caccaggcaa gtgtgtaaag tgaacaatgg
      181 ccagtaatca caaatcttca gcccctcgcc ctatttctcg gggtggaata ggactaacag
      241 gaaggcctcc ttctggaata agacctccat ctggcaatgt tcgagtggca actgcaatgc
      301 caccaacaac agcaagacca ggttctcgtg gtggtccctt agggactggt ggagttttgt
      361 catctcaaat caaagttgct gatcgtcctg tgacccaaca aggtttgagt ggaatgaaga
      421 ctggcatgaa aggtccccag aggcaaattt tagacaaatc ttactatctt ggacttctta
      481 ggagcaaaat aagtgaactt acaactgaaa ttaataagct tcagaaagaa atagaaatgt
      541 acaaccaaga aaattcagtg tatttgtcat atgaaaagag ggcagagaca ttagctgttg
      601 aaattaaaga ctttcaagga caactagcag actacaacat gttggtagat aaacttaata
      661 ccaatactga aatggaagaa gtaatgagtg attacaacat gcttaaagct caaaatgaca
      721 gagaaacaca aagtatggat gtcatattta ctgaaagaca agcgaaggaa aaacaaatca
      781 gaagtgtaga agaagaagtt gaacaagaaa agcaagcagc agatggcatt atcaaaaata
      841 tgtctcctga aaaacaagtc aagtacatag aaatgaaaac cacaaatgag aaactgttgc
      901 aggaattaga tacacttcag caacagctag attctctgaa catgaaaaag gagagcctag
      961 aaactgaaat agcacactcc caagtaaaac aagaggctgt attgctgtat gaaaaacttt
     1021 atgagttaga gtcccatcga gatcaaatga ttgcagaaga caaaagcatg ggatcgccaa
     1081 tggaggaaag ggagagattg cttaagcagg ttaaagaaga taatcaggaa atagccagca
     1141 tggagagaca gttaacagat ataaaagaaa aaataaacca atttagtgaa gaaattagac
     1201 aacttgacat ggatttagag gagcaccaag gtgaaatgaa tcaaaaatac aaggagctta
     1261 aaaaaaggga ggaaaatatg gatgctttta tagagacttt tgaggaaacg aagaatcagg
     1321 aactagagcg gaaggcacag atagaagcca gcatcatcac actgttagag cattgcagtc
     1381 ggaatataaa tcgtatgaag cagatatcct ccatcaccaa ccaagagctg aagatgatgc
     1441 aggatgacct cagctttaaa tcaactgaga tgcagaagtc acagacaaca gctaggaatt
     1501 tgacctcaga cagtcagcgt ctgcagctgg atctacagaa aatggaactt ctggaaagta
     1561 agatgacaga agagcaacag tctctgaaaa acaaaattaa gcaaatgact gctgacctgg
     1621 agacatacag tgacctggca gctttaaaat catcagctga agaaaagaag aagaaattgc
     1681 atcaagaaag aacagtattg tcaactcaca gaaatgcctt taagaaaata atggagaagc
     1741 tgacctcaga ttatgatacc cttaaaaggc aacttcaaga caatgagaca catgctcagc
     1801 ttacaaattt ggagaggaag tggcagcacc tggagcaaaa taacttcgta atgaaagagt
     1861 tcatagcaac caagagtcaa gagagtgatt accagccggt gattaaaaat gtgatgaagc
     1921 agattgcaga gtataataaa accatcatgg atgctctaca taatgccagc agaagctgaa
     1981 actgagccga ctgagtctac aagcatcctc aaggatgcta aaagtaaact agcttcccct
     2041 tgaagagtta gaccccagct tcttgaatgc cctggctttg tgatctcccc gaaggagaga
     2101 tagcttgtat agttaaataa gtcaataaaa tgtttgcata gaaaaaaaaa aaaaaaa
//
