LOCUS       NM_010509               3051 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus interferon (alpha and beta) receptor 2 (Ifnar2),
            transcript variant 1, mRNA.
ACCESSION   NM_010509
VERSION     NM_010509.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3051)
  AUTHORS   Alicea-Torres,K., Sanseviero,E., Gui,J., Chen,J., Veglia,F., Yu,Q.,
            Donthireddy,L., Kossenkov,A., Lin,C., Fu,S., Mulligan,C., Nam,B.,
            Masters,G., Denstman,F., Bennett,J., Hockstein,N., Rynda-Apple,A.,
            Nefedova,Y., Fuchs,S.Y. and Gabrilovich,D.I.
  TITLE     Immune suppressive activity of myeloid-derived suppressor cells in
            cancer requires inactivation of the type I interferon pathway
  JOURNAL   Nat Commun 12 (1), 1717 (2021)
   PUBMED   33741967
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3051)
  AUTHORS   Zanin,N., Viaris de Lesegno,C., Lamaze,C. and Blouin,C.M.
  TITLE     Interferon Receptor Trafficking and Signaling: Journey to the Cross
            Roads
  JOURNAL   Front Immunol 11, 615603 (2021)
   PUBMED   33552080
  REMARK    GeneRIF: Interferon Receptor Trafficking and Signaling: Journey to
            the Cross Roads.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3051)
  AUTHORS   Karki,R., Sharma,B.R., Tuladhar,S., Williams,E.P., Zalduondo,L.,
            Samir,P., Zheng,M., Sundaram,B., Banoth,B., Malireddi,R.K.S.,
            Schreiner,P., Neale,G., Vogel,P., Webby,R., Jonsson,C.B. and
            Kanneganti,T.D.
  TITLE     Synergism of TNF-alpha and IFN-gamma Triggers Inflammatory Cell
            Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and
            Cytokine Shock Syndromes
  JOURNAL   Cell 184 (1), 149-168 (2021)
   PUBMED   33278357
REFERENCE   4  (bases 1 to 3051)
  AUTHORS   Karki,R., Sharma,B.R., Tuladhar,S., Williams,E.P., Zalduondo,L.,
            Samir,P., Zheng,M., Sundaram,B., Banoth,B., Malireddi,R.K.S.,
            Schreiner,P., Neale,G., Vogel,P., Webby,R., Jonsson,C.B. and
            Kanneganti,T.D.
  TITLE     Synergism of TNF-alpha and IFN-gamma triggers inflammatory cell
            death, tissue damage, and mortality in SARS-CoV-2 infection and
            cytokine shock syndromes
  JOURNAL   bioRxiv (2020)
   PUBMED   33140051
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3051)
  AUTHORS   Place,D.E., Briard,B., Samir,P., Karki,R., Bhattacharya,A.,
            Guy,C.S., Peters,J.L., Frase,S., Vogel,P., Neale,G., Yamamoto,M.
            and Kanneganti,T.D.
  TITLE     Interferon inducible GBPs restrict Burkholderia thailandensis
            motility induced cell-cell fusion
  JOURNAL   PLoS Pathog 16 (3), e1008364 (2020)
   PUBMED   32150572
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3051)
  AUTHORS   Gaikwad,J.S., Cavender,A. and D'Souza,R.N.
  TITLE     Identification of tooth-specific downstream targets of Runx2
  JOURNAL   Gene 279 (1), 91-97 (2001)
   PUBMED   11722849
REFERENCE   7  (bases 1 to 3051)
  AUTHORS   Hardy,M.P., Owczarek,C.M., Trajanovska,S., Liu,X., Kola,I. and
            Hertzog,P.J.
  TITLE     The soluble murine type I interferon receptor Ifnar-2 is present in
            serum, is independently regulated, and has both agonistic and
            antagonistic properties
  JOURNAL   Blood 97 (2), 473-482 (2001)
   PUBMED   11154225
REFERENCE   8  (bases 1 to 3051)
  AUTHORS   Owczarek,C.M., Hwang,S.Y., Holland,K.A., Gulluyan,L.M., Tavaria,M.,
            Weaver,B., Reich,N.C., Kola,I. and Hertzog,P.J.
  TITLE     Cloning and characterization of soluble and transmembrane isoforms
            of a novel component of the murine type I interferon receptor,
            IFNAR 2
  JOURNAL   J Biol Chem 272 (38), 23865-23870 (1997)
   PUBMED   9295335
REFERENCE   9  (bases 1 to 3051)
  AUTHORS   Kim,S.H., Cohen,B., Novick,D. and Rubinstein,M.
  TITLE     Mammalian type I interferon receptors consists of two subunits:
            IFNaR1 and IFNaR2
  JOURNAL   Gene 196 (1-2), 279-286 (1997)
   PUBMED   9322767
REFERENCE   10 (bases 1 to 3051)
  AUTHORS   Beebe,A.M., Mauze,S., Schork,N.J. and Coffman,R.L.
  TITLE     Serial backcross mapping of multiple loci associated with
            resistance to Leishmania major in mice
  JOURNAL   Immunity 6 (5), 551-557 (1997)
   PUBMED   9175833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX515017.1, AK139169.1, AK153317.1, AV351897.1, AC152503.5 and
            BE691178.1.
            
            On Nov 16, 2007 this sequence version replaced NM_010509.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150386.1, AK153317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BX515017.1         24-44
            22-67               AK139169.1         2-47
            68-2832             AK153317.1         2-2766
            2833-2836           AV351897.1         59-62
            2837-2853           AC152503.5         181322-181338
            2854-3051           BE691178.1         1-198               c
FEATURES             Location/Qualifiers
     source          1..3051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 52.82 cM"
     gene            1..3051
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /note="interferon (alpha and beta) receptor 2"
                     /db_xref="GeneID:15976"
                     /db_xref="MGI:MGI:1098243"
     exon            1..292
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..385
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1872
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; interferon alpha/beta receptor 2; interferon
                     receptor 2c; type I interferon alpha/beta receptor 2a;
                     IFN-alpha/beta receptor 2; type I interferon receptor 2;
                     interferon receptor 2a'"
                     /codon_start=1
                     /product="interferon alpha/beta receptor 2 isoform a
                     precursor"
                     /protein_id="NP_034639.2"
                     /db_xref="CCDS:CCDS28325.1"
                     /db_xref="GeneID:15976"
                     /db_xref="MGI:MGI:1098243"
                     /translation="MRSRCTVSAVGLLSLCLVVSASLETITPSAFDGYPDEPCTINIT
                     IRNSRLILSWELENKSGPPANYTLWYTVMSKDENLTKVKNCSDTTKSSCDVTDKWLEG
                     MESYVVAIVIVHRGDLTVCRCSDYIVPANAPLEPPEFEIVGFTDHINVTMEFPPVTSK
                     IIQEKMKTTPFVIKEQIGDSVRKKHEPKVNNVTGNFTFVLRDLLPKTNYCVSLYFDDD
                     PAIKSPLKCIVLQPGQESGLSESAIVGITTSCLVVMVFVSTIVMLKRIGYICLKDNLP
                     NVLNFRHFLTWIIPERSPSEAIDRLEIIPTNKKKRLWNYDYEDGSDSDEEVPTASVTG
                     YTMHGLTGKPLQQTSDTSASPEDPLHEEDSGAEESDEAGAGAGAEPELPTEAGAGPSE
                     DPTGPYERRKSVLEDSFPREDNSSMDEPGDNIIFNVNLNSVFLRVLHDEDASETLSLE
                     EDTILLDEGPQRTESDLRIAGGDRTQPPLPSLPSQDLWTEDGSSEKSDTSDSDADVGD
                     GYIMR"
     exon            386..427
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..551
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..724
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..882
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1039
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1167
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..3045
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3045
                     /gene="Ifnar2"
                     /gene_synonym="IFN-R-2; Ifnar-2"
ORIGIN      
        1 ccgggccccg cctctcgcct cgttctctgt tcaccgctaa ccccgcggct gggaaccctt
       61 ggcctccggg agcctgcgtg gtctagccct agaccagggg aaaccaggct gccagcggag
      121 actcttcggg tcgcggggca ccggccatcc cgccgccgtc cctttcgcct ggctcggctc
      181 ccgcctgcct ccactgctcg ccagccgcgc gcagctgcgc ctgatgccca gagcagctcg
      241 gaggtggccc caggacatcc cagaggggga ttcacgagac ccggcgattc aggtgtgaga
      301 gcagaaaaac ggacttaaga gctgagcagg atgcgttcac ggtgcaccgt ctctgccgtc
      361 ggtctcctca gcttgtgtct tgtggtgtct gcgagcctag agactatcac accgtctgct
      421 tttgatgggt atccagatga accttgcact ataaacataa caatacgaaa ttcccggcta
      481 attttatcct gggaattaga gaacaagtct ggcccacccg ctaactacac cctctggtac
      541 acagtcatga gcaaagacga aaatctgacg aaggttaaga actgttcaga taccacgaag
      601 tcatcatgtg acgtgacaga taagtggttg gagggcatgg agagctacgt cgtcgccatc
      661 gtcatagtgc acagagggga cttgaccgtg tgccgctgct cagactacat cgtgcctgca
      721 aacgctcctc ttgagccgcc agaatttgag atcgttggct ttacagacca cataaacgtg
      781 acgatggaat ttccacctgt cacttccaaa ataatccagg aaaagatgaa gactacaccc
      841 tttgtcatca aagaacagat aggggacagc gttaggaaga agcacgagcc caaagtgaat
      901 aatgtcactg ggaacttcac atttgtcctt agagacttac ttccaaagac aaactactgt
      961 gtatctcttt attttgatga tgaccccgca ataaaatctc ccttaaaatg catcgtcctt
     1021 cagcctggcc aggaatcagg attatcagaa tctgctatag taggaataac tacttcgtgt
     1081 ttggtagtga tggttttcgt gagcactatc gtaatgctga aacggattgg ttatatatgc
     1141 ctaaaagaca atttgcccaa tgtcttgaac ttccgccact ttttaacctg gataatccct
     1201 gaacggtcac cttcagaagc catcgatcgg ctggaaatca tccccacaaa caagaagaag
     1261 agactgtgga attacgatta tgaggatggc agtgacagtg acgaagaggt ccccacagca
     1321 agtgtcactg gctacaccat gcatggactg acgggcaagc ctctgcaaca aacctctgac
     1381 acctcagcca gccccgagga tcccctgcat gaagaagatt caggcgctga ggaatctgat
     1441 gaagctggag caggggctgg agctgagcca gaactcccca cagaggcggg ggcggggcct
     1501 tcagaagacc ccactggccc ctatgagaga agaaagagtg tgctcgagga ctcattcccc
     1561 agggaggaca acagctccat ggatgagcct ggggacaaca ttatcttcaa cgtgaactta
     1621 aactctgtgt ttctgagggt tctccatgat gaagatgcct cagagacatt atctctcgaa
     1681 gaagacacca tcctcctaga cgaaggtccc cagaggacag agtcagacct tcggatagct
     1741 ggtggggaca ggacacagcc gcccctcccc agccttcctt cccaggatct atggactgaa
     1801 gatgggtcat ctgagaaatc agacacctca gattccgatg ctgatgtggg ggacggctac
     1861 atcatgagat gactccaaag aggttcactg actggcgctg ggcacctaca gggtttctct
     1921 tcagagtccg acttgatgcc ttgtggtctc caggtgtctg tcatggaggg actagagaac
     1981 tctacagccc tcttggccct tgctgattgg ccttctctat gcagattgac aatttgggca
     2041 tcaggattgt ttacaggggt catgagcgtg atctgcccac cccctttcca ctaatgcact
     2101 aaggtggttt gtgttacatt tcccagggaa caggttcagt gtggttttca gaggcagccc
     2161 aaggtctcct atccctatgt tgtttctagg aaatgattaa attgggggga gagaaaggga
     2221 aagaaaaact ggccaagcag tgttcaggag gactccagga atgaacctga aagggggcgg
     2281 aagggtcaga ggtaaggcat gctgagctgg ctgctggcac aagaaaagcc atcaaggttt
     2341 gagcccctgc tgtctgggcc cttcccagat gtcaacatct gtctcctcta ctctaggaag
     2401 ttcattcacc cataaagccc cgcacagtgc acgtgaggag ggggagaagc cgcaggaata
     2461 attctaggat ccaacgcgtg actcagagag agggatatca tggccatatt ttaaggtcat
     2521 ttctcgtcac ctctttaacc ttcagttttc tcaacttatg aaataaaggg actgagcagg
     2581 tagccttggg agagatgccc aaagtggatg aagggtgtag ggtcctccca tcttactctt
     2641 ctcaccccca aaccagtgtt tcacattttc ttcttttcaa agaagaactg gtacatgggt
     2701 cctggctcaa agacttccaa tggatcaccc atgtaaagcg gttcaaaaga aacccttgtg
     2761 ggactgataa aacccttgtc ggacttttta tcctgtgtga taaaaatccc acaggaagga
     2821 gacacccccc cccaaaaaaa aaaaaaaaaa acacagagca accctttctc tgccctctga
     2881 atacagctat cctcattctc ccggagcagc agctttcttt taagctttgc ataattgctg
     2941 ggagttggct ttttaatgct tgcacttcat tgtttgtttg tttgttttta aattttatac
     3001 gatgtttgaa attgtcagtg taatacaaaa gtacttttca tacaaaaaaa a
//
