LOCUS       NP_038590                449 aa            linear   ROD 04-MAR-2025
DEFINITION  interferon-related developmental regulator 1 [Mus musculus].
ACCESSION   NP_038590
VERSION     NP_038590.2
DBSOURCE    REFSEQ: accession NM_013562.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 449)
  AUTHORS   Fashemi,B.E., Rougeau,A.K., Salazar,A.M., Bark,S.J., Chappidi,R.,
            Brown,J.W., Cho,C.J., Mills,J.C. and Mysorekar,I.U.
  TITLE     IFRD1 is required for maintenance of bladder epithelial homeostasis
  JOURNAL   iScience 27 (12), 111282 (2024)
   PUBMED   39628564
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 449)
  AUTHORS   Vietor,I., Cikes,D., Piironen,K., Vasakou,T., Heimdorfer,D.,
            Gstir,R., Erlacher,M.D., Tancevski,I., Eller,P., Demetz,E.,
            Hess,M.W., Kuhn,V., Degenhart,G., Rozman,J., Klingenspor,M., Hrabe
            de Angelis,M., Valovka,T. and Huber,L.A.
  TITLE     The negative adipogenesis regulator Dlk1 is transcriptionally
            regulated by Ifrd1 (TIS7) and translationally by its orthologue
            Ifrd2 (SKMc15)
  JOURNAL   Elife 12, e88350 (2023)
   PUBMED   37603466
  REMARK    GeneRIF: The negative adipogenesis regulator Dlk1 is
            transcriptionally regulated by Ifrd1 (TIS7) and translationally by
            its orthologue Ifrd2 (SKMc15).
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 449)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 449)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 449)
  AUTHORS   Chang,M., Zhang,Y., Hui,Z., Wang,D. and Guo,H.
  TITLE     IFRD1 regulates the asthmatic responses of airway via NF-kappaB
            pathway
  JOURNAL   Mol Immunol 127, 186-192 (2020)
   PUBMED   32992150
  REMARK    GeneRIF: IFRD1 regulates the asthmatic responses of airway via
            NF-kappaB pathway.
REFERENCE   6  (residues 1 to 449)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   7  (residues 1 to 449)
  AUTHORS   Guardavaccaro,D., Ciotti,M.T., Schafer,B.W., Montagnoli,A. and
            Tirone,F.
  TITLE     Inhibition of differentiation in myoblasts deprived of the
            interferon-related protein PC4
  JOURNAL   Cell Growth Differ 6 (2), 159-169 (1995)
   PUBMED   7756174
  REMARK    GeneRIF: The gene IFRD1/PC4 is required for muscle differentiation.
            Inhibition of PC4 expression in myoblasts prevents morphological
            differentiation, impairing myogenin and myosin gene expression.
            This finding has been confirmed by gene knockout in mice.
REFERENCE   8  (residues 1 to 449)
  AUTHORS   Varnum,B.C., Lim,R.W. and Herschman,H.R.
  TITLE     Characterization of TIS7, a gene induced in Swiss 3T3 cells by the
            tumor promoter tetradecanoyl phorbol acetate
  JOURNAL   Oncogene 4 (10), 1263-1265 (1989)
   PUBMED   2797820
  REMARK    GeneRIF: This reference shows the cloning and the sequence of the
            original IFRD1 homolog isolated in mouse as TPA-inducible immediate
            early gene (named Tis7).
REFERENCE   9  (residues 1 to 449)
  AUTHORS   Tippetts,M.T., Varnum,B.C., Lim,R.W. and Herschman,H.R.
  TITLE     Tumor promoter-inducible genes are differentially expressed in the
            developing mouse
  JOURNAL   Mol Cell Biol 8 (10), 4570-4572 (1988)
   PUBMED   3185562
REFERENCE   10 (residues 1 to 449)
  AUTHORS   Skup,D., Windass,J.D., Sor,F., George,H., Williams,B.R.,
            Fukuhara,H., De Maeyer-Guignard,J. and De Maeyer,E.
  TITLE     Molecular cloning of partial cDNA copies of two distinct mouse
            IFN-beta mRNAs
  JOURNAL   Nucleic Acids Res 10 (10), 3069-3084 (1982)
   PUBMED   6179042
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157571.6 and AC174598.2.
            
            On Apr 1, 2009 this sequence version replaced NP_038590.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043723.1, AK078888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 18.06 cM"
     Protein         1..449
                     /product="interferon-related developmental regulator 1"
                     /note="nerve growth factor-inducible protein PC4;
                     TPA-induced sequence 7"
                     /calculated_mol_wt=49804
     Region          1..42
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P19182.2)"
     Region          50..345
                     /region_name="IFRD"
                     /note="Interferon-related developmental regulator (IFRD);
                     pfam05004"
                     /db_xref="CDD:461515"
     Region          390..443
                     /region_name="IFRD_C"
                     /note="Interferon-related protein conserved region;
                     pfam04836"
                     /db_xref="CDD:461452"
     CDS             1..449
                     /gene="Ifrd1"
                     /gene_synonym="Ifnl; PC4; Tis7"
                     /coded_by="NM_013562.3:230..1579"
                     /db_xref="CCDS:CCDS25893.1"
                     /db_xref="GeneID:15982"
                     /db_xref="MGI:MGI:1316717"
ORIGIN      
        1 mpknkkrnap hrgggggggs gaatsaatag gphrtvqpfs dedasietms hcsgysdpss
       61 faedgpevld eegtqedley klkglidltl dksaktrqaa leglknalss kvlyefvler
      121 rmtltdsier clkkgksdeq raaaavasvl ciqlgpgfes eeilktlgpi lkkiicdgaa
      181 siqarqtcat cfgvccfiat dditelystl ecfeniftks ylkekdtnvt cstpntvlhi
      241 ssllawtlll ticpinevkk klelhfhklp sllscddvnm riaageslal lfelargmes
      301 dffyedmdsl tqmlralatd gnkhrakvdk rkqrsvfrdv lraveerdfp tetvkfgper
      361 myidswvkkh tydtfkevlg sgmqyhlqtn eflrnvfelg ppvmldaatl ktmkisrfer
      421 hlynsaafka rtkarskcrd kradvgefl
//
