LOCUS       NM_199157                872 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus interferon kappa (Ifnk), mRNA.
ACCESSION   NM_199157
VERSION     NM_199157.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 872)
  AUTHORS   Philip,D.T., Goins,N.M., Catanzaro,N.J., Misumi,I., Whitmire,J.K.,
            Atkins,H.M. and Lazear,H.M.
  TITLE     Interferon lambda restricts herpes simplex virus skin disease by
            suppressing neutrophil-mediated pathology
  JOURNAL   mBio 15 (4), e0262323 (2024)
   PUBMED   38426749
REFERENCE   2  (bases 1 to 872)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 872)
  AUTHORS   Gharaee-Kermani,M., Estadt,S.N., Tsoi,L.C., Wolf-Fortune,S.J.,
            Liu,J., Xing,X., Theros,J., Reed,T.J., Lowe,L., Gruszka,D.,
            Ward,N.L., Gudjonsson,J.E. and Kahlenberg,J.M.
  TITLE     IFN-kappa Is a Rheostat for Development of Psoriasiform
            Inflammation
  JOURNAL   J Invest Dermatol 142 (1), 155-165 (2022)
   PUBMED   34364883
  REMARK    GeneRIF: IFN-kappa Is a Rheostat for Development of Psoriasiform
            Inflammation.
REFERENCE   4  (bases 1 to 872)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 872)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 872)
  AUTHORS   Vassileva,G., Chen,S.C., Zeng,M., Abbondanzo,S., Jensen,K.,
            Gorman,D., Baroudy,B.M., Jiang,Y., Murgolo,N. and Lira,S.A.
  TITLE     Expression of a novel murine type I IFN in the pancreatic islets
            induces diabetes in mice
  JOURNAL   J Immunol 170 (11), 5748-5755 (2003)
   PUBMED   12759458
  REMARK    GeneRIF: Mouse IFN-kappa is expressed at low levels in peritoneal
            macrophages, its expression up-regulated by double-stranded RNA and
            IFN-gamma; transgenic mice overexpressing murine IFN-kappa in the
            pancreatic islets develop overt diabetes with hyperglycemia.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099376.1.
            
            On Jul 31, 2005 this sequence version replaced NM_199157.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099376.1, CK023191.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 17.08 cM"
     gene            1..872
                     /gene="Ifnk"
                     /gene_synonym="If1fa"
                     /note="interferon kappa"
                     /db_xref="GeneID:387510"
                     /db_xref="MGI:MGI:2683287"
     exon            1..587
                     /gene="Ifnk"
                     /gene_synonym="If1fa"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..619
                     /gene="Ifnk"
                     /gene_synonym="If1fa"
                     /note="IFN-kappa; interferon 1fa"
                     /codon_start=1
                     /product="interferon kappa precursor"
                     /protein_id="NP_954608.1"
                     /db_xref="CCDS:CCDS18037.1"
                     /db_xref="GeneID:387510"
                     /db_xref="MGI:MGI:2683287"
                     /translation="MTPKFLWLVALVALYIPPIQSLNCVYLDDSILENVKLLGSTMTG
                     FPLRCLKDITDFKFPKEILPYIQHMKREINAVSYRISSLALTIFNLKGSIPPVTEEHW
                     ERIRSGLFKQVRQAQECFMDEEKENREHPHSEDFLTVYLELGKYFFRIKKFLINKKYS
                     FCAWKIVTVEIRRCFIIFSKSRKLLKMISESPTFKQELK"
     exon            588..820
                     /gene="Ifnk"
                     /gene_synonym="If1fa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaagcacca gggttgagaa tgactccaaa gtttttatgg ctggtggccc ttgtggctct
       61 atacattccg cccatccaat ctctgaactg tgtttacctg gatgatagca tcttggaaaa
      121 tgtgaaactt ctgggcagta ccatgaccgg ctttccctta agatgtctaa aagatatcac
      181 agattttaag tttcctaaag agattttgcc atacatccag catatgaaaa gggagataaa
      241 cgccgtctcc tatcgtatat cctctctggc actaactatc ttcaatctta aaggctccat
      301 ccctccagtg acagaggaac actgggaacg tatcagatcg ggacttttca aacaagtgcg
      361 gcaagctcaa gagtgcttca tggacgagga gaaagagaac agggaacatc ctcactccga
      421 ggacttcctg acagtctacc tggagttggg caagtatttc ttcagaatca aaaagttcct
      481 gataaataag aaatacagtt tctgtgcatg gaagattgtc acagtggaaa taagaagatg
      541 tttcattata ttttccaagt ccagaaaact actcaaaatg atatcagaat cacccacctt
      601 caagcaagaa cttaaataga agctgcaatt gctcaaatgt ctccaagaac gctttattct
      661 aaagccatta ccaggatgct gctaatgcta ccttcagatg caagactttt caagttcagg
      721 gttcaaggca gtgcagtcaa agaaagtctt aagcaaaaga tgaacttcag tggaaaagtt
      781 agcagaaatg ttaacttata ataaaaccaa agttatacat aaaaaaaaaa aaaaaaaaaa
      841 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
