LOCUS       NM_027835               5519 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus interferon induced with helicase C domain 1 (Ifih1),
            transcript variant 1, mRNA.
ACCESSION   NM_027835
VERSION     NM_027835.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5519)
  AUTHORS   Yermalovich,A.V., Mohsenin,Z., Cowdin,M., Giotti,B., Gupta,A.,
            Feng,A., Golomb,L., Wheeler,D.B., Xu,K., Tsankov,A., Cleaver,O. and
            Meyerson,M.
  TITLE     An essential role for Cmtr2 in mammalian embryonic development
  JOURNAL   Dev Biol 516, 47-58 (2024)
   PUBMED   39094818
REFERENCE   2  (bases 1 to 5519)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5519)
  AUTHORS   Gan,W.L., Ren,X., Ng,V.H.E., Ng,L., Song,Y., Tano,V., Han,J.,
            An,O., Xie,J., Ng,B.Y.L., Tay,D.J.T., Tang,S.J., Shen,H., Khare,S.,
            Chong,K.H.C., Young,D.Y., Wu,B., DasGupta,R. and Chen,L.
  TITLE     Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates
            ADAR1-mediated immunity in the liver
  JOURNAL   Cell Rep 43 (7), 114400 (2024)
   PUBMED   38935501
REFERENCE   4  (bases 1 to 5519)
  AUTHORS   Luca,D., Lee,S., Hirota,K., Okabe,Y., Uehori,J., Izawa,K.,
            Lanz,A.L., Schutte,V., Sivri,B., Tsukamoto,Y., Hauck,F.,
            Behrendt,R., Roers,A., Fujita,T., Nishikomori,R., Lee-Kirsch,M.A.
            and Kato,H.
  TITLE     Aberrant RNA sensing in regulatory T cells causes systemic
            autoimmunity
  JOURNAL   Sci Adv 10 (9), eadk0820 (2024)
   PUBMED   38427731
REFERENCE   5  (bases 1 to 5519)
  AUTHORS   Stock,A.J., Gonzalez Paredes,P., de Almeida,L.P., Kosanke,S.D.,
            Chetlur,S., Budde,H., Wakenight,P., Zwingman,T.A., Rosen,A.B.I.,
            Allenspach,E.J., Millen,K.J., Buckner,J.H., Rawlings,D.J. and
            Gorman,J.A.
  TITLE     The IFIH1-A946T risk variant promotes diabetes in a sex-dependent
            manner
  JOURNAL   Front Immunol 15, 1349601 (2024)
   PUBMED   38487540
  REMARK    GeneRIF: The IFIH1-A946T risk variant promotes diabetes in a
            sex-dependent manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5519)
  AUTHORS   Yoneyama,M., Kikuchi,M., Matsumoto,K., Imaizumi,T., Miyagishi,M.,
            Taira,K., Foy,E., Loo,Y.M., Gale,M. Jr., Akira,S., Yonehara,S.,
            Kato,A. and Fujita,T.
  TITLE     Shared and unique functions of the DExD/H-box helicases RIG-I,
            MDA5, and LGP2 in antiviral innate immunity
  JOURNAL   J Immunol 175 (5), 2851-2858 (2005)
   PUBMED   16116171
  REMARK    GeneRIF: Shared and unique functions of the DExD/H-box helicases
            RIG-I, MDA5, and LGP2 in antiviral innate immunity.
REFERENCE   7  (bases 1 to 5519)
  AUTHORS   Ernst,P., Fisher,J.K., Avery,W., Wade,S., Foy,D. and Korsmeyer,S.J.
  TITLE     Definitive hematopoiesis requires the mixed-lineage leukemia gene
  JOURNAL   Dev Cell 6 (3), 437-443 (2004)
   PUBMED   15030765
REFERENCE   8  (bases 1 to 5519)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   9  (bases 1 to 5519)
  AUTHORS   Kovacsovics,M., Martinon,F., Micheau,O., Bodmer,J.L., Hofmann,K.
            and Tschopp,J.
  TITLE     Overexpression of Helicard, a CARD-containing helicase cleaved
            during apoptosis, accelerates DNA degradation
  JOURNAL   Curr Biol 12 (10), 838-843 (2002)
   PUBMED   12015121
  REMARK    Erratum:[Curr Biol. 2002 Sep 17;12(18):1633.]
REFERENCE   10 (bases 1 to 5519)
  AUTHORS   Kang,D.C., Gopalkrishnan,R.V., Wu,Q., Jankowsky,E., Pyle,A.M. and
            Fisher,P.B.
  TITLE     mda-5: An interferon-inducible putative RNA helicase with
            double-stranded RNA-dependent ATPase activity and melanoma
            growth-suppressive properties
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 637-642 (2002)
   PUBMED   11805321
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929246.7, AK168646.1 and AY075132.1.
            
            On Sep 2, 2009 this sequence version replaced NM_027835.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153018.1, AF374384.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL929246.7         67902-67906         c
            6-325               AK168646.1         7-326
            326-3403            AY075132.1         1-3078
            3404-5519           AL929246.7         17444-19559         c
FEATURES             Location/Qualifiers
     source          1..5519
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 35.85 cM"
     gene            1..5519
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /note="interferon induced with helicase C domain 1"
                     /db_xref="GeneID:71586"
                     /db_xref="MGI:MGI:1918836"
     exon            1..778
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..3403
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     interferon-induced helicase C domain-containing protein 1;
                     helicase with 2 CARD domains; melanoma
                     differentiation-associated protein 5; interferon induced
                     with helicase C domain protein 1; RIG-I-like receptor 2"
                     /codon_start=1
                     /product="interferon-induced helicase C domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_082111.2"
                     /db_xref="CCDS:CCDS16068.1"
                     /db_xref="GeneID:71586"
                     /db_xref="MGI:MGI:1918836"
                     /translation="MSIVCSAEDSFRNLILFFRPRLKMYIQVEPVLDHLIFLSAETKE
                     QILKKINTCGNTSAAELLLSTLEQGQWPLGWTQMFVEALEHSGNPLAARYVKPTLTDL
                     PSPSSETAHDECLHLLTLLQPTLVDKLLINDVLDTCFEKGLLTVEDRNRISAAGNSGN
                     ESGVRELLRRIVQKENWFSTFLDVLRQTGNDALFQELTGGGCPEDNTDLANSSHRDGP
                     AANECLLPAVDESSLETEAWNVDDILPEASCTDSSVTTESDTSLAEGSVSCFDESLGH
                     NSNMGRDSGTMGSDSDESVIQTKRVSPEPELQLRPYQMEVAQPALDGKNIIICLPTGS
                     GKTRVAVYITKDHLDKKKQASESGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLS
                     GDTQLKISFPEVVKSYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTN
                     KEAVYNNIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEKHIL
                     NICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMASIQTYC
                     QKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIRMIDAY
                     SHLETFYTDEKEKKFAVLNDSDKSDDEASSCNDQLKGDVKKSLKLDETDEFLMNLFFD
                     NKKMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFTKTRQSTYALSQWIME
                     NAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEEGLDI
                     KECNIVIRYGLVTNEIAMVQARGRARADESTYVLVTSSGSGVTEREIVNDFREKMMYK
                     AINRVQNMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLV
                     CSGENIHVIEKMHHVNMTPEFKGLYIVRENKALQKKFADYQTNGEIICKCGQAWGTMM
                     VHKGLDLPCLKIRNFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCLYSDED"
     exon            779..947
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1094
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1199
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1423
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1634
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1852
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1969
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2093
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2369
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2629
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2779
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2941
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3132
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3223
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..5519
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3846..3851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /note="hexamer: AATAAA"
     polyA_site      3865
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /note="major polyA site"
     regulatory      3988..3993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /note="hexamer: TATAAA"
     polyA_site      4011
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
     regulatory      5031..5036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
                     /note="hexamer: ATTAAA"
     polyA_site      5053
                     /gene="Ifih1"
                     /gene_synonym="9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2"
ORIGIN      
        1 gttgacgtta ggaaagtctg gagaagagaa tcgaaacaga aaccgatctg tgggtggaag
       61 gcaatactta aagctccctg agggtgaacg tcccagcggc cgcagagcga gagcggtccc
      121 gggtctgtgc ccaccagttg cagcgctgtc ctggctcgtc tgccccctgc cgggtgccac
      181 cgatcgatcc ggtgctcgga ggctacttgg tacctgcggc tctcaggcag ttcaggcggg
      241 gacacattca ctgccacctg aggatcgtcc tcccgcccgc cccgcccgcc cgggagactc
      301 ctctcccatt tcctgagacc tcacgatgtc gattgtctgt tctgcagagg acagcttcag
      361 gaatctcatc ttattcttca ggcccaggct gaaaatgtac attcaggtgg agccagtgct
      421 ggaccacctc atctttctgt ctgcagaaac caaagagcag attcttaaaa agatcaacac
      481 ctgtggtaac accagcgcgg cagaactgct gctgagcacc ttggagcagg gacaatggcc
      541 tctgggatgg acgcagatgt tcgtggaggc cctagagcac agtggcaatc ccctagccgc
      601 gcgctatgtc aaacccacac tcactgatct gccctctcct tcctctgaga ctgcccatga
      661 cgagtgtctc cacttgctga ccctcctcca gcccactttg gtggacaaac ttctgattaa
      721 cgatgtcttg gacacttgct tcgagaaggg actattgaca gtcgaagaca gaaatcggat
      781 ttctgctgca ggaaacagcg ggaatgagtc aggtgtaaga gagctgctga gaaggattgt
      841 gcagaaggaa aactggtttt ctaccttcct ggatgttctg cgccaaactg gaaatgatgc
      901 actattccaa gaactaacag gtggaggctg cccagaagac aacacagact tggctaactc
      961 gtctcacaga gatgggcctg cagctaatga gtgtcttctg cctgctgtcg atgagtcaag
     1021 tctggagaca gaggcctgga acgtagacga catattacca gaggcttctt gtacagattc
     1081 gtctgtgacc acagaatcag acacaagttt ggcagaagga agtgtcagct gcttcgatga
     1141 aagtcttgga cataacagca acatgggcag ggattcaggc accatgggaa gtgattcaga
     1201 tgaaagtgtc atccagacaa aaagagtatc ccccgagcca gaactgcagc tcaggcctta
     1261 ccaaatggaa gtggcccaac cagctctaga tgggaagaat attattatct gcctccccac
     1321 ggggagtggg aaaaccagag tggctgttta catcaccaaa gatcacttag acaagaagaa
     1381 gcaggcatct gaatccggga aggttatcgt tcttgtcaat aaggtaatgt tagcagaaca
     1441 acttttccga aaagagttca acccatattt gaagaaatgg tatcgaatta ttggattaag
     1501 tggcgatacc cagctgaaaa tatcatttcc agaagttgtc aaatcttacg atgttattat
     1561 cagcactgct caaatccttg aaaactccct cttaaatctg gagagtggag acgatgacgg
     1621 tgtgcagctg tcagacttct ctctcattat cattgatgag tgccatcaca ccaacaagga
     1681 ggcagtctat aacaacatca tgagacgata tttgaagcag aagctgagaa acaatgacct
     1741 caagaaacaa aacaaaccag ccattcccct gccgcagata ctaggactga cagcttcacc
     1801 tggtgttgga gcagccaaaa agcagtctga ggctgaaaaa catattttaa atatatgtgc
     1861 caatcttgat gcctttacca ttaaaacagt gaaagagaat cttggtcaac tcaaacacca
     1921 aataaaggaa ccatgcaaga aatttgtgat tgctgatgac accagagaaa atccatttaa
     1981 agagaaactt ctagaaatta tggcaagcat tcagacttac tgccaaaaaa gtccaatgtc
     2041 agattttgga acccaacatt atgagcagtg ggccattcaa atggagaaaa aagctgctaa
     2101 agacggaaat cgcaaagatc gcgtctgtgc agaacatttg aggaagtaca acgaagccct
     2161 acaaatcaac gacacgatcc gaatgattga tgcatatagc cacctggaga cattctacac
     2221 tgatgagaaa gaaaagaagt tcgcagtcct caatgacagc gacaagagtg atgacgaggc
     2281 cagcagttgc aatgaccaac ttaagggcga tgtaaagaaa tctttgaaac tggacgaaac
     2341 ggatgaattt ctcatgaatt tgttctttga taacaagaaa atgttgaaaa aactagctga
     2401 aaacccaaaa tacgagaatg aaaaactcat taaattaaga aacacgatac tggaacaatt
     2461 cacaaggtct gaggagtcct cccgaggaat tatttttaca aaaacacgac agagcaccta
     2521 cgcactttcc cagtggatca tggaaaatgc aaagtttgcg gaagttggag tcaaagcgca
     2581 tcacctgatt ggcgcggggc acagcagtga agtcaagccc atgactcaga ctgaacaaaa
     2641 agaagtcatt agtaaatttc gcactggcga aataaatctg cttatcgcta cgacggtggc
     2701 agaggaaggc ctggatatca aagagtgcaa tattgttatt cgttatggcc ttgtcacgaa
     2761 cgagatagcc atggtccagg cccggggtcg agccagagct gatgaaagca cgtatgtcct
     2821 ggtcaccagc agtggctcag gagttaccga acgggagatt gttaatgatt tccgagagaa
     2881 gatgatgtat aaagctatta accgtgttca aaacatgaaa ccagaggagt atgcacataa
     2941 gattttggaa ttgcaggtgc aaagtatcct ggaaaagaaa atgaaagtca aaagaagcat
     3001 tgcaaagcaa tacaacgaca atccatcgtt aataacactt ctctgcaaaa attgtagcat
     3061 gctggtctgc tcgggagaaa acatccatgt cattgagaag atgcatcatg tcaatatgac
     3121 accagaattc aagggactct acattgtaag agaaaacaaa gcactgcaaa agaaatttgc
     3181 tgattatcag accaatggag agattatctg caagtgtggc caggcttggg gaacaatgat
     3241 ggtgcacaaa ggtttagatt tgccttgtct taaaataagg aattttgtag tcaatttcaa
     3301 aaataactca ccgaagaaac agtacaagaa gtgggtggaa ttgcctatca gatttcctga
     3361 tcttgactac tcagaatact gcttgtatag tgatgaagat tagcacttga ttcatgatta
     3421 ttttaaaata ttgccaactc aacattgaat atgattttaa ttgttgtttt cgctacacta
     3481 ctgagctaac tctagaatat gtagaggatg cttttgtttg gctttcagtg atgtaacaga
     3541 acaccaaaaa tgtaaacatc ttattggttg gtaaatgtaa ttggtaatca aaattgtcaa
     3601 tttgatgagt tctaaaatca cctgggctca gggaatgccc atgaggtatt gtcctaaatt
     3661 aattaaggaa gatctgttct ctgtgggtga tctcgggcta cataaaatta agaaaactag
     3721 ctgagtccac atttgctctc ataactttgc acttcattgt gcaatgcaat gtggcaagct
     3781 acttcaagct cctgtcactg tgactaccac acagtcatgg attaaaacct caaactgcaa
     3841 gctacaataa atcatttctt ccaaagttgt tatggtcagg gtgtttcatc acagcaacag
     3901 aaaagtaact aaaacatcag ggataaggaa aatctaccaa caatactcat aactgcaaag
     3961 tgttatagta ttatggaaac actggaatat aaatgagaac ccaagtacca atattagccc
     4021 tgtcactgat ttttttttcc agatctattt attttatgtc tatgtctgct tggcccgcat
     4081 gtatgtatgg gcaccatatg catttctggt gcctctggag gtcagagaaa ggcaccagat
     4141 cccctgaagt tggagttata gatgattgtg agccaccacg tgggggccgg gaatcaaaca
     4201 tgggtcctct gcatgagcaa caagtactca accactaaac cattgtccca gactctcggt
     4261 cactgatttc cacagtcaag ttcatctcct cagttcaccc ttcttccgca gcctccttat
     4321 ggtgaaatgt tgattgaact acctgcttct attgacaccc ttcagggttt taaatacacc
     4381 tacgcattat agcagctgtt ttgtatgcca aacatctaga tgtcgttttc ttacaaggct
     4441 gaaatcagtt tcagccagac tgttctgatc caaaggcctt gaaggaggaa acggtgctca
     4501 ctgacaatcc gtttccttgc agctgtctgg ctaggatttc tgttttcttg ctacatttcc
     4561 accaggaatt gctctcacat cctaggaatg ctttagcctg tggcttcttc aggaaggcct
     4621 cacagtacat atcatgtgtt tcttcaaggg cgagcagtag aaactctcaa agctactaag
     4681 gaatcttatg taacttaact atagtattag gagcacaata cattatgctt tggatgaggc
     4741 atcttatcga taagcagact tgaaacttac tctggattgt taactggtaa gattggcagt
     4801 gacctgggat aaggatgtct gggcattcct atcccgtgtg gctggtaggc catgcccaca
     4861 ctcaaagcaa ggggatatag ataattcagg atatcacgca tgaactgaca tgatttggga
     4921 aggaatcttg gaggtcattt tatagtcact tgttcatttt ttgctgttat gatgtatatc
     4981 cataggtgat catattgaca aacaggaaac tcgataaaga aagtaatgtt attaaaacac
     5041 agtatcaagt gggttcaggc ttgcttcttc tgccttctct tctgcaaaca cagtaccatc
     5101 ctggaatacg acctaatcat ctcttatgat gaagggagtg aagaaagtat tttttgtagt
     5161 tttttttttg tagtttaatt ccatattaag atatcttgaa tcttttattg atgagaactg
     5221 agccaaaatg aaaatattaa tcagaactct taggaatata aatggacaaa agaagaattg
     5281 gttttcttaa aatacttgaa gcattccatc taaatctatt taaagtattg ttctattcta
     5341 aagaattttg gaaactatgc aggaaatcaa atatctaaga tatccaagta gaccactgta
     5401 acatatatat tctgtttctg aaacatcaac aaatatcagg gtgtatattt gtttggtttt
     5461 gtcaatattt tatttcaata gttatttcta aattaaagat gtatatttca gatactatt
//
