LOCUS       NM_010503                573 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus interferon alpha 2 (Ifna2), mRNA.
ACCESSION   NM_010503
VERSION     NM_010503.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 573)
  AUTHORS   Tian,L., Lei,B., Shao,J., Wei,L., Kijlstra,A. and Yang,P.
  TITLE     AAV2-mediated combined subretinal delivery of IFN-alpha and IL-4
            reduces the severity of experimental autoimmune uveoretinitis
  JOURNAL   PLoS One 7 (6), e37995 (2012)
   PUBMED   22685550
  REMARK    GeneRIF: Data indicate that the combination of AAV2.IL-4 and
            AAV2.IFN-alpha was not significantly different as compared to
            AAV2.IL-4 alone.
REFERENCE   2  (bases 1 to 573)
  AUTHORS   Gregorio,J., Meller,S., Conrad,C., Di Nardo,A., Homey,B.,
            Lauerma,A., Arai,N., Gallo,R.L., Digiovanni,J. and Gilliet,M.
  TITLE     Plasmacytoid dendritic cells sense skin injury and promote wound
            healing through type I interferons
  JOURNAL   J Exp Med 207 (13), 2921-2930 (2010)
   PUBMED   21115688
  REMARK    GeneRIF: Data show that pDCs and type I IFNs promote inflammatory
            responses and wound healing in injured skin.
REFERENCE   3  (bases 1 to 573)
  AUTHORS   Pan,M., Kalie,E., Scaglione,B.J., Raveche,E.S., Schreiber,G. and
            Langer,J.A.
  TITLE     Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2
            generates type I IFN competitive antagonists
  JOURNAL   Biochemistry 47 (46), 12018-12027 (2008)
   PUBMED   18937499
  REMARK    GeneRIF: Mutation of the IFNAR-1 receptor binding site of human
            IFN-alpha2 generates type I IFN competitive antagonists.
REFERENCE   4  (bases 1 to 573)
  AUTHORS   Baig,E. and Fish,E.N.
  TITLE     Distinct signature type I interferon responses are determined by
            the infecting virus and the target cell
  JOURNAL   Antivir Ther 13 (3), 409-422 (2008)
   PUBMED   18572754
  REMARK    GeneRIF: Infecting virus and the target cell type dictate the
            extent and signature of inducible IFN-alpha2 gene expression.
REFERENCE   5  (bases 1 to 573)
  AUTHORS   Wang,Y.X., da Cunha,V., Vincelette,J., White,K., Velichko,S.,
            Xu,Y., Gross,C., Fitch,R.M., Halks-Miller,M., Larsen,B.R.,
            Yajima,T., Knowlton,K.U., Vergona,R., Sullivan,M.E. and Croze,E.
  TITLE     Antiviral and myocyte protective effects of murine interferon-beta
            and -{alpha}2 in coxsackievirus B3-induced myocarditis and
            epicarditis in Balb/c mice
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (1), H69-H76 (2007)
   PUBMED   17434974
  REMARK    GeneRIF: These data demonstrate antiviral effects for both
            mIFN-beta and mIFN-alpha(2), which lead to protection of the mice
            from CVB3-induced myocarditis.
REFERENCE   6  (bases 1 to 573)
  AUTHORS   Krall,M., Ruff,N., Zimmerman,K., Aggarwal,A., Dosik,J., Reeves,R.
            and Mock,B.A.
  TITLE     Isolation and mapping of four new DNA markers from mouse chromosome
            4
  JOURNAL   Mamm Genome 3 (11), 653-655 (1992)
   PUBMED   1360280
REFERENCE   7  (bases 1 to 573)
  AUTHORS   van der Korput,J.A., Hilkens,J., Kroezen,V., Zwarthoff,E.C. and
            Trapman,J.
  TITLE     Mouse interferon alpha and beta genes are linked at the centromere
            proximal region of chromosome 4
  JOURNAL   J Gen Virol 66 (Pt 3), 493-502 (1985)
   PUBMED   3973562
REFERENCE   8  (bases 1 to 573)
  AUTHORS   Zwarthoff,E.C., Mooren,A.T. and Trapman,J.
  TITLE     Organization, structure and expression of murine interferon alpha
            genes
  JOURNAL   Nucleic Acids Res 13 (3), 791-804 (1985)
   PUBMED   2987810
REFERENCE   9  (bases 1 to 573)
  AUTHORS   Kelley,K.A., Kozak,C.A., Dandoy,F., Sor,F., Skup,D., Windass,J.D.,
            DeMaeyer-Guignard,J., Pitha,P.M. and DeMaeyer,E.
  TITLE     Mapping of murine interferon-alpha genes to chromosome 4
  JOURNAL   Gene 26 (2-3), 181-188 (1983)
   PUBMED   6689487
REFERENCE   10 (bases 1 to 573)
  AUTHORS   Shaw,G.D., Boll,W., Taira,H., Mantei,N., Lengyel,P. and
            Weissmann,C.
  TITLE     Structure and expression of cloned murine IFN-alpha genes
  JOURNAL   Nucleic Acids Res 11 (3), 555-573 (1983)
   PUBMED   6188104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928605.22.
            
            On Mar 8, 2007 this sequence version replaced NM_010503.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC100689.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-573               AL928605.22        44774-45346         c
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 42.02 cM"
     gene            1..573
                     /gene="Ifna2"
                     /gene_synonym="If1ai7; Ifa2"
                     /note="interferon alpha 2"
                     /db_xref="GeneID:15965"
                     /db_xref="MGI:MGI:107666"
     CDS             1..573
                     /gene="Ifna2"
                     /gene_synonym="If1ai7; Ifa2"
                     /note="IFN-alpha-2; interferon alpha family, gene 2;
                     interferon 1ai7"
                     /codon_start=1
                     /product="interferon alpha-2 precursor"
                     /protein_id="NP_034633.2"
                     /db_xref="CCDS:CCDS18326.1"
                     /db_xref="GeneID:15965"
                     /db_xref="MGI:MGI:107666"
                     /translation="MARLCAFLVMLIVMSYWSTCSLGCDLPHTYNLRNKRALKVLAQM
                     RRLPFLSCLKDRQDFGFPLEKVDNQQIQKAQAIPVLRDLTQQTLNLFTSKASSAAWNT
                     TLLDSFCNDLHQQLNDLQTCLMQQVGVQEPPLTQEDALLAVRKYFHRITVYLREKKHS
                     PCAWEVVRAEVWRALSSSVNLLPRLSEEKE"
     exon            1..573
                     /gene="Ifna2"
                     /gene_synonym="If1ai7; Ifa2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctagac tctgtgcttt cctcgtgatg ctgatagtga tgagctactg gtcaacctgt
       61 tctctaggat gcgatctgcc tcacacttat aacctcagga acaagagggc cttgaaggtc
      121 ctggcacaga tgaggaggct cccctttctc tcctgcctga aggacaggca ggactttgga
      181 ttccccctgg agaaggtgga taaccagcag atccagaagg ctcaagccat ccctgtgctg
      241 cgagatctta ctcagcagac cttgaacctc ttcacatcaa aggcttcatc tgctgcttgg
      301 aatacaaccc tcctagactc attctgcaat gacctccacc agcagctcaa tgacctgcaa
      361 acctgtctga tgcagcaggt gggggtgcag gaacctcctc tgacccagga agacgccctg
      421 ctggctgtga ggaaatattt ccacaggatc actgtgtacc tgagagagaa gaaacacagc
      481 ccctgtgcct gggaggtggt cagagcagaa gtctggagag ccctgtcttc ctcagtcaac
      541 ttgctgccaa gactgagtga agagaaggag tga
//
