LOCUS       NM_206871                643 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus interferon alpha 6 (Ifna6), mRNA.
ACCESSION   NM_206871 NM_008335 NM_010506 XM_357422
VERSION     NM_206871.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 643)
  AUTHORS   Paulsen,M., Varese,A., Pinpathomrat,N., Kirsebom,F.C.M., Paulsen,M.
            and Johansson,C.
  TITLE     MAVS Deficiency Is Associated With a Reduced T Cell Response Upon
            Secondary RSV Infection in Mice
  JOURNAL   Front Immunol 11, 572747 (2020)
   PUBMED   33123150
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 643)
  AUTHORS   Webb,L.M., Lundie,R.J., Borger,J.G., Brown,S.L., Connor,L.M.,
            Cartwright,A.N., Dougall,A.M., Wilbers,R.H., Cook,P.C.,
            Jackson-Jones,L.H., Phythian-Adams,A.T., Johansson,C., Davis,D.M.,
            Dewals,B.G., Ronchese,F. and MacDonald,A.S.
  TITLE     Type I interferon is required for T helper (Th) 2 induction by
            dendritic cells
  JOURNAL   EMBO J 36 (16), 2404-2418 (2017)
   PUBMED   28716804
REFERENCE   3  (bases 1 to 643)
  AUTHORS   Goritzka,M., Makris,S., Kausar,F., Durant,L.R., Pereira,C.,
            Kumagai,Y., Culley,F.J., Mack,M., Akira,S. and Johansson,C.
  TITLE     Alveolar macrophage-derived type I interferons orchestrate innate
            immunity to RSV through recruitment of antiviral monocytes
  JOURNAL   J Exp Med 212 (5), 699-714 (2015)
   PUBMED   25897172
REFERENCE   4  (bases 1 to 643)
  AUTHORS   Miyake,T., Kumagai,Y., Kato,H., Guo,Z., Matsushita,K., Satoh,T.,
            Kawagoe,T., Kumar,H., Jang,M.H., Kawai,T., Tani,T., Takeuchi,O. and
            Akira,S.
  TITLE     Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic
            cells via the IPS-1 and TRIF-dependent pathways
  JOURNAL   J Immunol 183 (4), 2522-2528 (2009)
   PUBMED   19635904
REFERENCE   5  (bases 1 to 643)
  AUTHORS   Kumagai,Y., Kumar,H., Koyama,S., Kawai,T., Takeuchi,O. and Akira,S.
  TITLE     Cutting Edge: TLR-Dependent viral recognition along with type I IFN
            positive feedback signaling masks the requirement of viral
            replication for IFN-{alpha} production in plasmacytoid dendritic
            cells
  JOURNAL   J Immunol 182 (7), 3960-3964 (2009)
   PUBMED   19299691
REFERENCE   6  (bases 1 to 643)
  AUTHORS   Ko,M.S., Wang,X., Horton,J.H., Hagen,M.D., Takahashi,N., Maezaki,Y.
            and Nadeau,J.H.
  TITLE     Genetic mapping of 40 cDNA clones on the mouse genome by PCR
  JOURNAL   Mamm Genome 5 (6), 349-355 (1994)
   PUBMED   8043949
REFERENCE   7  (bases 1 to 643)
  AUTHORS   Hughes,T.K. Jr., Chin,R., Tyring,S.K. and Rady,P.L.
  TITLE     Distinction of mouse interferon-alpha subtypes by polymerase chain
            reaction utilizing consensus primers and type-specific
            oligonucleotide probes
  JOURNAL   J Interferon Res 14 (3), 117-120 (1994)
   PUBMED   7523540
REFERENCE   8  (bases 1 to 643)
  AUTHORS   Navarro,S., Dion,M., Vodjdani,G., Berlot-Picard,F. and Doly,J.
  TITLE     Isolation and characterization of a functional murine interferon
            alpha gene which is not expressed in fibroblasts upon virus
            induction
  JOURNAL   J Gen Virol 70 (Pt 6), 1381-1389 (1989)
   PUBMED   2471809
REFERENCE   9  (bases 1 to 643)
  AUTHORS   Kelley,K.A. and Pitha,P.M.
  TITLE     Characterization of a mouse interferon gene locus I. Isolation of a
            cluster of four alpha interferon genes
  JOURNAL   Nucleic Acids Res 13 (3), 805-823 (1985)
   PUBMED   2987811
REFERENCE   10 (bases 1 to 643)
  AUTHORS   Zwarthoff,E.C., Mooren,A.T. and Trapman,J.
  TITLE     Organization, structure and expression of murine interferon alpha
            genes
  JOURNAL   Nucleic Acids Res 13 (3), 791-804 (1985)
   PUBMED   2987810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928605.22.
            
            On Mar 3, 2022 this sequence version replaced NM_206871.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC151087.1, SRR9219383.142439.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-643               AL928605.22        188957-189599
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 42.03 cM"
     gene            1..643
                     /gene="Ifna6"
                     /gene_synonym="If1ai11; Ifa6; Ifa8; IFN-alpha-6;
                     IFN-alpha-8; Ifna8; IFNa8/6"
                     /note="interferon alpha 6"
                     /db_xref="GeneID:15969"
                     /db_xref="MGI:MGI:107662"
     exon            1..643
                     /gene="Ifna6"
                     /gene_synonym="If1ai11; Ifa6; Ifa8; IFN-alpha-6;
                     IFN-alpha-8; Ifna8; IFNa8/6"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..596
                     /gene="Ifna6"
                     /gene_synonym="If1ai11; Ifa6; Ifa8; IFN-alpha-6;
                     IFN-alpha-8; Ifna8; IFNa8/6"
                     /note="interferon alpha 8/6; interferon alpha-8;
                     interferon alpha family, gene 8; interferon alpha family,
                     gene 6; interferon 1ai11"
                     /codon_start=1
                     /product="interferon alpha-6 precursor"
                     /protein_id="NP_996754.1"
                     /db_xref="CCDS:CCDS38811.1"
                     /db_xref="GeneID:15969"
                     /db_xref="MGI:MGI:107662"
                     /translation="MARLCAFLMVLVVLSYWSTCSLGCDLPQTHNLRNKKALTLLVQM
                     RRLSPLSCLKDRKDFGFPLEKVDAQQIQEAQAIPVLTELTQQILTLFTSKDSSAAWNA
                     TLLDSFCNDLHQQLNDLKACVMQEVGVQESPLTQEDSLLAVRTYFHRITVYLREKKHS
                     PCAWEVVRAEVWRALSSSAKLLARLSEDE"
ORIGIN      
        1 gaccagaagc attggcaaca ctcaccatgg ctaggctctg tgctttcctg atggttttgg
       61 tggtgttgag ctactggtca acctgctctc taggatgtga cctgcctcag actcataacc
      121 tcaggaacaa gaaagccttg acactcctgg tacaaatgag gagactctcc cctctctcct
      181 gcctgaagga caggaaggac tttggattcc ccttggagaa ggtggatgcc cagcagatcc
      241 aggaggctca agccatccct gtcctgactg agctgaccca gcagatcctg accctcttca
      301 catcaaagga ctcatctgct gcatggaatg caaccctcct agactcattc tgcaatgacc
      361 tccatcagca gctcaatgac ctcaaagcct gtgtgatgca ggaggtgggg gtgcaggaat
      421 ctcccctgac ccaggaagac tccctgctgg ctgtgaggac atacttccac aggatcactg
      481 tgtacctgag agagaagaaa cacagcccct gtgcctggga ggtggtcaga gcagaagtct
      541 ggagagccct gtcttcctca gccaagttgc tggcaagact gagtgaggac gagtgagtcc
      601 tgagacaaag tgtggagaga cctcccctgg actagaacac tgc
//
