LOCUS       NM_008338               2105 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus interferon gamma receptor 2 (Ifngr2), mRNA.
ACCESSION   NM_008338 XM_982759
VERSION     NM_008338.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Friedline,R.H., Noh,H.L., Suk,S., Albusharif,M., Dagdeviren,S.,
            Saengnipanthkul,S., Kim,B., Kim,A.M., Kim,L.H., Tauer,L.A., Baez
            Torres,N.M., Choi,S., Kim,B.Y., Rao,S.D., Kasina,K., Sun,C.,
            Toles,B.J., Zhou,C., Li,Z., Benoit,V.M., Patel,P.R., Zheng,D.X.T.,
            Inashima,K., Beaverson,A., Hu,X., Tran,D.A., Muller,W.,
            Greiner,D.L., Mullen,A.C., Lee,K.W. and Kim,J.K.
  TITLE     IFNgamma-IL12 axis regulates intercellular crosstalk in metabolic
            dysfunction-associated steatotic liver disease
  JOURNAL   Nat Commun 15 (1), 5506 (2024)
   PUBMED   38951527
  REMARK    Erratum:[Nat Commun. 2024 Jul 23;15(1):6195. doi:
            10.1038/s41467-024-50607-3. PMID: 39043691]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2105)
  AUTHORS   Martin,A.T., Giri,S., Safronova,A., Eliseeva,S.I., Kwok,S.F. and
            Yarovinsky,F.
  TITLE     Parasite-induced IFN-gamma regulates host defense via CD115 and
            mTOR-dependent mechanism of tissue-resident macrophage death
  JOURNAL   PLoS Pathog 20 (2), e1011502 (2024)
   PUBMED   38377133
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2105)
  AUTHORS   Munoz-Ruiz,M., Llorian,M., D'Antuono,R., Pavlova,A.,
            Mavrigiannaki,A.M., McKenzie,D., Garcia-Cassani,B., Iannitto,M.L.,
            Wu,Y., Dart,R., Davies,D., Jamal-Hanjani,M., Jandke,A.,
            Ushakov,D.S. and Hayday,A.C.
  TITLE     IFN-gamma-dependent interactions between tissue-intrinsic
            gammadelta T cells and tissue-infiltrating CD8 T cells limit
            allergic contact dermatitis
  JOURNAL   J Allergy Clin Immunol 152 (6), 1520-1540 (2023)
   PUBMED   37562754
REFERENCE   4  (bases 1 to 2105)
  AUTHORS   Krug,J., Rodrian,G., Petter,K., Yang,H., Khoziainova,S., Guo,W.,
            Benard,A., Merkel,S., Gellert,S., Maschauer,S., Spermann,M.,
            Waldner,M., Bailey,P., Pilarsky,C., Liebl,A., Tripal,P.,
            Christoph,J., Naschberger,E., Croner,R., Schellerer,V.S.,
            Becker,C., Hartmann,A., Tuting,T., Prante,O., Grutzmann,R.,
            Grivennikov,S.I., Sturzl,M. and Britzen-Laurent,N.
  TITLE     N-glycosylation Regulates Intrinsic IFN-gamma Resistance in
            Colorectal Cancer: Implications for Immunotherapy
  JOURNAL   Gastroenterology 164 (3), 392-406 (2023)
   PUBMED   36402190
REFERENCE   5  (bases 1 to 2105)
  AUTHORS   Garnier,L., Pick,R., Montorfani,J., Sun,M., Brighouse,D.,
            Liaudet,N., Kammertoens,T., Blankenstein,T., Page,N.,
            Bernier-Latamani,J., Tran,N.L., Petrova,T.V., Merkler,D.,
            Scheiermann,C. and Hugues,S.
  TITLE     IFN-gamma-dependent tumor-antigen cross-presentation by lymphatic
            endothelial cells promotes their killing by T cells and inhibits
            metastasis
  JOURNAL   Sci Adv 8 (23), eabl5162 (2022)
   PUBMED   35675399
REFERENCE   6  (bases 1 to 2105)
  AUTHORS   Ebensperger,C., Rhee,S., Muthukumaran,G., Lembo,D., Donnelly,R.,
            Pestka,S. and Dembic,Z.
  TITLE     Genomic organization and promoter analysis of the gene ifngr2
            encoding the second chain of the mouse interferon-gamma receptor
  JOURNAL   Scand J Immunol 44 (6), 599-606 (1996)
   PUBMED   8972742
REFERENCE   7  (bases 1 to 2105)
  AUTHORS   Mariano,T.M., Muthukumaran,G., Donnelly,R.J., Wang,N.,
            Adamson,M.C., Pestka,S. and Kozak,C.A.
  TITLE     Genetic mapping of the gene for the mouse interferon-gamma receptor
            signaling subunit to the distal end of chromosome 16
  JOURNAL   Mamm Genome 7 (4), 321-322 (1996)
   PUBMED   8661709
REFERENCE   8  (bases 1 to 2105)
  AUTHORS   Marsters,S.A., Pennica,D., Bach,E., Schreiber,R.D. and Ashkenazi,A.
  TITLE     Interferon gamma signals via a high-affinity multisubunit receptor
            complex that contains two types of polypeptide chain
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5401-5405 (1995)
   PUBMED   7777519
REFERENCE   9  (bases 1 to 2105)
  AUTHORS   Hemmi,S., Bohni,R., Stark,G., Di Marco,F. and Aguet,M.
  TITLE     A novel member of the interferon receptor family complements
            functionality of the murine interferon gamma receptor in human
            cells
  JOURNAL   Cell 76 (5), 803-810 (1994)
   PUBMED   8124717
REFERENCE   10 (bases 1 to 2105)
  AUTHORS   Hibino,Y., Mariano,T.M., Kumar,C.S., Kozak,C.A. and Pestka,S.
  TITLE     Expression and reconstitution of a biologically active mouse
            interferon gamma receptor in hamster cells. Chromosomal location of
            an accessory factor
  JOURNAL   J Biol Chem 266 (11), 6948-6951 (1991)
   PUBMED   1826681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159199.3.
            
            On Apr 18, 2018 this sequence version replaced NM_008338.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055745.1, AK165193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC159199.3         156628-156801
            175-307             AC159199.3         164517-164649
            308-501             AC159199.3         167454-167647
            502-650             AC159199.3         169546-169694
            651-810             AC159199.3         170114-170273
            811-968             AC159199.3         171189-171346
            969-2105            AC159199.3         172440-173576
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.07 cM"
     gene            1..2105
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /note="interferon gamma receptor 2"
                     /db_xref="GeneID:15980"
                     /db_xref="MGI:MGI:107654"
     exon            1..174
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1103
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /codon_start=1
                     /product="interferon gamma receptor 2 precursor"
                     /protein_id="NP_032364.1"
                     /db_xref="CCDS:CCDS28327.1"
                     /db_xref="GeneID:15980"
                     /db_xref="MGI:MGI:107654"
                     /translation="MRPLPLWLPSLLLCGLGAAASSPDSFSQLAAPLNPRLHLYNDEQ
                     ILTWEPSPSSNDPRPVVYQVEYSFIDGSWHRLLEPNCTDITETKCDLTGGGRLKLFPH
                     PFTVFLRVRAKRGNLTSKWVGLEPFQHYENVTVGPPKNISVTPGKGSLVIHFSPPFDV
                     FHGATFQYLVHYWEKSETQQEQVEGPFKSNSIVLGNLKPYRVYCLQTEAQLILKNKKI
                     RPHGLLSNVSCHETTANASARLQQVILIPLGIFALLLGLTGACFTLFLKYQSRVKYWF
                     QAPPNIPEQIEEYLKDPDQFILEVLDKDGSPKEDSWDSVSIISSPEKERDDVLQTP"
     exon            175..307
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /inference="alignment:Splign:2.1.0"
     exon            308..501
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /inference="alignment:Splign:2.1.0"
     exon            502..650
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /inference="alignment:Splign:2.1.0"
     exon            651..810
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /inference="alignment:Splign:2.1.0"
     exon            811..968
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /inference="alignment:Splign:2.1.0"
     exon            969..2105
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2083..2088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /note="hexamer: AATAAA"
     polyA_site      2105
                     /gene="Ifngr2"
                     /gene_synonym="Ifgr2; Ifgt"
                     /note="major polyA site"
ORIGIN      
        1 ggctctgcgg ctaggctggg gaagaggcgg gcgctcggct cgccatggcc gctgcggtgc
       61 gagtctgagc ggcgtccacc ccgcggtccc gggccgcccg ggccatgcgg cctttgccac
      121 tgtggctgcc gtcgctgctg ctctgtgggc tcggtgccgc ggcgtcctcg ccagactcgt
      181 tttcccagct tgcggcccct ctgaacccaa ggcttcacct gtacaatgat gagcagattc
      241 taacttggga gccgtcacct tccagcaatg acccaagacc agtggtctac caggtggaat
      301 atagcttcat cgatggctct tggcataggt tgctggagcc gaactgtacg gacatcacag
      361 agacaaagtg tgacttaaca ggaggcggcc gcttgaagct tttcccacac ccattcacag
      421 tcttcctgcg ggtgcgagcc aagcgaggga acctcacttc caagtgggtg gggctggagc
      481 catttcaaca ctatgagaat gttactgttg gacctccgaa aaacatctcg gtgaccccag
      541 gaaaaggttc cctcgtcata cacttctccc ctccctttga tgtgttccac ggggcaactt
      601 ttcagtatct tgtccactac tgggaaaagt cagaaaccca acaggaacag gttgaaggcc
      661 ctttcaagag caactccatt gtgctgggca atctgaagcc atacagagta tattgtttac
      721 aaactgaggc acaactgatt ttgaaaaaca aaaaaatccg accacatggg ctcttgagca
      781 atgtatcctg tcacgaaaca acagcaaatg cctccgccag gctgcagcaa gtcatcctga
      841 ttccgttggg catcttcgca ttgctgctcg gcctgacggg cgcctgcttc accctgttcc
      901 tcaaatacca aagccgagtg aagtactggt ttcaggctcc gccaaacatc ccggaacaaa
      961 tcgaagagta tctaaaggac ccagaccaat tcatcttaga ggtcttggac aaggacggtt
     1021 caccgaagga ggactcctgg gactccgtgt caattatttc ttctccagaa aaggagcgag
     1081 atgatgtgct ccaaacaccg tgaaccaggc cagggtctct gcttgcccag gagggcagcg
     1141 atcagtgcac ccgagagaga tccccagggc cccaggactg gggaagatgg tgtagtgttt
     1201 gttctttatg agttttctgg atgctacaag tatttaaaag gattccacag aaagatatct
     1261 cagaaacaaa acaaaaacaa aaacaaacca agcgcttctc ttaaacacta aaaagacaac
     1321 tgctcattac tggcaacgtg gcggcaaacc tgtgtgtggt gctttctcca gtgttagctg
     1381 cccctgctgt cagaagactg ggtccttcct tgccttcact ctggaaaatg agttgtccca
     1441 gccaaccctg cctgtcacaa agaggggccc ttagtgtccc cttcatgtcc aatgtgatgg
     1501 cttaaatgtg agacccctgg gctcggtgct tgcctagcac gtacacgccc cacccacccc
     1561 agcacctcac tcacagagag gtgattaatc ttgtaaataa tgtcctggta atttaagtct
     1621 tttttttttt tttttaatct agagataaaa gattgtatgt taaacttttt ttttttttaa
     1681 gtctatctgc cgggtggtgg tggtgcacac ctttactcct ggcacttggg aggcagaggc
     1741 aggaggatct ctgtgagttc gaggccagcc tggtctagag tcctggtcta ggacagccaa
     1801 ggctacacag agaaaccctg tctggtaaac aaaacaggaa aaagaagtgc acgtgtttct
     1861 tcttttcttg tcccttacca cgtcgccttc tttgcctgtt ttccgtaaag tattgacttg
     1921 tgaaaagtct tagccaggca tggtgacaca tgcctttatt cccagcactt gaaagcagag
     1981 gccagtagat ttctgtgagt ttgaggccag cctggtctac atagtgagtt ccaggacagc
     2041 cagggctatg tagagagatc ctggctctct aaataaataa taaataaata ccaaacttaa
     2101 aaata
//
