LOCUS       NM_008332               3949 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus interferon-induced protein with tetratricopeptide
            repeats 2 (Ifit2), transcript variant 1, mRNA.
ACCESSION   NM_008332
VERSION     NM_008332.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3949)
  AUTHORS   Chen,H., Wu,H., Wang,Q. and Zhang,H.
  TITLE     IFIT2 mediates iron retention and cholesterol efflux in
            atherosclerosis
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113131 (2024)
   PUBMED   39276454
  REMARK    GeneRIF: IFIT2 mediates iron retention and cholesterol efflux in
            atherosclerosis.
REFERENCE   2  (bases 1 to 3949)
  AUTHORS   Poddar,D., Sharma,N., Ogino,T., Qi,X., Kessler,P.M., Mendries,H.,
            Dutta,R. and Sen,G.C.
  TITLE     The interferon-induced protein, IFIT2, requires RNA-binding
            activity and neuronal expression to protect mice from intranasal
            vesicular stomatitis virus infection
  JOURNAL   mBio 15 (7), e0056824 (2024)
   PUBMED   38888342
  REMARK    GeneRIF: The interferon-induced protein, IFIT2, requires
            RNA-binding activity and neuronal expression to protect mice from
            intranasal vesicular stomatitis virus infection.
REFERENCE   3  (bases 1 to 3949)
  AUTHORS   Zhang,X., He,H., Yu,H., Teng,X., Wang,Z., Li,C., Li,J., Yang,H.,
            Shen,J., Wu,T., Zhang,F., Zhang,Y. and Wu,Q.
  TITLE     Maternal RNA transcription in Dlk1-Dio3 domain is critical for
            proper development of the mouse placental vasculature
  JOURNAL   Commun Biol 7 (1), 363 (2024)
   PUBMED   38521877
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3949)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3949)
  AUTHORS   Sharma,M., Chakravarty,D., Hussain,A., Zalavadia,A., Burrows,A.,
            Rayman,P., Sharma,N., Kenyon,L.C., Bergmann,C., Sen,G.C. and Das
            Sarma,J.
  TITLE     Ifit2 restricts murine coronavirus spread to the spinal cord white
            matter and its associated myelin pathology
  JOURNAL   J Virol 97 (8), e0074923 (2023)
   PUBMED   37504572
  REMARK    GeneRIF: Ifit2 restricts murine coronavirus spread to the spinal
            cord white matter and its associated myelin pathology.
REFERENCE   6  (bases 1 to 3949)
  AUTHORS   Saha,S., Sugumar,P., Bhandari,P. and Rangarajan,P.N.
  TITLE     Identification of Japanese encephalitis virus-inducible genes in
            mouse brain and characterization of GARG39/IFIT2 as a
            microtubule-associated protein
  JOURNAL   J Gen Virol 87 (Pt 11), 3285-3289 (2006)
   PUBMED   17030862
  REMARK    GeneRIF: IFIT2/GARG39 was identified as a microtubule-associated
            protein enriched in the mitotic spindle of mouse NIH3T3 and B16F10
            melanoma cells.
REFERENCE   7  (bases 1 to 3949)
  AUTHORS   Smith,J.B. and Herschman,H.R.
  TITLE     The glucocorticoid attenuated response genes GARG-16, GARG-39, and
            GARG-49/IRG2 encode inducible proteins containing multiple
            tetratricopeptide repeat domains
  JOURNAL   Arch Biochem Biophys 330 (2), 290-300 (1996)
   PUBMED   8660659
REFERENCE   8  (bases 1 to 3949)
  AUTHORS   Smith,J.B. and Herschman,H.R.
  TITLE     Glucocorticoid-attenuated response genes encode intercellular
            mediators, including a new C-X-C chemokine
  JOURNAL   J Biol Chem 270 (28), 16756-16765 (1995)
   PUBMED   7622488
REFERENCE   9  (bases 1 to 3949)
  AUTHORS   Bluyssen,H.A., Vlietstra,R.J., Faber,P.W., Smit,E.M., Hagemeijer,A.
            and Trapman,J.
  TITLE     Structure, chromosome localization, and regulation of expression of
            the interferon-regulated mouse Ifi54/Ifi56 gene family
  JOURNAL   Genomics 24 (1), 137-148 (1994)
   PUBMED   7896268
REFERENCE   10 (bases 1 to 3949)
  AUTHORS   Lee,C.G., Demarquoy,J., Jackson,M.J. and O'Brien,W.E.
  TITLE     Molecular cloning and characterization of a murine LPS-inducible
            cDNA
  JOURNAL   J Immunol 152 (12), 5758-5767 (1994)
   PUBMED   8207206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ044173.1, BC050835.1, U43085.1 and BF730115.1.
            
            On Dec 14, 2007 this sequence version replaced NM_008332.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.154016.1, BC050835.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               CJ044173.1         2-253
            253-2135            BC050835.1         1-1883
            2136-3938           U43085.1           1711-3513
            3939-3949           BF730115.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..3949
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.73 cM"
     gene            1..3949
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /note="interferon-induced protein with tetratricopeptide
                     repeats 2"
                     /db_xref="GeneID:15958"
                     /db_xref="MGI:MGI:99449"
     exon            1..329
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /inference="alignment:Splign:2.1.0"
     exon            330..481
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..1889
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /note="IFIT-2; interferon-induced 54 kDa protein;
                     glucocorticoid-attenuated response gene 39 protein"
                     /codon_start=1
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 2"
                     /protein_id="NP_032358.1"
                     /db_xref="CCDS:CCDS29761.1"
                     /db_xref="GeneID:15958"
                     /db_xref="MGI:MGI:99449"
                     /translation="MSTTSKESLESNLRQLKCHFTWNLIAEDESLDEFEDRVFNKDEF
                     QNSEFKATMCNILAYVKHCRGLNEAALQCLGEAEGFIQQQHPDQVEIRSLVTWGNYAW
                     VYYHMGQFSKAQAYLDKVKQVCKKFSSPYRIENPALDCEEGWARLKCTKNQNERVKVC
                     FQKALEKDPKNPEFTSGWAIANYRLDDWPARNYCIDSLEQAIQLSPDNTYVKVLLALK
                     LDAVHKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNA
                     YVHYYMGCCYRSKVHHMLNRREMVFSGDRKKLEELIQLAVNHLRKAEEIKEMLEYSCS
                     FLADLYIIAKKYDEADYYFQKELSKDLPPGPKQLLHLRYGNFQFFQMKRQDKAIYHYM
                     EGVKIKKKTIPQKKMREKLQRIALRRLHEDESDSEALHILAFLQENGGGQQADKDSER
                     GVDSANQVPSASLDEAGAEY"
     exon            482..3949
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3917..3922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /note="hexamer: AATAAA"
     polyA_site      3938
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /note="major polyA site"
ORIGIN      
        1 agtgatgtgg ggacccagcg agatggagct cactttagga aacagcgggg agtcccccaa
       61 aggactaagg tattccagcc acacccgact aacgctgcaa atatgtagga aagagagtga
      121 agcaagatat ttttaatgag tagccctgtc tagtagtaga tccctcaaag caccaagtgt
      181 gggtaggggt tacatccggc acccggcagt caggagtcat tggccacgca cccttcgcca
      241 gcgtccattc tgccgaaaag caagttctgg ccttctgcag ttaatgcttt tttacccatc
      301 agcaagatgc accaagatga gacttagagg tgctgcacag aagcaggaaa aggaaccagc
      361 tgctcctata tataggtctg gagcacttca ttagaaggca gaggaagagg ttgcctggag
      421 agtggctgca gccctgcttt gagcgctttg acacagcaga cagttacaca gcagtcatga
      481 gtacaacgag taaggagtca ctggagagca atctgcgaca gctaaaatgc catttcacct
      541 ggaacctgat agcagaagat gagtccttgg atgagtttga ggacagggtg tttaacaagg
      601 atgagtttca gaacagtgag tttaaagcca ccatgtgcaa catactggcc tatgtaaagc
      661 actgcagagg tctaaatgag gcagcactgc aatgcttagg ggaagctgag ggcttcatcc
      721 agcaacagca tcctgaccaa gtagaaatca gaagtctggt cacctgggga aactatgctt
      781 gggtctacta tcacatgggc cagttctcaa aggctcaggc ttatctggat aaagtgaaac
      841 aggtctgcaa gaagttttcc agcccctaca ggattgagaa tcctgctctt gactgtgagg
      901 aggggtgggc ccgattaaag tgtaccaaga accaaaacga gagagtgaag gtgtgtttcc
      961 agaaggctct ggaaaaggac ccgaagaacc cagaattcac ctctggatgg gccattgcga
     1021 actaccgtct ggatgactgg ccagcaagga attactgcat tgactctctg gagcaagcca
     1081 ttcaactgtc tcctgacaac acttatgtta aagtcctctt ggcactgaag cttgacgcgg
     1141 tacataaaaa ccaagcaatg gcgctggttg aagaagcctt aaagaaagac ccaagtgcaa
     1201 tagatacact cctcagggca gccaggtttt attgcaaggt atatgacaca gacagagcta
     1261 tacagttgct tagaaaggct ttggaaaagc tgccaaacaa cgcctatgtg cattactata
     1321 tggggtgctg ttataggtca aaagtccatc atatgttgaa cagaagggaa atggtattta
     1381 gtggggatag gaagaagtta gaggaactaa tacaactggc agtgaatcac ttacggaaag
     1441 cagaggaaat caaggagatg cttgaatatt cctgtagctt ccttgctgat ctttatatca
     1501 tagcaaaaaa gtatgacgaa gccgattact acttccagaa agaattgagc aaggacctcc
     1561 ctcctggccc taaacagtta ctccaccttc ggtatggcaa ctttcagttt tttcaaatga
     1621 agcgtcaaga caaggctatc taccattata tggagggtgt gaaaataaag aagaaaacaa
     1681 tcccccaaaa aaagatgaga gagaaacttc aaagaattgc cctaaggcgg cttcatgaag
     1741 atgagtctga ttctgaggcc ttgcatatct tggcatttct tcaggagaat ggaggaggtc
     1801 agcaagctga taaagactct gagaggggag tggactctgc aaaccaggta ccttcagcat
     1861 ctttggatga agcaggtgct gaatactagt gatgtggtac ccggcctact gctggaagga
     1921 aaaagaaagc cctcaccaag ctgccattca aaatacttaa ccacttcctg gatcaagaat
     1981 gggctatcat actgactata gtatttgtca ggagtttggg gaactctgct atcagattct
     2041 agcacctgag tttctggatc gtgggatggt ctgggagagg gaccagatga ggtgatagat
     2101 acaggatctt ggcaaacagc ctagagctct ttcaattttt ttttggaaaa atagtttcca
     2161 cagtagtaaa ttctttaatc acacccaccc ctcagtggag gcttgtcttg ggcttgtttc
     2221 agtatttgta taaagcagcc aaattcctca catgggtgaa tgttccatcc ttgaattatt
     2281 ttagatattg cacagcattt tcttcataga taatagtgtc catcaaaaag ctgaggagtc
     2341 agagactgtg gctcaggact gtaatcctag cacttggaat ctgagacagg aggattacag
     2401 tgaacttgag gtcagcctga gcatgacctg gaagggatgg tgggaggtga gaattatatg
     2461 tataaatatt aatgattatg tacattacct tgttagtttg ggtgagtata tgtctatata
     2521 accactatca catatatcta aaaatacaga agggagaggt tttgctttat tgaataactt
     2581 taagacttac caaataatgt tcaatattaa ttgagctcaa aatataaatt gaatagtgag
     2641 tcccaggtct ggaagggatg gtgggaggtg agaattaaat gtgtaaatat taatgattat
     2701 gtacattacc ttgttagttt gggtgagtat atgtctatat aaccactact atcacatata
     2761 tataaaaaca cagaagggag aggttttgct ttattgaata actttaagac ttaccaaata
     2821 atgttcaata ttaattgagc tcaaaataga aattgaatag tgagtcccag gtctaaaaac
     2881 aaacaacaaa agttgtggga ccaagtcatt cctccaatta ccagccagtt ctcaatctat
     2941 ggtgtcccac acacatgagt tcaactgttc cattagctca ggtggcagca ggattcgaaa
     3001 aactgaggac agggtgagtc agaagggtca catctgtgca aagcagtaga ctcaggcagc
     3061 cacaccagac ttccaggagt cgcatgggaa gatgtctccc tactctgccc tcctagaact
     3121 atatagttgt aggaaaagaa gggagattct gtctaccacc atgacaattc atataaacat
     3181 ttatttcaag agtatggaaa caccagtggg gatgaaggga ttgctgattt atacgcgatg
     3241 attataaact catgaggaaa aagtttatag tcactgttag gaagatttct ctgtcaaata
     3301 aataatttat tcagaaatgc tataaagaaa tgccaggaag acagctgcct agaaggataa
     3361 cttggattga tgcttgggtc aagggacttt gaaaatgtca tgggtactgg agttgagttg
     3421 ttttattcca tgtgaaatgt gtcacaccaa gggatataaa taatttttat aactctgaaa
     3481 aaaaatacag aaacaccaca aacttgataa ttgccatttc ctaggtagat ctggaagggc
     3541 ctaaatgtta aggttggtgt gaattgacag agtcaagtgg cccagtatga gacggtcagc
     3601 cacactctgg gataaaaaaa tgtttctcta ctgggttcag cttgtctcta tgtatatatg
     3661 aacattttat tcagcaatta aaacatccat gattcataga ttgttaaaac taaacattct
     3721 aacagctgta tcagtgcttc ataatatttt aaaaatgaaa atattctcta tgcattaagt
     3781 ccatcgatat tcaccatttg aatttctgga aaaataataa actttgttta taagtaacac
     3841 ataatgtaac attaagctat gctctggttc ccctgaactt tactgtacct tcgtattttt
     3901 agactcaagt actgataata aagagtgcat taactgtttg ttcttttta
//
