LOCUS       NM_025378                648 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus interferon induced transmembrane protein 3 (Ifitm3),
            mRNA.
ACCESSION   NM_025378
VERSION     NM_025378.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 648)
  AUTHORS   Denz,P.J., Speaks,S., Kenney,A.D., Eddy,A.C., Papa,J.L.,
            Roettger,J., Scace,S.C., Rubrum,A., Hemann,E.A., Forero,A.,
            Webby,R.J., Bowman,A.S. and Yount,J.S.
  TITLE     Innate immune control of influenza virus interspecies adaptation
            via IFITM3
  JOURNAL   Nat Commun 15 (1), 9375 (2024)
   PUBMED   39477971
  REMARK    GeneRIF: Innate immune control of influenza virus interspecies
            adaptation via IFITM3.
            Erratum:[Nat Commun. 2024 Dec 11;15(1):10671. doi:
            10.1038/s41467-024-54981-w.. PMID: 39663387]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 648)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 648)
  AUTHORS   Liu,X., Zhang,W., Han,Y., Cheng,H., Liu,Q., Ke,S., Zhu,F., Lu,Y.,
            Dai,X., Wang,C., Huang,G., Su,B., Zou,Q., Li,H., Zhao,W., Xiao,L.,
            Lu,L., Tong,X., Pan,F., Li,H. and Li,B.
  TITLE     FOXP3+ regulatory T cell perturbation mediated by the
            IFNgamma-STAT1-IFITM3 feedback loop is essential for anti-tumor
            immunity
  JOURNAL   Nat Commun 15 (1), 122 (2024)
   PUBMED   38167862
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 648)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 648)
  AUTHORS   Son,Y., Lee,C.G., Kim,J.S. and Lee,H.J.
  TITLE     Low-dose-rate ionizing radiation affects innate immunity protein
            IFITM3 in a mouse model of Alzheimer's disease
  JOURNAL   Int J Radiat Biol 99 (11), 1649-1659 (2023)
   PUBMED   37162420
  REMARK    GeneRIF: Low-dose-rate ionizing radiation affects innate immunity
            protein IFITM3 in a mouse model of Alzheimer's disease.
REFERENCE   6  (bases 1 to 648)
  AUTHORS   Ropolo,A., Tomasini,R., Grasso,D., Dusetti,N.J., Cerquetti,M.C.,
            Iovanna,J.L. and Vaccaro,M.I.
  TITLE     Cloning of IP15, a pancreatitis-induced gene whose expression
            inhibits cell growth
  JOURNAL   Biochem Biophys Res Commun 319 (3), 1001-1009 (2004)
   PUBMED   15184081
  REMARK    GeneRIF: cloning and expression of the mouse gene
            interferon-inducible-protein 15 (IP15), whose activation is related
            to the acute phase of experimental pancreatitis [IP15]
REFERENCE   7  (bases 1 to 648)
  AUTHORS   Saitou,M., Payer,B., Lange,U.C., Erhardt,S., Barton,S.C. and
            Surani,M.A.
  TITLE     Specification of germ cell fate in mice
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 358 (1436), 1363-1370 (2003)
   PUBMED   14511483
REFERENCE   8  (bases 1 to 648)
  AUTHORS   Lange,U.C., Saitou,M., Western,P.S., Barton,S.C. and Surani,M.A.
  TITLE     The fragilis interferon-inducible gene family of transmembrane
            proteins is associated with germ cell specification in mice
  JOURNAL   BMC Dev Biol 3, 1 (2003)
   PUBMED   12659663
REFERENCE   9  (bases 1 to 648)
  AUTHORS   Tanaka,S.S. and Matsui,Y.
  TITLE     Developmentally regulated expression of mil-1 and mil-2, mouse
            interferon-induced transmembrane protein like genes, during
            formation and differentiation of primordial germ cells
  JOURNAL   Mech Dev 119 Suppl 1, S261-S267 (2002)
   PUBMED   14516695
REFERENCE   10 (bases 1 to 648)
  AUTHORS   Saitou,M., Barton,S.C. and Surani,M.A.
  TITLE     A molecular programme for the specification of germ cell fate in
            mice
  JOURNAL   Nature 418 (6895), 293-300 (2002)
   PUBMED   12124616
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK003407.1.
            
            On Apr 6, 2007 this sequence version replaced NM_025378.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003407.1, AY594690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-648               AK003407.1         2-649
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.25 cM"
     gene            1..648
                     /gene="Ifitm3"
                     /gene_synonym="1110004C05Rik; Cd225; Cdw217; DSPA2b; Fgls;
                     IP15; mil-1"
                     /note="interferon induced transmembrane protein 3"
                     /db_xref="GeneID:66141"
                     /db_xref="MGI:MGI:1913391"
     exon            1..348
                     /gene="Ifitm3"
                     /gene_synonym="1110004C05Rik; Cd225; Cdw217; DSPA2b; Fgls;
                     IP15; mil-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..513
                     /gene="Ifitm3"
                     /gene_synonym="1110004C05Rik; Cd225; Cdw217; DSPA2b; Fgls;
                     IP15; mil-1"
                     /note="fragilis protein; ifitm-like protein 1;
                     interferon-inducible protein 15; dispanin subfamily A
                     member 2b"
                     /codon_start=1
                     /product="interferon-induced transmembrane protein 3"
                     /protein_id="NP_079654.1"
                     /db_xref="CCDS:CCDS21996.1"
                     /db_xref="GeneID:66141"
                     /db_xref="MGI:MGI:1913391"
                     /translation="MNHTSQAFITAASGGQPPNYERIKEEYEVAEMGAPHGSASVRTT
                     VINMPREVSVPDHVVWSLFNTLFMNFCCLGFIAYAYSVKSRDRKMVGDVTGAQAYAST
                     AKCLNISTLVLSILMVVITIVSVIIIVLNAQNLHT"
     exon            349..648
                     /gene="Ifitm3"
                     /gene_synonym="1110004C05Rik; Cd225; Cdw217; DSPA2b; Fgls;
                     IP15; mil-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      648
                     /gene="Ifitm3"
                     /gene_synonym="1110004C05Rik; Cd225; Cdw217; DSPA2b; Fgls;
                     IP15; mil-1"
                     /note="putative"
ORIGIN      
        1 aggaaaagga aacttctgag aaaccgaaac tgccgcagaa agggcagacc cgcagcgcgc
       61 tccatccttt gcccttcagt gctgcctttg ctccgcacca tgaaccacac ttctcaagcc
      121 ttcatcaccg ctgccagtgg aggacagccc ccaaactacg aaagaatcaa ggaagaatat
      181 gaggtggctg agatgggggc accgcacgga tcggcttctg tcagaactac tgtgatcaac
      241 atgcccagag aggtgtcggt gcctgaccat gtggtctggt ccctgttcaa tacactcttc
      301 atgaacttct gctgcctggg cttcatagcc tatgcctact ccgtgaagtc tagggatcgg
      361 aagatggtgg gtgatgtgac tggagcccag gcctacgcct ccactgctaa gtgcctgaac
      421 atcagcacct tggtcctcag catcctgatg gttgttatca ccattgttag tgtcatcatc
      481 attgttctta acgctcaaaa ccttcacact taatagagga ttccgacttc cggtcctgaa
      541 gtgcttcacc ctccgcagct gcgtccctcc ttgcccctcc ctacacgcag gtgtaacact
      601 catttatcta tccacagtgg attcaataaa gtgcacttga taaccacc
//
