LOCUS       NM_026073                911 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus intraflagellar transport 22 (Ift22), mRNA.
ACCESSION   NM_026073
VERSION     NM_026073.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 911)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 911)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 911)
  AUTHORS   Katoh,Y., Terada,M., Nishijima,Y., Takei,R., Nozaki,S., Hamada,H.
            and Nakayama,K.
  TITLE     Overall Architecture of the Intraflagellar Transport (IFT)-B
            Complex Containing Cluap1/IFT38 as an Essential Component of the
            IFT-B Peripheral Subcomplex
  JOURNAL   J Biol Chem 291 (21), 10962-10975 (2016)
   PUBMED   26980730
REFERENCE   4  (bases 1 to 911)
  AUTHORS   Liew,G.M., Ye,F., Nager,A.R., Murphy,J.P., Lee,J.S., Aguiar,M.,
            Breslow,D.K., Gygi,S.P. and Nachury,M.V.
  TITLE     The intraflagellar transport protein IFT27 promotes BBSome exit
            from cilia through the GTPase ARL6/BBS3
  JOURNAL   Dev Cell 31 (3), 265-278 (2014)
   PUBMED   25443296
REFERENCE   5  (bases 1 to 911)
  AUTHORS   Ishikawa,H., Ide,T., Yagi,T., Jiang,X., Hirono,M., Sasaki,H.,
            Yanagisawa,H., Wemmer,K.A., Stainier,D.Y., Qin,H., Kamiya,R. and
            Marshall,W.F.
  TITLE     TTC26/DYF13 is an intraflagellar transport protein required for
            transport of motility-related proteins into flagella
  JOURNAL   Elife 3, e01566 (2014)
   PUBMED   24596149
  REMARK    Erratum:[Elife. 2014 Apr 01;3:e02897. doi: 10.7554/eLife.02897..
            PMID: 24692455]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 911)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 911)
  AUTHORS   Follit,J.A., Xu,F., Keady,B.T. and Pazour,G.J.
  TITLE     Characterization of mouse IFT complex B
  JOURNAL   Cell Motil Cytoskeleton 66 (8), 457-468 (2009)
   PUBMED   19253336
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC147987.5.
            
            On Nov 17, 2006 this sequence version replaced NM_026073.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009150.1, CA979986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC147987.5         98072-98192
            122-198             AC147987.5         101046-101122
            199-288             AC147987.5         101224-101313
            289-491             AC147987.5         101611-101813
            492-911             AC147987.5         102747-103166
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.03 cM"
     gene            1..911
                     /gene="Ift22"
                     /gene_synonym="3110017O03Rik; Rabl5"
                     /note="intraflagellar transport 22"
                     /db_xref="GeneID:67286"
                     /db_xref="MGI:MGI:1914536"
     exon            1..121
                     /gene="Ift22"
                     /gene_synonym="3110017O03Rik; Rabl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..640
                     /gene="Ift22"
                     /gene_synonym="3110017O03Rik; Rabl5"
                     /note="rab-like protein 5; RAB, member of RAS oncogene
                     family-like 5"
                     /codon_start=1
                     /product="intraflagellar transport protein 22 homolog"
                     /protein_id="NP_080349.1"
                     /db_xref="CCDS:CCDS19756.1"
                     /db_xref="GeneID:67286"
                     /db_xref="MGI:MGI:1914536"
                     /translation="MLKAKILFVGPCESGKTVLANFLTESSDITEYNPTQGVRILEFE
                     NPHVTSNNKGTGCEFELWDCGGDSKFESCWPALMKDAHGVVIVFNADIPSHLKEIEMW
                     YSCFVQQQFLQDSHCMLVAHHKPGSGGERGSLALSPPLNKLKLVHSNLEEDPEEVRVE
                     FIKYLKSIINSMSESRDREEMLIIT"
     exon            122..198
                     /gene="Ift22"
                     /gene_synonym="3110017O03Rik; Rabl5"
                     /inference="alignment:Splign:2.1.0"
     exon            199..288
                     /gene="Ift22"
                     /gene_synonym="3110017O03Rik; Rabl5"
                     /inference="alignment:Splign:2.1.0"
     exon            289..491
                     /gene="Ift22"
                     /gene_synonym="3110017O03Rik; Rabl5"
                     /inference="alignment:Splign:2.1.0"
     exon            492..911
                     /gene="Ift22"
                     /gene_synonym="3110017O03Rik; Rabl5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      887..892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ift22"
                     /gene_synonym="3110017O03Rik; Rabl5"
                     /note="hexamer: CATAAA"
     polyA_site      911
                     /gene="Ift22"
                     /gene_synonym="3110017O03Rik; Rabl5"
                     /note="major polyA site"
ORIGIN      
        1 tgcggcccag actggcggac gcggcgggga gcttagcgcg ctttggtggt gggcttccgc
       61 gggttcgtgt taacggacag cgatgctgaa ggctaagatc ctcttcgtgg gcccctgcga
      121 gagcggcaaa acagtgttgg ccaactttct cactgaatct tcggacatca ctgaatataa
      181 cccaacacaa ggtgtgagga tcctagagtt tgagaaccca catgtcacca gcaacaacaa
      241 aggcacgggc tgcgaattcg agctctggga ctgtggtggc gactctaagt ttgagtcctg
      301 ttggcccgct ctgatgaagg atgctcatgg agtggtgatc gtcttcaatg ctgatattcc
      361 aagccactta aaggaaattg aaatgtggta ttcctgcttt gtccagcaac agttcctcca
      421 agacagtcac tgcatgcttg tggcccacca caaaccgggc tccggaggag aaaggggcag
      481 cctggctttg tctcccccct tgaacaagct gaagctggtg cactcaaacc tggaggaaga
      541 ccctgaggag gtccgggtgg agttcatcaa gtatttaaaa agcatcatca actccatgtc
      601 agagagcaga gaccgcgagg agatgctcat catcacctag tgtcccagtg ccaccgcctc
      661 ccaaaggacg ctgactaacc ccacccagcc gctgacgcac ccttctcctc tagaaggctc
      721 caggaagatc aggcatggtg ccacacacct gtgatcccag ctctcaggag gctgaggtgg
      781 gaggagggtt gagagttcaa ggccagccct ggctgcatag gagcgcttat ctcctccctt
      841 ctccagaagc aaaaagctgc cctgcttgcc tgtctcagtt gtcatgcata aacatgtcct
      901 tccttccggc a
//
