LOCUS       NM_010510                831 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus interferon beta 1, fibroblast (Ifnb1), mRNA.
ACCESSION   NM_010510
VERSION     NM_010510.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 831)
  AUTHORS   Wei,W., Gao,X., Qian,J., Li,L., Zhao,C., Xu,L., Zhu,Y., Liu,Z.,
            Liu,N., Wang,X., Jin,Z., Liu,B., Xu,L., Dong,J., Zhang,S., Wang,J.,
            Zhang,Y., Yu,Y., Yan,Z., Yang,Y., Lu,J., Fang,Y., Yuan,N. and
            Wang,J.
  TITLE     Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal
            hematopoiesis and survival
  JOURNAL   J Clin Invest 135 (3), e177375 (2025)
   PUBMED   39589832
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 831)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity 57 (9), 2077-2094 (2024)
   PUBMED   38906145
REFERENCE   3  (bases 1 to 831)
  AUTHORS   Ashby,K.M., Voboril,M., Salgado,O.C., Lee,S.T., Martinez,R.J.,
            O'Connor,C.H., Breed,E.R., Xuan,S., Roll,C.R., Bachigari,S.,
            Heiland,H., Stetson,D.B., Kotenko,S.V. and Hogquist,K.A.
  TITLE     Sterile production of interferons in the thymus affects T cell
            repertoire selection
  JOURNAL   Sci Immunol 9 (97), eadp1139 (2024)
   PUBMED   39058762
REFERENCE   4  (bases 1 to 831)
  AUTHORS   Imai,T., Lin,J., Kaya,G.G., Ju,E., Kondylis,V., Kelepouras,K.,
            Liccardi,G., Kim,C. and Pasparakis,M.
  TITLE     The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death
            and inflammation
  JOURNAL   Immunity 57 (7), 1497-1513 (2024)
   PUBMED   38744293
REFERENCE   5  (bases 1 to 831)
  AUTHORS   Singh,H., Koury,J., Maung,R., Roberts,A.J. and Kaul,M.
  TITLE     Interferon-beta deficiency alters brain response to chronic HIV-1
            envelope protein exposure in a transgenic model of NeuroHIV
  JOURNAL   Brain Behav Immun 118, 1-21 (2024)
   PUBMED   38360376
  REMARK    GeneRIF: Interferon-beta deficiency alters brain response to
            chronic HIV-1 envelope protein exposure in a transgenic model of
            NeuroHIV.
REFERENCE   6  (bases 1 to 831)
  AUTHORS   Senda,T., Shimazu,T., Matsuda,S., Kawano,G., Shimizu,H.,
            Nakamura,K.T. and Mitsui,Y.
  TITLE     Three-dimensional crystal structure of recombinant murine
            interferon-beta
  JOURNAL   EMBO J 11 (9), 3193-3201 (1992)
   PUBMED   1505514
REFERENCE   7  (bases 1 to 831)
  AUTHORS   Cornall,R.J., Friedman,J.M. and Todd,J.A.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   8  (bases 1 to 831)
  AUTHORS   Tanaka,N. and Taniguchi,T.
  TITLE     Cytokine gene regulation: regulatory cis-elements and DNA binding
            factors involved in the interferon system
  JOURNAL   Adv Immunol 52, 263-281 (1992)
   PUBMED   1442307
  REMARK    Review article
REFERENCE   9  (bases 1 to 831)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   10 (bases 1 to 831)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772316.6.
            
            On Sep 13, 2022 this sequence version replaced NM_010510.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: K00020.1, BC119395.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-831               AL772316.6         134165-134995       c
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 41.91 cM"
     gene            1..831
                     /gene="Ifnb1"
                     /gene_synonym="If1da1; Ifb; IFN-beta; IFNB"
                     /note="interferon beta 1, fibroblast"
                     /db_xref="GeneID:15977"
                     /db_xref="MGI:MGI:107657"
     exon            1..831
                     /gene="Ifnb1"
                     /gene_synonym="If1da1; Ifb; IFN-beta; IFNB"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..621
                     /gene="Ifnb1"
                     /gene_synonym="If1da1; Ifb; IFN-beta; IFNB"
                     /note="interferon 1da1"
                     /codon_start=1
                     /product="interferon beta precursor"
                     /protein_id="NP_034640.1"
                     /db_xref="CCDS:CCDS18318.1"
                     /db_xref="GeneID:15977"
                     /db_xref="MGI:MGI:107657"
                     /translation="MNNRWILHAAFLLCFSTTALSINYKQLQLQERTNIRKCQELLEQ
                     LNGKINLTYRADFKIPMEMTEKMQKSYTAFAIQEMLQNVFLVFRNNFSSTGWNETIVV
                     RLLDELHQQTVFLKTVLEEKQEERLTWEMSSTALHLKSYYWRVQRYLKLMKYNSYAWM
                     VVRAEIFRNFLIIRRLTRNFQN"
ORIGIN      
        1 attctcactg cagcctttga cagcctttgc ctcatcttgc aggtagcagc cgacaccagc
       61 ctggcttcca tcatgaacaa caggtggatc ctccacgctg cgttcctgct gtgcttctcc
      121 accacagccc tctccatcaa ctataagcag ctccagctcc aagaaaggac gaacattcgg
      181 aaatgtcagg agctcctgga gcagctgaat ggaaagatca acctcaccta cagggcggac
      241 ttcaagatcc ctatggagat gacggagaag atgcagaaga gttacactgc ctttgccatc
      301 caagagatgc tccagaatgt ctttcttgtc ttcagaaaca atttctccag cactgggtgg
      361 aatgagacta ttgttgtacg tctcctggat gaactccacc agcagacagt gtttctgaag
      421 acagtactag aggaaaagca agaggaaaga ttgacgtggg agatgtcctc aactgctctc
      481 cacttgaaga gctattactg gagggtgcaa aggtacctta aactcatgaa gtacaacagc
      541 tacgcctgga tggtggtccg agcagagatc ttcaggaact ttctcatcat tcgaagactt
      601 accagaaact tccaaaactg aagacctgtc agttgatgcc tcagaatgag tggtggttgc
      661 aggcaacctt taagcatcag aggcggactc tgggactggt agtgaatcta ctgcatttga
      721 aaggtcaaag gaaaacagag tttttattaa tttataattt aaattatttt ctacttttta
      781 tttaaacttt ttaacctcag aaaataaaat atttataata caaaaagtca a
//
