LOCUS       NM_010501               1998 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus interferon-induced protein with tetratricopeptide
            repeats 3 (Ifit3), mRNA.
ACCESSION   NM_010501
VERSION     NM_010501.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1998)
  AUTHORS   Huang,X., Liu,Y., Rong,X., Zhao,Y., Feng,D., Wang,J. and Xing,W.
  TITLE     IFIT3 mediates TBK1 phosphorylation to promote activation of pDCs
            and exacerbate systemic sclerosis in mice
  JOURNAL   Clin Transl Med 14 (9), e1800 (2024)
   PUBMED   39305055
  REMARK    GeneRIF: IFIT3 mediates TBK1 phosphorylation to promote activation
            of pDCs and exacerbate systemic sclerosis in mice.
REFERENCE   2  (bases 1 to 1998)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1998)
  AUTHORS   Sun,R., Wang,Y.F. and Yang,X.
  TITLE     Knockdown of IFIT3 ameliorates multiple sclerosis via selectively
            regulating M1 polarization of microglia in an experimental
            autoimmune encephalomyelitis model
  JOURNAL   Int Immunopharmacol 128, 111501 (2024)
   PUBMED   38232539
  REMARK    GeneRIF: Knockdown of IFIT3 ameliorates multiple sclerosis via
            selectively regulating M1 polarization of microglia in an
            experimental autoimmune encephalomyelitis model.
REFERENCE   4  (bases 1 to 1998)
  AUTHORS   Hu,H., Li,B., Chen,H., Fan,G., Ye,Z., Ji,S., Yu,X., Xu,X. and
            Qin,Y.
  TITLE     NMI promotes tumor progression and gemcitabine resistance in
            pancreatic cancer via STAT3-IFIT3 axis
  JOURNAL   Mol Carcinog 63 (2), 195-208 (2024)
   PUBMED   37846815
  REMARK    GeneRIF: NMI promotes tumor progression and gemcitabine resistance
            in pancreatic cancer via STAT3-IFIT3 axis.
REFERENCE   5  (bases 1 to 1998)
  AUTHORS   Lu,Y.J., Deng,Y.T., Ko,H.H., Peng,H.H., Lee,H.C., Kuo,M.Y. and
            Cheng,S.J.
  TITLE     Lysyl oxidase-like 2 promotes stemness and enhances antitumor
            effects of gefitinib in head and neck cancer via IFIT1 and IFIT3
  JOURNAL   Cancer Sci 114 (10), 3957-3971 (2023)
   PUBMED   37496288
  REMARK    GeneRIF: Lysyl oxidase-like 2 promotes stemness and enhances
            antitumor effects of gefitinib in head and neck cancer via IFIT1
            and IFIT3.
REFERENCE   6  (bases 1 to 1998)
  AUTHORS   Wacher,C., Muller,M., Hofer,M.J., Getts,D.R., Zabaras,R.,
            Ousman,S.S., Terenzi,F., Sen,G.C., King,N.J. and Campbell,I.L.
  TITLE     Coordinated regulation and widespread cellular expression of
            interferon-stimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the
            central nervous system after infection with distinct viruses
  JOURNAL   J Virol 81 (2), 860-871 (2007)
   PUBMED   17079283
  REMARK    GeneRIF: Expression increased significantly during LCMV and WNV
            infection, being widespread and localized predominantly to common
            as well as distinct neuronal populations in the brain.
REFERENCE   7  (bases 1 to 1998)
  AUTHORS   Yoshida,H., Okabe,Y., Kawane,K., Fukuyama,H. and Nagata,S.
  TITLE     Lethal anemia caused by interferon-beta produced in mouse embryos
            carrying undigested DNA
  JOURNAL   Nat Immunol 6 (1), 49-56 (2005)
   PUBMED   15568025
REFERENCE   8  (bases 1 to 1998)
  AUTHORS   Smith,J.B. and Herschman,H.R.
  TITLE     The glucocorticoid attenuated response genes GARG-16, GARG-39, and
            GARG-49/IRG2 encode inducible proteins containing multiple
            tetratricopeptide repeat domains
  JOURNAL   Arch Biochem Biophys 330 (2), 290-300 (1996)
   PUBMED   8660659
REFERENCE   9  (bases 1 to 1998)
  AUTHORS   Smith,J.B. and Herschman,H.R.
  TITLE     Glucocorticoid-attenuated response genes encode intercellular
            mediators, including a new C-X-C chemokine
  JOURNAL   J Biol Chem 270 (28), 16756-16765 (1995)
   PUBMED   7622488
REFERENCE   10 (bases 1 to 1998)
  AUTHORS   Lee,C.G., Demarquoy,J., Jackson,M.J. and O'Brien,W.E.
  TITLE     Molecular cloning and characterization of a murine LPS-inducible
            cDNA
  JOURNAL   J Immunol 152 (12), 5758-5767 (1994)
   PUBMED   8207206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153226.1.
            
            On May 4, 2007 this sequence version replaced NM_010501.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077459.1, AK153226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1998              AK153226.1         2-1999
FEATURES             Location/Qualifiers
     source          1..1998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.74 cM"
     gene            1..1998
                     /gene="Ifit3"
                     /gene_synonym="Ifi49; P49"
                     /note="interferon-induced protein with tetratricopeptide
                     repeats 3"
                     /db_xref="GeneID:15959"
                     /db_xref="MGI:MGI:1101055"
     exon            1..76
                     /gene="Ifit3"
                     /gene_synonym="Ifi49; P49"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1283
                     /gene="Ifit3"
                     /gene_synonym="Ifi49; P49"
                     /note="IRG2; IFIT-3; GARG-49; glucocorticoid-attenuated
                     response gene 49 protein"
                     /codon_start=1
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 3"
                     /protein_id="NP_034631.1"
                     /db_xref="CCDS:CCDS29762.1"
                     /db_xref="GeneID:15959"
                     /db_xref="MGI:MGI:1101055"
                     /translation="MSEVNRESLEAILPQLKCHFTWNLFREGSMSSHMEDRVCNQVEH
                     LNSEEKATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHNDQSEIRRLVTWGNYAW
                     IYYHMGRLSEAQAYVDKVRQVCQKFANPYSMECPELECEEGWTRLKCGRNERAKMCFE
                     KALEEKPKDPECSSGMAIAMFRLEEKPEKQFSVDALKQAMELNPQNQYLKVLLALKLL
                     RMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSP
                     LYSLVMCRYREILEQLQNKGDADSSERRQRMAELRRLTMEFMQKTLQRRRSPLNSYSD
                     LIDFPEVERCYQMVISKESPDVEEEDLYERYCNLQEYHRKSEDLAALECLLQFPRNER
                     SIEKEEVKEQT"
     exon            77..1998
                     /gene="Ifit3"
                     /gene_synonym="Ifi49; P49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1724..1729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifit3"
                     /gene_synonym="Ifi49; P49"
                     /note="hexamer: AATAAA"
     polyA_site      1747
                     /gene="Ifit3"
                     /gene_synonym="Ifi49; P49"
                     /note="major polyA site"
ORIGIN      
        1 gtggactgag atttctgaac tgctcagccc acacccagct tttcccagca gcacagaaac
       61 agatcaccat catgagtgag gtcaaccggg aatctctgga agcgatcctt ccacagctga
      121 agtgccattt cacctggaat ttattcaggg aaggaagtat gtccagtcat atggaagaca
      181 gggtgtgcaa ccaggtcgaa catttaaact ctgaggagaa ggcaacaatg tatgacttat
      241 tggcctacat aaagcaccta gatggcgaaa gcaaggccgc cctggagtgc ttagggcaag
      301 ctgaagattt aaggaagtca gagcacaatg atcaatcaga aattcgtcga ctggtcacct
      361 ggggaaacta cgcctggatc tactatcaca tgggccgtct ctcagaagct caggcttacg
      421 ttgacaaggt gagacaagtt tgccaaaagt ttgcgaatcc ttacagcatg gaatgcccag
      481 aacttgaatg tgaggaagga tggacacgcc taaagtgtgg aagaaatgaa cgagcaaaaa
      541 tgtgctttga aaaggctcta gaagagaagc caaaggaccc agagtgctcc tctgggatgg
      601 ccatcgccat gttccgccta gaagaaaaac ctgagaagca gttctccgtg gatgctctga
      661 agcaggccat ggagttgaat cctcagaacc agtacctgaa agttctcctg gccctgaaac
      721 tgctgaggat gggagaagaa gctgaagggg agcgattgat taaagatgct ttggggaaag
      781 ctcctaatca aacggatgtc ctccaaaagg cagctcagtt ttacaagaaa aagggtaacc
      841 tagacagagc tattgagtta cttggaaaag cactgcgatc cacagtgaac aacagtcctc
      901 tctactcttt ggtcatgtgc cgttacaggg aaatactgga gcagctacag aataaaggag
      961 atgctgacag cagtgagaga agacagagga tggcagaact gagacgatta acgatggagt
     1021 tcatgcagaa gactcttcag aggaggcgaa gtcctttgaa ctcctactca gatctcatcg
     1081 atttcccgga agtagagaga tgctatcaga tggtcatcag taaggagagc cccgatgttg
     1141 aggaagaaga cctctatgag cgctattgca acctccagga gtaccacagg aagtctgaag
     1201 acctcgcagc cctggagtgt ttgttgcaat ttcccagaaa tgaaaggtca atcgagaagg
     1261 aagaggttaa agagcaaaca tagcaagcag atcttaacct ccagtagcaa attgtggtgg
     1321 attcttggca gttgcaggga taaaggagtg gctgaatggt tttggggttt gggaggcaac
     1381 gcactttggg gcacaggcag gcttttcctg gcaccatgaa cctgaggaca accggaagtg
     1441 tgtcagagtg cagacagaca gtctctcagc tctgtactgt gagacagatg tgctgtggag
     1501 tgctgcttat ggggagaatg tgctgaaaaa agcatgagcc ttcctgccaa ggattgctga
     1561 caaactgctc ttgattgttt ctttaaggaa ctgctttctc tccctgactc ctctgctcat
     1621 cctagccata caattttcca gtcagcaaac ctcattacta atcatgtagg gaatggagct
     1681 taaagcagac agagcacctt ttgatcacat tttttttctc tgcaataaat gacaactccc
     1741 aacaaaattc actcttgttt cttcattcca tttcactgta gttgcttaag cctgaaggat
     1801 taacctttgc ctaaggctag aatattcttt gcacatcatt tttgtattct actgtggttt
     1861 tagggctgtg tgtgtgtgag tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt
     1921 tgtgtatccc taagaatgat tctaaagtta acatatatgc caaatagaaa ttgtagaata
     1981 aatgtaaaag tttcaatc
//
