LOCUS       NM_030694                641 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus interferon induced transmembrane protein 2 (Ifitm2),
            mRNA.
ACCESSION   NM_030694
VERSION     NM_030694.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 641)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 641)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 641)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 641)
  AUTHORS   Yanez,D.C., Sahni,H., Ross,S., Solanki,A., Lau,C.I.,
            Papaioannou,E., Barbarulo,A., Powell,R., Lange,U.C., Adams,D.J.,
            Barenco,M., Ono,M., D'Acquisto,F., Furmanski,A.L. and Crompton,T.
  TITLE     IFITM proteins drive type 2 T helper cell differentiation and
            exacerbate allergic airway inflammation
  JOURNAL   Eur J Immunol 49 (1), 66-78 (2019)
   PUBMED   30365177
  REMARK    GeneRIF: this study shows that IFITM2 drives type 2 T helper cell
            differentiation and exacerbate allergic airway inflammation
REFERENCE   5  (bases 1 to 641)
  AUTHORS   Patoine,A., Husseini,A., Kasaai,B., Gaumond,M.H. and Moffatt,P.
  TITLE     The osteogenic cell surface marker BRIL/IFITM5 is dispensable for
            bone development and homeostasis in mice
  JOURNAL   PLoS One 12 (9), e0184568 (2017)
   PUBMED   28880886
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 641)
  AUTHORS   Inoue,T., Sugiyama,D., Kurita,R., Oikawa,T., Kulkeaw,K., Kawano,H.,
            Miura,Y., Okada,M., Suehiro,Y., Takahashi,A., Marumoto,T.,
            Inoue,H., Komatsu,N. and Tani,K.
  TITLE     APOA-1 is a novel marker of erythroid cell maturation from
            hematopoietic stem cells in mice and humans
  JOURNAL   Stem Cell Rev Rep 7 (1), 43-52 (2011)
   PUBMED   20376577
REFERENCE   7  (bases 1 to 641)
  AUTHORS   Brass,A.L., Huang,I.C., Benita,Y., John,S.P., Krishnan,M.N.,
            Feeley,E.M., Ryan,B.J., Weyer,J.L., van der Weyden,L., Fikrig,E.,
            Adams,D.J., Xavier,R.J., Farzan,M. and Elledge,S.J.
  TITLE     The IFITM proteins mediate cellular resistance to influenza A H1N1
            virus, West Nile virus, and dengue virus
  JOURNAL   Cell 139 (7), 1243-1254 (2009)
   PUBMED   20064371
REFERENCE   8  (bases 1 to 641)
  AUTHORS   Lange,U.C., Adams,D.J., Lee,C., Barton,S., Schneider,R., Bradley,A.
            and Surani,M.A.
  TITLE     Normal germ line establishment in mice carrying a deletion of the
            Ifitm/Fragilis gene family cluster
  JOURNAL   Mol Cell Biol 28 (15), 4688-4696 (2008)
   PUBMED   18505827
REFERENCE   9  (bases 1 to 641)
  AUTHORS   Lange,U.C., Saitou,M., Western,P.S., Barton,S.C. and Surani,M.A.
  TITLE     The fragilis interferon-inducible gene family of transmembrane
            proteins is associated with germ cell specification in mice
  JOURNAL   BMC Dev Biol 3, 1 (2003)
   PUBMED   12659663
REFERENCE   10 (bases 1 to 641)
  AUTHORS   Tanaka,S.S. and Matsui,Y.
  TITLE     Developmentally regulated expression of mil-1 and mil-2, mouse
            interferon-induced transmembrane protein like genes, during
            formation and differentiation of primordial germ cells
  JOURNAL   Mech Dev 119 Suppl 1, S261-S267 (2002)
   PUBMED   14516695
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162287.4.
            
            On Mar 28, 2023 this sequence version replaced NM_030694.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC084679.1, AY082486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC162287.4         133995-134298       c
            305-641             AC162287.4         133162-133498       c
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.18 cM"
     gene            1..641
                     /gene="Ifitm2"
                     /gene_synonym="DSPA2c; fragilis3; Ifitm3l; mil-3"
                     /note="interferon induced transmembrane protein 2"
                     /db_xref="GeneID:80876"
                     /db_xref="MGI:MGI:1933382"
     exon            1..304
                     /gene="Ifitm2"
                     /gene_synonym="DSPA2c; fragilis3; Ifitm3l; mil-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..493
                     /gene="Ifitm2"
                     /gene_synonym="DSPA2c; fragilis3; Ifitm3l; mil-3"
                     /note="dispanin subfamily A member 2c; interferon induced
                     transmembrane protein, like; fragilis R; fragilis protein
                     3"
                     /codon_start=1
                     /product="interferon-induced transmembrane protein 2"
                     /protein_id="NP_109619.1"
                     /db_xref="CCDS:CCDS21994.1"
                     /db_xref="GeneID:80876"
                     /db_xref="MGI:MGI:1933382"
                     /translation="MSHNSQAFLSTNAGLPPSYETIKEEYGVTELGEPSNSAVVRTTV
                     INMPREVSVPDHVVWSLFNTLFFNACCLGFVAYAYSVKSRDRKMVGDVVGAQAYASTA
                     KCLNISSLIFSILMVIICIIIFSTTSVVVFQSFAQRTPHSGF"
     exon            305..641
                     /gene="Ifitm2"
                     /gene_synonym="DSPA2c; fragilis3; Ifitm3l; mil-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      615..620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifitm2"
                     /gene_synonym="DSPA2c; fragilis3; Ifitm3l; mil-3"
                     /note="hexamer: AATAAA"
     polyA_site      641
                     /gene="Ifitm2"
                     /gene_synonym="DSPA2c; fragilis3; Ifitm3l; mil-3"
                     /note="major polyA site"
ORIGIN      
        1 agaaccagga tagcagcagc catcctccag acggggcgat tgttccagag tcagtaccat
       61 gagccacaat tctcaagcct tcttgtccac caatgccggg cttcctccaa gctatgagac
      121 aatcaaagag gagtacgggg tgactgagct gggggaaccc agcaactcag ctgttgtgag
      181 gaccaccgtg atcaacatgc ccagagaggt gtcggtgcct gaccatgtgg tctggtccct
      241 gttcaataca ctcttcttca acgcctgctg cctgggcttc gttgcctatg cctactctgt
      301 gaagtctagg gacaggaaga tggtgggcga tgtggttgga gcccaggcct acgcctccac
      361 tgccaagtgc ctgaatatca gctccctgat cttcagcatc cttatggtca ttatctgcat
      421 cattattttc tctaccacct ctgtggtagt ctttcagtct tttgcacaaa gaacacccca
      481 ttctggattc tagctgccct gtgctccacg gtccacatct gccccgcccc tgccccgccc
      541 ccaggctcaa gcctcgaccc tttaccctac gcgtatgcaa atgttacctt cacctatctg
      601 tccacagtgg attcaataaa gtgcacgggg tggcaactct g
//
