LOCUS       NM_013562               1812 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus interferon-related developmental regulator 1 (Ifrd1),
            transcript variant 1, mRNA.
ACCESSION   NM_013562
VERSION     NM_013562.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Vietor,I., Cikes,D., Piironen,K., Vasakou,T., Heimdorfer,D.,
            Gstir,R., Erlacher,M.D., Tancevski,I., Eller,P., Demetz,E.,
            Hess,M.W., Kuhn,V., Degenhart,G., Rozman,J., Klingenspor,M., Hrabe
            de Angelis,M., Valovka,T. and Huber,L.A.
  TITLE     The negative adipogenesis regulator Dlk1 is transcriptionally
            regulated by Ifrd1 (TIS7) and translationally by its orthologue
            Ifrd2 (SKMc15)
  JOURNAL   Elife 12, e88350 (2023)
   PUBMED   37603466
  REMARK    GeneRIF: The negative adipogenesis regulator Dlk1 is
            transcriptionally regulated by Ifrd1 (TIS7) and translationally by
            its orthologue Ifrd2 (SKMc15).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1812)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1812)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1812)
  AUTHORS   Chang,M., Zhang,Y., Hui,Z., Wang,D. and Guo,H.
  TITLE     IFRD1 regulates the asthmatic responses of airway via NF-kappaB
            pathway
  JOURNAL   Mol Immunol 127, 186-192 (2020)
   PUBMED   32992150
  REMARK    GeneRIF: IFRD1 regulates the asthmatic responses of airway via
            NF-kappaB pathway.
REFERENCE   5  (bases 1 to 1812)
  AUTHORS   Miao,Z.F., Lewis,M.A., Cho,C.J., Adkins-Threats,M., Park,D.,
            Brown,J.W., Sun,J.X., Burclaff,J.R., Kennedy,S., Lu,J., Mahar,M.,
            Vietor,I., Huber,L.A., Davidson,N.O., Cavalli,V., Rubin,D.C.,
            Wang,Z.N. and Mills,J.C.
  TITLE     A Dedicated Evolutionarily Conserved Molecular Network Licenses
            Differentiated Cells to Return to the Cell Cycle
  JOURNAL   Dev Cell 55 (2), 178-194 (2020)
   PUBMED   32768422
REFERENCE   6  (bases 1 to 1812)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   7  (bases 1 to 1812)
  AUTHORS   Guardavaccaro,D., Ciotti,M.T., Schafer,B.W., Montagnoli,A. and
            Tirone,F.
  TITLE     Inhibition of differentiation in myoblasts deprived of the
            interferon-related protein PC4
  JOURNAL   Cell Growth Differ 6 (2), 159-169 (1995)
   PUBMED   7756174
  REMARK    GeneRIF: The gene IFRD1/PC4 is required for muscle differentiation.
            Inhibition of PC4 expression in myoblasts prevents morphological
            differentiation, impairing myogenin and myosin gene expression.
            This finding has been confirmed by gene knockout in mice.
REFERENCE   8  (bases 1 to 1812)
  AUTHORS   Varnum,B.C., Lim,R.W. and Herschman,H.R.
  TITLE     Characterization of TIS7, a gene induced in Swiss 3T3 cells by the
            tumor promoter tetradecanoyl phorbol acetate
  JOURNAL   Oncogene 4 (10), 1263-1265 (1989)
   PUBMED   2797820
  REMARK    GeneRIF: This reference shows the cloning and the sequence of the
            original IFRD1 homolog isolated in mouse as TPA-inducible immediate
            early gene (named Tis7).
REFERENCE   9  (bases 1 to 1812)
  AUTHORS   Tippetts,M.T., Varnum,B.C., Lim,R.W. and Herschman,H.R.
  TITLE     Tumor promoter-inducible genes are differentially expressed in the
            developing mouse
  JOURNAL   Mol Cell Biol 8 (10), 4570-4572 (1988)
   PUBMED   3185562
REFERENCE   10 (bases 1 to 1812)
  AUTHORS   Skup,D., Windass,J.D., Sor,F., George,H., Williams,B.R.,
            Fukuhara,H., De Maeyer-Guignard,J. and De Maeyer,E.
  TITLE     Molecular cloning of partial cDNA copies of two distinct mouse
            IFN-beta mRNAs
  JOURNAL   Nucleic Acids Res 10 (10), 3069-3084 (1982)
   PUBMED   6179042
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157571.6 and AC174598.2.
            
            On Oct 7, 2022 this sequence version replaced NM_013562.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043723.1, AK078888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AC157571.6         158358-158674       c
            318-422             AC157571.6         152867-152971       c
            423-507             AC157571.6         152647-152731       c
            508-632             AC157571.6         151679-151803       c
            633-790             AC157571.6         149467-149624       c
            791-841             AC157571.6         148698-148748       c
            842-1020            AC157571.6         148428-148606       c
            1021-1129           AC157571.6         147799-147907       c
            1130-1264           AC157571.6         142478-142612       c
            1265-1393           AC157571.6         139786-139914       c
            1394-1489           AC157571.6         139408-139503       c
            1490-1812           AC174598.2         32-354
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 18.06 cM"
     gene            1..1812
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /note="interferon-related developmental regulator 1"
                     /db_xref="GeneID:15982"
                     /db_xref="MGI:MGI:1316717"
     exon            1..317
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            318..422
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            423..507
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            508..632
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            633..790
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            791..841
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1020
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1129
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1264
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1393
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1489
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1812
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /note="hexamer: AATAAA"
     polyA_site      1812
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /note="major polyA site"
ORIGIN      
        1 gccttcgctc ccgcgctaga gagaaacatg tatcgtttcc gctcgcagct cttcacgggg
       61 atttctgctg ctgctgctgc cgcttctcac ccgcgccgct cctcgcctct cttgttagcc
      121 cgagactcgc ctctcagccg cccgccgcac agacgcacga gtagacagtg cagctccatc
      181 ggctgatcct cgctgagctc caagtgtagg cggcaccggg cggcccacga tgccgaagaa
      241 caagaagcgg aacgctcccc accgcggtgg cgggggtggc ggcggctccg gggcagcgac
      301 gtcggcggcc acggcaggtg gcccgcatcg gactgttcaa cctttcagtg atgaagatgc
      361 atccattgaa acaatgagcc actgcagcgg ctatagcgat ccttccagtt ttgcggagga
      421 tgggccagaa gttcttgatg aggaaggaac tcaagaagac ttagagtaca agttgaaggg
      481 attaattgac ctaacccttg ataagagtgc gaagacaaga caggcagctc ttgaaggtct
      541 taagaatgca ctgtcttcaa aagtgctgta tgagtttgtt ctcgagagaa gaatgacttt
      601 aactgatagc attgagcgct gtctgaaaaa aggaaagagt gacgagcagc gtgcggctgc
      661 agctgtcgca tctgttcttt gtattcagct gggccctgga tttgagagtg aagagatttt
      721 aaagactctt ggaccaatcc taaaaaaaat aatttgtgat ggagcagcta gtatccaggc
      781 taggcagact tgtgcaactt gctttggtgt ttgctgtttt attgccacag atgatatcac
      841 tgagctgtat tcaactctgg aatgcttcga aaatatcttc accaagtcct atcttaaaga
      901 gaaagacact aatgttactt gcagcactcc aaatacagtg cttcacatca gctcgcttct
      961 cgcgtggaca ttattactga ccatatgccc aatcaatgag gtgaagaaaa agctggagct
     1021 gcatttccat aaacttccaa gcctcctttc ttgtgatgat gtaaacatga gaattgctgc
     1081 tggcgaatct ttggcacttc tgtttgaatt ggccagagga atggagagtg acttttttta
     1141 tgaagatatg gattctttga cccagatgct ccgggctctg gctacagatg gaaataaaca
     1201 ccgtgccaaa gtggacaaga gaaagcagcg gtctgtcttc agagacgttc tgagggctgt
     1261 ggaggaacgg gattttccaa cagaaactgt taaatttggt cctgagcgca tgtatattga
     1321 tagctgggtc aaaaaacata cctatgacac gtttaaagag gttcttggat cagggatgca
     1381 gtaccacttg cagacaaatg aattccttcg aaatgtattt gagcttggac cccctgtgat
     1441 gcttgatgct gcaacactta aaaccatgaa gatttctcgt tttgaaaggc atttatataa
     1501 ctctgcagct ttcaaagctc gaacaaaagc tcgaagcaaa tgccgagata agagagcaga
     1561 tgttggagaa ttcttgtaga tgtctgaatt tgatggctgt tttctaatct cttcctttat
     1621 tattattttt gctacttcta atgtatataa gcttttagag acagtttttt atcttggtca
     1681 acttaaataa tttttgatgt aggggtgggt tgtattttaa tttaatgtac agtgttacaa
     1741 attaatgagt tctttattct ctgtaaaaat aactggtaac cacaaataaa gtgtttgtga
     1801 tgtttggtcg ta
//
