LOCUS       NM_053088                733 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interferon induced transmembrane protein 5 (Ifitm5),
            mRNA.
ACCESSION   NM_053088
VERSION     NM_053088.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 733)
  AUTHORS   Wang,Z., Wang,K., Yu,Y., Fu,J., Zhang,S., Li,M., Yang,J., Zhang,X.,
            Liu,X., Lv,F., Ma,L., Cai,H., Tian,W. and Liao,L.
  TITLE     Identification of human cranio-maxillofacial skeletal stem cells
            for mandibular development
  JOURNAL   Sci Adv 11 (1), eado7852 (2025)
   PUBMED   39742474
REFERENCE   2  (bases 1 to 733)
  AUTHORS   Marom,R., Song,I.W., Busse,E.C., Washington,M.E., Berrier,A.S.,
            Rossi,V.C., Ortinau,L., Jeong,Y., Jiang,M.M., Dawson,B.C.,
            Adeyeye,M., Leynes,C., Lietman,C.D., Stroup,B.M., Batkovskyte,D.,
            Jain,M., Chen,Y., Cela,R., Castellon,A., Tran,A.A., Lorenzo,I.,
            Meyers,D.N., Huang,S., Turner,A., Shenava,V., Wallace,M.,
            Orwoll,E., Park,D., Ambrose,C.G., Nagamani,S.C., Heaney,J.D. and
            Lee,B.H.
  TITLE     The IFITM5 mutation in osteogenesis imperfecta type V is associated
            with an ERK/SOX9-dependent osteoprogenitor differentiation defect
  JOURNAL   J Clin Invest 134 (15), e170369 (2024)
   PUBMED   38885336
  REMARK    GeneRIF: The IFITM5 mutation in osteogenesis imperfecta type V is
            associated with an ERK/SOX9-dependent osteoprogenitor
            differentiation defect.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 733)
  AUTHORS   Hedjazi,G., Guterman-Ram,G., Blouin,S., Schemenz,V., Wagermaier,W.,
            Fratzl,P., Hartmann,M.A., Zwerina,J., Fratzl-Zelman,N. and
            Marini,J.C.
  TITLE     Alterations of bone material properties in growing Ifitm5/BRIL
            p.S42 knock-in mice, a new model for atypical type VI osteogenesis
            imperfecta
  JOURNAL   Bone 162, 116451 (2022)
   PUBMED   35654352
REFERENCE   4  (bases 1 to 733)
  AUTHORS   Jing,J., Feng,J., Yuan,Y., Guo,T., Lei,J., Pei,F., Ho,T.V. and
            Chai,Y.
  TITLE     Spatiotemporal single-cell regulatory atlas reveals neural crest
            lineage diversification and cellular function during tooth
            morphogenesis
  JOURNAL   Nat Commun 13 (1), 4803 (2022)
   PUBMED   35974052
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 733)
  AUTHORS   Farmer,D.T., Mlcochova,H., Zhou,Y., Koelling,N., Wang,G.,
            Ashley,N., Bugacov,H., Chen,H.J., Parvez,R., Tseng,K.C.,
            Merrill,A.E., Maxson,R.E. Jr., Wilkie,A.O.M., Crump,J.G. and
            Twigg,S.R.F.
  TITLE     The developing mouse coronal suture at single-cell resolution
  JOURNAL   Nat Commun 12 (1), 4797 (2021)
   PUBMED   34376651
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 733)
  AUTHORS   Brass,A.L., Huang,I.C., Benita,Y., John,S.P., Krishnan,M.N.,
            Feeley,E.M., Ryan,B.J., Weyer,J.L., van der Weyden,L., Fikrig,E.,
            Adams,D.J., Xavier,R.J., Farzan,M. and Elledge,S.J.
  TITLE     The IFITM proteins mediate cellular resistance to influenza A H1N1
            virus, West Nile virus, and dengue virus
  JOURNAL   Cell 139 (7), 1243-1254 (2009)
   PUBMED   20064371
REFERENCE   7  (bases 1 to 733)
  AUTHORS   Moffatt,P., Gaumond,M.H., Salois,P., Sellin,K., Bessette,M.C.,
            Godin,E., de Oliveira,P.T., Atkins,G.J., Nanci,A. and Thomas,G.
  TITLE     Bril: a novel bone-specific modulator of mineralization
  JOURNAL   J Bone Miner Res 23 (9), 1497-1508 (2008)
   PUBMED   18442316
  REMARK    GeneRIF: Bril is a novel osteoblast protein and showed a role in
            mineralization, possibly identifying a new regulatory pathway in
            bone formation.
REFERENCE   8  (bases 1 to 733)
  AUTHORS   Lange,U.C., Adams,D.J., Lee,C., Barton,S., Schneider,R., Bradley,A.
            and Surani,M.A.
  TITLE     Normal germ line establishment in mice carrying a deletion of the
            Ifitm/Fragilis gene family cluster
  JOURNAL   Mol Cell Biol 28 (15), 4688-4696 (2008)
   PUBMED   18505827
REFERENCE   9  (bases 1 to 733)
  AUTHORS   Lange,U.C., Saitou,M., Western,P.S., Barton,S.C. and Surani,M.A.
  TITLE     The fragilis interferon-inducible gene family of transmembrane
            proteins is associated with germ cell specification in mice
  JOURNAL   BMC Dev Biol 3, 1 (2003)
   PUBMED   12659663
REFERENCE   10 (bases 1 to 733)
  AUTHORS   Baird,J.W., Ryan,K.M., Hayes,I., Hampson,L., Heyworth,C.M.,
            Clark,A., Wootton,M., Ansell,J.D., Menzel,U., Hole,N. and
            Graham,G.J.
  TITLE     Differentiating embryonal stem cells are a rich source of
            haemopoietic gene products and suggest erythroid preconditioning of
            primitive haemopoietic stem cells
  JOURNAL   J Biol Chem 276 (12), 9189-9198 (2001)
   PUBMED   11106657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY703620.1, BC103790.1 and FJ200451.1.
            
            On Jun 5, 2018 this sequence version replaced NM_053088.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ200451.1, BC103790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY703620.1         28-31
            5-713               BC103790.1         1-709
            714-733             FJ200451.1         762-781
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.17 cM"
     gene            1..733
                     /gene="Ifitm5"
                     /gene_synonym="1110003J06Rik; Bril; DSPA1; Hrmp1; Hrtm1"
                     /note="interferon induced transmembrane protein 5"
                     /db_xref="GeneID:73835"
                     /db_xref="MGI:MGI:1934923"
     exon            1..226
                     /gene="Ifitm5"
                     /gene_synonym="1110003J06Rik; Bril; DSPA1; Hrmp1; Hrtm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..439
                     /gene="Ifitm5"
                     /gene_synonym="1110003J06Rik; Bril; DSPA1; Hrmp1; Hrtm1"
                     /note="bone-restricted interferon induced transmembrane
                     protein-like protein; fragilis family member 4;
                     haemopoiesis related membrane protein 1; dispanin
                     subfamily A member 1"
                     /codon_start=1
                     /product="interferon-induced transmembrane protein 5"
                     /protein_id="NP_444318.1"
                     /db_xref="CCDS:CCDS21993.1"
                     /db_xref="GeneID:73835"
                     /db_xref="MGI:MGI:1934923"
                     /translation="MDTSYPREDPRAPSSRKADAAAHTALSMGTPGPTPRDHMLWSVF
                     STMYLNLCCLGFLALVHSVKARDQKMAGNLEAARQYGSKAKCYNILAAMWTLVPPLLL
                     LGLVVTGALHLSKLAKDSAAFFSTKFDEEDYN"
     exon            227..717
                     /gene="Ifitm5"
                     /gene_synonym="1110003J06Rik; Bril; DSPA1; Hrmp1; Hrtm1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      694..699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifitm5"
                     /gene_synonym="1110003J06Rik; Bril; DSPA1; Hrmp1; Hrtm1"
                     /note="hexamer: ATTAAA"
     polyA_site      713
                     /gene="Ifitm5"
                     /gene_synonym="1110003J06Rik; Bril; DSPA1; Hrmp1; Hrtm1"
                     /note="major polyA site"
ORIGIN      
        1 aagtctcagc taggaagaca cggcgctgga acccatggac acttcatatc cccgtgagga
       61 cccccgggct ccatcatccc gcaaggctga tgctgcagcc cacacagccc tctccatggg
      121 aacacctggc cctacaccac gagatcacat gctctggtct gtcttcagca cgatgtacct
      181 gaatctgtgc tgccttggat tcctggcgct ggtccactct gtcaaggccc gagaccagaa
      241 gatggctggg aacttggagg ctgcaaggca gtatggctcc aaagccaagt gctacaacat
      301 cctggctgca atgtggacat tggtgccccc attgctgctc ctgggactgg tggtgactgg
      361 cgccttgcac ctgtccaagt tagccaaaga ctctgcggct ttcttcagca ccaagtttga
      421 tgaggaggac tataactaag agttccgagc ctgtccctga accgaggaca accatgtcag
      481 gtcagctgtg cccaacacca gctcctggga gttacagcct actatagcac ctcgatccct
      541 gcccagccgt gacctcagag gcggccctct tgtccacgat gtgtatttga tgctgcccca
      601 ctcagatccc tcagacttaa cttataacct agagggtcct cagtgcttgg ctttgtccct
      661 ttccccactt accaggccga gcctctgttc acgattaaaa gtggcagatt ccagaaaaaa
      721 aaaaaaaaaa aaa
//
