LOCUS       NM_001362130            3218 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus interferon induced protein with tetratricopeptide
            repeats 1B like 2 (Ifit1bl2), transcript variant 2, mRNA.
ACCESSION   NM_001362130 XM_017318045
VERSION     NM_001362130.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3218)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3218)
  AUTHORS   Mears,H.V. and Sweeney,T.R.
  TITLE     Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse
            coronavirus translation and is regulated by complexing with Ifit1c
  JOURNAL   J Biol Chem 295 (51), 17781-17801 (2020)
   PUBMED   33454014
  REMARK    GeneRIF: Mouse Ifit1b is a cap1-RNA-binding protein that inhibits
            mouse coronavirus translation and is regulated by complexing with
            Ifit1c.
REFERENCE   3  (bases 1 to 3218)
  AUTHORS   Langlais,D., Barreiro,L.B. and Gros,P.
  TITLE     The macrophage IRF8/IRF1 regulome is required for protection
            against infections and is associated with chronic inflammation
  JOURNAL   J Exp Med 213 (4), 585-603 (2016)
   PUBMED   27001747
REFERENCE   4  (bases 1 to 3218)
  AUTHORS   Fensterl,V. and Sen,G.C.
  TITLE     Interferon-induced Ifit proteins: their role in viral pathogenesis
  JOURNAL   J Virol 89 (5), 2462-2468 (2015)
   PUBMED   25428874
  REMARK    Review article
REFERENCE   5  (bases 1 to 3218)
  AUTHORS   Diamond,M.S. and Farzan,M.
  TITLE     The broad-spectrum antiviral functions of IFIT and IFITM proteins
  JOURNAL   Nat Rev Immunol 13 (1), 46-57 (2013)
   PUBMED   23237964
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016791.23.
            
            On Apr 6, 2018 this sequence version replaced XM_017318045.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136525.1, BC138202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC016791.23        78358-78441         c
            85-3218             AC016791.23        65679-68812         c
FEATURES             Location/Qualifiers
     source          1..3218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.76 cM"
     gene            1..3218
                     /gene="Ifit1bl2"
                     /gene_synonym="2010002M12Rik; Ifit1b"
                     /note="interferon induced protein with tetratricopeptide
                     repeats 1B like 2"
                     /db_xref="GeneID:112419"
                     /db_xref="MGI:MGI:2148249"
     exon            1..84
                     /gene="Ifit1bl2"
                     /gene_synonym="2010002M12Rik; Ifit1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1453
                     /gene="Ifit1bl2"
                     /gene_synonym="2010002M12Rik; Ifit1b"
                     /codon_start=1
                     /product="interferon induced protein with
                     tetratricopeptide repeats 1B like 2"
                     /protein_id="NP_001349059.1"
                     /db_xref="CCDS:CCDS29765.1"
                     /db_xref="GeneID:112419"
                     /db_xref="MGI:MGI:2148249"
                     /translation="MEQLLSPSNMSEESHKSHIHDSLDELRCHFTWELDIKDKHIHDL
                     EIKISETEFRDPIYSIGMHNLLAYVRHLKGQQDEALQSLKEAEALIQSEQLSKRSLAT
                     WGNCAWLHYHRGSLAEAQVYLDKVEKVCKEFSSPFRYRLECAEMDCEEGWALRKCGSQ
                     NYTRAMACFERALKVEPENPEYNAGYADVAYHLDYYDGNSLQPLKKAVSVKPEDPYLK
                     VLLALKLQDLRKTDEAEKHIKEATLTISSQNNIFGYVAKFYRRKGCVEEALGFLKKAL
                     ETKPSSPYLHFQIGLCHKTQFFQMKKATSRENRKRADQSCHLAICHFKKTLELKPTYD
                     RAYIDLAEVYAKNHQQKEAEDNFQEVLSMSNLGDYMQQEIHFRYGNFQQYYKKSEEAA
                     ITHYLKGLKIEVTSHYRDKLLKALEELAEGRKEDHVLESLSLLGLVCRLRGDTSEAMS
                     CYEKALRLTGAVNPEF"
     exon            85..3218
                     /gene="Ifit1bl2"
                     /gene_synonym="2010002M12Rik; Ifit1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2164..2169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifit1bl2"
                     /gene_synonym="2010002M12Rik; Ifit1b"
                     /note="hexamer: GATAAA"
     polyA_site      2185
                     /gene="Ifit1bl2"
                     /gene_synonym="2010002M12Rik; Ifit1b"
                     /note="major polyA site"
ORIGIN      
        1 agaacacctt tgattgagtt tggaagcatc tcttggcctg aattaaagtg ctatggagca
       61 acttctgagt cccagcaaca tgagtgaaga atctcataaa agtcatatac atgacagcct
      121 ggatgagctg agatgccact ttacctggga gctggacata aaagataagc acatccatga
      181 cttagaaatc aaaatctcag agactgagtt ccgtgatccc atctacagca tcgggatgca
      241 caacctcctg gcctacgtga ggcacctgaa aggccagcag gacgaagccc tgcagagctt
      301 gaaagaagct gaagccttga tccagagcga gcagctgagc aagagaagcc tggcgacctg
      361 gggcaactgt gcctggctgc attaccacag gggcagcttg gcagaagccc aggtctacct
      421 ggacaaggtg gagaaggtgt gcaaggaatt ttcaagtccc ttccgctaca ggctggagtg
      481 tgctgagatg gactgtgagg aaggctgggc cttgcggaag tgtggctcac aaaattatac
      541 acgagccatg gcctgctttg aaagggctct gaaagtggag ccagaaaacc ctgagtacaa
      601 cgctggctat gcagatgtag cctatcacct ggattactat gatggtaatt ctctacaacc
      661 cttaaagaag gctgtcagtg taaaaccaga agatccatac cttaaagttc tccttgccct
      721 aaagctgcag gatttaagaa aaacagatga agcagaaaaa cacattaaag aagctacgct
      781 cacaatatcc tcccagaaca atatctttgg atatgtagcc aaattttacc gaaggaaagg
      841 ttgtgtggag gaagctctcg ggttccttaa aaaagccttg gagacaaaac cttcctctcc
      901 ttacttgcat ttccagattg gcctttgcca taaaacacaa ttttttcaaa tgaaaaaagc
      961 tacaagcagg gagaatagaa aaagagcaga ccaatcatgc catttggcta tatgtcattt
     1021 taaaaagact ttagagctga aacccacata tgacagagca tatattgatt tggctgaggt
     1081 gtacgcaaaa aatcatcaac aaaaagaggc agaggacaat tttcaggaag tgttgagcat
     1141 gagtaacttg ggagattata tgcagcaaga aattcatttc cggtatggca acttccaaca
     1201 atactataag aaatcagaag aggcagccat cacacattac ttaaaaggcc tgaaaataga
     1261 ggtaacttct cactacaggg ataaacttct caaggctttg gaggaactgg ctgaaggacg
     1321 caaggaggat catgtcctgg aaagcttgag cctccttggg ctcgtctgca gactgagagg
     1381 ggacacaagt gaagccatgt catgttatga gaaggccctg aggctcacag gagcagtgaa
     1441 ccctgagttt tgaggtagag cttcttgtta agcgtgagca tgacttccta ttctactagt
     1501 cttttccagc tgttgcctta actatataga accccatgaa gcaagataca tatgatgcct
     1561 tttctattgc ttgcttttct acagccctaa tttattgttg agggcctatg agtgtgtgac
     1621 aagcgtgtcc attctcctgc cacacatgct ggacattttc cttatgagtg tgcctttgga
     1681 ttgcatctcc tataacatca gtcttccagt accctgatca aaggacactt gacacattaa
     1741 ggctcatttt tcatgggatc ttccaaactt cagcaacttc tgacagcaaa ataaatgagc
     1801 aatggtgagc attaaaaggg agaggaattc aagatatctt tacagtgttt cagtccatag
     1861 gcccattttc ataggcttta ctgcagccag aacctgctgg tcaatgacct ccaccctaat
     1921 aatcaatgca tctttttgta tacaagtggt tgatttcaga taattgtggt ggatttctgt
     1981 ggtctacata tattggtctt tattcaccac taagaaagat ttaatgcttc aggaagatag
     2041 aataaagcag taacttctgt gggatgtgcc aacaaaaaaa tgacaaaatt gctaccggac
     2101 agtgttcaga ctatgaagtg ttgtgtaata tcaccttgtt gctttcctaa ccctattata
     2161 ttcgataaaa tctgctaata tcacagactt gtgagtgtat tttttttttt ggaacattaa
     2221 gatctgtatt ctatgattgg atggaaccag agcacagcaa aatcaaactg catagggtta
     2281 ggagggacaa agcaaggaag ctctgggaat atacacacta ctgaacctta aagaatacag
     2341 ggggaaagag agaggaggtt agactatgag aagggtgtct gaaagactcc taagaagttg
     2401 tattagttac tctctatgta aaattcttta atacctgtaa gtcagtgtgt gtcatgcgct
     2461 ctggttgagt cagcttaagc cgagaggctt aaaagtcact catgaggcaa agagcttcaa
     2521 ggaagctctc ttcctggagt ctggcgtttc ctttaaccca tacattaatt tttcattctt
     2581 gagttagtct agtgtatgga tctacatgct ttcttttagt attttcctat tataagtgcc
     2641 ttttaagatt aaattttgac atagctaaag ccttttgtca gtgttccaac agtcttagaa
     2701 cgtccttgag gaagatcatg ggcttaaaat ttagtaggaa tgttactaat cagaatagcc
     2761 ttttgtacta tactatcact tttaataaaa gctaggtcac tcccttacac aggaatttac
     2821 tatcactagg aagaaggaag tttcagacca aaggagaaac cagaatagat acttagaact
     2881 atagcgaagt tacacccata cacacgtatt tacaatggcc taaggggaag gtaaactata
     2941 taatagagta aaataggaac tatggcaaag gagcatagcc cttgaccctg gcttctaaga
     3001 ttagtgaatc ttagatagag cccttgttta tcccagttgt tatcaataaa ttttatccca
     3061 ggtaattttc gttagacctt ttgtgtttgc atttctctgt tttacgtaag attccagtta
     3121 cctcatttgt accttgcaaa tatgtcaccc aacttcctta ttgtcttcta cataaaaagt
     3181 ctaatgcttg atttaaaaaa tacattcaga tctaacac
//
