LOCUS       NM_206870                573 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus interferon alpha 15 (Ifna15), mRNA.
ACCESSION   NM_206870 XM_143812
VERSION     NM_206870.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 573)
  AUTHORS   Bjorck P, Leong HX and Engleman EG.
  TITLE     Plasmacytoid dendritic cell dichotomy: identification of IFN-alpha
            producing cells as a phenotypically and functionally distinct
            subset
  JOURNAL   J Immunol 186 (3), 1477-1485 (2011)
   PUBMED   21172865
  REMARK    GeneRIF: A distinct subset of plasmacytoid dendritic cells (pDC) is
            responsible for nearly all IFN-alpha production, while in bone
            marrow and spleen, cells that ultimately differentiate into pDC
            produce little or no IFN-alpha and instead promote immune
            tolerance.
REFERENCE   2  (bases 1 to 573)
  AUTHORS   Woelk CH, Frost SD, Richman DD, Higley PE and Kosakovsky Pond SL.
  TITLE     Evolution of the interferon alpha gene family in eutherian mammals
  JOURNAL   Gene 397 (1-2), 38-50 (2007)
   PUBMED   17512142
REFERENCE   3  (bases 1 to 573)
  AUTHORS   Battcock SM, Collier TW, Zu D and Hirasawa K.
  TITLE     Negative regulation of the alpha interferon-induced antiviral
            response by the Ras/Raf/MEK pathway
  JOURNAL   J Virol 80 (9), 4422-4430 (2006)
   PUBMED   16611902
  REMARK    GeneRIF: results suggest that activation of the Ras/Raf/MEK pathway
            downregulates IFN-induced antiviral response
REFERENCE   4  (bases 1 to 573)
  AUTHORS   Daugherty,B., Martin-Zanca,D., Kelder,B., Collier,K., Seamans,T.C.,
            Hotta,K. and Pestka,S.
  TITLE     Isolation and bacterial expression of a murine alpha leukocyte
            interferon gene
  JOURNAL   J Interferon Res 4 (4), 635-643 (1984)
   PUBMED   6094686
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M28587.1.
            
            On Apr 5, 2004 this sequence version replaced XM_143812.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC116216.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 41.96 cM"
     gene            1..573
                     /gene="Ifna15"
                     /gene_synonym="Gm12597; If1ai1; Ifnaa; MuIFN-alpha-A"
                     /note="interferon alpha 15"
                     /db_xref="GeneID:242517"
                     /db_xref="MGI:MGI:3649418"
     CDS             1..573
                     /gene="Ifna15"
                     /gene_synonym="Gm12597; If1ai1; Ifnaa; MuIFN-alpha-A"
                     /note="novel interferon alpha (Ifna) family member;
                     interferon 1ai1"
                     /codon_start=1
                     /product="interferon alpha 15 precursor"
                     /protein_id="NP_996753.1"
                     /db_xref="CCDS:CCDS18319.1"
                     /db_xref="GeneID:242517"
                     /db_xref="MGI:MGI:3649418"
                     /translation="MARLCAFLMTLLVMSYWSTCSLGCDLPQTHNLRNKRALTLLVQM
                     RRLSPLSCLKDRKDFRFPQEKVDAQQIQNAQAIPVLQELTQQVLNIFTSKDSSAAWDA
                     SLLDSFCNDLHQQLNDLKACVMQEVGVQEPPLTQEDYLLAVRTYFHRITVYLREKKHS
                     PCAWEVVRAEVWRAMSSSAKLLARLSEEKE"
     exon            1..573
                     /gene="Ifna15"
                     /gene_synonym="Gm12597; If1ai1; Ifnaa; MuIFN-alpha-A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctaggc tctgtgcttt cctgatgacc ctgctagtga tgagctactg gtcaacctgc
       61 tctctaggat gtgacctgcc tcagactcat aacctcagga acaagagagc cttgaccctc
      121 ctggtacaaa tgaggagact ctcccctctc tcctgcctga aggacagaaa ggactttaga
      181 ttcccccagg agaaggtgga tgcccagcag atccagaatg ctcaagccat ccctgtccta
      241 caagagctga cccagcaggt cctgaacatc ttcacatcaa aggactcatc tgctgcttgg
      301 gatgcatccc tcctagactc attctgcaat gacctccatc agcagctcaa tgacctcaaa
      361 gcctgtgtga tgcaggaggt gggggtgcag gaacctcccc tgacccagga agactacctg
      421 ctggctgtga ggacatactt ccacaggatc actgtgtacc tgagagagaa gaaacacagc
      481 ccctgtgcct gggaggtggt cagagcagaa gtctggagag ccatgtcttc ctcagccaag
      541 ttgctggcaa gactgagtga ggagaaggag tga
//
