LOCUS       NM_197889               1462 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus interferon zeta (Ifnz), mRNA.
ACCESSION   NM_197889 XM_131436
VERSION     NM_197889.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Cochet M, Vaiman D and Lefevre F.
  TITLE     Novel interferon delta genes in mammals: cloning of one gene from
            the sheep, two genes expressed by the horse conceptus and discovery
            of related sequences in several taxa by genomic database screening
  JOURNAL   Gene 433 (1-2), 88-99 (2009)
   PUBMED   19110041
  REMARK    Erratum:[Gene. 2009 15;439(1-2):113]
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Ishida N, Oritani K, Shiraga M, Yoshida H, Kawamoto S, Ujiie H,
            Masaie H, Ichii M, Tomiyama Y and Kanakura Y.
  TITLE     Differential effects of a novel IFN-zeta/limitin and IFN-alpha on
            signals for Daxx induction and Crk phosphorylation that couple with
            growth control of megakaryocytes
  JOURNAL   Exp Hematol 33 (4), 495-503 (2005)
   PUBMED   15781341
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   van Pesch V, Lanaya H, Renauld JC and Michiels T.
  TITLE     Characterization of the murine alpha interferon gene family
  JOURNAL   J Virol 78 (15), 8219-8228 (2004)
   PUBMED   15254193
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Aoki K, Shimoda K, Oritani K, Matsuda T, Kamezaki K, Muromoto R,
            Numata A, Tamiya S, Haro T, Ishikawa F, Takase K, Yamamoto T,
            Yumioka T, Miyamoto T, Nagafuji K, Gondo H, Nagafuchi S, Nakayama K
            and Harada M.
  TITLE     Limitin, an interferon-like cytokine, transduces inhibitory signals
            on B-cell growth through activation of Tyk2, but not Stat1,
            followed by induction and nuclear translocation of Daxx
  JOURNAL   Exp Hematol 31 (12), 1317-1322 (2003)
   PUBMED   14662340
  REMARK    GeneRIF: Limitin suppresses B-cell growth through activation of
            Tyk2, resulting in the up-regulation and nuclear translocation of
            Daxx
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Oritani K, Hirota S, Nakagawa T, Takahashi I, Kawamoto S, Yamada M,
            Ishida N, Kadoya T, Tomiyama Y, Kincade PW and Matsuzawa Y.
  TITLE     T lymphocytes constitutively produce an interferonlike cytokine
            limitin characterized as a heat- and acid-stable and
            heparin-binding glycoprotein
  JOURNAL   Blood 101 (1), 178-185 (2003)
   PUBMED   12393653
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Oritani K, Kincade PW, Zhang C, Tomiyama Y and Matsuzawa Y.
  TITLE     Type I interferons and limitin: a comparison of structures,
            receptors, and functions
  JOURNAL   Cytokine Growth Factor Rev 12 (4), 337-348 (2001)
   PUBMED   11544103
  REMARK    Review article
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Oritani K, Medina KL, Tomiyama Y, Ishikawa J, Okajima Y, Ogawa M,
            Yokota T, Aoyama K, Takahashi I, Kincade PW and Matsuzawa Y.
  TITLE     Limitin: An interferon-like cytokine that preferentially influences
            B-lymphocyte precursors
  JOURNAL   Nat Med 6 (6), 659-666 (2000)
   PUBMED   10835682
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK046550.1.
            
            On Apr 5, 2007 this sequence version replaced NM_197889.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK046550.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1462              AK046550.1         2-1463
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 42.03 cM"
     gene            1..1462
                     /gene="Ifnz"
                     /gene_synonym="6030405N23Rik; BGIF; If1ha4; Lmtn"
                     /note="interferon zeta"
                     /db_xref="GeneID:319146"
                     /db_xref="MGI:MGI:2448469"
     exon            1..1462
                     /gene="Ifnz"
                     /gene_synonym="6030405N23Rik; BGIF; If1ha4; Lmtn"
                     /inference="alignment:Splign:2.1.0"
     CDS             656..1204
                     /gene="Ifnz"
                     /gene_synonym="6030405N23Rik; BGIF; If1ha4; Lmtn"
                     /note="limitin; interferon 1ha4"
                     /codon_start=1
                     /product="interferon zeta precursor"
                     /protein_id="NP_922871.1"
                     /db_xref="CCDS:CCDS18333.1"
                     /db_xref="GeneID:319146"
                     /db_xref="MGI:MGI:2448469"
                     /translation="MLPVHLFLVGGVMLSCSPASSLDSGKSGSLHLERSETARFLAEL
                     RSVPGHQCLRDRTDFPCPWKEGTNITPMTLGETTSCYSQTLKQVLHLFDTEASRAAWH
                     ERALDQLLSSLWRELQVLKRPREQGQSCPLPFALAIRTYFRGFFRYLKAKAYSACSWE
                     IVRVQLQVDLPAFPLSARRGPR"
     regulatory      1443..1448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifnz"
                     /gene_synonym="6030405N23Rik; BGIF; If1ha4; Lmtn"
                     /note="putative"
     polyA_site      1462
                     /gene="Ifnz"
                     /gene_synonym="6030405N23Rik; BGIF; If1ha4; Lmtn"
                     /note="putative"
ORIGIN      
        1 tccctgctca gcagagctcc tgagaggaga ggggcaagac catactgtct gtcctctctc
       61 tggaactgtc tgcctgttgg ggcccagctc tcctctctgc caactccact tccttcttct
      121 ccactcgcgt tagagagctg gaagggtctg gcgggccacc caaacgcacc aagatgcgaa
      181 acaaacaaac gaaaggaaac cgaaccaaag gagaccaaac caaacccagc ctagccaaac
      241 caaaacgctg ctctctgggc tttggagcct tcccggttcc ccgaaaacat gtcccctggc
      301 ccaccaattc cgtctgggtt caattctcaa ggcgcgatgg atggcgtaca gtcctgtacg
      361 cgaaggggcc cgggagagag gcaggagaca ctccctgcct gcccggagtc gagcgctgaa
      421 cggggcgaac ggcctccgca ggcgcccgct gctgccctcc ggtggcccgc gccctctgct
      481 gctgctcctg gcctcagaag tcgcgtccag cgtccagcgc agcgcaggca gtcagcgagc
      541 aagagcccga agctccgagt gaactattaa agcagcaaac tccaggctca atgggaaggc
      601 ggccttgccc tcgcgctccc cctgcaggcc agccccgcaa tcgtcaggct tcagcatgct
      661 gcctgtgcat ctattcctgg tgggaggggt gatgctgagc tgcagcccag ccagctcact
      721 tgattctggt aaatctggga gcctgcacct ggagcgcagc gaaaccgcgc gcttcctagc
      781 agagctccga agcgtgccgg gtcaccagtg cctgcgggac aggaccgatt tcccatgtcc
      841 ctggaaggaa ggaactaaca tcacaccgat gactctggga gaaaccacca gttgctactc
      901 ccagaccctc aagcaggtcc tccacctctt tgacacagag gccagcagag ctgcctggca
      961 cgagagggcg ctggaccagc tactatctag cctgtggcgt gagctgcaag tgctgaagag
     1021 gccaagagag cagggccagt cctgtccact gccttttgcc ctggccatcc gcacctactt
     1081 ccgaggtttc ttccgctatc tgaaggcaaa ggcatacagc gcttgctcct gggagatcgt
     1141 cagagtccaa ttgcaagtgg accttccagc gttcccactg tctgcgagaa gaggcccaag
     1201 atgaggagaa gccccgtgca ggaatctctc tgctctcgtg acaccacgca ccctctctcc
     1261 attcaaagca gacgcacgga ttcggattca gcaccaacag gcgaaatggg cgtgcatcga
     1321 caaagaactt cgagttcttt atgtcttccc tgccagaggc cccgaagcat cctactgtac
     1381 atcatacact gcgaaagatg tttgtaagaa aacctgtgct cttgcatttg aggtggcttc
     1441 tgaataaatt gatgatctcg gt
//
