LOCUS       NM_001167763            4080 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus intraflagellar transport 122 (Ift122), transcript
            variant 2, mRNA.
ACCESSION   NM_001167763
VERSION     NM_001167763.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4080)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4080)
  AUTHORS   Brooks,E.R., Islam,M.T., Anderson,K.V. and Zallen,J.A.
  TITLE     Sonic hedgehog signaling directs patterned cell remodeling during
            cranial neural tube closure
  JOURNAL   Elife 9, e60234 (2020)
   PUBMED   33103996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4080)
  AUTHORS   Lee,H. and Ko,H.W.
  TITLE     Cell cycle-related kinase is a crucial regulator for ciliogenesis
            and Hedgehog signaling in embryonic mouse lung development
  JOURNAL   BMB Rep 53 (7), 367-372 (2020)
   PUBMED   32317081
REFERENCE   4  (bases 1 to 4080)
  AUTHORS   Takahara,M., Kunii,M., Nakamura,K., Harada,A., Hirano,T., Katoh,Y.
            and Nakayama,K.
  TITLE     C11ORF74 interacts with the IFT-A complex and participates in
            ciliary BBSome localization
  JOURNAL   J Biochem 165 (3), 257-267 (2019)
   PUBMED   30476139
  REMARK    GeneRIF: The C11ORF74, interacts with the IFT-A complex via the
            IFT122 subunit and is accumulated at the distal tip in the absence
            of an IFT-A subunit IFT139, suggesting that at least a fraction of
            C11ORF74 molecules can be transported towards the ciliary tip by
            associating with the IFT-A complex, although its majority might be
            out of cilia at steady state.
REFERENCE   5  (bases 1 to 4080)
  AUTHORS   Burnett,J.B., Lupu,F.I. and Eggenschwiler,J.T.
  TITLE     Proper ciliary assembly is critical for restricting Hedgehog
            signaling during early eye development in mice
  JOURNAL   Dev Biol 430 (1), 32-40 (2017)
   PUBMED   28778798
REFERENCE   6  (bases 1 to 4080)
  AUTHORS   Cortellino,S., Wang,C., Wang,B., Bassi,M.R., Caretti,E.,
            Champeval,D., Calmont,A., Jarnik,M., Burch,J., Zaret,K.S., Larue,L.
            and Bellacosa,A.
  TITLE     Defective ciliogenesis, embryonic lethality and severe impairment
            of the Sonic Hedgehog pathway caused by inactivation of the mouse
            complex A intraflagellar transport gene Ift122/Wdr10, partially
            overlapping with the DNA repair gene Med1/Mbd4
  JOURNAL   Dev Biol 325 (1), 225-237 (2009)
   PUBMED   19000668
  REMARK    GeneRIF: Studies on a complex A mutant mouse, defective for the
            Ift122 gene, is reported.
REFERENCE   7  (bases 1 to 4080)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   8  (bases 1 to 4080)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   9  (bases 1 to 4080)
  AUTHORS   Cortellino,S., Turner,D., Masciullo,V., Schepis,F., Albino,D.,
            Daniel,R., Skalka,A.M., Meropol,N.J., Alberti,C., Larue,L. and
            Bellacosa,A.
  TITLE     The base excision repair enzyme MED1 mediates DNA damage response
            to antitumor drugs and is associated with mismatch repair system
            integrity
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15071-15076 (2003)
   PUBMED   14614141
REFERENCE   10 (bases 1 to 4080)
  AUTHORS   Gross,C., De Baere,E., Lo,A., Chang,W. and Messiaen,L.
  TITLE     Cloning and characterization of human WDR10, a novel gene located
            at 3q21 encoding a WD-repeat protein that is highly expressed in
            pituitary and testis
  JOURNAL   DNA Cell Biol 20 (1), 41-52 (2001)
   PUBMED   11242542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY085672.1, AK167412.1 and CO043683.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is one aa
            shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066083.1, AK131115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BY085672.1         59-104
            47-3914             AK167412.1         2-3869
            3915-4080           CO043683.1         1-166               c
FEATURES             Location/Qualifiers
     source          1..4080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.72 cM"
     gene            1..4080
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /note="intraflagellar transport 122"
                     /db_xref="GeneID:81896"
                     /db_xref="MGI:MGI:1932386"
     exon            1..182
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..3690
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     intraflagellar transport protein 122 homolog; WD
                     repeat-containing protein 10; WD repeat domain 10;
                     intraflagellar transport 122 homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 122 homolog
                     isoform 2"
                     /protein_id="NP_001161235.1"
                     /db_xref="CCDS:CCDS51880.1"
                     /db_xref="GeneID:81896"
                     /db_xref="MGI:MGI:1932386"
                     /translation="MRAVLTWRDKAEQCIYDLAFKPDGTQLILAAGNRLLVYDTSDGT
                     LLQPLKGHKDTVYCVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYN
                     PVTHQLASCSSSDFGLWSPEQKSVSKHKSSSKITCCSWTNDGQYLALGMANGIISIRN
                     KNGEEKVKIERPGGSLSPIWSICWNPSREEHNDILAVADWGQKLSFYQLSGKQIGKDR
                     PLNFDPCCISYFTKGEYILVGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCRVKPDSNY
                     VVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCRELVKK
                     IAIYKNRLAIQLPEKILIYELYSEDSTDMHYRVKEKIVKKFECNLLVVCADHIILCQE
                     KRLQCLSFSGVKEREWQMESLIRYIKVIGGPAGREGLLVGLKNGQILKIFVDNLFAIV
                     LLKQATAVRCLDMSASRNKLAVVDENDTCLVYDIHTKELLFQEPNANSVAWNTQCEDM
                     LCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYL
                     DRKMFKEAYQIACLGVTDADWRELAMEALEGLEFETARKAFTRVQDLRYLELISSIEE
                     RKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTDLCMFEYAKDFLGS
                     GDPKETKMLITKQADWARNINEPKAAVEMYISAGEHAKAIEISGSHGWVDMLIDIARK
                     LDKAEREPLLMCACYFKKLDSPGYAAETYLKIGDLKSLVQLYVDTKRWDEAFALGEKH
                     PEFKDDVYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFNDAA
                     YYYWMLSMQCLDMAQDPAQKDAMLDKFHHFQHLAELYHGYQTIHRYTEEPFSFDLPET
                     LFNISKFLLHSLTKATPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLRGLQIPARI
                     QKSIELGTLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYE
                     VLHLVEFYLEEGITDEEAVALIDLEAPRHKREGKWRETSSNNSQTLKLDETMDSIGED
                     DPFTAKLSFEQGSSEFVPVVVNRSVLRSMSRRDVLIKRWPPPLQWQYFRSLLPDASIT
                     MCPSCFQMFHSEDYELLVLQHACCPYCRRRIDDTGP"
     exon            183..249
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            250..334
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            335..413
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            414..490
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            491..557
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            558..704
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            705..780
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            781..972
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1111
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1314
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1452
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1617
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1815
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1956
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2010
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2172
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2339
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2511
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2614
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2755
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2850
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2951
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3117
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3229
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3355
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3435
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3600
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            3601..4064
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4038..4043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /note="hexamer: AATAAA"
     polyA_site      4060
                     /gene="Ift122"
                     /gene_synonym="sopb; Wdr10"
                     /note="major polyA site"
ORIGIN      
        1 ttggagcttt gggaaactca tgcgcggttc attgcgcatg tgcgttgcta agggtagcgc
       61 aggtagctga agtggtttgt ggaaagaagc ctgttgctgc cgaggctggg aggaggggcc
      121 cgaagcgtga gggaaacggc gatgagggcc gtgttgacgt ggagagacaa agcggagcag
      181 tgtatctacg acctcgcatt taagcctgat ggaacacaac tgattctggc tgcaggaaac
      241 agattgctgg tttatgacac ctctgatggc accttacttc agcccctgaa gggacacaaa
      301 gacaccgtgt actgtgtggc gtatgcaaag gatggcaagc gctttgcatc tggatctgct
      361 gacaagagca tcattatctg gacctcaaaa cttgaaggca ttctgaagta cacgcacaac
      421 gactctatac agtgtgtctc ctacaatcct gttacccacc agctggcatc ttgttcctcc
      481 agtgactttg ggttatggtc tcctgagcag aagtctgtgt ccaagcacaa atccagcagc
      541 aagatcacgt gctgcagctg gacaaacgat ggtcagtacc tggctctggg catggccaat
      601 ggcatcatca gtatacggaa caagaatggt gaagagaaag tgaagatcga gcgccctggg
      661 ggctccctct ccccaatatg gtccatctgc tggaaccctt caagagagga acataatgac
      721 atcctggctg tagctgactg gggacagaaa ctttccttct accagctgag tggaaaacag
      781 attgggaagg atcggccact gaactttgac ccctgttgca tcagctactt cactaaagga
      841 gagtacattt tggtgggagg ttcagacaag caggtatctc ttttcaccaa ggatggagtg
      901 cgactgggga ccgttgggga gcagaactcc tgggtgtgga cctgtagagt gaaacctgac
      961 tccaattatg tggtggtcgg ctgccaggat ggcaccatct ccttctacca gctcatcttc
     1021 agcacagtcc atgggctcta caaagatcgg tatgcctaca gggacagcat gacagacgtc
     1081 atcgtgcagc acctcatcac agagcagaaa gttaggatta agtgcagaga gcttgtcaag
     1141 aaaattgcca tctacaaaaa tcgattagct atccagctgc cagagaagat cctcatctac
     1201 gagctgtact ctgaagactc gacagacatg cactaccggg taaaggagaa aattgtcaag
     1261 aagtttgagt gcaacctgct ggtggtgtgt gctgaccaca tcatcctgtg ccaggagaaa
     1321 cggctacagt gcctgtcctt cagtggagtg aaggaaaggg aatggcagat ggaatctctc
     1381 atccgctaca tcaaggtgat cggtggccct gctggaagag aaggtctgtt ggtaggcctg
     1441 aaaaacggcc agatcctgaa gatctttgtg gacaatcttt ttgctattgt cctgctgaag
     1501 caggccacag ccgtgcgctg cctggacatg agtgcctccc ggaacaagct ggctgtggtg
     1561 gatgagaatg acacgtgcct ggtgtacgac atccacacga aggaactgct tttccaggaa
     1621 ccgaatgcta acagcgtggc ctggaacacg cagtgtgagg acatgctctg cttctctgga
     1681 ggaggctacc tcaacatcaa ggccagcacc ttcccagtgc accagcagaa gctgcagggc
     1741 tttgtggttg gctacaacgg ctccaagatc ttctgccttc atgtcttctc tatgtctgcc
     1801 gtggaggtgc cacagtccgc tccaatgtac cagtacctcg ataggaagat gttcaaagaa
     1861 gcatatcaga tcgcttgctt gggagtgaca gacgctgatt ggcgtgaact ggccatggaa
     1921 gctctagaag gactagagtt tgagacggca aggaaggcct tcaccagagt ccaggacctt
     1981 cgatacctag aactgatcag cagtattgag gagaggaaga agaggggaga gaccaacaat
     2041 gacctgtttc tggcagatgt gttttcctac caggggaagt ttcatgaagc cgccaaacta
     2101 tacaagagga gcgggcatga gaacctcgct ctcgacatgt atactgacct ctgcatgttt
     2161 gagtacgcca aggatttcct tggatctgga gaccctaaag aaacgaagat gctcatcacc
     2221 aagcaggccg actgggccag aaacatcaat gagcccaaag ctgcagtgga gatgtacatc
     2281 tcagcagggg agcacgccaa ggccatagag atcagcggca gccatggctg ggtggacatg
     2341 ttgatagaca ttgctcggaa gctggacaag gctgaacggg agcccctgct catgtgtgct
     2401 tgctacttta agaagctgga cagtcctggc tatgctgctg agacctacct gaagatcggg
     2461 gacctgaagt ctctggtgca gctgtatgtg gacaccaagc gctgggatga ggcctttgcg
     2521 ttaggtgaga agcacccgga gttcaaggat gacgtctacg tgccctacgc gcagtggctg
     2581 gcggagaacg accgctttga ggaagcccag aaagccttcc acaaggccgg gaggcaggga
     2641 gaagcagtcc gggtgctgga gcagctcacg cacaatgctg tggtggagag caggtttaac
     2701 gacgctgcct attattactg gatgctgtcc atgcagtgcc tcgacatggc tcaagatcct
     2761 gcccagaagg acgcgatgct ggacaagttt caccacttcc aacacctggc tgagctgtac
     2821 catggctatc aaaccattca ccgatacacg gaggagccat tcagctttga cctccctgaa
     2881 accctcttca acatctccaa gttcttgctg cacagcctga ccaaggccac ccccttgggt
     2941 atctccaaag tgaatacact cttcacactg gctaagcaga gcaaggctct gggtgcttac
     3001 aagctggccc ggcatgccta tgacaagcta cgggggctgc agatccccgc caggatccag
     3061 aagtccattg agctgggcac cctgaccatc cgctccaagc ccttccatga cagtgaggag
     3121 ctggtaccct tgtgctaccg ctgttctacc aacaacccgc tgctgaacaa ccttggcaac
     3181 gtctgcatca actgccgcca gcccttcatc ttctccgcct cttcctatga ggtgctgcac
     3241 ctggtggaat tctacctgga agaggggatc actgacgaag aagctgttgc cctcatcgat
     3301 ctggaggcac caagacacaa gagggagggc aagtggcgag agacctcaag caacaattcc
     3361 cagacgttga agctggacga gaccatggac tccataggag aagatgaccc atttacagcc
     3421 aagctgagct ttgagcaagg tagctctgag tttgtgcctg tggtggtgaa ccggtcagta
     3481 ctacgctcca tgagccgaag agatgttctc atcaagcgct ggcccccgcc gctgcaatgg
     3541 caatatttcc gctcgctgtt gcctgatgcc tccatcacca tgtgcccctc ctgctttcag
     3601 atgttccatt cagaggacta cgaactgctt gtgctccagc acgcctgctg cccttactgc
     3661 cgaaggcgta tcgacgacac tggcccgtga gcagcgacag cctctgggac cacggctccc
     3721 atggtctcct tgctgtcccc agactgttgg gagaaggaat taaaccctca gaacacgtct
     3781 cctgcccaga tgaagtttgt atgttgcaaa gggggggggg gctgccttgt gtaaccacag
     3841 atttcctatt tatggcattt cattccttgt aaatagcacc aggagacggg gaagagaaca
     3901 cacacatatt ttctaagaaa aaaaaaaatc tgttactttt agaagggctc atgtgttcat
     3961 agcagcctgc tggagtccgt agatccgtca gaccattacc gtgcacacgt tgccaacaga
     4021 ttgcctcaat aacgacaaat aaaagggcta ctcgttttca tcagaaaaaa aaaaaaaaaa
//
