LOCUS       NM_001355262            3806 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus interferon-induced protein with tetratricopeptide
            repeats 2 (Ifit2), transcript variant 2, mRNA.
ACCESSION   NM_001355262 XM_006526706
VERSION     NM_001355262.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3806)
  AUTHORS   Chen,H., Wu,H., Wang,Q. and Zhang,H.
  TITLE     IFIT2 mediates iron retention and cholesterol efflux in
            atherosclerosis
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113131 (2024)
   PUBMED   39276454
  REMARK    GeneRIF: IFIT2 mediates iron retention and cholesterol efflux in
            atherosclerosis.
REFERENCE   2  (bases 1 to 3806)
  AUTHORS   Poddar,D., Sharma,N., Ogino,T., Qi,X., Kessler,P.M., Mendries,H.,
            Dutta,R. and Sen,G.C.
  TITLE     The interferon-induced protein, IFIT2, requires RNA-binding
            activity and neuronal expression to protect mice from intranasal
            vesicular stomatitis virus infection
  JOURNAL   mBio 15 (7), e0056824 (2024)
   PUBMED   38888342
  REMARK    GeneRIF: The interferon-induced protein, IFIT2, requires
            RNA-binding activity and neuronal expression to protect mice from
            intranasal vesicular stomatitis virus infection.
REFERENCE   3  (bases 1 to 3806)
  AUTHORS   Zhang,X., He,H., Yu,H., Teng,X., Wang,Z., Li,C., Li,J., Yang,H.,
            Shen,J., Wu,T., Zhang,F., Zhang,Y. and Wu,Q.
  TITLE     Maternal RNA transcription in Dlk1-Dio3 domain is critical for
            proper development of the mouse placental vasculature
  JOURNAL   Commun Biol 7 (1), 363 (2024)
   PUBMED   38521877
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3806)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3806)
  AUTHORS   Sharma,M., Chakravarty,D., Hussain,A., Zalavadia,A., Burrows,A.,
            Rayman,P., Sharma,N., Kenyon,L.C., Bergmann,C., Sen,G.C. and Das
            Sarma,J.
  TITLE     Ifit2 restricts murine coronavirus spread to the spinal cord white
            matter and its associated myelin pathology
  JOURNAL   J Virol 97 (8), e0074923 (2023)
   PUBMED   37504572
  REMARK    GeneRIF: Ifit2 restricts murine coronavirus spread to the spinal
            cord white matter and its associated myelin pathology.
REFERENCE   6  (bases 1 to 3806)
  AUTHORS   Saha,S., Sugumar,P., Bhandari,P. and Rangarajan,P.N.
  TITLE     Identification of Japanese encephalitis virus-inducible genes in
            mouse brain and characterization of GARG39/IFIT2 as a
            microtubule-associated protein
  JOURNAL   J Gen Virol 87 (Pt 11), 3285-3289 (2006)
   PUBMED   17030862
  REMARK    GeneRIF: IFIT2/GARG39 was identified as a microtubule-associated
            protein enriched in the mitotic spindle of mouse NIH3T3 and B16F10
            melanoma cells.
REFERENCE   7  (bases 1 to 3806)
  AUTHORS   Smith,J.B. and Herschman,H.R.
  TITLE     The glucocorticoid attenuated response genes GARG-16, GARG-39, and
            GARG-49/IRG2 encode inducible proteins containing multiple
            tetratricopeptide repeat domains
  JOURNAL   Arch Biochem Biophys 330 (2), 290-300 (1996)
   PUBMED   8660659
REFERENCE   8  (bases 1 to 3806)
  AUTHORS   Smith,J.B. and Herschman,H.R.
  TITLE     Glucocorticoid-attenuated response genes encode intercellular
            mediators, including a new C-X-C chemokine
  JOURNAL   J Biol Chem 270 (28), 16756-16765 (1995)
   PUBMED   7622488
REFERENCE   9  (bases 1 to 3806)
  AUTHORS   Bluyssen,H.A., Vlietstra,R.J., Faber,P.W., Smit,E.M., Hagemeijer,A.
            and Trapman,J.
  TITLE     Structure, chromosome localization, and regulation of expression of
            the interferon-regulated mouse Ifi54/Ifi56 gene family
  JOURNAL   Genomics 24 (1), 137-148 (1994)
   PUBMED   7896268
REFERENCE   10 (bases 1 to 3806)
  AUTHORS   Lee,C.G., Demarquoy,J., Jackson,M.J. and O'Brien,W.E.
  TITLE     Molecular cloning and characterization of a murine LPS-inducible
            cDNA
  JOURNAL   J Immunol 152 (12), 5758-5767 (1994)
   PUBMED   8207206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102249.16.
            
            On Sep 20, 2017 this sequence version replaced XM_006526706.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.187705.1,
                                           SRR1660811.88378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC102249.16        180309-180494
            187-338             AC102249.16        199440-199591
            339-3806            AC102249.16        202288-205755
FEATURES             Location/Qualifiers
     source          1..3806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.73 cM"
     gene            1..3806
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /note="interferon-induced protein with tetratricopeptide
                     repeats 2"
                     /db_xref="GeneID:15958"
                     /db_xref="MGI:MGI:99449"
     exon            1..186
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /inference="alignment:Splign:2.1.0"
     exon            187..338
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1746
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /note="IFIT-2; interferon-induced 54 kDa protein;
                     glucocorticoid-attenuated response gene 39 protein"
                     /codon_start=1
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 2"
                     /protein_id="NP_001342191.1"
                     /db_xref="CCDS:CCDS29761.1"
                     /db_xref="GeneID:15958"
                     /db_xref="MGI:MGI:99449"
                     /translation="MSTTSKESLESNLRQLKCHFTWNLIAEDESLDEFEDRVFNKDEF
                     QNSEFKATMCNILAYVKHCRGLNEAALQCLGEAEGFIQQQHPDQVEIRSLVTWGNYAW
                     VYYHMGQFSKAQAYLDKVKQVCKKFSSPYRIENPALDCEEGWARLKCTKNQNERVKVC
                     FQKALEKDPKNPEFTSGWAIANYRLDDWPARNYCIDSLEQAIQLSPDNTYVKVLLALK
                     LDAVHKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNA
                     YVHYYMGCCYRSKVHHMLNRREMVFSGDRKKLEELIQLAVNHLRKAEEIKEMLEYSCS
                     FLADLYIIAKKYDEADYYFQKELSKDLPPGPKQLLHLRYGNFQFFQMKRQDKAIYHYM
                     EGVKIKKKTIPQKKMREKLQRIALRRLHEDESDSEALHILAFLQENGGGQQADKDSER
                     GVDSANQVPSASLDEAGAEY"
     exon            339..3806
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3774..3779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /note="hexamer: AATAAA"
     polyA_site      3795
                     /gene="Ifit2"
                     /gene_synonym="GARG-39; IFI-54K; Ifi54; P54"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgtggt ggactctggg tcctaagcta tatatctagt cactctttta tccagaaccc
       61 accctcagct cactcaaagg ctttcaaaaa cagctttttt ttttttttac ttccggttgt
      121 ttatttgaga aggaatgcac cagaaattac agaaaccttt ttaatgtccc acaacctctc
      181 aactctgtgc tgcacagaag caggaaaagg aaccagctgc tcctatatat aggtctggag
      241 cacttcatta gaaggcagag gaagaggttg cctggagagt ggctgcagcc ctgctttgag
      301 cgctttgaca cagcagacag ttacacagca gtcatgagta caacgagtaa ggagtcactg
      361 gagagcaatc tgcgacagct aaaatgccat ttcacctgga acctgatagc agaagatgag
      421 tccttggatg agtttgagga cagggtgttt aacaaggatg agtttcagaa cagtgagttt
      481 aaagccacca tgtgcaacat actggcctat gtaaagcact gcagaggtct aaatgaggca
      541 gcactgcaat gcttagggga agctgagggc ttcatccagc aacagcatcc tgaccaagta
      601 gaaatcagaa gtctggtcac ctggggaaac tatgcttggg tctactatca catgggccag
      661 ttctcaaagg ctcaggctta tctggataaa gtgaaacagg tctgcaagaa gttttccagc
      721 ccctacagga ttgagaatcc tgctcttgac tgtgaggagg ggtgggcccg attaaagtgt
      781 accaagaacc aaaacgagag agtgaaggtg tgtttccaga aggctctgga aaaggacccg
      841 aagaacccag aattcacctc tggatgggcc attgcgaact accgtctgga tgactggcca
      901 gcaaggaatt actgcattga ctctctggag caagccattc aactgtctcc tgacaacact
      961 tatgttaaag tcctcttggc actgaagctt gacgcggtac ataaaaacca agcaatggcg
     1021 ctggttgaag aagccttaaa gaaagaccca agtgcaatag atacactcct cagggcagcc
     1081 aggttttatt gcaaggtata tgacacagac agagctatac agttgcttag aaaggctttg
     1141 gaaaagctgc caaacaacgc ctatgtgcat tactatatgg ggtgctgtta taggtcaaaa
     1201 gtccatcata tgttgaacag aagggaaatg gtatttagtg gggataggaa gaagttagag
     1261 gaactaatac aactggcagt gaatcactta cggaaagcag aggaaatcaa ggagatgctt
     1321 gaatattcct gtagcttcct tgctgatctt tatatcatag caaaaaagta tgacgaagcc
     1381 gattactact tccagaaaga attgagcaag gacctccctc ctggccctaa acagttactc
     1441 caccttcggt atggcaactt tcagtttttt caaatgaagc gtcaagacaa ggctatctac
     1501 cattatatgg agggtgtgaa aataaagaag aaaacaatcc cccaaaaaaa gatgagagag
     1561 aaacttcaaa gaattgccct aaggcggctt catgaagatg agtctgattc tgaggccttg
     1621 catatcttgg catttcttca ggagaatgga ggaggtcagc aagctgataa agactctgag
     1681 aggggagtgg actctgcaaa ccaggtacct tcagcatctt tggatgaagc aggtgctgaa
     1741 tactagtgat gtggtacccg gcctactgct ggaaggaaaa agaaagccct caccaagctg
     1801 ccattcaaaa tacttaacca cttcctggat caagaatggg ctatcatact gactatagta
     1861 tttgtcagga gtttggggaa ctctgctatc agattctagc acctgagttt ctggatcgtg
     1921 ggatggtctg ggagagggac cagatgaggt gatagataca ggatcttggc aaacagccta
     1981 gagctctttc aatttttttt tggaaaaata gtttccacag tagtaaattc tttaatcaca
     2041 cccacccctc agtggaggct tgtcttgggc ttgtttcagt atttgtataa agcagccaaa
     2101 ttcctcacat gggtgaatgt tccatccttg aattatttta gatattgcac agcattttct
     2161 tcatagataa tagtgtccat caaaaagctg aggagtcaga gactgtggct caggactgta
     2221 atcctagcac ttggaatctg agacaggagg attacagtga acttgaggtc agcctgagca
     2281 tgacctggaa gggatggtgg gaggtgagaa ttatatgtat aaatattaat gattatgtac
     2341 attaccttgt tagtttgggt gagtatatgt ctatataacc actatcacat atatctaaaa
     2401 atacagaagg gagaggtttt gctttattga ataactttaa gacttaccaa ataatgttca
     2461 atattaattg agctcaaaat ataaattgaa tagtgagtcc caggtctgga agggatggtg
     2521 ggaggtgaga attaaatgtg taaatattaa tgattatgta cattaccttg ttagtttggg
     2581 tgagtatatg tctatataac cactactatc acatatatat aaaaacacag aagggagagg
     2641 ttttgcttta ttgaataact ttaagactta ccaaataatg ttcaatatta attgagctca
     2701 aaatagaaat tgaatagtga gtcccaggtc taaaaacaaa caacaaaagt tgtgggacca
     2761 agtcattcct ccaattacca gccagttctc aatctatggt gtcccacaca catgagttca
     2821 actgttccat tagctcaggt ggcagcagga ttcgaaaaac tgaggacagg gtgagtcaga
     2881 agggtcacat ctgtgcaaag cagtagactc aggcagccac accagacttc caggagtcgc
     2941 atgggaagat gtctccctac tctgccctcc tagaactata tagttgtagg aaaagaaggg
     3001 agattctgtc taccaccatg acaattcata taaacattta tttcaagagt atggaaacac
     3061 cagtggggat gaagggattg ctgatttata cgcgatgatt ataaactcat gaggaaaaag
     3121 tttatagtca ctgttaggaa gatttctctg tcaaataaat aatttattca gaaatgctat
     3181 aaagaaatgc caggaagaca gctgcctaga aggataactt ggattgatgc ttgggtcaag
     3241 ggactttgaa aatgtcatgg gtactggagt tgagttgttt tattccatgt gaaatgtgtc
     3301 acaccaaggg atataaataa tttttataac tctgaaaaaa aatacagaaa caccacaaac
     3361 ttgataattg ccatttccta ggtagatctg gaagggccta aatgttaagg ttggtgtgaa
     3421 ttgacagagt caagtggccc agtatgagac ggtcagccac actctgggat aaaaaaatgt
     3481 ttctctactg ggttcagctt gtctctatgt atatatgaac attttattca gcaattaaaa
     3541 catccatgat tcatagattg ttaaaactaa acattctaac agctgtatca gtgcttcata
     3601 atattttaaa aatgaaaata ttctctatgc attaagtcca tcgatattca ccatttgaat
     3661 ttctggaaaa ataataaact ttgtttataa gtaacacata atgtaacatt aagctatgct
     3721 ctggttcccc tgaactttac tgtaccttcg tatttttaga ctcaagtact gataataaag
     3781 agtgcattaa ctgtttgttc ttttta
//
