LOCUS       NM_174851               4267 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus interferon lambda receptor 1 (Ifnlr1), mRNA.
ACCESSION   NM_174851
VERSION     NM_174851.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4267)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell (2024) In press
   PUBMED   39500322
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4267)
  AUTHORS   Ashby,K.M., Voboril,M., Salgado,O.C., Lee,S.T., Martinez,R.J.,
            O'Connor,C.H., Breed,E.R., Xuan,S., Roll,C.R., Bachigari,S.,
            Heiland,H., Stetson,D.B., Kotenko,S.V. and Hogquist,K.A.
  TITLE     Sterile production of interferons in the thymus affects T cell
            repertoire selection
  JOURNAL   Sci Immunol 9 (97), eadp1139 (2024)
   PUBMED   39058762
REFERENCE   3  (bases 1 to 4267)
  AUTHORS   Sojati,J., Parks,O.B., Zhang,Y., Walters,S., Lan,J., Eddens,T.,
            Lou,D., Fan,L., Chen,K., Oury,T.D. and Williams,J.V.
  TITLE     IFN-lambda drives distinct lung immune landscape changes and
            antiviral responses in human metapneumovirus infection
  JOURNAL   mBio 15 (5), e0055024 (2024)
   PUBMED   38530032
REFERENCE   4  (bases 1 to 4267)
  AUTHORS   Aggarwal,S., Walker,F.C., Weagley,J.S., McCune,B.T., Wu,X.,
            Schriefer,L.A., Makimaa,H., Lawrence,D., Sridhar,P. and
            Baldridge,M.T.
  TITLE     Interferons and tuft cell numbers are bottlenecks for persistent
            murine norovirus infection
  JOURNAL   PLoS Pathog 20 (5), e1011961 (2024)
   PUBMED   38701091
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4267)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4267)
  AUTHORS   Frieman,M.B., Chen,J., Morrison,T.E., Whitmore,A., Funkhouser,W.,
            Ward,J.M., Lamirande,E.W., Roberts,A., Heise,M., Subbarao,K. and
            Baric,R.S.
  TITLE     SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type
            I, II and III interferon receptor independent mechanism
  JOURNAL   PLoS Pathog 6 (4), e1000849 (2010)
   PUBMED   20386712
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4267)
  AUTHORS   Mordstein,M., Kochs,G., Dumoutier,L., Renauld,J.C., Paludan,S.R.,
            Klucher,K. and Staeheli,P.
  TITLE     Interferon-lambda contributes to innate immunity of mice against
            influenza A virus but not against hepatotropic viruses
  JOURNAL   PLoS Pathog 4 (9), e1000151 (2008)
   PUBMED   18787692
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4267)
  AUTHORS   Ank,N., Iversen,M.B., Bartholdy,C., Staeheli,P., Hartmann,R.,
            Jensen,U.B., Dagnaes-Hansen,F., Thomsen,A.R., Chen,Z., Haugen,H.,
            Klucher,K. and Paludan,S.R.
  TITLE     An important role for type III interferon (IFN-lambda/IL-28) in
            TLR-induced antiviral activity
  JOURNAL   J Immunol 180 (4), 2474-2485 (2008)
   PUBMED   18250457
REFERENCE   9  (bases 1 to 4267)
  AUTHORS   Lasfar,A., Lewis-Antes,A., Smirnov,S.V., Anantha,S., Abushahba,W.,
            Tian,B., Reuhl,K., Dickensheets,H., Sheikh,F., Donnelly,R.P.,
            Raveche,E. and Kotenko,S.V.
  TITLE     Characterization of the mouse IFN-lambda ligand-receptor system:
            IFN-lambdas exhibit antitumor activity against B16 melanoma
  JOURNAL   Cancer Res 66 (8), 4468-4477 (2006)
   PUBMED   16618774
REFERENCE   10 (bases 1 to 4267)
  AUTHORS   Kotenko,S.V., Gallagher,G., Baurin,V.V., Lewis-Antes,A., Shen,M.,
            Shah,N.K., Langer,J.A., Sheikh,F., Dickensheets,H. and
            Donnelly,R.P.
  TITLE     IFN-lambdas mediate antiviral protection through a distinct class
            II cytokine receptor complex
  JOURNAL   Nat Immunol 4 (1), 69-77 (2003)
   PUBMED   12483210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662911.21.
            
            On Sep 7, 2022 this sequence version replaced NM_174851.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057856.1, AK141338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               AL662911.21        30822-31219
            399-522             AL662911.21        35142-35265
            523-704             AL662911.21        43410-43591
            705-847             AL662911.21        45848-45990
            848-1007            AL662911.21        48330-48489
            1008-1138           AL662911.21        48789-48919
            1139-4267           AL662911.21        49673-52801
FEATURES             Location/Qualifiers
     source          1..4267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.94 cM"
     gene            1..4267
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /note="interferon lambda receptor 1"
                     /db_xref="GeneID:242700"
                     /db_xref="MGI:MGI:2429859"
     exon            1..398
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /inference="alignment:Splign:2.1.0"
     exon            399..522
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /inference="alignment:Splign:2.1.0"
     exon            523..704
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /inference="alignment:Splign:2.1.0"
     exon            705..847
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1007
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1138
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..4267
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4242..4247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /note="hexamer: AATAAA"
     polyA_site      4267
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /note="major polyA site"
ORIGIN      
        1 aagcctgccg ggaattcctg cagaaactca gtaagaaact cgcaagacag gctgggtgcc
       61 atcccccgct ccgcctgcaa aacgggagtc ttgccagtct cctcgaactc taccctaggt
      121 gctatttact cctcaacgga accccagaac tggatttctt gtctgatttt taaaaaatgt
      181 tactgagagc cccgccccca cccacggcag gcgacgcggg gcagccctag gtgaatcccc
      241 accggtggca ccgccggagg ctcctcctcc ctgggccgcc gcccttgtca cctgccgccc
      301 aggggccttg cggcgggcgg cggggacccc agggaccgaa atgtggcggg ccgaccggtg
      361 ggcgccccta ctcctgttcc tgttgcagag cgccctagga aggccccgtc tagccccacc
      421 cagaaacgtg acactcttct cccagaactt cactgtttac ctgacatggc ttccggggct
      481 tgggagcccc ccaaatgtga cctatttcgt gacctaccaa agctatatca aaaccggttg
      541 gcgaccagtg gagcattgtg caggtatcaa ggctctggtg tgtcccctga tgtgcctgaa
      601 gaaactgaac ctgtactcca agttcaaagg acgagtacag gcagcttccg cacacggcag
      661 gtccccacgg gtggagtccc ggtacctgga ataccttttt gacgtggagc tagccccgcc
      721 caccctggtg ctcacccaga tggagaagat cctaagggtc aacgctacct accagctgcc
      781 accttgcatg ccgtcgctgg aactgaagta ccaggtggaa ttctggaagg agggtctggg
      841 aagcaagacc ctgtttcctg acactcccta tggccagcca gtgcagattc ctctccagca
      901 aggtgctagc cgacgccact gcctcagcgc cagaaccgtc tataccttaa ttgacattaa
      961 gtacagccag ttctctgagc ccagctgcat cttcctagag gctccagggg acaaaagagc
     1021 tgtcctggca atgccctcac tcttgcttct actgatagca gccgttgcag caggtgtggc
     1081 atggaagata atgaaaggaa acccctggtt tcagggggtg aagacgcccc gggcactgga
     1141 cttttctgaa tacagatacc cagtggcaac ctttcagccc agtggacctg agttctctga
     1201 tgacttgatc ctttgtcccc agaaggaact gaccataagg aacaggccag cccctcaggt
     1261 cagaaaccca gccacgctac aggcaggacc agaaagagac agtactgagg atgaagacga
     1321 ggacacagac tacgatgacg acggtgacag cgtccagccc tacctggaac ggcccctctt
     1381 catcagcgag aagccccggg ttatggaaca ctcggagaca gacgagtctg gggtggattc
     1441 aggggggcct tggacatccc cagttgggag tgacggctcc tctgcatggg actcttcaga
     1501 caggagctgg tccagcacag gggactcctc atataaggat gaagttgggt cttccagctg
     1561 tttggaccga aaggagccgg accaggcgcc ctgtggggat tggctccagg aggctctccc
     1621 atgcctggaa ttttctgagg acttgggcac cgtggaagag cctctgaagg atggcctctc
     1681 cgggtggagg atttctggtt ccttatcctc aaagagagat ctggctcctg tggagccccc
     1741 agtttctctt cagacactga ctttctgctg ggtcaacaat cctgaggggg aggaggaaca
     1801 ggaggacgag gaggaagagg aggaggagga ggaggaggaa gactgggaat cagaacctaa
     1861 gggcagcaat gccggctgtt ggggcacttc aagcgtgcag aggacggagg tcaggggccg
     1921 gatgctggga gattacttgg tcaggtgagc tggccctggt ggtccatcta cacattctct
     1981 actgcacttc ccctggacca cagacacctc cgagagtcat gtccctttga gtggtagcca
     2041 aggtcctggc cattcgtaat ggatctttat ggcactttgt cgttgggatt gagttgtaag
     2101 atgtcaccat ttccaatgac ccaccagcta taggtgacct gtgagcggga cagagctgtg
     2161 atcagagact agttgagttc caatctgccc attgtccctg ggatgacggg cctgatggaa
     2221 aaatcatcct gtgataaaat gaaacaggtg aagccaggtg actgtggaca ccaagggtag
     2281 atacgcccta gtccataagt cacacacagc attgcgcaaa acagacctcg gtccaaatca
     2341 ctactctgct gtttctgata gtcactgagc aagcgactct taacctctca acctcagctt
     2401 ccccttctgc agcagtcctg tgggtatggg gaggtaacag gtgacacagg gccaccaatg
     2461 tcacatgtac tgactaggca ctagaaccct ccatcaatcc agactcctgg gagaccccag
     2521 gcatctctcc ccagcaactc ctaagccaag agtgataaga catcgacctt ccaacctgtc
     2581 tgccctctag gtcaccccat ttcttccttg ccaccttcta ttcaggggct cctggaaacc
     2641 acagcccaac caactttgct tcgttctcaa gcatagtaca ccttccaggg tcgacattgg
     2701 ttggttcagg gcagaaactg cactcctggc ctggtgtcct ttttgaatgg cattgtatca
     2761 gggtttaagt ttttttgggt gtgtttgttt gtttgtttgt ttgtttgttt ttatctgttt
     2821 tggctataat gaggttccag tatctgagaa gctagtgtct tttgaaaaca ggtgactgtc
     2881 ctttttgggg tgtgatgtgt gtccttgtgg ctgaggatct aaacagacca tgaagcagga
     2941 aagagctcac agccccttta ctctcggagc tgtgtggctc tgaggctggc ataaagccat
     3001 agccttacag aactcatgtg aagacccccc ccccgtaagg cagaggttct caaccttcct
     3061 aacactacca gccttaaaca gtgttccttg tggtgtggtg acccccaatc ataaaatcat
     3121 ttcattgcta cttcataatt ataattttgc tattggtatg aatcacaatg tgttttccaa
     3181 tggtctcagg caaccactgt gaaaacgtca atggaccccc aaaggggtca tgacccacac
     3241 aggctgagaa acatgacctt aagggcatct gactcaaggg ttctctagct cattcccaaa
     3301 ggcctttggg gctccaggat cctcactctt caatgggagt ggcctcactc agctaatgca
     3361 catgtagtgg ctttacataa aaggtgtctt gaaaggggtt cacagctaac aaaacctcaa
     3421 atcactgtcc ttggtacata tctgtattgt ttcaaacaaa cttggatgtc aactagcaag
     3481 gctgccctag tgacttcatt tgtgtgtccc caagagtccc cagagtcacc aatctgacag
     3541 gaggtctttg caagcacctc tgggacacac acacacacac acacacacac acacacctac
     3601 ctctctgggg tttccctaca atgatgtttg accacatcac tgagcccaga agcagaacaa
     3661 atgcacatgc gtgagggcgg tcagagcacg ggagaagccc ctagaaatgt cccagcaagg
     3721 ccagtgtcct tcctgagact cagctgagct gcaccacgga ggatgctctg tcaggaatcc
     3781 ttggaaatga tggtgatgac agcattggcc tcgcctttca agcttgctct ctccggtagt
     3841 ccttactgtt tacagtgttt cccaatgttt tctttctgat ctagccttcc tgtcattctt
     3901 aatcctagct cctttcagcc attaggtcat tgacagaaga cctgtgggaa gcctgtggaa
     3961 agggcgggag gtgcaaccca gaagttcata atgtgtgctc agcacttaac ttacataata
     4021 gccctgtaca cagacagcct ccggggacct caaggagagc aagatcagag tgaccgcctg
     4081 gagtcagtgt ggtgggcagc ttcggcacac tgaggctata cgtcttacgt gtttgtatta
     4141 cctgtcttgc atgtttgtat ttttgtcgaa atcgtgccct gtattttata ccctatttaa
     4201 gtaatacttt aatatctgtt ggtataatac ccaaaacctt aaataaagag atttattttt
     4261 agagaaa
//
