LOCUS       NM_028680               2540 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus intraflagellar transport 57 (Ift57), mRNA.
ACCESSION   NM_028680
VERSION     NM_028680.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2540)
  AUTHORS   Katoh,Y., Terada,M., Nishijima,Y., Takei,R., Nozaki,S., Hamada,H.
            and Nakayama,K.
  TITLE     Overall Architecture of the Intraflagellar Transport (IFT)-B
            Complex Containing Cluap1/IFT38 as an Essential Component of the
            IFT-B Peripheral Subcomplex
  JOURNAL   J Biol Chem 291 (21), 10962-10975 (2016)
   PUBMED   26980730
REFERENCE   2  (bases 1 to 2540)
  AUTHORS   Liew,G.M., Ye,F., Nager,A.R., Murphy,J.P., Lee,J.S., Aguiar,M.,
            Breslow,D.K., Gygi,S.P. and Nachury,M.V.
  TITLE     The intraflagellar transport protein IFT27 promotes BBSome exit
            from cilia through the GTPase ARL6/BBS3
  JOURNAL   Dev Cell 31 (3), 265-278 (2014)
   PUBMED   25443296
REFERENCE   3  (bases 1 to 2540)
  AUTHORS   Ishikawa,H., Ide,T., Yagi,T., Jiang,X., Hirono,M., Sasaki,H.,
            Yanagisawa,H., Wemmer,K.A., Stainier,D.Y., Qin,H., Kamiya,R. and
            Marshall,W.F.
  TITLE     TTC26/DYF13 is an intraflagellar transport protein required for
            transport of motility-related proteins into flagella
  JOURNAL   Elife 3, e01566 (2014)
   PUBMED   24596149
  REMARK    Erratum:[Elife. 2014 Apr 01;3:e02897. doi: 10.7554/eLife.02897..
            PMID: 24692455]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2540)
  AUTHORS   Wang,C., Low,W.C., Liu,A. and Wang,B.
  TITLE     Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting
            cytoplasmic retention of transcription factor GLI3 and affecting
            ciliogenesis
  JOURNAL   J Biol Chem 288 (41), 29518-29529 (2013)
   PUBMED   23955340
REFERENCE   5  (bases 1 to 2540)
  AUTHORS   Howard,P.W., Jue,S.F. and Maurer,R.A.
  TITLE     Interaction of mouse TTC30/DYF-1 with multiple intraflagellar
            transport complex B proteins and KIF17
  JOURNAL   Exp Cell Res 319 (14), 2275-2281 (2013)
   PUBMED   23810713
REFERENCE   6  (bases 1 to 2540)
  AUTHORS   Tsujikawa,M. and Malicki,J.
  TITLE     Intraflagellar transport genes are essential for differentiation
            and survival of vertebrate sensory neurons
  JOURNAL   Neuron 42 (5), 703-716 (2004)
   PUBMED   15182712
REFERENCE   7  (bases 1 to 2540)
  AUTHORS   Baker,S.A., Freeman,K., Luby-Phelps,K., Pazour,G.J. and
            Besharse,J.C.
  TITLE     IFT20 links kinesin II with a mammalian intraflagellar transport
            complex that is conserved in motile flagella and sensory cilia
  JOURNAL   J Biol Chem 278 (36), 34211-34218 (2003)
   PUBMED   12821668
REFERENCE   8  (bases 1 to 2540)
  AUTHORS   Ferrier,V.
  TITLE     Hip, hip, hippi!
  JOURNAL   Nat Cell Biol 4 (2), E30 (2002)
   PUBMED   11835052
  REMARK    GeneRIF: Hip-1 and Hippi cooperate to induce neuronal apoptosis in
            a caspase-8-dependent manner.
REFERENCE   9  (bases 1 to 2540)
  AUTHORS   Gervais,F.G., Singaraja,R., Xanthoudakis,S., Gutekunst,C.A.,
            Leavitt,B.R., Metzler,M., Hackam,A.S., Tam,J., Vaillancourt,J.P.,
            Houtzager,V., Rasper,D.M., Roy,S., Hayden,M.R. and Nicholson,D.W.
  TITLE     Recruitment and activation of caspase-8 by the
            Huntingtin-interacting protein Hip-1 and a novel partner Hippi
  JOURNAL   Nat Cell Biol 4 (2), 95-105 (2002)
   PUBMED   11788820
  REMARK    GeneRIF: Results show that pro-apoptotic Hippi-Hip-1 heterodimers
            can recruit procaspase-8 into a complex of Hippi, Hip-1 and
            procaspase-8, and launch apoptosis through components of the
            'extrinsic' cell-death pathway.
REFERENCE   10 (bases 1 to 2540)
  AUTHORS   Huttenhofer,A., Kiefmann,M., Meier-Ewert,S., O'Brien,J.,
            Lehrach,H., Bachellerie,J.P. and Brosius,J.
  TITLE     RNomics: an experimental approach that identifies 201 candidates
            for novel, small, non-messenger RNAs in mouse
  JOURNAL   EMBO J 20 (11), 2943-2953 (2001)
   PUBMED   11387227
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK047217.1.
            
            On Apr 6, 2007 this sequence version replaced NM_028680.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047217.1, BC138143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2540              AK047217.1         1-2540
FEATURES             Location/Qualifiers
     source          1..2540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 31.08 cM"
     gene            1..2540
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /note="intraflagellar transport 57"
                     /db_xref="GeneID:73916"
                     /db_xref="MGI:MGI:1921166"
     exon            1..256
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1334
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /note="Vestrogen-related receptor beta like 1;
                     estrogen-related receptor beta like 1;
                     huntingtin-interacting protein-1 protein interactor;
                     HIP1-interacting protein; intraflagellar transport 57
                     homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 57 homolog"
                     /protein_id="NP_082956.2"
                     /db_xref="CCDS:CCDS28211.1"
                     /db_xref="GeneID:73916"
                     /db_xref="MGI:MGI:1921166"
                     /translation="MAAAAAVIPPSGLDDGVSRARGEGAGEAVVERGPGAAYHMFVVM
                     EDLVEKLKLLRYEEELLRKSNLKPPSRHYFALPTNPGEQFYMFCTLAAWLINKTGRAF
                     EQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEQVCYVLDCLAEEALKYIG
                     FTWKRPSYPVEELEEETVPEDDAELTLSKVDEEFVEEETDNEENFIDLNVLKAQTYRL
                     DTNESAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHKSGIE
                     SALKETKGFLDKLHNEISRTLEKIGSREKYINNQLEHLVQEYRGAQAQLSEARERYQQ
                     GNGGVTERTRLLSEVTEELEKVKQEMEEKGSSMTDGTPLVKIKQSLTKLKQETVQMDI
                     RIGVVEHTLLQSKLKEKCNMTRDMHAAVTPESAIGFY"
     exon            257..419
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..538
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..629
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..698
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..821
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..893
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1025
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1088
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1155
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..2540
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1513..1518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /note="hexamer: AATAAA"
     polyA_site      1531
                     /gene="Ift57"
                     /gene_synonym="4833420A15Rik; Esrrbl1; Hippi; MHS4R2"
                     /note="major polyA site"
ORIGIN      
        1 gatcctggcc ggagcccagc cgggcgctgg gggtctgagc agggatggcc gccgcggccg
       61 cggtgatccc gccgtcgggc ttggacgatg gggtgtctcg ggctcgcggg gaaggcgcag
      121 gggaggctgt ggtggagcgc gggccaggag cggcctacca catgttcgtg gtgatggaag
      181 acttagtgga gaagctgaag ctgctccgct acgaggagga gctactccga aagagcaatc
      241 tgaagccccc gtccagacac tactttgctc tgcctaccaa cccaggcgag cagttctaca
      301 tgttttgcac tcttgctgcg tggctgatca acaaaactgg ccgtgccttt gagcagcctc
      361 aagaatacga cgatcccaat gcaactatat ctaatatact ctctgagctt cgctcttttg
      421 ggagaactgc agattttcct ccttcaaaat taaagtctgg ttacggagaa caagtgtgct
      481 atgttcttga ttgcttagct gaagaagctt taaaatatat tggtttcact tggaaaaggc
      541 catcataccc agtggaagaa ctagaagaag aaactgttcc agaagatgat gccgagttaa
      601 cattaagtaa agtggatgaa gaatttgtgg aagaggagac agataatgaa gaaaacttta
      661 ttgatctcaa cgttttaaag gcccagacct atcgcttgga cacaaacgag tctgccaaac
      721 aagaagatat tttggaatct acgacagatg ctgcggaatg gagcctagaa gttgagcgtg
      781 tactaccgca gctgaaagtc acgattagga ctgacaataa ggattggagg atccatgttg
      841 accaaatgca ccagcacaaa agtgggattg aatctgctct gaaggagacc aaggggtttt
      901 tggacaagct ccataatgaa attagcagga ctctggaaaa gattggcagc cgagaaaagt
      961 acattaacaa tcaacttgag cacttggttc aagaatatcg tggggcccaa gcccagctaa
     1021 gtgaggcaag ggagcgctac cagcagggca atggcggagt aactgaacgg accagactcc
     1081 tctctgaggt tacagaagaa ttagaaaagg taaagcaaga aatggaagag aagggcagca
     1141 gcatgacgga cggcactcct ttggtgaaga ttaagcagag cttaaccaag ctgaagcaag
     1201 aaactgttca gatggacatt agaatcggtg tggtggagca cacgctactt cagtcaaaac
     1261 tcaaggagaa gtgcaacatg accagggaca tgcatgcagc tgtcacccca gagtcagcaa
     1321 ttggcttcta ttaaacacgt gggcttccat gcttctgatt atttcgtttt tatatcaaat
     1381 gattttttaa tgttgcattg atttccaaac acaatttata cttcttcaag catattcagt
     1441 gggtattttt gcacatgtgt taatatcatg gtgattatga tggccaaagc ctgtacaatg
     1501 aatatagtat ttaataaagt acttaaaatt atcatgttca gagaagtgtt cactggcatt
     1561 accaatggca tactgctgcc tggtggctca ttagtatttt ttgtctaagt gacacatgga
     1621 tcatgtgtat cctgtgaccc tctggactac tgacagagga ctggtacctc tgaggatgcc
     1681 cagagctggt accattctac agtgaccact agtacttaca tattagagaa gctaagaata
     1741 ggagttagag ttcttcgtag gaagccaaac tttcttgcct catctctaga gttgatatta
     1801 ccacctcctt aactgtaaaa acaagaaagt tcagtatcca cgttaacagg tgaaatctag
     1861 tatttgaaat agtagctctg ccatatttgg ctcagctact gtaacgaggg aaacgatgcc
     1921 tatgcctgtg tctgcaacct atgcattcac atggagtcag ctctgcaaac atggttctgt
     1981 agaagccacc atgatgaatc ccatggtcac cctctggtag tgacagtcct ttattaggca
     2041 ccctactcag caatttttct agactatgat ttctaagtca gccacataag cattattgaa
     2101 gagtagcttt tctgggctgg gggtctgggt cagttagcac agttcttgtc tgacaggcag
     2161 gctctggatt tgatcctcag cactatagaa acaagttggt gatgcacacc tatgatgtag
     2221 ctctccaggt gaagcagggg actgaagttc aaactcatgg accggcaaga tgactcagtg
     2281 ggtaaaggct cttgctacta agtctaataa ctggggtttt atccccagct ccagtggttt
     2341 gtacacatgt gtacacctag acacaagtgt gcacacatag acacacacac acaataggta
     2401 ggtagataga cagagagaca gacagatacc cttcattagt ttgaagaagt aaaaatcact
     2461 tcatagtaaa ttttgactta aaaatgctta cgtttatttt tatgtttagg aaaaacatat
     2521 taaaatataa ttttaaatcc
//
