LOCUS       NM_008337               1210 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interferon gamma (Ifng), mRNA.
ACCESSION   NM_008337
VERSION     NM_008337.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1210)
  AUTHORS   Lin,C.I., Wang,Y.W., Su,K.Y. and Chuang,Y.H.
  TITLE     Interleukin-37 exacerbates liver inflammation and promotes
            IFN-gamma production in NK cells
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113086 (2024)
   PUBMED   39260304
  REMARK    GeneRIF: Interleukin-37 exacerbates liver inflammation and promotes
            IFN-gamma production in NK cells.
REFERENCE   2  (bases 1 to 1210)
  AUTHORS   Qin,Y., Qian,Y., Liu,S. and Chen,R.
  TITLE     A double-edged sword role of IFN-gamma-producing iNKT cells in
            sepsis: Persistent suppression of Treg cell formation in an
            Nr4a1-dependent manner
  JOURNAL   iScience 27 (12), 111462 (2024)
   PUBMED   39720538
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1210)
  AUTHORS   Rodenberg,R.R., Spadafora,D., Fitzpatrick,S., Daly,G., Lausch,R.
            and Barrington,R.A.
  TITLE     gammadelta T17 Cells Regulate the Acute Antiviral Response of NK
            Cells in HSV-1-Infected Corneas
  JOURNAL   Invest Ophthalmol Vis Sci 65 (13), 16 (2024)
   PUBMED   39504049
REFERENCE   4  (bases 1 to 1210)
  AUTHORS   Khan,M.Z., Hunt,D.M., Singha,B., Kapoor,Y., Singh,N.K.,
            Prasad,D.V.S., Dharmarajan,S., Sowpati,D.T., de Carvalho,L.P.S. and
            Nandicoori,V.K.
  TITLE     Divergent downstream biosynthetic pathways are supported by
            <sc>L</sc>-cysteine synthases of Mycobacterium tuberculosis
  JOURNAL   Elife 12, 91970 (2024)
   PUBMED   39207917
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1210)
  AUTHORS   Dalton,D.K., Pitts-Meek,S., Keshav,S., Figari,I.S., Bradley,A. and
            Stewart,T.A.
  TITLE     Multiple defects of immune cell function in mice with disrupted
            interferon-gamma genes
  JOURNAL   Science 259 (5102), 1739-1742 (1993)
   PUBMED   8456300
REFERENCE   6  (bases 1 to 1210)
  AUTHORS   Beier,D.R., Dushkin,H. and Sussman,D.J.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   7  (bases 1 to 1210)
  AUTHORS   Shimizu,A., Sakai,Y., Ohno,K., Masaki,S., Kuwano,R., Takahashi,Y.,
            Miyashita,N. and Watanabe,T.
  TITLE     A molecular genetic linkage map of mouse chromosome 10, including
            the Myb, S100b, Pah, Sl, and Ifg genes
  JOURNAL   Biochem Genet 30 (9-10), 529-535 (1992)
   PUBMED   1359872
REFERENCE   8  (bases 1 to 1210)
  AUTHORS   Crnic,L.S. and Segall,M.A.
  TITLE     Behavioral effects of mouse interferons-alpha and -gamma and human
            interferon-alpha in mice
  JOURNAL   Brain Res 590 (1-2), 277-284 (1992)
   PUBMED   1422836
REFERENCE   9  (bases 1 to 1210)
  AUTHORS   Salkowski,C.A. and Vogel,S.N.
  TITLE     IFN-gamma mediates increased glucocorticoid receptor expression in
            murine macrophages
  JOURNAL   J Immunol 148 (9), 2770-2777 (1992)
   PUBMED   1315358
REFERENCE   10 (bases 1 to 1210)
  AUTHORS   Hamilton,T.A., Bredon,N., Ohmori,Y. and Tannenbaum,C.S.
  TITLE     IFN-gamma and IFN-beta independently stimulate the expression of
            lipopolysaccharide-inducible genes in murine peritoneal macrophages
  JOURNAL   J Immunol 142 (7), 2325-2331 (1989)
   PUBMED   2494257
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153498.17.
            
            On Sep 10, 2015 this sequence version replaced NM_008337.3.
            
            Summary: This gene encodes a soluble cytokine that is a member of
            the type II interferon class. The encoded protein is secreted by
            cells of both the innate and adaptive immune systems. The active
            protein is a homodimer that binds to the interferon gamma receptor
            which triggers a cellular response to viral and microbial
            infections. Mice deficient in this gene have increased
            susceptibility to viral, bacterial and parasitic infections and to
            several autoimmune diseases. [provided by RefSeq, Dec 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M28621.1, K00083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC153498.17        64549-64768         c
            221-286             AC153498.17        63289-63354         c
            287-469             AC153498.17        63019-63201         c
            470-1210            AC153498.17        59920-60660         c
FEATURES             Location/Qualifiers
     source          1..1210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 66.75 cM"
     gene            1..1210
                     /gene="Ifng"
                     /gene_synonym="If2f; Ifg; IFN-g"
                     /note="interferon gamma"
                     /db_xref="GeneID:15978"
                     /db_xref="MGI:MGI:107656"
     exon            1..220
                     /gene="Ifng"
                     /gene_synonym="If2f; Ifg; IFN-g"
                     /inference="alignment:Splign:2.1.0"
     exon            221..286
                     /gene="Ifng"
                     /gene_synonym="If2f; Ifg; IFN-g"
                     /inference="alignment:Splign:2.1.0"
     exon            287..469
                     /gene="Ifng"
                     /gene_synonym="If2f; Ifg; IFN-g"
                     /inference="alignment:Splign:2.1.0"
     exon            470..1210
                     /gene="Ifng"
                     /gene_synonym="If2f; Ifg; IFN-g"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1187..1192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifng"
                     /gene_synonym="If2f; Ifg; IFN-g"
                     /note="hexamer: AATAAA"
     polyA_site      1210
                     /gene="Ifng"
                     /gene_synonym="If2f; Ifg; IFN-g"
                     /note="major polyA site"
ORIGIN      
        1 tatagctgcc atcggctgac ctagagaaga cacatcagct gatcctttgg accctctgac
       61 ttgagacaga agttctgggc ttctcctcct gcggcctagc tctgagacaa tgaacgctac
      121 acactgcatc ttggctttgc agctcttcct catggctgtt tctggctgtt actgccacgg
      181 cacagtcatt gaaagcctag aaagtctgaa taactatttt aactcaagtg gcatagatgt
      241 ggaagaaaag agtctcttct tggatatctg gaggaactgg caaaaggatg gtgacatgaa
      301 aatcctgcag agccagatta tctctttcta cctcagactc tttgaagtct tgaaagacaa
      361 tcaggccatc agcaacaaca taagcgtcat tgaatcacac ctgattacta ccttcttcag
      421 caacagcaag gcgaaaaagg atgcattcat gagtattgcc aagtttgagg tcaacaaccc
      481 acaggtccag cgccaagcat tcaatgagct catccgagtg gtccaccagc tgttgccgga
      541 atccagcctc aggaagcgga aaaggagtcg ctgctgattc ggggtgggga agagattgtc
      601 ccaataagaa taattctgcc agcactattt gaatttttaa atctaaacct atttattaat
      661 atttaaaact atttatatgg agaatctatt ttagatgcat caaccaaaga agtatttata
      721 gtaacaactt atatgtgata agagtgaatt cctattaata tatgtgttat ttataatttc
      781 tgtctcctca actatttctc tttgaccaat taattattct ttctgactaa ttagccaaga
      841 ctgtgattgc ggggttgtat ctgggggtgg gggacagcca agcggctgac tgaactcaga
      901 ttgtagcttg tacctttact tcactgacca ataagaaaca ttcagagctg cagtgacccc
      961 gggaggtgct gctgatggga ggagatgtct acactccggg ccagcgcttt aacagcaggc
     1021 cagacagcac tcgaatgtgt caggtagtaa caggctgtcc ctgaaagaaa gcagtgtctc
     1081 aagagacttg acacctggtg cttccctata cagctgaaaa ctgtgactac acccgaatga
     1141 caaataactc gctcatttat agtttatcac tgtctaattg catatgaata aagtatacct
     1201 ttgcaaccaa
//
