LOCUS       NP_034632                189 aa            linear   ROD 13-MAY-2024
DEFINITION  interferon alpha-1 precursor [Mus musculus].
ACCESSION   NP_034632
VERSION     NP_034632.2
DBSOURCE    REFSEQ: accession NM_010502.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 189)
  AUTHORS   Loftus,S.N., Gharaee-Kermani,M., Xu,B., Moore,T.M., Hannoudi,A.,
            Mallbris,M.J., Klein,B., Gudjonsson,J.E. and Kahlenberg,J.M.
  TITLE     Interferon alpha promotes caspase-8 dependent ultraviolet
            light-mediated keratinocyte apoptosis via interferon regulatory
            factor 1
  JOURNAL   Front Immunol 15, 1384606 (2024)
   PUBMED   38660315
  REMARK    GeneRIF: Interferon alpha promotes caspase-8 dependent ultraviolet
            light-mediated keratinocyte apoptosis via interferon regulatory
            factor 1.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 189)
  AUTHORS   Du,L., Liu,W., Rosen,S.T. and Chen,Y.
  TITLE     Mechanism of SUMOylation-Mediated Regulation of Type I IFN
            Expression
  JOURNAL   J Mol Biol 435 (5), 167968 (2023)
   PUBMED   36681180
  REMARK    GeneRIF: Mechanism of SUMOylation-Mediated Regulation of Type I IFN
            Expression.
REFERENCE   3  (residues 1 to 189)
  AUTHORS   Kim,K.S., Kim,D.K., Na,S.Y., Jung,Y.S., Cho,S.J., Kim,J., Lee,I.K.,
            Kim,Y.H., Lee,C.H., Jeong,W.I., Jo,E.K. and Choi,H.S.
  TITLE     Frontline Science: Estrogen-related receptor gamma increases
            poly(I:C)-mediated type I IFN expression in mouse macrophages
  JOURNAL   J Leukoc Biol 109 (5), 865-875 (2021)
   PUBMED   33615540
  REMARK    GeneRIF: Frontline Science: Estrogen-related receptor gamma
            increases poly(I:C)-mediated type I IFN expression in mouse
            macrophages.
REFERENCE   4  (residues 1 to 189)
  AUTHORS   Yang,X., Cheng,X., Tang,Y., Qiu,X., Wang,Z., Fu,G., Wu,J., Kang,H.,
            Wang,J., Wang,H., Chen,F., Xiao,X., Billiar,T.R. and Lu,B.
  TITLE     The role of type 1 interferons in coagulation induced by
            gram-negative bacteria
  JOURNAL   Blood 135 (14), 1087-1100 (2020)
   PUBMED   32016282
  REMARK    GeneRIF: The role of type 1 interferons in coagulation induced by
            gram-negative bacteria.
REFERENCE   5  (residues 1 to 189)
  AUTHORS   Namkoong,H., Ishii,M., Fujii,H., Asami,T., Yagi,K., Suzuki,S.,
            Azekawa,S., Tasaka,S., Hasegawa,N. and Betsuyaku,T.
  TITLE     Obesity worsens the outcome of influenza virus infection associated
            with impaired type I interferon induction in mice
  JOURNAL   Biochem Biophys Res Commun 513 (2), 405-411 (2019)
   PUBMED   30967261
  REMARK    GeneRIF: Obesity worsens survival of influenza infected mice with
            impaired type I interferon. In particular, IFN-alpha and IFN-beta
            levels were significantly suppressed in the bronchoalveolar lavage
            fluid of diet-induced obese mice.
REFERENCE   6  (residues 1 to 189)
  AUTHORS   Crnic,L.S. and Segall,M.A.
  TITLE     Behavioral effects of mouse interferons-alpha and -gamma and human
            interferon-alpha in mice
  JOURNAL   Brain Res 590 (1-2), 277-284 (1992)
   PUBMED   1422836
REFERENCE   7  (residues 1 to 189)
  AUTHORS   Tanaka,N. and Taniguchi,T.
  TITLE     Cytokine gene regulation: regulatory cis-elements and DNA binding
            factors involved in the interferon system
  JOURNAL   Adv Immunol 52, 263-281 (1992)
   PUBMED   1442307
  REMARK    Review article
REFERENCE   8  (residues 1 to 189)
  AUTHORS   Fultz,M.J. and Vogel,S.N.
  TITLE     The physical separation of Lps and Ifa loci in BXH recombinant
            inbred mice
  JOURNAL   J Immunol 143 (9), 3001-3006 (1989)
   PUBMED   2572648
REFERENCE   9  (residues 1 to 189)
  AUTHORS   Kelley,K.A. and Pitha,P.M.
  TITLE     Characterization of a mouse interferon gene locus I. Isolation of a
            cluster of four alpha interferon genes
  JOURNAL   Nucleic Acids Res 13 (3), 805-823 (1985)
   PUBMED   2987811
REFERENCE   10 (residues 1 to 189)
  AUTHORS   Zwarthoff,E.C., Mooren,A.T. and Trapman,J.
  TITLE     Organization, structure and expression of murine interferon alpha
            genes
  JOURNAL   Nucleic Acids Res 13 (3), 791-804 (1985)
   PUBMED   2987810
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX530016.11.
            
            On Nov 1, 2006 this sequence version replaced NP_034632.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 42.04 cM"
     Protein         1..189
                     /product="interferon alpha-1 precursor"
                     /note="interferon alpha family gene 1; IFN-alpha-1;
                     interferon 1ai14"
                     /calculated_mol_wt=19118
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2546
     mat_peptide     24..189
                     /product="Interferon alpha-1. /id=PRO_0000016375"
                     /note="propagated from UniProtKB/Swiss-Prot (P01572.2)"
                     /calculated_mol_wt=19118
     Region          26..185
                     /region_name="Interferon"
                     /note="Interferon alpha/beta domain; pfam00143"
                     /db_xref="CDD:459689"
     Site            order(28..29,32,35..36,39,42..43,100..101,103..104,
                     106..107,110,113..114,117..118,121)
                     /site_type="active"
                     /note="putative IFNAR-1 binding site [active]"
                     /db_xref="CDD:238047"
     Site            order(53..60,62..64,70..71,141..142,144..145,148..149,
                     151..152,155..160)
                     /site_type="active"
                     /note="putative IFNAR-2 binding site [active]"
                     /db_xref="CDD:238047"
     Site            101
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000305|PubMed:15254193; propagated from
                     UniProtKB/Swiss-Prot (P01572.2)"
     Site            101
                     /site_type="other"
                     /note="N-glycosylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238047"
     CDS             1..189
                     /gene="Ifna1"
                     /gene_synonym="If1ai14; Ifa1"
                     /coded_by="NM_010502.2:1..570"
                     /db_xref="CCDS:CCDS18347.1"
                     /db_xref="GeneID:15962"
                     /db_xref="MGI:MGI:107668"
ORIGIN      
        1 marlcaflmv lavlsywptc slgcdlpqth nlrnkraltl lvqmrrlspl sclkdrkdfg
       61 fpqekvdaqq ikkaqaipvl seltqqilni ftskdssaaw nttlldsfcn dlhqqlndlq
      121 gclmqqvgvq efpltqedal lavrkyfhri tvylrekkhs pcawevvrae vwralsssan
      181 vlgrlreek
//
