LOCUS       NM_153600               4162 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus intraflagellar transport 56 (Ift56), mRNA.
ACCESSION   NM_153600
VERSION     NM_153600.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4162)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4162)
  AUTHORS   Bernhardt,N., Memic,F., Velica,A., Tran,M.A., Vieillard,J.,
            Sayyab,S., Chersa,T., Andersson,L., Whelan,P.J., Boije,H. and
            Kullander,K.
  TITLE     Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally
            Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26
  JOURNAL   eNeuro 9 (2) (2022)
   PUBMED   35210288
  REMARK    GeneRIF: Hop Mice Display Synchronous Hindlimb Locomotion and a
            Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in
            Ttc26.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4162)
  AUTHORS   Xin,D., Christopher,K.J., Zeng,L., Kong,Y. and Weatherbee,S.D.
  TITLE     IFT56 regulates vertebrate developmental patterning by maintaining
            IFTB complex integrity and ciliary microtubule architecture
  JOURNAL   Development 144 (8), 1544-1553 (2017)
   PUBMED   28264835
  REMARK    GeneRIF: These studies define a distinct and novel role for IFT56
            in IFTB complex integrity that is crucial for cilia structure and
            function and, ultimately, animal development.
REFERENCE   4  (bases 1 to 4162)
  AUTHORS   Katoh,Y., Terada,M., Nishijima,Y., Takei,R., Nozaki,S., Hamada,H.
            and Nakayama,K.
  TITLE     Overall Architecture of the Intraflagellar Transport (IFT)-B
            Complex Containing Cluap1/IFT38 as an Essential Component of the
            IFT-B Peripheral Subcomplex
  JOURNAL   J Biol Chem 291 (21), 10962-10975 (2016)
   PUBMED   26980730
REFERENCE   5  (bases 1 to 4162)
  AUTHORS   Swiderski,R.E., Nakano,Y., Mullins,R.F., Seo,S. and Banfi,B.
  TITLE     A mutation in the mouse ttc26 gene leads to impaired hedgehog
            signaling
  JOURNAL   PLoS Genet 10 (10), e1004689 (2014)
   PUBMED   25340710
  REMARK    GeneRIF: Our analysis of the hop mouse line provides novel insights
            into Hh signaling, demonstrating that Ttc26 is necessary for
            efficient coupling between the accumulation of Gli at the ciliary
            tip and its dissociation from Sufu.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4162)
  AUTHORS   Schumacher,J.M., Artzt,K. and Braun,R.E.
  TITLE     Spermatid perinuclear ribonucleic acid-binding protein binds
            microtubules in vitro and associates with abnormal manchettes in
            vivo in mice
  JOURNAL   Biol Reprod 59 (1), 69-76 (1998)
   PUBMED   9674995
REFERENCE   7  (bases 1 to 4162)
  AUTHORS   Bryan,J.H.
  TITLE     Spermatogenesis revisited. V. Spermiogenesis in mice homozygous for
            two different male-sterile mutations (ps and hpy)
  JOURNAL   Cell Tissue Res 221 (1), 169-180 (1981)
   PUBMED   7317942
REFERENCE   8  (bases 1 to 4162)
  AUTHORS   Bryan,J.H., Hughes,R.L. and Bates,T.J.
  TITLE     Brain development in hydrocephalic-polydactyl, a recessive
            pleiotropic mutant in the mouse
  JOURNAL   Virchows Arch A Pathol Anat Histol 374 (3), 205-214 (1977)
   PUBMED   142347
REFERENCE   9  (bases 1 to 4162)
  AUTHORS   Bryan,J.H.
  TITLE     Spermatogenesis revisited. IV. Abnormal spermiogenesis in mice
            homozygous for another male-sterility-inducing mutation, hpy
            (hydrocephalic-polydactyl)
  JOURNAL   Cell Tissue Res 180 (2), 187-201 (1977)
   PUBMED   872193
REFERENCE   10 (bases 1 to 4162)
  AUTHORS   Johnson,D.R. and Hunt,D.M.
  TITLE     Hop-sterile, a mutant gene affecting sperm tail development in the
            mouse
  JOURNAL   J Embryol Exp Morphol 25 (2), 223-236 (1971)
   PUBMED   5088020
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC066060.1.
            
            On Feb 22, 2004 this sequence version replaced NM_153600.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066060.1, AK035185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.76 cM"
     gene            1..4162
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /note="intraflagellar transport 56"
                     /db_xref="GeneID:264134"
                     /db_xref="MGI:MGI:2444853"
     exon            1..70
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1732
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /note="tetratricopeptide repeat protein 26; TPR repeat
                     protein 26; protein hop-sterile; hydrocephalic-polydactyl;
                     tetratricopeptide repeat domain 26"
                     /codon_start=1
                     /product="intraflagellar transport protein 56"
                     /protein_id="NP_705828.2"
                     /db_xref="CCDS:CCDS51750.1"
                     /db_xref="GeneID:264134"
                     /db_xref="MGI:MGI:2444853"
                     /translation="MMLSRAKPAVGGESPHTDKRKKKGRKIPKLEDLLSQRDFTGAIT
                     LLEFKRHVGEQEDDTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYF
                     FLGMYKQAEAAGFKAPKSRLQNRLLFHLAHKFNDEKKLMNFHQNLQDIKEDQLSLASI
                     HYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDS
                     TIALNLKACNHFRLYNGKAAEAELKSLMDNASSPFEFAKELIRHNLVVFRGGEGALQV
                     LPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMG
                     SRDHMKIAQQFFQLVGGSASECDTIPGRQCMASCFFLLKQFDDVLIYLNSFKSYFYND
                     DIFNFNYAQAKAATGNTSEGEEVFLLIQSEKLKNDYIYLSWLARCYIMNKKPRLAWEL
                     YLKMETSGESFSLLQLIANDCYKMGQFYYSAKAFDVLERLDPNPEYWEGKRGACVGIF
                     QMILAGREPKETLREVLHLLRSTGNTQVEYIIRIMKKWAKENRVPI"
     exon            71..208
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            209..301
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            302..416
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            417..466
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            467..612
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            613..784
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            785..859
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            860..962
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1018
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1072
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1136
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1225
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1309
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1379
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1486
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1620
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..4140
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4113..4118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /note="hexamer: ATTAAA"
     polyA_site      4135
                     /gene="Ift56"
                     /gene_synonym="9330141E21Rik; 9430097H08Rik; hop; hpy;
                     Ttc26"
                     /note="major polyA site"
ORIGIN      
        1 tggcaactcg ccgaagcaca gcctttgcag actatctgca gcgggggctc acaggaccga
       61 cgccaagatg atgctttcaa gggccaaacc cgctgtgggc ggggagtcac cgcacactga
      121 caaaagaaag aagaaaggga ggaagattcc aaaactagag gatctacttt cgcagagaga
      181 tttcactggc gccattaccc tattggagtt caagcgccac gttggggagc aagaagacga
      241 cactaactta tggattggat actgtgcttt tcacctgggt gactacaaga gagctttgga
      301 ggaatatgaa aatgcaacga aggaggaaaa ttgcaatcca gaagtgtggg tgaacttggc
      361 ctgcacctac ttttttcttg ggatgtataa acaagcagaa gctgctgggt ttaaagctcc
      421 aaaaagccgg ctccaaaacc gcctactgtt ccatctggct cacaagttta atgatgagaa
      481 gaaattaatg aactttcatc agaatcttca ggatatcaag gaagaccagc ttagtttggc
      541 ctcaatccac tacatgcgat cccattacca agaagctatt gatatataca agcggatcct
      601 gctggacaac agggaatacc tggccctcaa tgtgtatgtg gccctctgct actacaaact
      661 ggattactat gatgtgtctc aagaagtcct ggctgtttac cttcagcaga ttcctgacag
      721 taccatcgcc ctcaacctta aggcctgcaa tcactttcgc ctttataacg gcaaagcagc
      781 tgaggcagag ctcaaaagct tgatggacaa tgcatcttca ccctttgaat ttgctaaaga
      841 actcatcagg cacaatctgg ttgttttccg aggaggcgaa ggggctttgc aggttttacc
      901 tcccctggtt gatgtcattc ctgaagctag gctcaaccta gtgatttact accttcgtca
      961 agatgatgtg caggaagcct ataatttaat caaggatttg gaacccacta cacctcagga
     1021 gtatatcctc aagggagttg tcaatgcagc ccttggccag gaaatgggtt caagggatca
     1081 tatgaaaatt gcccagcagt ttttccagtt ggtaggagga tcagctagtg aatgtgatac
     1141 aataccagga aggcagtgca tggcttcctg tttcttccta cttaaacaat ttgatgatgt
     1201 cttgatttac ctcaactctt ttaagagtta cttctataat gatgacatct ttaactttaa
     1261 ttatgcccaa gccaaagctg caacaggcaa taccagtgag ggtgaagagg ttttcctctt
     1321 gatccaaagt gagaaactga aaaatgacta catttacctt agctggttag ctcgctgcta
     1381 tattatgaat aagaaaccaa gactagcttg ggagctttat ctcaagatgg aaacctctgg
     1441 cgagtccttc agcctcttac agctcattgc caatgactgt tacaagatgg gccagttcta
     1501 ctattcagcc aaagcttttg atgtcttaga aagactggat cccaaccctg agtactggga
     1561 aggcaagagg ggtgcctgtg tgggcatctt ccagatgatc ttagctggga gagaacccaa
     1621 agagaccctc cgagaagtgc tgcatttact gagaagcaca ggaaacaccc aagtggagta
     1681 tatcatcagg atcatgaaga agtgggccaa ggagaataga gtgcccatct aagcagccaa
     1741 accctaggcc aggaccagct tcctctcacg tcaaattgga actgttttct tgcacttgaa
     1801 tatgcaatcc aggaccctgc ttgattgaca tttctttcct tgctcttaga gcattaggat
     1861 gagtgggtgg tatgtgtgga cttaggcatc aggcaacagg aatctccctg gcctgctgac
     1921 acccaatgta atctactggt gcctttcttc cataatcatt ctgaacacta ttctgtaatt
     1981 tactggcttt aggaatagat actagttttg tttttctttc tctgttagca tttcaggaca
     2041 tatctttttt cttcttcttt tttttttttt tctgagacag ggtttctctg tataagccct
     2101 gcctgtcctg gaactcactt tgtagaccag gctggcctcg aactcagaaa tccacctgcc
     2161 tctgcctcct gagtgctggg attaaaggcg tgtgccacca tgcccggcag gacattttct
     2221 cctacctgca gtaacaagta cctttatact agagaattgc catcatttga tcatattcca
     2281 tcattttgta cattagccca tccatgacta catctctgac tcctgggaga cgtctttctg
     2341 agctgtgtga ttctgaggat ggccatgagg ccctctacca aacagcagtc agtagtagtt
     2401 agttagctta tgagaccact ctctgtgagt agcttgttac gttgagacaa gctgagtata
     2461 tggttttaaa aaggtgagtg aaaggaaaaa cttggcatct ctgaaggtgt gtaagtctca
     2521 gagttaggtc tcccttgtat tttaggaaac aaagccaggg cagggttctt actatcttct
     2581 gaatgaacag caattttgaa cataggactg ggaaagtttt catgaaatat atatatatgt
     2641 atattttttc tgagacaggg tttctctgtg tagccttggc tgtcatggaa ctcactctgt
     2701 agactaggct ggccttgaac tcggagatcc gcctgcctct gcctcccgag tgctcgtatc
     2761 aaagatgtgt gcaccactgc tcagcatacg tacctgttta tattgcgcac acatgaacac
     2821 atcgtaggga tttattgata caagtataaa gcaggtcctt tgaagagacc tcctaatggc
     2881 tagcctctcc atcatatctc agcctcgtgt ctctgagctg tcatcacata aacttctttt
     2941 ttctacaaca aagtattgtc aggcttccat cctactttca gaaaacagac atacatcttt
     3001 ttgtgtatca gattacctgc ttgtttgtat gctctgtaat tttcttctgt aggtctgagg
     3061 tacacaagct agaacataca gacccatcct catagagcag ggactgcaca gaggaggagg
     3121 tggaggaatt tttagaaaca ccattaattc ttcttccttc ccagcctcct gctgcagatg
     3181 gcagatggga gttctgcaca gaaaggagag ggaaacctgt acagagtaaa acagctgaag
     3241 caacaggacc agaggctgaa cacagccttc atctctagcc agtcccaagg tgttcctcag
     3301 ctctgtatct ctgagtcctg ggacaagtct tcccgagaag atggccagtg tgccatcttt
     3361 tacattagga tcagatatga ttgggccaaa gcacaaaaca cagtactggt ctaacagaac
     3421 tgcaggaaac aaaactgcac catttcctta tgccagagct tcttgtcttg ttctggtgtt
     3481 ccctcttttt cagtagcacc tggttctctt tgccaaaggt actaggtgga tcagatatga
     3541 ctaaacctgc tatagttctg tgaatcattc ttatgaaact tattttgctt taaatacttg
     3601 gaagcaaaag agtgggatgc agatcaactc ctgggagctg ttgacatctt cagtgacaca
     3661 ctgttcagtt ccagcttcct gaaagacact cattcacagt catggacttc ccagtgagac
     3721 attgtgagtt tactacttag tagtctctga cattttcctt gagagaagac ggtctgtccc
     3781 caacagcaga attttagatt actgttaaaa gtttttaatc tacaggattg agacagaaac
     3841 atgaaggctt gttaaagaga agcacattca attctgttag gagggataat tgtttctgat
     3901 tgtcttgaca gggcatcaag ttcgtactgt gttctctcac agatgacagc ctggaaaaga
     3961 agggcttggc tggggaatgt gtaatttata cagtctatca tagcaatgta ctatttaaaa
     4021 atagtctgta gtgtatactt aaaaatggaa aaaacacttt tacaactatt tttgtacaac
     4081 aaaagaatca cataccactg tactatattt aaattaaaat ttattttttg gtttttgtca
     4141 aaaaaaaaaa aaaaaaaaaa aa
//
