LOCUS       NM_177348                664 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus interferon epsilon (Ifne), mRNA.
ACCESSION   NM_177348
VERSION     NM_177348.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 664)
  AUTHORS   Fung,K.Y., de Geus,E.D., Ying,L., Cumming,H., Bourke,N.,
            Foster,S.C. and Hertzog,P.J.
  TITLE     Expression of Interferon Epsilon in Mucosal Epithelium is Regulated
            by Elf3
  JOURNAL   Mol Cell Biol 44 (8), 334-343 (2024)
   PUBMED   38975675
  REMARK    GeneRIF: Expression of Interferon Epsilon in Mucosal Epithelium is
            Regulated by Elf3.
REFERENCE   2  (bases 1 to 664)
  AUTHORS   Marks,Z.R.C., Campbell,N.K., Mangan,N.E., Vandenberg,C.J.,
            Gearing,L.J., Matthews,A.Y., Gould,J.A., Tate,M.D., Wray-McCann,G.,
            Ying,L., Rosli,S., Brockwell,N., Parker,B.S., Lim,S.S.,
            Bilandzic,M., Christie,E.L., Stephens,A.N., de Geus,E.,
            Wakefield,M.J., Ho,G.Y., McNally,O., McNeish,I.A., Bowtell,D.D.L.,
            de Weerd,N.A., Scott,C.L., Bourke,N.M. and Hertzog,P.J.
  CONSRTM   Australian Ovarian Cancer Study
  TITLE     Interferon-epsilon is a tumour suppressor and restricts ovarian
            cancer
  JOURNAL   Nature 620 (7976), 1063-1070 (2023)
   PUBMED   37587335
REFERENCE   3  (bases 1 to 664)
  AUTHORS   Coldbeck-Shackley,R.C., Romeo,O., Rosli,S., Gearing,L.J.,
            Gould,J.A., Lim,S.S., Van der Hoek,K.H., Eyre,N.S., Shue,B.,
            Robertson,S.A., Best,S.M., Tate,M.D., Hertzog,P.J. and Beard,M.R.
  TITLE     Constitutive expression and distinct properties of IFN-epsilon
            protect the female reproductive tract from Zika virus infection
  JOURNAL   PLoS Pathog 19 (3), e1010843 (2023)
   PUBMED   36897927
  REMARK    GeneRIF: Constitutive expression and distinct properties of
            IFN-epsilon protect the female reproductive tract from Zika virus
            infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 664)
  AUTHORS   Hermant,P., Francius,C., Clotman,F. and Michiels,T.
  TITLE     IFN-epsilon is constitutively expressed by cells of the
            reproductive tract and is inefficiently secreted by fibroblasts and
            cell lines
  JOURNAL   PLoS One 8 (8), e71320 (2013)
   PUBMED   23951133
  REMARK    GeneRIF: IFN-epsilon is constitutively expressed by cells of the
            reproductive tract and is inefficiently secreted by fibroblasts and
            cell lines.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 664)
  AUTHORS   Fung,K.Y., Mangan,N.E., Cumming,H., Horvat,J.C., Mayall,J.R.,
            Stifter,S.A., De Weerd,N., Roisman,L.C., Rossjohn,J.,
            Robertson,S.A., Schjenken,J.E., Parker,B., Gargett,C.E.,
            Nguyen,H.P., Carr,D.J., Hansbro,P.M. and Hertzog,P.J.
  TITLE     Interferon-epsilon protects the female reproductive tract from
            viral and bacterial infection
  JOURNAL   Science 339 (6123), 1088-1092 (2013)
   PUBMED   23449591
  REMARK    GeneRIF: Ifn-epsilon-deficient mice had increased susceptibility to
            infection of the female reproductive tract by the common sexually
            transmitted infections (STIs) herpes simplex virus 2 and Chlamydia
            muridarum.
REFERENCE   6  (bases 1 to 664)
  AUTHORS   Kwiatkowski,A.V., Rubinson,D.A., Dent,E.W., Edward van Veen,J.,
            Leslie,J.D., Zhang,J., Mebane,L.M., Philippar,U., Pinheiro,E.M.,
            Burds,A.A., Bronson,R.T., Mori,S., Fassler,R. and Gertler,F.B.
  TITLE     Ena/VASP Is Required for neuritogenesis in the developing cortex
  JOURNAL   Neuron 56 (3), 441-455 (2007)
   PUBMED   17988629
REFERENCE   7  (bases 1 to 664)
  AUTHORS   Hervas-Stubbs,S., Rueda,P., Lopez,L. and Leclerc,C.
  TITLE     Insect baculoviruses strongly potentiate adaptive immune responses
            by inducing type I IFN
  JOURNAL   J Immunol 178 (4), 2361-2369 (2007)
   PUBMED   17277142
  REMARK    Erratum:[J Immunol. 2007 May 15;178(10):6653]
REFERENCE   8  (bases 1 to 664)
  AUTHORS   Chen,J., Baig,E. and Fish,E.N.
  TITLE     Diversity and relatedness among the type I interferons
  JOURNAL   J Interferon Cytokine Res 24 (12), 687-698 (2004)
   PUBMED   15684736
REFERENCE   9  (bases 1 to 664)
  AUTHORS   Hardy,M.P., Owczarek,C.M., Jermiin,L.S., Ejdeback,M. and
            Hertzog,P.J.
  TITLE     Characterization of the type I interferon locus and identification
            of novel genes
  JOURNAL   Genomics 84 (2), 331-345 (2004)
   PUBMED   15233997
REFERENCE   10 (bases 1 to 664)
  AUTHORS   Harada,K. and Yamagishi,H.
  TITLE     Lack of feedback inhibition of V kappa gene rearrangement by
            productively rearranged alleles
  JOURNAL   J Exp Med 173 (2), 409-415 (1991)
   PUBMED   1988542
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY190044.1.
            
            On Jun 3, 2003 this sequence version replaced NM_177348.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY190044.1, BC104376.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 42.04 cM"
     gene            1..664
                     /gene="Ifne"
                     /gene_synonym="If1ea; Ifn-tau-1; Ifne1; Ifnt1; Infe1"
                     /note="interferon epsilon"
                     /db_xref="GeneID:230405"
                     /db_xref="MGI:MGI:2667156"
     exon            1..664
                     /gene="Ifne"
                     /gene_synonym="If1ea; Ifn-tau-1; Ifne1; Ifnt1; Infe1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..601
                     /gene="Ifne"
                     /gene_synonym="If1ea; Ifn-tau-1; Ifne1; Ifnt1; Infe1"
                     /note="interferon epsilon 1; interferon tau-1;
                     IFN-epsilon; interferon 1ea"
                     /codon_start=1
                     /product="interferon epsilon precursor"
                     /protein_id="NP_796322.1"
                     /db_xref="CCDS:CCDS18348.1"
                     /db_xref="GeneID:230405"
                     /db_xref="MGI:MGI:2667156"
                     /translation="MVHRQLPETVLLLLVSSTIFSLEPKRIPFQLWMNRESLQLLKPL
                     PSSSVQQCLAHRKNFLLPQQPVSPHQYQEGQVLAVVHEILQQIFTLLQTHGTMGIWEE
                     NHIEKVLAALHRQLEYVESLGGLNAAQKSGGSSAQNLRLQIKAYFRRIHDYLENQRYS
                     SCAWIIVQTEIHRCMFFVFRFTTWLSRQDPDP"
ORIGIN      
        1 agatccctgt gtgccctcca ccatggttca cagacagctc cctgaaacgg tgttgctgct
       61 cttggtttct tccactatct tctccctaga accgaaacgg attcccttcc aattgtggat
      121 gaacagagaa agcctacaac tactgaaacc tttgccaagc tcgtcagtcc agcagtgtct
      181 agcacacagg aagaatttcc tgcttcctca gcagcctgtg agtcctcacc agtaccaaga
      241 gggacaggtg ctggctgttg tgcacgagat ccttcagcag atcttcacgc tcctccagac
      301 acatgggact atgggcattt gggaggaaaa ccatatagaa aaagtcttag ctgcgcttca
      361 ccggcagctg gaatacgtgg agtcactggg tggactgaac gcagcgcaga agagtggggg
      421 ctcgagtgcg cagaacctta ggttacagat taaagcatac ttcaggagga tccacgatta
      481 cttggaaaac caaaggtaca gcagctgtgc ctggatcatt gtccagacag aaatccaccg
      541 ctgtatgttc tttgtgttca ggttcacaac atggctgagc agacaagacc cagacccttg
      601 aacactgaga agcaagagcc aacaggggat ttgaaagaca taggttggtg gcggagtggg
      661 agga
//
