LOCUS       NM_001024673             582 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus interferon lambda 2 (Ifnl2), mRNA.
ACCESSION   NM_001024673 XM_284291
VERSION     NM_001024673.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 582)
  AUTHORS   Zhang,J., Cheng,D., Zhang,H., Liu,Z., Gao,M., Wei,L., Yan,F.,
            Li,C., Wang,L., Dong,G., Wang,C., Zhao,M., Zhu,Y. and Xiong,H.
  TITLE     Interleukin 28A aggravates Con A-induced acute liver injury by
            promoting the recruitment of M1 macrophages
  JOURNAL   FASEB J 38 (2), e23443 (2024)
   PUBMED   38265281
  REMARK    GeneRIF: Interleukin 28A aggravates Con A-induced acute liver
            injury by promoting the recruitment of M1 macrophages.
REFERENCE   2  (bases 1 to 582)
  AUTHORS   Ingle,H., Makimaa,H., Aggarwal,S., Deng,H., Foster,L., Li,Y.,
            Kennedy,E.A., Peterson,S.T., Wilen,C.B., Lee,S., Suthar,M.S. and
            Baldridge,M.T.
  TITLE     IFN-lambda derived from nonsusceptible enterocytes acts on tuft
            cells to limit persistent norovirus
  JOURNAL   Sci Adv 9 (37), eadi2562 (2023)
   PUBMED   37703370
REFERENCE   3  (bases 1 to 582)
  AUTHORS   Chong,Z., Karl,C.E., Halfmann,P.J., Kawaoka,Y., Winkler,E.S.,
            Keeler,S.P., Holtzman,M.J., Yu,J. and Diamond,M.S.
  TITLE     Nasally delivered interferon-lambda protects mice against infection
            by SARS-CoV-2 variants including Omicron
  JOURNAL   Cell Rep 39 (6), 110799 (2022)
   PUBMED   35523172
REFERENCE   4  (bases 1 to 582)
  AUTHORS   Peterson,S.T., Kennedy,E.A., Brigleb,P.H., Taylor,G.M., Urbanek,K.,
            Bricker,T.L., Lee,S., Shin,H., Dermody,T.S., Boon,A.C.M. and
            Baldridge,M.T.
  TITLE     Disruption of Type III Interferon (IFN) Genes Ifnl2 and Ifnl3
            Recapitulates Loss of the Type III IFN Receptor in the Mucosal
            Antiviral Response
  JOURNAL   J Virol 93 (22), e01073-19 (2019)
   PUBMED   31462571
  REMARK    GeneRIF: Results support the idea of an exclusive role for known
            type III interferon cytokines in signaling via IFNLR to mediate
            antiviral effects at mucosal surfaces. These findings emphasize the
            importance of type III interferons in regulation of a variety of
            viral pathogens and provide important genetic evidence to support
            our understanding of the ligand-receptor interactions in this
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 582)
  AUTHORS   Jacobs,S., Zeippen,C., Wavreil,F., Gillet,L. and Michiels,T.
  TITLE     IFN-lambda Decreases Murid Herpesvirus-4 Infection of the Olfactory
            Epithelium but Fails to Prevent Virus Reactivation in the Vaginal
            Mucosa
  JOURNAL   Viruses 11 (8), 757 (2019)
   PUBMED   31426334
  REMARK    GeneRIF: IFN-lambda Decreases Murid Herpesvirus-4 Infection of the
            Olfactory Epithelium but Fails to Prevent Virus Reactivation in the
            Vaginal Mucosa.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 582)
  AUTHORS   Okamoto,M., Oshiumi,H., Azuma,M., Kato,N., Matsumoto,M. and Seya,T.
  TITLE     IPS-1 is essential for type III IFN production by hepatocytes and
            dendritic cells in response to hepatitis C virus infection
  JOURNAL   J Immunol 192 (6), 2770-2777 (2014)
   PUBMED   24532585
  REMARK    GeneRIF: Data indicate that IPS-1-dependent pathway plays a crucial
            role in type III IFN production by CD8(+) dendritic cells (DCs) and
            hepatocytes in response to hepatitis C virus (HCV), leading to
            cytoplasmic antiviral protein expressions.
REFERENCE   7  (bases 1 to 582)
  AUTHORS   Pott,J., Mahlakoiv,T., Mordstein,M., Duerr,C.U., Michiels,T.,
            Stockinger,S., Staeheli,P. and Hornef,M.W.
  TITLE     IFN-lambda determines the intestinal epithelial antiviral host
            defense
  JOURNAL   Proc Natl Acad Sci U S A 108 (19), 7944-7949 (2011)
   PUBMED   21518880
REFERENCE   8  (bases 1 to 582)
  AUTHORS   Lasfar,A., Lewis-Antes,A., Smirnov,S.V., Anantha,S., Abushahba,W.,
            Tian,B., Reuhl,K., Dickensheets,H., Sheikh,F., Donnelly,R.P.,
            Raveche,E. and Kotenko,S.V.
  TITLE     Characterization of the mouse IFN-lambda ligand-receptor system:
            IFN-lambdas exhibit antitumor activity against B16 melanoma
  JOURNAL   Cancer Res 66 (8), 4468-4477 (2006)
   PUBMED   16618774
REFERENCE   9  (bases 1 to 582)
  AUTHORS   Bartlett,N.W., Buttigieg,K., Kotenko,S.V. and Smith,G.L.
  TITLE     Murine interferon lambdas (type III interferons) exhibit potent
            antiviral activity in vivo in a poxvirus infection model
  JOURNAL   J Gen Virol 86 (Pt 6), 1589-1596 (2005)
   PUBMED   15914836
REFERENCE   10 (bases 1 to 582)
  AUTHORS   Kotenko,S.V. and Langer,J.A.
  TITLE     Full house: 12 receptors for 27 cytokines
  JOURNAL   Int Immunopharmacol 4 (5), 593-608 (2004)
   PUBMED   15120645
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC149606.6.
            
            On Mar 14, 2007 this sequence version replaced NM_001024673.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY869695.1, BC150796.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849379,
                                           SAMN00849383 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC149606.6         2984-3157
            175-252             AC149606.6         3630-3707
            253-396             AC149606.6         3971-4114
            397-483             AC149606.6         4216-4302
            484-582             AC149606.6         4385-4483
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.8 cM"
     gene            1..582
                     /gene="Ifnl2"
                     /gene_synonym="EG330496; If1ia1; IL-28A; Il28a"
                     /note="interferon lambda 2"
                     /db_xref="GeneID:330496"
                     /db_xref="MGI:MGI:3647279"
     CDS             1..582
                     /gene="Ifnl2"
                     /gene_synonym="EG330496; If1ia1; IL-28A; Il28a"
                     /note="interferon-lambda2; interleukin-28A; IFN-lambda2;
                     IFN-lambda-2; interferon 1ia1"
                     /codon_start=1
                     /product="interferon lambda-2 precursor"
                     /protein_id="NP_001019844.2"
                     /db_xref="CCDS:CCDS39861.1"
                     /db_xref="GeneID:330496"
                     /db_xref="MGI:MGI:3647279"
                     /translation="MLLLLLPLLLAAVLTRTQADPVPRATRLPVEAKDCHIAQFKSLS
                     PKELQAFKKAKDAIEKRLLEKDLRCSSHLFPRAWDLKQLQVQERPKALQAEVALTLKV
                     WENMTDSALATILGQPLHTLSHIHSQLQTCTQLQATAEPRSPSRRLSRWLHRLQEAQS
                     KETPGCLEASVTSNLFRLLTRDLKCVANGDQCV"
     exon            1..174
                     /gene="Ifnl2"
                     /gene_synonym="EG330496; If1ia1; IL-28A; Il28a"
                     /inference="alignment:Splign:2.1.0"
     exon            175..252
                     /gene="Ifnl2"
                     /gene_synonym="EG330496; If1ia1; IL-28A; Il28a"
                     /inference="alignment:Splign:2.1.0"
     exon            253..396
                     /gene="Ifnl2"
                     /gene_synonym="EG330496; If1ia1; IL-28A; Il28a"
                     /inference="alignment:Splign:2.1.0"
     exon            397..483
                     /gene="Ifnl2"
                     /gene_synonym="EG330496; If1ia1; IL-28A; Il28a"
                     /inference="alignment:Splign:2.1.0"
     exon            484..582
                     /gene="Ifnl2"
                     /gene_synonym="EG330496; If1ia1; IL-28A; Il28a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctcctcc tgctgttgcc tctgctgctg gccgcagtgc tgacaagaac ccaagctgac
       61 cctgtcccca gggccaccag gctcccagtg gaagcaaagg attgccacat tgctcagttc
      121 aagtctctgt ccccaaaaga gctgcaggcc ttcaaaaagg ccaaggatgc catcgagaag
      181 aggctgcttg agaaggacct gaggtgcagt tcccacctct tccccagggc ctgggacctg
      241 aagcagctgc aggtccaaga gcgccccaag gccttgcagg ctgaggtggc cctgaccctg
      301 aaggtctggg agaacatgac tgactcagcc ctggccacca tcctgggcca gcctcttcat
      361 acactgagcc acattcactc ccagctgcag acctgtacac agcttcaggc cacagcagag
      421 cccaggtccc cgagccgccg cctctcccgc tggctgcaca ggctccagga ggcccagagc
      481 aaggagaccc ctggctgcct ggaggcctct gtcacctcca acctgtttcg cctgctcacc
      541 cgggacctca agtgtgtggc caatggagac cagtgtgtct ga
//
