LOCUS       NM_023831               3337 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus intraflagellar transport 46 (Ift46), mRNA.
ACCESSION   NM_023831
VERSION     NM_023831.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3337)
  AUTHORS   Seo,S., Sonn,S.K., Kweon,H.Y., Jin,J., Kume,T., Ko,J.Y., Park,J.H.
            and Oh,G.T.
  TITLE     Primary Cilium in Neural Crest Cells Crucial for Anterior Segment
            Development and Corneal Avascularity
  JOURNAL   Invest Ophthalmol Vis Sci 65 (3), 30 (2024)
   PUBMED   38517430
REFERENCE   2  (bases 1 to 3337)
  AUTHORS   Lee,E.J., Ko,J.Y., Oh,S., Jun,J., Mun,H., Lim,C.J., Seo,S.,
            Ko,H.W., Kim,H., Oh,Y.K., Ahn,C., Kang,M., Kim,M.J., Yoo,K.H.,
            Oh,G.T. and Park,J.H.
  TITLE     Autophagy induction promotes renal cyst growth in polycystic kidney
            disease
  JOURNAL   EBioMedicine 60, 102986 (2020)
   PUBMED   32949996
REFERENCE   3  (bases 1 to 3337)
  AUTHORS   Inaba,Y., Shinohara,K., Botilde,Y., Nabeshima,R., Takaoka,K.,
            Ajima,R., Lamri,L., Takeda,H., Saga,Y., Nakamura,T. and Hamada,H.
  TITLE     Transport of the outer dynein arm complex to cilia requires a
            cytoplasmic protein Lrrc6
  JOURNAL   Genes Cells 21 (7), 728-739 (2016)
   PUBMED   27353389
REFERENCE   4  (bases 1 to 3337)
  AUTHORS   Katoh,Y., Terada,M., Nishijima,Y., Takei,R., Nozaki,S., Hamada,H.
            and Nakayama,K.
  TITLE     Overall Architecture of the Intraflagellar Transport (IFT)-B
            Complex Containing Cluap1/IFT38 as an Essential Component of the
            IFT-B Peripheral Subcomplex
  JOURNAL   J Biol Chem 291 (21), 10962-10975 (2016)
   PUBMED   26980730
REFERENCE   5  (bases 1 to 3337)
  AUTHORS   Lee,M.S., Hwang,K.S., Oh,H.W., Ji-Ae,K., Kim,H.T., Cho,H.S.,
            Lee,J.J., Yeong Ko,J., Choi,J.H., Jeong,Y.M., You,K.H., Kim,J.,
            Park,D.S., Nam,K.H., Aizawa,S., Kiyonari,H., Shioi,G., Park,J.H.,
            Zhou,W., Kim,N.S. and Kim,C.H.
  TITLE     IFT46 plays an essential role in cilia development
  JOURNAL   Dev Biol 400 (2), 248-257 (2015)
   PUBMED   25722189
REFERENCE   6  (bases 1 to 3337)
  AUTHORS   Ahmed,N.T., Gao,C., Lucker,B.F., Cole,D.G. and Mitchell,D.R.
  TITLE     ODA16 aids axonemal outer row dynein assembly through an
            interaction with the intraflagellar transport machinery
  JOURNAL   J Cell Biol 183 (2), 313-322 (2008)
   PUBMED   18852297
REFERENCE   7  (bases 1 to 3337)
  AUTHORS   Gouttenoire,J., Valcourt,U., Bougault,C., Aubert-Foucher,E.,
            Arnaud,E., Giraud,L. and Mallein-Gerin,F.
  TITLE     Knockdown of the intraflagellar transport protein IFT46 stimulates
            selective gene expression in mouse chondrocytes and affects early
            development in zebrafish
  JOURNAL   J Biol Chem 282 (42), 30960-30973 (2007)
   PUBMED   17720815
  REMARK    GeneRIF: the ciliary protein IFT46 has a specific function in
            chondrocytes and is also essential for normal development of
            vertebrates.
REFERENCE   8  (bases 1 to 3337)
  AUTHORS   Hou,Y., Qin,H., Follit,J.A., Pazour,G.J., Rosenbaum,J.L. and
            Witman,G.B.
  TITLE     Functional analysis of an individual IFT protein: IFT46 is required
            for transport of outer dynein arms into flagella
  JOURNAL   J Cell Biol 176 (5), 653-665 (2007)
   PUBMED   17312020
REFERENCE   9  (bases 1 to 3337)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   10 (bases 1 to 3337)
  AUTHORS   O'Brien,K.P., Tapia-Paez,I., Stahle-Backdahl,M., Kedra,D. and
            Dumanski,J.P.
  TITLE     Characterization of five novel human genes in the 11q13-q22 region
  JOURNAL   Biochem Biophys Res Commun 273 (1), 90-94 (2000)
   PUBMED   10873569
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK032880.1.
            
            On Apr 5, 2007 this sequence version replaced NM_023831.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032880.1, SRR1660817.144739.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3337              AK032880.1         2-3338
FEATURES             Location/Qualifiers
     source          1..3337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..3337
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /note="intraflagellar transport 46"
                     /db_xref="GeneID:76568"
                     /db_xref="MGI:MGI:1923818"
     exon            1..165
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     exon            166..262
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     exon            263..339
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1203
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /note="intraflagellar transport 46 homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 46 homolog"
                     /protein_id="NP_076320.2"
                     /db_xref="CCDS:CCDS23119.1"
                     /db_xref="GeneID:76568"
                     /db_xref="MGI:MGI:1923818"
                     /translation="MADNSSDEYEEDNKEKKKPSQLTPQQGFSENDDDDDDDSSETDS
                     DDDDDDEEHGAPLEGAYDPADYEHLPVSAEIKELFEYISRYTPQLIDLDHKLKPFIPD
                     FIPAVGDIDAFLKVPRPDGKPDHLGLLVLDEPSTKQSDPTVLSLWLTENSKQHNITQH
                     MKVKSLEDAEKNPKAIDTWIESISELHRSKPPATVHYTRPMPDIDTLMQEWSPEFEEL
                     LGKVSLPTVEIDCSLAEYIDMICAILDIPFYKSRIQSLHLLFSLYSEFKNSQHFKALA
                     EGKKVFTPPPNSASQAGDAETLTFI"
     exon            340..473
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..548
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..642
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..771
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..893
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..960
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1021
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1107
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..3337
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /note="hexamer: AATACA"
     polyA_site      1516
                     /gene="Ift46"
                     /gene_synonym="1500035H01Rik; c11orf2"
                     /note="major polyA site"
ORIGIN      
        1 cagactctcg ctttgttttg atttatttat ctttttccct aacgactgac aacaggcggc
       61 ttgttgcact tagggatcct tgaagtggct gggcctgaga gtgagacccc agtcctcggc
      121 tggggttctt tccaaataga agaaacggat ccagaggggc tacagaccaa aattgttgag
      181 aaccagacat acgatgagcg tctagagatt aacgactcgg aagaggttgc cagtattagc
      241 actccaaccc caggacagca aggccctcct ttttctgccg ctcttcccaa caagacgatg
      301 gctgataaca gcagtgacga gtacgaggag gacaataagg agaagaagaa gccctcccag
      361 ctgacaccgc agcagggctt cagtgagaac gatgatgatg acgacgatga ctcctctgag
      421 acggattccg atgacgacga tgacgatgag gagcatggag cacctctgga aggggcgtat
      481 gatcctgccg actacgagca tctgccagtc tcggccgaga tcaaggagct ctttgagtac
      541 atcagccggt acacacctca gttgatcgat ctggaccaca aactgaaacc tttcattcct
      601 gattttatcc cagctgttgg ggatatcgat gcatttttaa aggtgccacg tcccgatgga
      661 aagcctgacc accttggcct cttggtgtta gatgaaccat cgacaaagca gtcggaccct
      721 accgtgcttt cgctgtggtt aacagagaat tccaagcagc ataatattac gcaacatatg
      781 aaagtaaaga gcctggagga tgcagagaag aatcccaaag ccattgacac ctggattgag
      841 agcatctctg agttacaccg ttccaagccc cctgcaactg tgcactacac caggcccatg
      901 cccgacattg acactctgat gcaggagtgg tccccggaat ttgaagagct cctgggaaag
      961 gtgagtctgc ccactgtcga gatcgattgc agcctggctg agtacattga catgatctgt
     1021 gcgatcctgg acattccttt ctataagagc cggattcagt ctctccacct gctcttttcc
     1081 ctctactcag agttcaagaa ctcccagcat tttaaagctc ttgctgaagg caaaaaagta
     1141 ttcacccctc cacccaactc tgcctcccag gctggggatg cggagacact gactttcatc
     1201 tgagcctcct cctgggactg tgcttcaaag ttagatgaag atgtggtctc tgttggcagc
     1261 ttaatgtctc cctgctccac agctgggctc tgtcaacatg aaccctgctg ccttgtcctc
     1321 gagggcaggg cacaccttgt ttacacctgc ctcccgttgc cattccagag gaaggatgta
     1381 gccactctgc tgtgggcctc tgagttggaa gaactgggac tctgagagcc ccaggacaca
     1441 ggttggggac agagcttcca gagacacaca gactgctctg tcaggttgtg atggaataca
     1501 tactggtttt cacccatggc ttctggctca ttagtgtccc attgccctga tgctctctag
     1561 agtgagtagg gtcgggttgg ggccttacag caggcctgcc tgtgcctctg agaatcatgt
     1621 ccttctattt gaccttctgc ccttctttca cctccctttc tccccaagca gcccacaacc
     1681 ccgaatcttt ccccaaggca atcatggaca tctgctccta caatcttaca ttcttttatt
     1741 ttacttttgt ttgtgttgtg aggcagcatc tcctgtagcc cagcttggct tcgaactatc
     1801 tgtgcaggct ggtcttgaag gcctgatctt cccgcctcca cctctacctc ccaggtacca
     1861 ggccttcagg tatattcagc aaacccagtt tattcttaaa tttgttgacc tatctggata
     1921 atagaccaag accctcattt agatgggcac ttgcccctta ccagcaagga agcaaactga
     1981 gtaatttcca gacctcactt ggcatcccac ccaaaccaca gcattagatc agaccatttt
     2041 tgcccagtca catgccagca tagtggtcca ggtttcagct gttccttcgt gtgatgtctc
     2101 catggaaact caaaaggtca ggccttggag agttttcaga cagtcagata cagggaggtt
     2161 cccaaaaggt ggcatgcatc ttacacatct ttgtgaattt taaaataatt gtatttgttt
     2221 tagactggtt ctctgtacag ccgagagtgg tctacagttc actatgaagc tcaggcgtta
     2281 cgagttcatt atcacctttt gcttctgggt actaggatta caggcctgag ccaccgtgcc
     2341 cactgttcac cccttcacct gcatcctttg accatctttc atgaaaaatt gagaaaagtg
     2401 tttctctagg ttctgcaata tgttgaactc cgaggagcgg gttgtgggga cgcctgacta
     2461 accactggtg gttgagaggc acaggcaaga gcgtgtggct ccagggagca cggctgtggc
     2521 agtgtttgga ggagctgctt aagcggggtg gaagtggagg agagattcag gagcaatttg
     2581 gagtggtatc aactggttcc cagccaggaa acctgaaacc gttctagagt tttgttgggt
     2641 ttttgtcgct gtcttcagac acaccagaag agagcatcgg atcccattgc agatggttgt
     2701 gagccactat gtggttgctg ggaattgaac tcaggacctc tggaagagca gccagtgctc
     2761 tgaactgctg agccatctct cctgccccat tctggatgtt tttaacaaag gacatttaac
     2821 acaacaattt ggtgacaaaa gtatggggaa ggaactgaca agatggcaca gcaggtaaag
     2881 gtgcttgtca caaagcttgg ccacctgagt tcaatccctg ggactcacat ggtggaagga
     2941 gaaaactact aaaacttgtg ttctgtaagc cacgtgcact tgcatgagca tgcacacaca
     3001 catacacatg cgggcacaca cacagtggtg catggtagtt taaaggttgg tatctaggag
     3061 gtggctgtgg ccagatgatg ctgagggcag aggagggttg cagagcctca cctaccactg
     3121 cagggacttt gagcaaagtg gttgcttcct ctcacctcct cacctcccat gacagacaaa
     3181 aatgcagacc aggaatcaga acccagcagc acaagaatga ggaattttcc tttgtccacg
     3241 tggaagctct cagccccacc cttggaattt ttatggggac ctcattgcac aggcttgatt
     3301 gactccagga caaatacgta gaaataaaac cagaccc
//
