LOCUS       NM_177396                582 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus interferon lambda 3 (Ifnl3), mRNA.
ACCESSION   NM_177396
VERSION     NM_177396.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 582)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell 187 (26), 7533-7550 (2024)
   PUBMED   39500322
REFERENCE   2  (bases 1 to 582)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 582)
  AUTHORS   De,M., Sukla,S., Bharatiya,S., Keshri,S., Roy,D.G., Roy,S.,
            Dutta,D., Saha,S., Ejazi,S.A., Ravichandiran,V., Ali,N.,
            Chatterjee,M. and Chinnaswamy,S.
  TITLE     IFN-lambda3 is induced by Leishmania donovani and can inhibit
            parasite growth in cell line models but not in the mouse model,
            while it shows a significant association with leishmaniasis in
            humans
  JOURNAL   Infect Immun 92 (2), e0050423 (2024)
   PUBMED   38193711
  REMARK    GeneRIF: IFN-lambda3 is induced by Leishmania donovani and can
            inhibit parasite growth in cell line models but not in the mouse
            model, while it shows a significant association with leishmaniasis
            in humans.
REFERENCE   4  (bases 1 to 582)
  AUTHORS   Ingle,H., Makimaa,H., Aggarwal,S., Deng,H., Foster,L., Li,Y.,
            Kennedy,E.A., Peterson,S.T., Wilen,C.B., Lee,S., Suthar,M.S. and
            Baldridge,M.T.
  TITLE     IFN-lambda derived from nonsusceptible enterocytes acts on tuft
            cells to limit persistent norovirus
  JOURNAL   Sci Adv 9 (37), eadi2562 (2023)
   PUBMED   37703370
REFERENCE   5  (bases 1 to 582)
  AUTHORS   Rich,H.E., Antos,D., McCourt,C.C., Zheng,W.Q., Devito,L.J.,
            McHugh,K.J., Gopal,R., Wang,J. and Alcorn,J.F.
  TITLE     Murine Type III interferons are functionally redundant and
            correlate with bacterial burden during influenza/bacterial
            super-infection
  JOURNAL   PLoS One 16 (10), e0255309 (2021)
   PUBMED   34618816
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 582)
  AUTHORS   Lasfar,A., Lewis-Antes,A., Smirnov,S.V., Anantha,S., Abushahba,W.,
            Tian,B., Reuhl,K., Dickensheets,H., Sheikh,F., Donnelly,R.P.,
            Raveche,E. and Kotenko,S.V.
  TITLE     Characterization of the mouse IFN-lambda ligand-receptor system:
            IFN-lambdas exhibit antitumor activity against B16 melanoma
  JOURNAL   Cancer Res 66 (8), 4468-4477 (2006)
   PUBMED   16618774
REFERENCE   7  (bases 1 to 582)
  AUTHORS   Bartlett,N.W., Buttigieg,K., Kotenko,S.V. and Smith,G.L.
  TITLE     Murine interferon lambdas (type III interferons) exhibit potent
            antiviral activity in vivo in a poxvirus infection model
  JOURNAL   J Gen Virol 86 (Pt 6), 1589-1596 (2005)
   PUBMED   15914836
REFERENCE   8  (bases 1 to 582)
  AUTHORS   Robek,M.D., Boyd,B.S. and Chisari,F.V.
  TITLE     Lambda interferon inhibits hepatitis B and C virus replication
  JOURNAL   J Virol 79 (6), 3851-3854 (2005)
   PUBMED   15731279
  REMARK    GeneRIF: IFN-lambda inhibits HBV replication and blocks replication
            of a subgenomic and a full-length genomic HCV replicon
REFERENCE   9  (bases 1 to 582)
  AUTHORS   Kotenko,S.V. and Langer,J.A.
  TITLE     Full house: 12 receptors for 27 cytokines
  JOURNAL   Int Immunopharmacol 4 (5), 593-608 (2004)
   PUBMED   15120645
  REMARK    Review article
REFERENCE   10 (bases 1 to 582)
  AUTHORS   Kotenko,S.V., Gallagher,G., Baurin,V.V., Lewis-Antes,A., Shen,M.,
            Shah,N.K., Langer,J.A., Sheikh,F., Dickensheets,H. and
            Donnelly,R.P.
  TITLE     IFN-lambdas mediate antiviral protection through a distinct class
            II cytokine receptor complex
  JOURNAL   Nat Immunol 4 (1), 69-77 (2003)
   PUBMED   12483210
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY184375.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY184375.1, AY869696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.81 cM"
     gene            1..582
                     /gene="Ifnl3"
                     /gene_synonym="If1ia2; IFL-1; IL-28B; Il28; Il28b;
                     INF-alpha; INF-lambda"
                     /note="interferon lambda 3"
                     /db_xref="GeneID:338374"
                     /db_xref="MGI:MGI:2450574"
     CDS             1..582
                     /gene="Ifnl3"
                     /gene_synonym="If1ia2; IFL-1; IL-28B; Il28; Il28b;
                     INF-alpha; INF-lambda"
                     /note="interleukin 28; interleukin-28B; IFN-lambda-3;
                     interferon alpha; interferon 1ia2"
                     /codon_start=1
                     /product="interferon lambda-3 precursor"
                     /protein_id="NP_796370.1"
                     /db_xref="CCDS:CCDS21047.1"
                     /db_xref="GeneID:338374"
                     /db_xref="MGI:MGI:2450574"
                     /translation="MLLLLLPLLLAAVLTRTQADPVPRATRLPVEAKDCHIAQFKSLS
                     PKELQAFKKAKGAIEKRLLEKDMRCSSHLISRAWDLKQLQVQERPKALQAEVALTLKV
                     WENINDSALTTILGQPLHTLSHIHSQLQTCTQLQATAEPKPPSRRLSRWLHRLQEAQS
                     KETPGCLEDSVTSNLFQLLLRDLKCVASGDQCV"
     exon            1..174
                     /gene="Ifnl3"
                     /gene_synonym="If1ia2; IFL-1; IL-28B; Il28; Il28b;
                     INF-alpha; INF-lambda"
                     /inference="alignment:Splign:2.1.0"
     exon            175..252
                     /gene="Ifnl3"
                     /gene_synonym="If1ia2; IFL-1; IL-28B; Il28; Il28b;
                     INF-alpha; INF-lambda"
                     /inference="alignment:Splign:2.1.0"
     exon            253..396
                     /gene="Ifnl3"
                     /gene_synonym="If1ia2; IFL-1; IL-28B; Il28; Il28b;
                     INF-alpha; INF-lambda"
                     /inference="alignment:Splign:2.1.0"
     exon            397..483
                     /gene="Ifnl3"
                     /gene_synonym="If1ia2; IFL-1; IL-28B; Il28; Il28b;
                     INF-alpha; INF-lambda"
                     /inference="alignment:Splign:2.1.0"
     exon            484..582
                     /gene="Ifnl3"
                     /gene_synonym="If1ia2; IFL-1; IL-28B; Il28; Il28b;
                     INF-alpha; INF-lambda"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctcctcc tgctgttgcc tctgctgctg gccgcagtgc tgacaagaac ccaagctgac
       61 cctgtcccca gggccaccag gctcccagtg gaagcaaagg attgccacat tgctcagttc
      121 aagtctctgt ccccaaaaga gctgcaggcc ttcaaaaagg ccaagggtgc catcgagaag
      181 aggctgcttg agaaggacat gaggtgcagt tcccacctca tctccagggc ctgggacctg
      241 aagcagctgc aggtccaaga gcgccccaag gccttgcagg ctgaggtggc cctgaccctg
      301 aaggtctggg agaacataaa tgactcagcc ctgaccacca tcctgggcca gcctcttcat
      361 acactgagcc acattcactc ccagctgcag acctgtacac agcttcaggc cacagcagag
      421 cccaagcccc cgagtcgccg cctctcccgc tggctgcaca ggctccagga ggcccagagc
      481 aaggagactc ctggctgcct ggaggactct gtcacctcca acctgtttca actgctcctc
      541 cgggacctca agtgtgtggc cagtggagac cagtgtgtct ga
//
